Cited by 292Fatty Acid Research and HealthNutritional Studies and DietLipoproteins and Cardiovascular Health

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Plasma Phospholipid Fatty Acid Concentration and Incident Coronary Heart Disease in Men and Women: The EPIC-Norfolk Prospective Study

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Khaw, Kay-Tee, Friesen, Marlin D., Riboli, Elio, Luben, Robert, Wareham, Nicholas·2012·PLoS Medicine

DOI 10.1371/journal.pmed.1001255PMC PMC3389034

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Abstract

BACKGROUND: The lack of association found in several cohort studies between dietary saturated fat and coronary heart disease (CHD) risk has renewed debate over the link between dietary fats and CHD. METHODS AND FINDINGS: We assessed the relationship between plasma phospholipid fatty acid (PFA) concentration and incident CHD using a nested case control design within a prospective study (EPIC-Norfolk) of 25,639 individuals aged 40-79 years examined in 1993-1997 and followed up to 2009. Plasma PFA concentrations were measured by gas chromatography in baseline samples retrieved from frozen storage. In 2,424 men and women with incident CHD compared with 4,930 controls alive and free of cardiovascular disease, mean follow-up 13 years, saturated PFA (14:0, 16:0,18:0) plasma concentrations were significantly associated with increased CHD risk (odds ratio [OR] 1.75, 95% CI 1.27-2.41, p<0.0001), in top compared to bottom quartiles (Q), and omega-6 polyunsaturated PFA concentrations were inversely related (OR 0.77, 0.60-0.99, p<0.05) after adjusting for age, sex, body mass index, blood pressure, smoking, alcohol intake, plasma vitamin C, social class, education, and other PFAs. Monounsaturated PFA, omega-3 PFA, and trans PFA concentrations were not significantly associated with CHD. Odd chain PFA (15:0, 17:0) concentrations were significantly inversely associated with CHD (OR 0.73, 0.59-0.91, p<0.001, Q4 versus Q1). Within families of saturated PFA or polyunsaturated PFA, significantly heterogeneous relationships with CHD were observed for individual fatty acids. CONCLUSIONS: In this study, plasma concentrations of even chain saturated PFA were found to be positively and omega-6 polyunsaturated PFA inversely related to subsequent coronary heart disease risk. These findings are consistent with accumulating evidence suggesting a protective role of omega-6 fats substituting for saturated fats for CHD prevention.

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Authors: Khaw, K.-T., Friesen, M. D., Riboli, E., Luben, R., & Wareham, N.
Affiliations: University of Cambridge (GB)
Johns Hopkins University (US)
MRC Epidemiology Unit (GB)
Corresponding author: Khaw, Kay-Tee
ORCID: Khaw, Kay-Tee
Luben, Robert
Wareham, Nicholas
Venue: PLoS Medicine
Publisher: Public Library of Science (PLoS)
Published: 2012-07-03
Volume: 9
Issue: 7
Pages: e1001255
ISSN: 1549-1277 (ISSN-L)
1549-1676
DOI: 10.1371/journal.pmed.1001255
PMC: PMC3389034
OpenAlex: W2071137319
Cited by: 291
References: 41
Citations by year: 2026: 17 · 2025: 15 · 2024: 21 · 2023: 26 · 2022: 28 · 2021: 33 · 2020: 22 · 2019: 19 · 2018: 26 · 2017: 20 · 2016: 14 · 2015: 12 · 2014: 18 · 2013: 18 · 2012: 1
FWCI: 14.64
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS Medicine (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Figshare (submittedVersion, cc-by)
Funders: Cancer Research UK
Medical Research Council
Japan Society for the Promotion of Science (24249057)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords: plasma phospholipid fatty acids, coronary artery disease, saturated fatty acids, omega-6 fatty acids, odd-chain fatty acids, dietary fat, cardiovascular risk, EPIC-Norfolk study, omega-3 fatty acids, trans fatty acids, monounsaturated fatty acids
MeSH terms: Adult, Aged, Coronary Disease, Fatty Acids, Female, United Kingdom, Humans, Male, Middle Aged, Phospholipids, Prospective Studies, Incidence, Odds Ratio, Case-Control Studies

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Plasma Phospholipid Fatty Acid Concentration and Incident Coronary Heart Disease in Men and Women: The EPIC-Norfolk Prospective Study

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