The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Promoter-Wide Hypermethylation of the Ribosomal RNA Gene Promoter in the Suicide Brain
Open accessAbstract
BACKGROUND: Alterations in gene expression in the suicide brain have been reported and for several genes DNA methylation as an epigenetic regulator is thought to play a role. rRNA genes, that encode ribosomal RNA, are the backbone of the protein synthesis machinery and levels of rRNA gene promoter methylation determine rRNA transcription. METHODOLOGY/PRINCIPAL FINDINGS: We test here by sodium bisulfite mapping of the rRNA promoter and quantitative real-time PCR of rRNA expression the hypothesis that epigenetic differences in critical loci in the brain are involved in the pathophysiology of suicide. Suicide subjects in this study were selected for a history of early childhood neglect/abuse, which is associated with decreased hippocampal volume and cognitive impairments. rRNA was significantly hypermethylated throughout the promoter and 5' regulatory region in the brain of suicide subjects, consistent with reduced rRNA expression in the hippocampus. This difference in rRNA methylation was not evident in the cerebellum and occurred in the absence of genome-wide changes in methylation, as assessed by nearest neighbor. CONCLUSIONS/SIGNIFICANCE: This is the first study to show aberrant regulation of the protein synthesis machinery in the suicide brain. The data implicate the epigenetic modulation of rRNA in the pathophysiology of suicide.
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Cites
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Epigenetic regulation in psychiatric disorders
Tsankova, N., Renthal, W., Kumar, A., & Nestler, E. J. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2132 · Cited by 1,400
Meaney, M. J., & Szyf, M. (2005) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2005.7.2/mmeaney · Cited by 958
Self-citationFERGUSSON, D. M., HORWOOD, L. J., & LYNSKEY, M. T. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199610000-00024 · Cited by 826 · cited 1×
“Similarly, childhood abuse is associated with an increased risk for psychopathology [7,8] and altered neural development [9].”
BackgroundChildhood trauma associated with smaller hippocampal volume in women with major depression
Vythilingam, M., Heim, C., Newport, J., Miller, A. H., Anderson, E., Bronen, R., Brummer, M., Staib, L., Vermetten, E., Charney, D. S., et al. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.12.2072 · Cited by 812
Dumais, A., Lesage, A. D., Alda, M., Rouleau, G., Dumont, M., Chawky, N., Roy, M., Mann, J. J., Benkelfat, C., & Turecki, G. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.11.2116 · Cited by 583
Self-citationChildhood Experience of Care and Abuse (CECA): A Retrospective Interview Measure
Bifulco, A., Brown, G. W., & Harris, T. O. (1994) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1994.tb01284.x · Cited by 579
Valproate Induces Replication-independent Active DNA Demethylation
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Self-citationValproate Induces widespread epigenetic reprogramming which involves demethylation of specific genes
Milutinovic, S., D'Alessio, A. C., Detich, N., & Szyf, M. (2007) · Carcinogenesis · doi:10.1093/carcin/bgl167 · Cited by 256
Self-citationDecreased RNA, and Increased RNA Oxidation, in Ribosomes from Early Alzheimer’s Disease
Ding, Q., Markesbery, W. R., Cecarini, V., & Keller, J. N. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9071-5 · Cited by 140
Cited by
Lasting epigenetic influence of early-life adversity on the BDNF gene
Roth, T. L., Lubin, F. D., Funk, A. J., & Sweatt, J. D. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.028 · Cited by 1,273
Dynamic DNA methylation programs persistent adverse effects of early-life stress
Murgatroyd, C., Patchev, A. V., Wu, Y., Micale, V., Bockmühl, Y., Fischer, D., Holsboer, F., Wotjak, C. T., Almeida, O. F. X., & Spengler, D. (2009) · Nature Neuroscience · doi:10.1038/nn.2436 · Cited by 1,162
Genome-wide epigenetic regulation by early-life trauma
Labonté, B., Suderman, M., Maussion, G., Navaro, L., Yerko, V., Mahar, I., Bureau, A., Mechawar, N., Szyf, M., Meaney, M. J., et al. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.2287 · Cited by 488
Self-citationEssex, M. J., Thomas Boyce, W., Hertzman, C., Lam, L. L., Armstrong, J. M., Neumann, S. M. A., & Kobor, M. S. (2013) · Child Development · doi:10.1111/j.1467-8624.2011.01641.x · Cited by 462
Broad Epigenetic Signature of Maternal Care in the Brain of Adult Rats
McGowan, P. O., Suderman, M., Sasaki, A., Huang, T. C. T., Hallett, M., Meaney, M. J., & Szyf, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014739 · Cited by 452
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Metadata
- Authors
- McGowan, P. O., Sasaki, A., Huang, T. C. T., Unterberger, A., Suderman, M., Ernst, C., Meaney, M. J., Turecki, G., & Szyf, M.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-05-07
- Volume
- 3
- Issue
- 5
- Pages
- e2085
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2016323760
- Cited by
- 372
- References
- 10
- FWCI
- 14.15
- Type
- journal article
- Language
- en
- Open access
- gold
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- McGowan, P. O., Sasaki, A., Huang, T. C. T., Unterberger, A., Suderman, M., Ernst, C., Meaney, M. J., Turecki, G., & Szyf, M. (2008). Promoter-Wide Hypermethylation of the Ribosomal RNA Gene Promoter in the Suicide Brain. PLoS ONE. https://doi.org/10.1371/journal.pone.0002085
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