Cited by 253Adipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and LipoproteinsAdipose Tissue and Metabolism

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Insulin Resistance and Body Fat Distribution in South Asian Men Compared to Caucasian Men

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Chandalia, Manisha, Lin, Ping, Seenivasan, Thanalakshmi, Livingston, Edward H., Snell, Peter G., Grundy, Scott M., Abate, Nicola·2007·PLoS ONE

DOI 10.1371/journal.pone.0000812PMC PMC1950568

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Abstract

OBJECTIVE: South Asians are susceptible to insulin resistance even without obesity. We examined the characteristics of body fat content, distribution and function in South Asian men and their relationships to insulin resistance compared to Caucasians. RESEARCH DESIGN AND METHODS: Twenty-nine South Asian and 18 Caucasian non-diabetic men (age 27+/-3 and 27+/-3 years, respectively) underwent euglycemic-hyperinsulinemic clamp for insulin sensitivity, underwater weighing for total body fat, MRI of entire abdomen for intraperitoneal (IP) and subcutaneous abdominal (SA) fat and biopsy of SA fat for adipocyte size. RESULTS: Compared to Caucasians, in spite of similar BMI, South Asians had higher total body fat (22+/-6 and 15+/-4% of body weight; p-value<0.0001), higher SA fat (3.5+/-1.9 and 2.2+/-1.3 kg, respectively; p-value = 0.004), but no differences in IP fat (1.0+/-0.5 and 1.0+/-0.7 kg, respectively; p-value = 0.4). SA adipocyte cell size was significantly higher in South Asians (3491+/-1393 and 1648+/-864 microm2; p-value = 0.0001) and was inversely correlated with both glucose disposal rate (r-value = -0.57; p-value = 0.0008) and plasma adiponectin concentrations (r-value = -0.71; p-value<0.0001). Adipocyte size differences persisted even when SA was matched between South Asians and Caucasians. CONCLUSIONS: Insulin resistance in young South Asian men can be observed even without increase in IP fat mass and is related to large SA adipocytes size. Hence ethnic excess in insulin resistance in South Asians appears to be related more to excess truncal fat and dysfunctional adipose tissue than to excess visceral fat.

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Authors: Chandalia, M., Lin, P., Seenivasan, T., Livingston, E. H., Snell, P. G., Grundy, S. M., & Abate, N.
Affiliations: The University of Texas Southwestern Medical Center (US)
Corresponding author: Chandalia, Manisha
Abate, Nicola
ORCID: Livingston, Edward H.
Grundy, Scott M.
Abate, Nicola
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2007-08-29
Volume: 2
Issue: 8
Pages: e812
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0000812
PMC: PMC1950568
OpenAlex: W2032530751
Cited by: 253
References: 18
Citations by year: 2026: 7 · 2025: 13 · 2024: 10 · 2023: 10 · 2022: 14 · 2021: 10 · 2020: 10 · 2019: 15 · 2018: 15 · 2017: 16 · 2016: 7 · 2015: 17 · 2014: 20 · 2013: 31 · 2012: 17
FWCI: 5.50
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS ONE (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK RO1, R01DK072158, DK072158)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: insulin resistance, South Asian men, body fat distribution, subcutaneous abdominal fat, intraperitoneal fat, adipocyte size, adiponectin, ethnic differences, abdominal obesity, insulin sensitivity, adipose tissue dysfunction
MeSH terms: Adipose Tissue, Adult, Glucose, Humans, Insulin Resistance, Male, Glucose Clamp Technique, White People, Asian People, Intra-Abdominal Fat, Body Fat Distribution

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Insulin Resistance and Body Fat Distribution in South Asian Men Compared to Caucasian Men

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