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Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study
Open accessAbstract
BACKGROUND: For virtually every patient with colorectal cancer (CRC), hematoxylin-eosin (HE)-stained tissue slides are available. These images contain quantitative information, which is not routinely used to objectively extract prognostic biomarkers. In the present study, we investigated whether deep convolutional neural networks (CNNs) can extract prognosticators directly from these widely available images. METHODS AND FINDINGS: We hand-delineated single-tissue regions in 86 CRC tissue slides, yielding more than 100,000 HE image patches, and used these to train a CNN by transfer learning, reaching a nine-class accuracy of >94% in an independent data set of 7,180 images from 25 CRC patients. With this tool, we performed automated tissue decomposition of representative multitissue HE images from 862 HE slides in 500 stage I-IV CRC patients in the The Cancer Genome Atlas (TCGA) cohort, a large international multicenter collection of CRC tissue. Based on the output neuron activations in the CNN, we calculated a "deep stroma score," which was an independent prognostic factor for overall survival (OS) in a multivariable Cox proportional hazard model (hazard ratio [HR] with 95% confidence interval [CI]: 1.99 [1.27-3.12], p = 0.0028), while in the same cohort, manual quantification of stromal areas and a gene expression signature of cancer-associated fibroblasts (CAFs) were only prognostic in specific tumor stages. We validated these findings in an independent cohort of 409 stage I-IV CRC patients from the "Darmkrebs: Chancen der Verhütung durch Screening" (DACHS) study who were recruited between 2003 and 2007 in multiple institutions in Germany. Again, the score was an independent prognostic factor for OS (HR 1.63 [1.14-2.33], p = 0.008), CRC-specific OS (HR 2.29 [1.5-3.48], p = 0.0004), and relapse-free survival (RFS; HR 1.92 [1.34-2.76], p = 0.0004). A prospective validation is required before this biomarker can be implemented in clinical workflows. CONCLUSIONS: In our retrospective study, we show that a CNN can assess the human tumor microenvironment and predict prognosis directly from histopathological images.
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“We applied Loki Annotate to four benchmark histopathology datasets including CRC7K41 (eight tissue types), WSSS-4LUAD42 (normal and tumor), PatchCamelyon43 (normal and tumor) and LC2500044 (benign and malignant).”
From A visual–omics foundation model to bridge histopathology with spatial transcriptomics (2025) · cites this paper as [41]
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“Prognostic AI models for colorectal cancer have been developed for various data modalities, including MRI (88), histopathology (89-91), and multiplex imaging (92,93).”
From Artificial Intelligence in Oncology: Current Landscape, Challenges, and Future Directions (2024) · cites this paper as [90]
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Cites
Deep Residual Learning for Image Recognition
He, K., Zhang, X., Ren, S., & Sun, J. (2016) · 2016 IEEE Conference on Computer Vision and Pattern Recognition (CVPR) · doi:10.1109/cvpr.2016.90 · Cited by 235,474
Very Deep Convolutional Networks for Large-Scale Image Recognition
Simonyan, K., & Zisserman, A. (2014) · arXiv · doi:10.48550/arxiv.1409.1556 · Cited by 114,148
ImageNet classification with deep convolutional neural networks
Krizhevsky, A., Sutskever, I., & Hinton, G. E. (2017) · Communications of the ACM · doi:10.1145/3065386 · Cited by 112,155
LeCun, Y., Bengio, Y., & Hinton, G. (2015) · Nature · doi:10.1038/nature14539 · Cited by 84,126
Going deeper with convolutions
Szegedy, C., Liu, W., Jia, Y., Sermanet, P., Reed, S., Anguelov, D., Erhan, D., Vanhoucke, V., & Rabinovich, A. (2015) · 2015 IEEE Conference on Computer Vision and Pattern Recognition (CVPR) · doi:10.1109/cvpr.2015.7298594 · Cited by 48,562
(2008) · Journal of Machine Learning Research · Cited by 33,051
Mastering the game of Go with deep neural networks and tree search
Silver, D., Huang, A., Maddison, C. J., Guez, A., Sifre, L., van den Driessche, G., Schrittwieser, J., Antonoglou, I., Panneershelvam, V., Lanctot, M., et al. (2016) · Nature · doi:10.1038/nature16961 · Cited by 15,612
Dermatologist-level classification of skin cancer with deep neural networks
Esteva, A., Kuprel, B., Novoa, R. A., Ko, J., Swetter, S. M., Blau, H. M., & Thrun, S. (2017) · Nature · doi:10.1038/nature21056 · Cited by 14,362
Hinton, G., Deng, L., Yu, D., Dahl, G., Mohamed, A.-R., Jaitly, N., Senior, A., Vanhoucke, V., Nguyen, P., Sainath, T., et al. (2012) · IEEE Signal Processing Magazine · doi:10.1109/msp.2012.2205597 · Cited by 10,260 · cited 1×
“Applications of CNNsrangewidely,from speechrecognition[14,15],facerecognition[16], or traffic sign classification[17] to masteringtheJapanese gameof Go [18].”
BackgroundQuPath: Open source software for digital pathology image analysis
Bankhead, P., Loughrey, M. B., Fernández, J. A., Dombrowski, Y., McArt, D. G., Dunne, P. D., McQuaid, S., Gray, R. T., Murray, L. J., Coleman, H. G., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-17204-5 · Cited by 8,908
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Items 201–300 of 1,001
Abbet, C., Studer, L., Fischer, A., Dawson, H., Zlobec, I., Bozorgtabar, B., & Thiran, J. (2022) · Medical Image Analysis · doi:10.1016/j.media.2022.102473 · Cited by 42
Fedsld: Federated Learning with Shared Label Distribution for Medical Image Classification
Luo, J., & Wu, S. (2022) · IEEE International Symposium on Biomedical Imaging (ISBI) · doi:10.1109/isbi52829.2022.9761404 · Cited by 40
Ma, J., Guo, Z., Zhou, F., Wang, Y., Xu, Y., Li, J., Yan, F., Cai, Y., Zhu, Z., Jin, C., et al. (2025) · Nature Biomedical Engineering · doi:10.1038/s41551-025-01488-4 · Cited by 94
Deep Learning of Histopathological Features for the Prediction of Tumour Molecular Genetics
Murchan, P., O’Brien, C. P., O’Connell, S., McNevin, C. S., Baird, A., Sheils, O. M., Broin, P. Ó., & Finn, S. P. (2021) · Diagnostics · doi:10.3390/diagnostics11081406 · Cited by 39
Deep learning can predict survival directly from histology in clear cell renal cell carcinoma
Wessels, F., Schmitt, M., Krieghoff‐Henning, E., Kather, J. N., Nientiedt, M., KRIEGMAIR, M. C., Worst, T. S., Neuberger, M., Steeg, M., Popović, Z. V., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0272656 · Cited by 41
Self-citationTajeddin, N. Z., Jahanifar, M., Bilal, M., Eastwood, M., & Rajpoot, N. (2024) · Medical Image Analysis · doi:10.1016/j.media.2023.103071 · Cited by 36
He, B., Wang, L., Zhou, W., Liu, H., Wang, Y., Lv, K., & He, K. (2025) · Scientific Reports · doi:10.1038/s41598-025-91420-2 · Cited by 42
Bianconi, F., Kather, J. N., & Reyes‐Aldasoro, C. C. (2020) · Cancers · doi:10.3390/cancers12113337 · Cited by 38
Self-citationSu, F., Li, J., Zhao, X., Wang, B., Hu, Y., Sun, Y. L., & Ji, J. (2022) · Laboratory Investigation · doi:10.1038/s41374-022-00742-6 · Cited by 43
Hao, D., Li, Q., Feng, Q.-X., Qi, L., Liu, X.-S., Arefan, D., Zhang, Y., & Wu, S. (2022) · Artificial Intelligence in Medicine · doi:10.1016/j.artmed.2022.102424 · Cited by 37
DRD-UNet, a UNet-Like Architecture for Multi-Class Breast Cancer Semantic Segmentation
Ortega-Ruíz, M. A., Karabağ, C., Román-Rangel, E., & Reyes‐Aldasoro, C. C. (2024) · IEEE Access · doi:10.1109/access.2024.3377428 · Cited by 39
Self-citationGenerative adversarial U-Net for domain-free few-shot medical diagnosis
Chen, X., Li, Y., Yao, L., Adeli, E., Zhang, Y., & Wang, X. (2022) · Pattern Recognition Letters · doi:10.1016/j.patrec.2022.03.022 · Cited by 37
Multi-modality artificial intelligence in digital pathology
Qiao, Y., Zhao, L., Luo, C., Luo, Y., Wu, Y., Li, S., Bu, D., & Zhao, Y. (2022) · Briefings in Bioinformatics · doi:10.1093/bib/bbac367 · Cited by 44
Guo, B., Li, X., Yang, M., Jonnagaddala, J., Zhang, H., & Xu, S. X. (2023) · The Journal of Pathology Clinical Research · doi:10.1002/cjp2.312 · Cited by 39
Acute myeloid leukemia and artificial intelligence, algorithms and new scores
Radakovich, N., Cortese, M. J., & Nazha, A. (2020) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2020.101192 · Cited by 34
Role of artificial intelligence in multidisciplinary imaging diagnosis of gastrointestinal diseases
Berbis, M. A., Aneiros‐Fernández, J., Olivares, F. J. M., Baro, E. N., & Luna, A. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i27.4395 · Cited by 39
Samadi, P., Soleimani, M., Nouri, F., Rahbarizadeh, F., Najafi, R., & Jalali, A. (2022) · BMC Cancer · doi:10.1186/s12885-022-09931-4 · Cited by 36
Fu, X., Sahai, E. A., & Wilkins, A. C. (2023) · The Journal of Pathology · doi:10.1002/path.6153 · Cited by 37
Pati, P., Foncubierta–Rodríguez, A., Göksel, O., & Gabrani, M. (2020) · Medical Image Analysis · doi:10.1016/j.media.2020.101859 · Cited by 36
Improving feature extraction from histopathological images through a fine-tuning ImageNet model
Li, X., Cen, M., Xu, J., Zhang, H., & Xu, X. S. (2022) · Journal of Pathology Informatics · doi:10.1016/j.jpi.2022.100115 · Cited by 36
LifeLonger: A Benchmark for Continual Disease Classification
Derakhshani, M. M., Najdenkoska, I., van Sonsbeek, T., Zhen, X., Mahapatra, D., Worring, M., & Snoek, C. G. M. (2022) · Lecture notes in computer science · doi:10.1007/978-3-031-16434-7_31 · Cited by 35
Mansur, A., Saleem, Z., Elhakim, T., & Daye, D. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1065402 · Cited by 36
Deep learning in digital pathology for personalized treatment plans of cancer patients
Wen, Z., Wang, S., Yang, D. M., Xie, Y., Chen, M., Bishop, J., & Xiao, G. (2023) · Seminars in Diagnostic Pathology · doi:10.1053/j.semdp.2023.02.003 · Cited by 34
Lee, S. H., & Jang, H. (2022) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2021.0394 · Cited by 39
Zhou, J., pour, A. F., Deirawan, H., Daaboul, F., Aung, T. N., Beydoun, R., Ahmed, F. S., & Chuang, J. H. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104726 · Cited by 35
Pseudo-Data Based Self-Supervised Federated Learning for Classification of Histopathological Images
Zhang, Y., Li, Z., Han, X., Ding, S., Li, J., Wang, J., Ying, S., & Shi, J. (2023) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2023.3323540 · Cited by 36
Role of artificial intelligence in digital pathology for gynecological cancers
Wang, Y., Gao, S., Xiao, Q., Li, C., Grzegorzek, M., Zhang, Y., Li, X., Kang, Y., Liu, F.-H., Huang, D., et al. (2024) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2024.03.007 · Cited by 33
Towards fairness-aware and privacy-preserving enhanced collaborative learning for healthcare
Zhang, F., Zhai, D., Bai, G., Jiang, J., Ye, Q., Ji, X., & Liu, X. (2025) · Nature Communications · doi:10.1038/s41467-025-58055-3 · Cited by 43
Predicting Metastasis Risk in Pancreatic Neuroendocrine Tumors Using Deep Learning Image Analysis
Klimov, S., Xue, Y., Gertych, A., Graham, R. P., Jiang, Y., Bhattarai, S., Pandol, S. J., Rakha, E. A., Reid, M. D., & Aneja, R. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.593211 · Cited by 34
Ananda, A., Ngan, K. H., Karabağ, C., Ter-Sarkisov, A., Alonso, E., & Reyes‐Aldasoro, C. C. (2021) · Sensors · doi:10.3390/s21165381 · Cited by 36
Self-citationA comprehensive survey of intestine histopathological image analysis using machine vision approaches
Jing, Y., Li, C., Du, T., Jiang, T., Sun, H., Yang, J., Shi, L., Gao, M., Grzegorzek, M., & Li, X. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.107388 · Cited by 40
Unsupervised Subtyping of Cholangiocarcinoma Using a Deep Clustering Convolutional Autoencoder
Hassan, M., Sigel, C., Campanella, G. S. V., Boerner, T., Pak, L. M., Büttner, S., IJzermans, J. N. M., Koerkamp, B. G., Doukas, M., Jarnagin, W. R., et al. (2019) · Lecture notes in computer science · doi:10.1007/978-3-030-32239-7_67 · Cited by 34
TeSLA: Test-Time Self-Learning With Automatic Adversarial Augmentation
Tomar, D., Vray, G., Bozorgtabar, B., & Thiran, J. (2023) · IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings - IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings · doi:10.1109/cvpr52729.2023.01948 · Cited by 33
Kockwelp, J., Thiele, S., Bartsch, J., Haalck, L., Gromoll, J., Schlatt, S., Exeler, R., Bleckmann, A., Lenz, G., Wolf, S., et al. (2023) · Blood Advances · doi:10.1182/bloodadvances.2023011076 · Cited by 39
Yoshida, H., & Kiyuna, T. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i21.2818 · Cited by 34
Artificial intelligence for solid tumour diagnosis in digital pathology
Klein, C., Zeng, Q., Arbaretaz, F., Devêvre, E., Caldéraro, J., Loménie, N., & Maiuri, M. C. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15633 · Cited by 36
Machine learning in gastrointestinal surgery
Sakamoto, T., Goto, T., Fujiogi, M., & Lefor, A. K. (2021) · Surgery Today · doi:10.1007/s00595-021-02380-9 · Cited by 33
Xu, Z., Li, Y., Wang, Y., Zhang, S., Huang, Y., Yao, S., Han, C., Pan, X., Shi, Z., Mao, Y. J., et al. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02297-w · Cited by 33
Nazari, E., Aghemiri, M., Avan, A., Mehrabian, A., & Tabesh, H. (2021) · Gene Reports · doi:10.1016/j.genrep.2021.101419 · Cited by 34
Heinz, C. N., Echle, A., Foersch, S., Bychkov, A., & Kather, J. N. (2022) · Histopathology · doi:10.1111/his.14659 · Cited by 34
Self-citationDARC: Deep adaptive regularized clustering for histopathological image classification
Li, J., Liu, J., Yue, H., Cheng, J., Kuang, H., Bai, H. X., Wang, Y., & Wang, J. (2022) · Medical Image Analysis · doi:10.1016/j.media.2022.102521 · Cited by 34
Sandarenu, P., Millar, E. K. A., Song, Y., Browne, L. H., Beretov, J., Lynch, J., Graham, P., Jonnagaddala, J., Hawkins, N. J., Huang, J., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-18647-1 · Cited by 32
Noguchi, T., Ando, T., Emoto, S., Nozawa, H., Kawai, K., Sasaki, K., Murono, K., Kishikawa, J., Ishi, H., Yokoyama, Y., et al. (2022) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izab350 · Cited by 34
Wagner, S. J., Matek, C., Boushehri, S. S., Boxberg, M., Lamm, L., Sadafi, A., Waibel, D., Marr, C., & Peng, T. (2023) · Modern Pathology · doi:10.1016/j.modpat.2023.100350 · Cited by 34
Li, X., Huang, G., Cheng, L., Zhong, G., Liu, W., Chen, X., & Cai, M. (2024) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2024.104728 · Cited by 32
Matías‐Guiu, X., Salvador, J. T., Lopez, P. G., Kammerer‐Jacquet, S., Rioux-Leclercq, N. C., Clark, D., Schürch, C. M., Fend, F., Mattern, S., Snead, D. R. J., et al. (2025) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-025-04064-y · Cited by 32
Shin, Y., Lee, M., Lee, Y. K., Kim, K., & Kim, T. J. (2025) · Life · doi:10.3390/life15040654 · Cited by 40
Benning, L., Peintner, A., & Peintner, L. (2022) · Cancers · doi:10.3390/cancers14030623 · Cited by 34
Li, F., Yang, Y., Wei, Y., Zhao, Y., Fu, J., Xiao, X., Zheng, Z., & Bu, H. (2022) · npj Breast Cancer · doi:10.1038/s41523-022-00491-1 · Cited by 33
Automated System for Colon Cancer Detection and Segmentation Based on Deep Learning Techniques
Azar, A. T., Tounsi, M., Fati, S. M., Javed, Y., Amin, S. U., Khan, Z. I., Alsenan, S. A., & Ganesan, J. (2023) · International Journal of Sociotechnology and Knowledge Development · doi:10.4018/ijskd.326629 · Cited by 32
Deep learning detects virus presence in cancer histologyPreprint
Kather, J. N., Schulte, J. J., Grabsch, H. I., Loeffler, C. M. L., Muti, H. S., Dolezal, J. M., Srisuwananukorn, A., Agrawal, N., Kochanny, S. E., von Stillfried, S. F., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/690206 · Cited by 32
Self-citationHuang, W., Randhawa, R. S., Jain, P., Hubbard, S., Eickhoff, J. C., Kummar, S., Wilding, G., Basu, H. S., & Roy, R. (2022) · JCO Clinical Cancer Informatics · doi:10.1200/cci.21.00131 · Cited by 31
Zhang, J., Cui, Y., Wei, K., Li, Z., Li, D., Song, R., Ren, J., Gao, X., & Yang, X. (2022) · Gastric Cancer · doi:10.1007/s10120-022-01328-3 · Cited by 31
Amin, M., & Ahn, H. (2023) · Cancers · doi:10.3390/cancers15041013 · Cited by 31
Graham, S., Minhas, F., Bilal, M., Ali, M., Tsang, Y. W., Eastwood, M., Wahab, N., Jahanifar, M., Hero, E., Dodd, K., et al. (2023) · Gut · doi:10.1136/gutjnl-2023-329512 · Cited by 33
Artifact Detection and Restoration in Histology Images With Stain-Style and Structural Preservation
Ke, J., Liu, K., Sun, Y., Yuying, X., Huang, J., Lu, Y., Dai, J., Chen, Y., Han, X., Shen, Y., et al. (2023) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2023.3288940 · Cited by 33
Rigamonti, A., Viatore, M., Polidori, R., Rahal, D., Erreni, M., Fumagalli, M. R., Zanini, D., Doni, A., Putignano, A. R., Bossi, P., et al. (2024) · Cancer Research · doi:10.1158/0008-5472.can-23-1698 · Cited by 30
Nguyen, H.-G., Blank, A., Dawson, H., Lugli, A., & Zlobec, I. (2021) · Scientific Reports · doi:10.1038/s41598-021-81352-y · Cited by 29
Applying artificial intelligence in the microbiome for gastrointestinal diseases: A review
Zeng, T., Yu, X., & Chen, Z. (2021) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15503 · Cited by 30
A self-supervised vision transformer to predict survival from histopathology in renal cell carcinoma
Wessels, F., Schmitt, M., Krieghoff‐Henning, E., Nientiedt, M., Waldbillig, F., Neuberger, M., KRIEGMAIR, M. C., Kowalewski, K., Worst, T. S., Steeg, M., et al. (2023) · World Journal of Urology · doi:10.1007/s00345-023-04489-7 · Cited by 29
Self-citationDiagnosis of lymph node metastasis in head and neck squamous cell carcinoma using deep learning
Tang, H., Li, G., Liu, C., Huang, D., Zhang, X., Qiu, Y., & Liu, Y. (2022) · Laryngoscope Investigative Otolaryngology · doi:10.1002/lio2.742 · Cited by 29
Nucleus classification in histology images using message passing network
Hassan, T., Javed, S., Mahmood, A., Qaiser, T., Werghi, N., & Rajpoot, N. (2022) · Medical Image Analysis · doi:10.1016/j.media.2022.102480 · Cited by 29
Altini, N., Marvulli, T. M., Zito, F. A., Caputo, M., Tommasi, S., Azzariti, A., Brunetti, A., Prencipe, B., Mattioli, E., Summa, S. D., et al. (2023) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2023.107511 · Cited by 29
Deep Learning in Single-cell Analysis
Molho, D., Ding, J., Tang, W., Li, Z., Wen, H., Wang, Y., Venegas, J., Jin, W., Liu, R., Su, R., et al. (2024) · ACM Transactions on Intelligent Systems and Technology · doi:10.1145/3641284 · Cited by 38
Wei, T., Yuan, X., Gao, R., Johnston, L. J., Zhou, J. N., Wang, Y., Kong, W., Xie, Y., Zhang, Y., Xu, D., et al. (2022) · Cancer Science · doi:10.1111/cas.15592 · Cited by 30
Liu, Y., Chen, W., Ruan, R., Zhang, Z., Wang, Z., Guan, T., Lin, Q., Tang, W., Deng, J., Wang, Z., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05262-z · Cited by 33
CPLIP: Zero-Shot Learning for Histopathology with Comprehensive Vision-Language Alignment
Javed, S., Mahmood, A., Ganapathi, I. I., Dharejo, F. A., Werghi, N., & Bennamoun, M. (2024) · IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings - IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings · doi:10.1109/cvpr52733.2024.01088 · Cited by 31
Failure Detection in Deep Neural Networks for Medical Imaging
Ahmed, S., Dera, D., Hassan, S. U., Bouaynaya, N. C., & Rasool, G. (2022) · Frontiers in Medical Technology · doi:10.3389/fmedt.2022.919046 · Cited by 28
histolab: A Python library for reproducible Digital Pathology preprocessing with automated testing
Marcolini, A., Bussola, N., Arbitrio, E., Amgad, M. T., Jurman, G., & Furlanello, C. (2022) · SoftwareX · doi:10.1016/j.softx.2022.101237 · Cited by 28
Oral epithelial dysplasia detection and grading in oral leukoplakia using deep learning
Peng, J., Xu, Z., Dan, H., Li, J., Wang, J., Luo, X., Xu, H. Y., Zeng, X. Y., & Chen, Q. (2024) · BMC Oral Health · doi:10.1186/s12903-024-04191-z · Cited by 27
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Shahadat, N., Lama, R., & Nguyen, A. (2024) · Cancers · doi:10.3390/cancers16223879 · Cited by 28
Mahbod, A., Saeidi, N., Hatamikia, S., & Woitek, R. (2025) · Engineering Applications of Artificial Intelligence · doi:10.1016/j.engappai.2025.110571 · Cited by 38
Aurelien, B., Castillo-Olea, C., García-Zapirain, B., & Zahia, S. (2019) · IEEE International Symposium on Signal Processing and Information Technology (ISSPIT) · doi:10.1109/isspit47144.2019.9001816 · Cited by 27
Xu, H., Cong, F., & Hwang, T. H. (2021) · European Urology Focus · doi:10.1016/j.euf.2021.07.006 · Cited by 27
Dabass, M., Vashisth, S., & Vig, R. (2022) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2022.106095 · Cited by 27
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Huang, Z., Bianchi, F., Yüksekgönül, M., Montine, T. J., & Zou, J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.29.534834 · Cited by 27
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Penrice, D. D., Rattan, P., & Simonetto, D. A. (2022) · Gastro Hep Advances · doi:10.1016/j.gastha.2022.02.025 · Cited by 28
Liu, M., Liu, Y., Xu, P., Cui, H., Ke, J., & Ma, J. (2024) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2024.3381994 · Cited by 27
Kumari, P., Chauhan, J., Bozorgpour, A., Huang, B., Azad, R., & Merhof, D. (2025) · Medical Image Analysis · doi:10.1016/j.media.2025.103730 · Cited by 46
Alqudah, A. M., & Alqudah, A. (2021) · Soft Computing · doi:10.1007/s00500-021-06555-x · Cited by 27
Zhang, D., Duan, Y., Guo, J., Wang, Y., Yang, Y., Li, Z., Wang, K., Wu, L., & Yu, M. (2022) · IEEE Journal of Translational Engineering in Health and Medicine · doi:10.1109/jtehm.2022.3156851 · Cited by 25
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Lin, A., Qi, C., Li, M., Guan, R., Имянитов, Е. Н., Mitiushkina, N. V., Cheng, Q., Liu, Z., Wang, X., Lyu, Q., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.869263 · Cited by 26
Chen, Z., Li, X., Yang, M., Zhang, H., & Xu, S. X. (2022) · The Journal of Pathology Clinical Research · doi:10.1002/cjp2.302 · Cited by 33
Zhang, K., Sun, K., Zhang, C., Ren, K., Li, C., Shen, L., & Jing, D. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-04446-8 · Cited by 27
Artificial intelligence in nephropathology
Boor, P. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0220-x · Cited by 26
Ye, H., Ye, Y., Wang, Y., Tong, T., Yao, S., Yao, X., Hu, Q., Liu, Y., Liang, C., Wang, G., et al. (2023) · Medicine Advances · doi:10.1002/med4.9 · Cited by 25
EOCSA: Predicting prognosis of Epithelial ovarian cancer with whole slide histopathological images
Liu, T., Su, R., Sun, C., Li, X., & Wei, L. (2022) · Expert Systems with Applications · doi:10.1016/j.eswa.2022.117643 · Cited by 28
Recent advances of pathomics in colorectal cancer diagnosis and prognosis
Wu, Y., Li, Y., Xiong, X., Liu, X., Lin, B., & Xu, B. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1094869 · Cited by 27
Two Stage Classification with CNN for Colorectal Cancer Detection
Sharma, P., Bora, K., Kasugai, K., & Balabantaray, B. K. (2020) · ONCOLOGIE · doi:10.32604/oncologie.2020.013870 · Cited by 26
EL-CNN: An enhanced lightweight classification method for colorectal cancer histopathological images
Pan, X.-L., Hua, B., Tong, K., Li, X., Luo, J.-L., Yang, H., & Ding, J.-R. (2024) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2024.106933 · Cited by 24
Patharia, P., Sethy, P. K., & Nanthaamornphong, A. (2024) · Cancer Informatics · doi:10.1177/11769351241290608 · Cited by 26
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Shen, Y., & Ke, J. (2021) · IEEE Transactions on Computational Biology and Bioinformatics · doi:10.1109/tcbb.2021.3062230 · Cited by 25
Zhang, L., Dong, D., Zhong, L., Li, C., Hu, C. Y., Yang, X., Liu, Z., Wang, R., Zhou, J., & Tian, J. (2021) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2021.3087634 · Cited by 24
Helman, S. M., Herrup, E. A., Christopher, A. B., & Al‐Zaiti, S. S. (2021) · Cardiology in the Young · doi:10.1017/s1047951121004212 · Cited by 25
Sun, K., Chen, Y., Bai, B., Gao, Y., Xiao, J., & Yu, G. (2023) · Diagnostics · doi:10.3390/diagnostics13071277 · Cited by 25
Teacher-Student chain for efficient semi-supervised histology image classificationPreprint
Shaw, S., Pajak, M., Lisowska, A., Tsaftaris, S. A., & O'Neil, A. Q. (2020) · arXiv (Cornell University) · doi:10.48550/arxiv.2003.08797 · Cited by 26
Registered multi-device/staining histology image dataset for domain-agnostic machine learning models
Ochi, M., Komura, D., Onoyama, T., Shinbo, K., Endo, H., Odaka, H., Kakiuchi, M., Katoh, H., Ushiku, T., & Ishikawa, S. (2024) · Scientific Data · doi:10.1038/s41597-024-03122-5 · Cited by 24
Benchmarking pathology foundation models: Adaptation strategies and scenarios
Lee, J., Lim, J., Byeon, K., & Kwak, J. T. (2025) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2025.110031 · Cited by 37
Schuhmacher, D., Schörner, S., Küpper, C., Großerueschkamp, F., Sternemann, C., Lugnier, C., Kraeft, A., Jütte, H., Tannapfel, A., Reinacher‐Schick, A., et al. (2022) · Medical Image Analysis · doi:10.1016/j.media.2022.102594 · Cited by 26
PlexusNet: A neural network architectural concept for medical image classification
Eminağa, O., Abbas, M., Shen, J., Laurie, M. A., Brooks, J. D., Liao, J. C., & Rubin, D. L. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.106594 · Cited by 27
Metadata
- Authors
- Kather, J. N., Krisam, J., Charoentong, P., Luedde, T., Herpel, E., Weis, C.-A., Gaiser, T., Marx, A., Valous, N. A., Ferber, D., Jansen, L., Reyes-Aldasoro, C. C., Zörnig, I., Jäger, D., Brenner, H., Chang-Claude, J., Hoffmeister, M., & Halama, N.
- Affiliations
- German Cancer Research Center (DE)
- University Hospital Heidelberg (DE)
- Universitätsklinikum Aachen (DE)
- Heidelberg University (DE)
- University Medical Centre Mannheim (DE)
- Corresponding author
- Kather, Jakob Nikolas
- ORCID
- Venue
- PLOS Medicine
- Publisher
- Public Library of Science (PLoS)
- Published
- 2019-01-24
- Volume
- 16
- Issue
- 1
- Pages
- e1002730
- ISSN
- 1549-1277 (ISSN-L)
- 1549-1676
- PMC
- PMC6345440
- OpenAlex
- W2914568698
- Cited by
- 1,082
- References
- 52
- Citations by year
- 2026: 158 · 2025: 164 · 2024: 180 · 2023: 170 · 2022: 175 · 2021: 129 · 2020: 87 · 2019: 17
- FWCI
- 46.54
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- City Research Online (City University London) (acceptedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- RWTH Publications (RWTH Aachen)
- Funders
- Deutsches Krebsforschungszentrum (Heidelberg School of Oncology)
- Bundesministerium für Bildung und Forschung (13GW0091E, 01ER0814, 01ER0815, 01ER1505A, 01ER1505B)
- Deutsche Forschungsgemeinschaft (BR 1704/6-1, BR 1704/6-3, BR 1704/6-4, BR 1704/17-1, CH 117/1-1, and HO 5117/2-1)
- Topics
- Physical Sciences › Computer Science › Artificial Intelligence › AI in cancer detection
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiomics and Machine Learning in Medical Imaging
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Keywords
- colorectal cancer, deep convolutional neural networks, tumor stroma, prognostic factors, overall survival, cancer-associated fibroblasts, cancer of unknown primary, relapse-free survival, TCGA, transfer learning, histopathology image analysis, digital pathology
- MeSH terms
- Deep Learning, Colon, Coloring Agents, Eosine Yellowish-(YS), Female, Hematoxylin, Humans, Image Interpretation, Computer-Assisted, Male, Prognosis, Rectum, Retrospective Studies, Colorectal Neoplasms
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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