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Cited by 118Autism Spectrum Disorder ResearchFace Recognition and PerceptionChild and Animal Learning Development

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Neural Basis of Self and Other Representation in Autism: An fMRI Study of Self-Face Recognition

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Uddin, Lucina Q., Davies, Mari S., Scott, Ashley A., Zaidel, Eran, Bookheimer, Susan Y., Iacoboni, Marco, Dapretto, Mirella·2008·PLoS ONE
DOI 10.1371/journal.pone.0003526PMC PMC2568959
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Abstract

BACKGROUND: Autism is a developmental disorder characterized by decreased interest and engagement in social interactions and by enhanced self-focus. While previous theoretical approaches to understanding autism have emphasized social impairments and altered interpersonal interactions, there is a recent shift towards understanding the nature of the representation of the self in individuals with autism spectrum disorders (ASD). Still, the neural mechanisms subserving self-representations in ASD are relatively unexplored. METHODOLOGY/PRINCIPAL FINDINGS: We used event-related fMRI to investigate brain responsiveness to images of the subjects' own face and to faces of others. Children with ASD and typically developing (TD) children viewed randomly presented digital morphs between their own face and a gender-matched other face, and made "self/other" judgments. Both groups of children activated a right premotor/prefrontal system when identifying images containing a greater percentage of the self face. However, while TD children showed activation of this system during both self- and other-processing, children with ASD only recruited this system while viewing images containing mostly their own face. CONCLUSIONS/SIGNIFICANCE: This functional dissociation between the representation of self versus others points to a potential neural substrate for the characteristic self-focus and decreased social understanding exhibited by these individuals, and suggests that individuals with ASD lack the shared neural representations for self and others that TD children and adults possess and may use to understand others.

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Crossref · 10.1371/journal.pone.0003526

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Figure 1 Examples of types of stimuli used in the experiment. For each participant, a series of morphed images were created between the participant's own face and another gender-matched face. This resulted in six face images, from 0% morphing (Self) to 100% morphing (Other).
Figure 1 Examples of types of stimuli used in the experiment. For each participant, a series of morphed images were created between the participant's own face and another gender-matched face. This resulted in six face images, from 0% morphing (Self) to 100% morphing (Other).CC BY · PubMed Central
Figure 2 a: Behavioral responses to the task. Both groups of children (ASD and TD) showed decreasing “self” responses as the image presented contained less of the self-face, demonstrating behavioral competence. Error bars represent standard error. b: Reaction Time. There were no significant differences between groups with respect to reaction time.
Figure 2 a: Behavioral responses to the task. Both groups of children (ASD and TD) showed decreasing “self” responses as the image presented contained less of the self-face, demonstrating behavioral competence. Error bars represent standard error. b: Reaction Time. There were no significant differences between groups with respect to reaction time.CC BY · PubMed Central
Figure 3 While both groups of children activated the right IFG while viewing of faces of themselves, only TD children also activated this region while viewing faces of others.
Figure 3 While both groups of children activated the right IFG while viewing of faces of themselves, only TD children also activated this region while viewing faces of others.CC BY · PubMed Central
Figure 4 TD children showed greater activation to other faces than children with ASD, specifically in the right IFG region-of-interest.
Figure 4 TD children showed greater activation to other faces than children with ASD, specifically in the right IFG region-of-interest.CC BY · PubMed Central
Figure 5 ROIs based on Harvard-Oxford atlas used to probe differences between TD and ASD groups.
Figure 5 ROIs based on Harvard-Oxford atlas used to probe differences between TD and ASD groups.CC BY · PubMed Central
Figure 6 ROI analyses indicated hypoactivation to Other faces in the ASD group in BA 44 and BA 45.
Figure 6 ROI analyses indicated hypoactivation to Other faces in the ASD group in BA 44 and BA 45.CC BY · PubMed Central

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Research works printed but not linked: 1

  1. T Behrens, 2003, Multi-subject null hypothesis testing using a fully bayesian framework: theory., Hum Brain Mapp

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Metadata

Authors
Uddin, L. Q., Davies, M. S., Scott, A. A., Zaidel, E., Bookheimer, S. Y., Iacoboni, M., & Dapretto, M.
Affiliations
University of California, Los Angeles (US)
Corresponding author
Uddin, Lucina Q.
ORCID
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2008-10-29
Volume
3
Issue
10
Pages
e3526
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0003526
PMC
PMC2568959
OpenAlex
W2005551003
Cited by
118
References
66
Citations by year
2026: 4 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 6 · 2021: 6 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 6 · 2015: 7 · 2014: 10 · 2013: 7 · 2012: 7
FWCI
5.69
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders
  • National Science Foundation
  • Brain Mapping Support Foundation
  • National Institutes of Health (RR13642)
  • National Center for Research Resources (P41RR013642, RR12169, RR 13642, RR00865, M01RR000865, C06RR012169)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD035470)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
  • Social Sciences › Psychology › Developmental and Educational Psychology › Child and Animal Learning Development
Keywords
autism spectrum disorder, self-face recognition, self and other representations, face perception, self-focus, social cognition, children with autism
MeSH terms
Adolescent, Autistic Disorder, Behavior, Brain Mapping, Child, Face, Facial Expression, Humans, Magnetic Resonance Imaging, Male, Mental Processes, Pattern Recognition, Visual, Photic Stimulation, Self Concept, Social Perception

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