The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Lifespan Mental Activity Predicts Diminished Rate of Hippocampal Atrophy
Open accessAbstract
OBJECTIVE: Epidemiological studies suggest that complex mental activity may reduce the risk for dementia, however an underlying mechanism remains unclear. Our objective was to determine whether individual differences in lifespan complex mental activity are linked to altered rates of hippocampal atrophy independent of global measures of neurodegeneration. METHODS: Thirty seven healthy older individuals had their complex mental activity levels estimated using the Lifetime of Experiences Questionnaire (LEQ) and completed serial MRI investigations at baseline and three years follow-up. Hippocampal volume and semi-automatic quantitation of whole brain volume (WBV) and white matter hyperintensities (WMHs) were compared at both time points. RESULTS: Higher LEQ scores were correlated with hippocampal volume independent of covariates at the three year follow-up stage (r = 0.43, p = 0.012). Moreover, those with higher LEQ scores experienced less hippocampal atrophy over the follow-up period (r = 0.41, p = 0.02). High LEQ individuals had less than half the hippocampal volume decline of low LEQ individuals in a multivariate analysis (F = 4.47, p = 0.042). No parallel changes were found in measures of WBV and WMHs. CONCLUSIONS: High level of complex mental activity across the lifespan was correlated with a reduced rate of hippocampal atrophy. This finding could not be explained by general differences in intracranial volume, larger hippocampi at baseline, presence of hypertensive disease, gender or low mood. Our results suggest that neuroprotection in medial temporal lobe may be one mechanism underlying the link between mental activity and lower rates of dementia observed in population-based studies. Additional studies are required to further explore this novel finding.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
Navigation-related structural change in the hippocampi of taxi drivers
Maguire, E. A., Gadian, D. G., Johnsrude, I. S., Good, C. D., Ashburner, J., Frackowiak, R. S. J., & Frith, C. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.070039597 · Cited by 3,225
Changes in grey matter induced by training
Draganski, B., Gaser, C., Busch, V., Schuierer, G., Bogdahn, U., & May, A. (2004) · Nature · doi:10.1038/427311a · Cited by 2,373
A molecular and cellular theory of depression
Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129
Enriched environments, experience-dependent plasticity and disorders of the nervous system
Nithianantharajah, J., & Hannan, A. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1970 · Cited by 1,771
Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment
Jack, C. R., Petersen, R. C., Xu, Y. C., O’Brien, P. C., Smith, G. E., Ivnik, R. J., Boeve, B. F., Waring, S. C., Tangalos, E. G., & Kokmen, E. (1999) · Neurology · doi:10.1212/wnl.52.7.1397 · Cited by 1,404
Brain reserve and dementia: a systematic review
VALENZUELA, M. J., & SACHDEV, P. (2006) · Psychological Medicine · doi:10.1017/s0033291705006264 · Cited by 932 · cited 2×
“Epidemiological studies [1] and clinical trials [3] that have linked increased complex mental activity to decreased dementia risk and decreased cognitive decline may therefore potentially be due to a neuroprotective effect in the medial temporal lobe.”
Self-citationSnowdon, D. A. (1996) · JAMA · doi:10.1001/jama.1996.03530310034029 · Cited by 696
Environmental Enrichment Mitigates Cognitive Deficits in a Mouse Model of Alzheimer's Disease
Jankowsky, J. L., Melnikova, T., Fadale, D. J., Xu, G. M., Slunt, H. H., Gonzales, V., Younkin, L. H., Younkin, S. G., Borchelt, D. R., & Savonenko, A. V. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5080-04.2005 · Cited by 517
Isaacs, K. R., Anderson, B. J., Alcantara, A. A., Black, J. E., & Greenough, W. T. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.14 · Cited by 405
Cited by
Cognitive reserve in ageing and Alzheimer's disease
Stern, Y. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70191-6 · Cited by 3,557
Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention
Qiu, C., Kivipelto, M., & von Strauss, E. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.2/cqiu · Cited by 1,261
Fjell, A. M., McEvoy, L., Holland, D., Dale, A. M., & Walhovd, K. B. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.02.004 · Cited by 799
Environment and Brain Plasticity: Towards an Endogenous Pharmacotherapy
Sale, A., Berardi, N., & Maffei, L. (2014) · Physiological Reviews · doi:10.1152/physrev.00036.2012 · Cited by 402
Cognitive Reserve and the Prevention of Dementia: the Role of Physical and Cognitive Activities
Cheng, S.-T. (2016) · Current Psychiatry Reports · doi:10.1007/s11920-016-0721-2 · Cited by 385
Suo, C., Singh, M. F., Gates, N., Wen, W., Sachdev, P., Brodaty, H., Saigal, N., Wilson, G. C., Meiklejohn, J., Singh, N., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.19 · Cited by 212
Self-citationBranger, P., Arenaza-Urquijo, E. M., Tomadesso, C., Mézenge, F., André, C., de Flores, R., Mutlu, J., de La Sayette, V., Eustache, F., Chételat, G., et al. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.02.009 · Cited by 186
A systematic review and meta-analysis of longitudinal hippocampal atrophy in healthy human ageing
Fraser, M. A., Shaw, M. E., & Cherbuin, N. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.03.035 · Cited by 175
for the FINGER study group, Stephen, R., Liu, Y., Ngandu, T., Antikainen, R., Hulkkonen, J., Koikkalainen, J., Kemppainen, N., Lötjönen, J., Levälahti, E., et al. (2019) · Alzheimer's Research & Therapy · doi:10.1186/s13195-019-0506-z · Cited by 116
Qiu, C., Xu, W., & Fratiglioni, L. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-091663 · Cited by 107
Multiple Biological Pathways Link Cognitive Lifestyle to Protection from Dementia
Valenzuela, M. J., Matthews, F. E., Brayne, C., Ince, P., Halliday, G., Kril, J. J., Dalton, M. A., Richardson, K., Forster, G., & Sachdev, P. S. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.07.036 · Cited by 100
Self-citationCognitive resilience/reserve: Myth or reality? A review of definitions and measurement methods
Pappalettera, C., Carrarini, C., Miraglia, F., Vecchio, F., & Rossini, P. M. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13744 · Cited by 99
Tse, Y. C., Montoya, I., Wong, A. S., Mathieu, A., Lissemore, J., Lagace, D. C., & Wong, T. P. (2014) · Hippocampus · doi:10.1002/hipo.22296 · Cited by 69
Education modulates brain maintenance in presymptomatic frontotemporal dementia
Gazzina, S., Grassi, M., Premi, E., Cosseddu, M., Alberici, A., Archetti, S., Gasparotti, R., Van Swieten, J., Galimberti, D., Sanchez-Valle, R., et al. (2019) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2019-320439 · Cited by 33
Bae, S., Harada, K., Lee, S., Harada, K., Makino, K., Chiba, I., Park, H., & Shimada, H. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051312 · Cited by 29
Präventionsstrategien gegen Demenz
Müller, P., Schmicker, M., & Müller, N. G. (2017) · Zeitschrift für Gerontologie und Geriatrie · doi:10.1007/s00391-017-1202-x · Cited by 25
Metadata
- Authors
- Valenzuela, M. J., Sachdev, P., Wen, W., Chen, X., & Brodaty, H.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-07-09
- Volume
- 3
- Issue
- 7
- Pages
- e2598
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W1965663626
- Cited by
- 249
- References
- 13
- FWCI
- 6.27
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
