The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
PhoP: A Missing Piece in the Intricate Puzzle of Mycobacterium tuberculosis Virulence
Open accessAbstract
Inactivation of the transcriptional regulator PhoP results in Mycobacterium tuberculosis attenuation. Preclinical testing has shown that attenuated M. tuberculosis phoP mutants hold promise as safe and effective live vaccine candidates. We focused this study to decipher the virulence networks regulated by PhoP. A combined transcriptomic and proteomic analysis revealed that PhoP controls a variety of functions including: hypoxia response through DosR crosstalking, respiratory metabolism, secretion of the major T-cell antigen ESAT-6, stress response, synthesis of pathogenic lipids and the M. tuberculosis persistence through transcriptional regulation of the enzyme isocitrate lyase. We also demonstrate that the M. tuberculosis phoP mutant SO2 exhibits an antigenic capacity similar to that of the BCG vaccine. Finally, we provide evidence that the SO2 mutant persists better in mouse organs than BCG. Altogether, these findings indicate that PhoP orchestrates a variety of functions implicated in M. tuberculosis virulence and persistence, making phoP mutants promising vaccine candidates.
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Cites
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The Enduring Hypoxic Response of Mycobacterium tuberculosis
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Secreted transcription factor controls Mycobacterium tuberculosis virulence
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A mycobacterium ESX-1-secreted virulence factor with unique requirements for export.
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Cited by
The Mycobacterium tuberculosis regulatory network and hypoxia
Galagan, J. E., Minch, K., Peterson, M., Lyubetskaya, A., Azizi, E., Sweet, L., Gomes, A., Rustad, T., Dolganov, G., Glotova, I., et al. (2013) · Nature · doi:10.1038/nature12337 · Cited by 431
Intracellular Mycobacterium tuberculosis Exploits Host-derived Fatty Acids to Limit Metabolic Stress
Lee, W., VanderVen, B. C., Fahey, R. J., & Russell, D. G. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.445056 · Cited by 424
Major roles of isocitrate lyase and malate synthase in bacterial and fungal pathogenesis
Dunn, M. F., Ramírez-Trujillo, J. A., & Hernández-Lucas, I. (2009) · Microbiology · doi:10.1099/mic.0.030858-0 · Cited by 304
Baker, J. J., Johnson, B. K., & Abramovitch, R. B. (2014) · Molecular Microbiology · doi:10.1111/mmi.12688 · Cited by 181
The PhoP-Dependent ncRNA Mcr7 Modulates the TAT Secretion System in Mycobacterium tuberculosis
Solans, L., Gonzalo-Asensio, J., Sala, C., Benjak, A., Uplekar, S., Rougemont, J., Guilhot, C., Malaga, W., Martín, C., & Cole, S. T. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004183 · Cited by 147
Self-citation
Metadata
- Authors
- Gonzalo-Asensio, J., Mostowy, S., Harders-Westerveen, J., Huygen, K., Hernández-Pando, R., Thole, J., Behr, M., Gicquel, B., & Martín, C.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-10-23
- Volume
- 3
- Issue
- 10
- Pages
- e3496
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W1974309182
- Cited by
- 223
- References
- 10
- FWCI
- 8.02
- Type
- journal article
- Language
- en
- Open access
- gold
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- Gonzalo-Asensio, J., Mostowy, S., Harders-Westerveen, J., Huygen, K., Hernández-Pando, R., Thole, J., Behr, M., Gicquel, B., & Martín, C. (2008). PhoP: A Missing Piece in the Intricate Puzzle of Mycobacterium tuberculosis Virulence. PLoS ONE. https://doi.org/10.1371/journal.pone.0003496
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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