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Cited by 33Dementia and Cognitive Impairment ResearchAmyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Education modulates brain maintenance in presymptomatic frontotemporal dementia

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Gazzina, Stefano, Grassi, Mario, Premi, Enrico, Cosseddu, Maura, Alberici, Antonella, Archetti, Silvana, Gasparotti, Roberto, Van Swieten, John +25 more·2019·Journal of Neurology, Neurosurgery & Psychiatry
DOI 10.1136/jnnp-2019-320439
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Abstract

Objective: Cognitively engaging lifestyles have been associated with reduced risk of conversion to dementia. Multiple mechanisms have been advocated, including increased brain volumes (ie, brain reserve) and reduced disease progression (ie, brain maintenance). In cross-sectional studies of presymptomatic frontotemporal dementia (FTD), higher education has been related to increased grey matter volume. Here, we examine the effect of education on grey matter loss over time. Methods: Two-hundred twenty-nine subjects at-risk of carrying a pathogenic mutation leading to FTD underwent longitudinal cognitive assessment and T1-weighted MRI at baseline and at 1 year follow-up. The first principal component score of the graph-Laplacian Principal Component Analysis on 112 grey matter region-of-interest volumes was used to summarise the grey matter volume (GMV). The effects of education on cognitive performances and GMV at baseline and on the change between 1 year follow-up and baseline (slope) were tested by Structural Equation Modelling. Results: Highly educated at-risk subjects had better cognition and higher grey matter volume at baseline; moreover, higher educational attainment was associated with slower loss of grey matter over time in mutation carriers. Conclusions: This longitudinal study demonstrates that even in presence of ongoing pathological processes, education may facilitate both brain reserve and brain maintenance in the presymptomatic phase of genetic FTD.

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  • Similar protective effects of education have been observed in Alzheimer's disease and frontotemporal dementia, indicating some commonality with other neurodegenerative conditions.

    “Similar protective effects of education have been observed in Alzheimer’s disease and frontotemporal dementia50,51, indicating some commonality with other neurodegenerative conditions.”

    From Locus for severity implicates CNS resilience in progression of multiple sclerosis (2023) · cites this paper as [50]

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Authors
Gazzina, S., Grassi, M., Premi, E., Cosseddu, M., Alberici, A., Archetti, S., Gasparotti, R., Van Swieten, J., Galimberti, D., Sanchez-Valle, R., Laforce, R. J., Moreno, F., Synofzik, M., Graff, C., Masellis, M., Tartaglia, M. C., Rowe, J. B., Vandenberghe, R., Finger, E., Tagliavini, F., de Mendonça, A., Santana, I., Butler, C. R., Ducharme, S., Gerhard, A., Danek, A., Levin, J., Otto, M., Frisoni, G., Sorbi, S., Padovani, A., Rohrer, J. D., & Borroni, B.
Affiliations
  • University of Brescia (IT)
  • University of Pavia (IT)
  • Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
  • University of Milan (IT)
  • Université Laval (CA)
  • German Center for Neurodegenerative Diseases (DE)
  • Karolinska Institutet (SE)
  • Sunnybrook Research Institute (CA)
  • Toronto Western Hospital (CA)
  • University of Cambridge (GB)
  • KU Leuven (BE)
  • Western University (CA)
  • Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
  • Unidade Local de Saúde de Coimbra (PT)
  • University of Oxford (GB)
  • Montreal Neurological Institute and Hospital (CA)
  • University Hospital Ulm (DE)
  • University of Geneva (CH)
  • Istituti di Ricovero e Cura a Carattere Scientifico (IT)
  • UCL Queen Square Institute of Neurology (GB)
Corresponding author
Borroni, Barbara
ORCID
Venue
Journal of Neurology, Neurosurgery & Psychiatry
Publisher
BMJ
Published
2019-06-10
Volume
90
Issue
10
Pages
1124-1130
ISSN
  • 0022-3050 (ISSN-L)
  • 1468-330X
DOI
10.1136/jnnp-2019-320439
OpenAlex
W2953382271
Cited by
33
References
4
Citations by year
2026: 1 · 2025: 4 · 2024: 5 · 2023: 6 · 2022: 6 · 2021: 4 · 2020: 6 · 2019: 1
FWCI
3.38
Type
journal article
Language
en
Open access
Locations
  • Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (acceptedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • Open access LMU (Ludwid Maxmilian's Universitat Munchen) (submittedVersion)
  • Florence Research (University of Florence) (submittedVersion)
  • Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
  • Institutional Research Information System (Università degli Studi di Trento) (submittedVersion)
  • Lirias (KU Leuven) (submittedVersion)
  • HighWire Press Open Archive (submittedVersion)
  • DZNE Pub (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
  • Wellcome Trust (103838/Z/14/Z, 103838)
  • National Institute for Health and Care Research (NF-SI-0617-10175, CL-2012-18-010)
  • Medical Research Council (MR/M023664/1, MR/M008525/1, MR/K010395/1, MR/J009482/1)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
educational attainment, gray matter volume, brain maintenance, brain reserve, gray matter loss, mutation carriers, cognitive performance
MeSH terms
Mental Status and Dementia Tests, C9orf72 Protein, Progranulins, Adult, Brain, Cerebrospinal Fluid, Educational Status, Female, Humans, Male, Middle Aged, Organ Size, tau Proteins, Genetic Predisposition to Disease, Principal Component Analysis, Frontotemporal Dementia, Asymptomatic Diseases, White Matter, Gray Matter

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