A longitudinal study of stress-induced hippocampal volume changes in mice that are susceptible or resilient to chronic social defeat
Abstract
Hippocampal shrinkage is a commonly found neuroanatomical change in stress‐related mood disorders such as depression and post‐traumatic stress disorders (PTSD). Since the onset and severity of these disorders have been found to be closely related to stressful life events, and as stress alone has been shown to reduce hippocampal volume in animal studies, vulnerability to mood disorders may be related to a susceptibility to stress‐induced hippocampal shrinkage. However, a smaller hippocampal volume before stress exposure has also been suggested to confer vulnerability of stressed individuals to PTSD or depression. In this study, we examined the contribution of either innate hippocampal volume differences or hippocampal susceptibility to stress‐induced shrinkage to the formation of stress‐related psychopathology using longitudinal MRI measurements of hippocampal volume in inbred C57 mice before and after chronic social defeat stress. We found that only half of the stressed C57 mice were susceptible to stress and developed psychopathological behaviors such as social avoidance. The other half was resilient to stress and exhibited no social avoidance. Before exposure to stress, we observed a positive correlation between hippocampal volume and social avoidance. After chronic social defeat stress, we found significant increases in left hippocampal volume in resilient and nonstressed control mice. Intriguingly, this increase in hippocampal volume was not found in susceptible mice, suggesting an arrestment of hippocampal growth in these mice. Our findings suggest that both a susceptibility to stress‐induced hippocampal volume changes and a larger hippocampus before stress exposure confer vulnerability to psychopathology after chronic stress. © 2014 Wiley Periodicals, Inc.
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A recent longitudinal study suggested that stress-susceptible mice have larger hippocampal volume than resilient mice before stress onset.
“However, a recent longitudinal study suggested that stress-susceptible mice have larger hippocampal volume than resilient mice before stress onset (56).”
From Neuroanatomic differences associated with stress susceptibility and resilience (2016) · cites this paper as [56]
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Network adaptability governs resilience and susceptibility to social defeat
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- Authors
- Tse, Y. C., Montoya, I., Wong, A. S., Mathieu, A., Lissemore, J., Lagace, D. C., & Wong, T. P.
- Affiliations
- Douglas Mental Health University Institute (CA)
- University of Ottawa (CA)
- Corresponding author
- Wong, Tak Pan
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 2014-05-07
- Volume
- 24
- Issue
- 9
- Pages
- 1120-1128
- ISSN
- 1050-9631 (ISSN-L)
- 1098-1063
- OpenAlex
- W2171193826
- Cited by
- 69
- References
- 44
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2022: 4 · 2021: 12 · 2020: 5 · 2019: 10 · 2018: 9 · 2017: 8 · 2016: 4 · 2015: 10 · 2014: 2
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hippocampus (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (MOP-106649)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- hippocampal volume, chronic social defeat stress, stress vulnerability, stress resilience, hippocampal plasticity, social avoidance, depression, post-traumatic stress disorder, stress-related psychopathology, C57 mice, inbred mouse strains
- MeSH terms
- Animals, Avoidance Learning, Body Weight, Chronic Disease, Disease Models, Animal, Dominance-Subordination, Hippocampus, Functional Laterality, Longitudinal Studies, Magnetic Resonance Imaging, Male, Mice, Inbred C57BL, Organ Size, Social Behavior, Stress, Psychological, Resilience, Psychological
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