Altered Functional Connectivity in Frontal Lobe Circuits Is Associated with Variation in the Autism Risk Gene CNTNAP2
Open accessAbstract
Children who carry one variant of a brain protein associated with autism exhibit fewer long-range connections between the prefrontal cortex and more posterior brain regions.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
CNTNAP2 is an ASD risk gene affecting primarily frontal lobe connectivity.
“CNTNAP2 has been identified as an ASD risk gene affecting primarily frontal lobe connectivity (Arking et al. 2008; Scott-Van Zeeland et al. 2010).”
From Dysfunctional Autism Risk Genes Cause Circuit-Specific Connectivity Deficits With Distinct Developmental Trajectories (2018) · cites this paper as Scott-Van Zeeland et al. 2010
These findings support the "developmental disconnection model" of the DMN in ASD.
“These findings support the “developmental disconnection model” of the DMN in ASD, which could be related to the reduced number of GABAergic interneurons in these same regions (Scott-Van Zeeland et al. 2010)”
From Dysfunctional Autism Risk Genes Cause Circuit-Specific Connectivity Deficits With Distinct Developmental Trajectories (2018) · cites this paper as Scott-Van Zeeland et al. 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190 · see citing works
Rizzolatti, G., & Craighero, L. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144230 · Cited by 7,433 · see citing works
The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions
Gottesman, I. I., & Gould, T. D. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.636 · Cited by 5,615 · see citing works
Cattaneo, L., & Rizzolatti, G. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.41 · Cited by 3,137 · see citing works
Prediction of individual brain maturity using fMRI
Dosenbach, N. U. F., Nardos, B., Cohen, A. L., Fair, D. A., Power, J. D., Church, J. A., Nelson, S. M., Wig, G. S., Vogel, A. C., Lessov-Schlaggar, C. N., et al. (2010) · Science · doi:10.1126/science.1194144 · Cited by 2,183 · see citing works
The Architecture of Cognitive Control in the Human Prefrontal Cortex
Koechlin, E., Ody, C., & Kouneiher, F. (2003) · Science · doi:10.1126/science.1088545 · Cited by 1,922 · see citing works
A neostriatal habit learning system in humans
Knowlton, B. J., Mangels, J. A., & Squire, L. R. (1996) · Science · doi:10.1126/science.273.5280.1399 · Cited by 1,777 · see citing works
Dapretto, M., Davies, M. S., Pfeifer, J. H., Scott, A. A., Sigman, M., Bookheimer, S. Y., & Iacoboni, M. (2006) · Nature Neuroscience · doi:10.1038/nn1611 · Cited by 1,694 · see citing works
Self-citationDefault-mode brain dysfunction in mental disorders: A systematic review
Broyd, S. J., Demanuele, C., Debener, S., Helps, S. K., James, C. J., & Sonuga-Barke, E. J. S. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.09.002 · Cited by 1,675 · see citing works
Functional brain networks develop from a local to distributed organization
Fair, D. A., Cohen, A. L., Power, J. D., Dosenbach, N. U. F., Church, J. A., Miezin, F. M., Schlaggar, B. L., & Petersen, S. E. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000381 · Cited by 1,530 · see citing works
Bookheimer, S. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142946 · Cited by 1,450 · see citing works
Self-citationAutism spectrum disorders: developmental disconnection syndromes
Geschwind, D. H., & Levitt, P. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.01.009 · Cited by 1,411 · see citing works
Self-citationEEG evidence for mirror neuron dysfunction in autism spectrum disorders
Oberman, L. M., Hubbard, E. M., McCleery, J. P., Altschuler, E. L., Ramachandran, V. S., & Pineda, J. A. (2005) · Cognitive Brain Research · doi:10.1016/j.cogbrainres.2005.01.014 · Cited by 1,146 · see citing works
Is the rostro-caudal axis of the frontal lobe hierarchical?
Badre, D., & D'Esposito, M. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2667 · Cited by 946 · see citing works
Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene
Alarcón, M., Abrahams, B. S., Stone, J. L., Duvall, J. A., Perederiy, J. V., Bomar, J. M., Sebat, J., Wigler, M., Martin, C. L., Ledbetter, D. H., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.09.005 · Cited by 818 · see citing works
Self-citationA functional genetic link between distinct developmental language disorders
Vernes, S. C., Newbury, D. F., Abrahams, B. S., Winchester, L., Nicod, J., Groszer, M., Alarcón, M., Oliver, P. L., Davies, K. E., Geschwind, D. H., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802828 · Cited by 676 · see citing works
Self-citationRecessive symptomatic focal epilepsy and mutant contactin-associated protein-like 2
Strauss, K. A., Puffenberger, E. G., Huentelman, M. J., Gottlieb, S., Dobrin, S. E., Parod, J. M., Stephan, D. A., & Morton, D. H. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052773 · Cited by 630 · see citing works
Badre, D., & D'Esposito, M. (2007) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2007.19.12.2082 · Cited by 615 · see citing works
Arking, D. E., Cutler, D. J., Brune, C. W., Teslovich, T. M., West, K., Ikeda, M., Rea, A., Guy, M., Lin, S., Cook, E. H., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.09.015 · Cited by 590 · see citing works
Anatomical Differences in the Mirror Neuron System and Social Cognition Network in Autism
Hadjikhani, N., Joseph, R. M., Snyder, J., & Tager-Flusberg, H. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhj069 · Cited by 554 · see citing works
Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1
Poliak, S., Salomon, D., Elhanany, H., Sabanay, H., Kiernan, B. W., Pevny, L., Stewart, C., Xu, X.-R., Chiu, S., Shrager, P., et al. (2003) · Journal of Cell Biology · doi:10.1083/jcb.200305018 · Cited by 542 · see citing works
Elia, J., Gai, X., Xie, H. M., Perin, J. C., Geiger, E., Glessner, J. T., D'arcy, M., deBerardinis, R., Frackelton, E., Kim, C., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.57 · Cited by 529 · see citing works
Scott‐Van Zeeland, A. A., Dapretto, M., Ghahremani, D. G., Poldrack, R. A., & Bookheimer, S. Y. (2010) · Autism Research · doi:10.1002/aur.122 · Cited by 458 · see citing works
Self-citationGenetic control over the resting brain
Glahn, D. C., Winkler, A. M., Kochunov, P., Almasy, L., Duggirala, R., Carless, M. A., Curran, J. C., Olvera, R. L., Laird, A. R., Smith, S. M., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909969107 · Cited by 450 · see citing works
Striatal activation during acquisition of a cognitive skill.
Poldrack, R. A., Prabhakaran, V., Seger, C. A., & Gabrieli, J. D. E. (1999) · Neuropsychology · doi:10.1037//0894-4105.13.4.564 · Cited by 428 · see citing works
Self-citationStriatal activation during acquisition of a cognitive skill.
Poldrack, R. A., Prabhakaran, V., Seger, C. A., & Gabrieli, J. D. E. (1999) · Neuropsychology · doi:10.1037/0894-4105.13.4.564 · Cited by 428 · see citing works
Self-citationBrain asymmetries in autism and developmental language disorder: a nested whole-brain analysis
Herbert, M. R. (2004) · Brain · doi:10.1093/brain/awh330 · Cited by 421 · see citing works
Courchesne, E., & Pierce, K. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2005.01.003 · Cited by 413 · see citing works
Autism: Many Genes, Common Pathways?
Geschwind, D. H. (2008) · Cell · doi:10.1016/j.cell.2008.10.016 · Cited by 328 · see citing works
Self-citationCNTNAP2 gene dosage variation is associated with schizophrenia and epilepsy
Friedman, J. I., Vrijenhoek, T., Markx, S., Janssen, I. M., van der Vliet, W. A., Faas, B. H. W., Knoers, N. V. A. M., Cahn, W., Kahn, R. S., Edelmann, L. J., et al. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002049 · Cited by 297 · see citing works
Verkerk, A., Mathews, C., Joosse, M., Eussen, B., Heutink, P., & Oostra, B. (2003) · Genomics · doi:10.1016/s0888-7543(03)00097-1 · Cited by 237 · see citing works
Genome-wide analyses of human perisylvian cerebral cortical patterning
Abrahams, B. S., Tentler, D., Perederiy, J. V., Oldham, M. C., Coppola, G., & Geschwind, D. H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706128104 · Cited by 198 · see citing works
Self-citationCracking the Language Code: Neural Mechanisms Underlying Speech Parsing
Mcnealy, K., Mazziotta, J., & Dapretto, M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5501-05.2006 · Cited by 198 · see citing works
Self-citationMechanisms and Roles of Axon-Schwann Cell Interactions
Corfas, G., Velardez, M., Ko, C.-P., Ratner, N., & Peles, E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3649-04.2004 · Cited by 197 · see citing works
COURCHESNE, E., REDCAY, E., MORGAN, J. T., & KENNEDY, D. P. (2005) · Development and Psychopathology · doi:10.1017/s0954579405050285 · Cited by 192 · see citing works
The phenotype and neural correlates of language in autism: An integrative review
Groen, W. B., Zwiers, M. P., VANDERGAAG, R., & Buitelaar, J. K. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.05.008 · Cited by 166 · see citing works
Developmental disruptions in neural connectivity in the pathophysiology of schizophrenia
Karlsgodt, K. H., Sun, D., Jimenez, A. M., Lutkenhoff, E. S., Willhite, R., van Erp, T. G. M., & Cannon, T. D. (2008) · Development and Psychopathology · doi:10.1017/s095457940800062x · Cited by 145 · see citing works
Cook, E. H. (2001) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/s1056-4993(18)30061-0 · Cited by 124 · see citing works
Neural Basis of Self and Other Representation in Autism: An fMRI Study of Self-Face Recognition
Uddin, L. Q., Davies, M. S., Scott, A. A., Zaidel, E., Bookheimer, S. Y., Iacoboni, M., & Dapretto, M. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003526 · Cited by 118 · see citing works
Self-citationTan, G. C. Y., Doke, T. F., Ashburner, J., Wood, N. W., & Frackowiak, R. S. J. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.02.018 · Cited by 116 · see citing works
New potential leads in the biology and treatment of attention deficit-hyperactivity disorder
Casey, B. J., Nigg, J. T., & Durston, S. (2007) · Current Opinion in Neurology · doi:10.1097/wco.0b013e3280a02f78 · Cited by 100 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [36]Arking DE Cutler DJ Brune CW Teslovich TM West K Ikeda M Rea A Guy M Lin S Cook EH Jr. Chakravarti A A common genetic variant in the neurexin super-family member CNTNAP2 increases familial risk of autism Am. J. Hum. Genet 2008 82 160 164 18179894 PMC2253968
Cited by
Sorted by citations
Interneuron dysfunction in psychiatric disorders
Marín, O. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3155 · Cited by 1,190 · see citing works
Peñagarikano, O., Abrahams, B. S., Herman, E. I., Winden, K. D., Gdalyahu, A., Dong, H., Sonnenblick, L. I., Gruver, R., Almajano, J., Bragin, A., et al. (2011) · Cell · doi:10.1016/j.cell.2011.08.040 · Cited by 1,075 · see citing works
Self-citationGilman, S. R., Iossifov, I., Levy, D., Ronemus, M., Wigler, M., & Vitkup, D. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.021 · Cited by 701 · see citing works
Genetics of autism spectrum disorders
Geschwind, D. H. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.07.003 · Cited by 696 · see citing works
Self-citationWolff, J. J., Gu, H., Gerig, G., Elison, J. T., Styner, M., Gouttard, S., Botteron, K. N., Dager, S. R., Dawson, G., Estes, A. M., et al. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11091447 · Cited by 671 · see citing works
Disentangling the heterogeneity of autism spectrum disorder through genetic findings
Jeste, S. S., & Geschwind, D. H. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.278 · Cited by 644 · see citing works
Self-citationGenetic architecture in autism spectrum disorder
Devlin, B., & Scherer, S. W. (2012) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2012.03.002 · Cited by 545 · see citing works
Neuroimaging in autism spectrum disorder: brain structure and function across the lifespan
Ecker, C., Bookheimer, S. Y., & Murphy, D. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00050-2 · Cited by 551 · see citing works
Self-citationPsychopathology and the Human Connectome: Toward a Transdiagnostic Model of Risk For Mental Illness
Buckholtz, J. W., & Meyer‐Lindenberg, A. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.002 · Cited by 433 · see citing works
Cerebral Asymmetry and Language Development: Cause, Correlate, or Consequence?
Bishop, D. (2013) · Science · doi:10.1126/science.1230531 · Cited by 391 · see citing works
Eyler, L. T., Pierce, K., & Courchesne, E. (2012) · Brain · doi:10.1093/brain/awr364 · Cited by 312 · see citing works
The conundrums of understanding genetic risks for autism spectrum disorders
State, M. W., & Levitt, P. (2011) · Nature Neuroscience · doi:10.1038/nn.2924 · Cited by 306 · see citing works
Ameis, S. H., & Catani, M. (2015) · Cortex · doi:10.1016/j.cortex.2014.10.014 · Cited by 301 · see citing works
Genes, circuits, and precision therapies for autism and related neurodevelopmental disorders
Sahin, M., & Sur, M. (2015) · Science · doi:10.1126/science.aab3897 · Cited by 295 · see citing works
Annual research review: re-thinking the classification of autism spectrum disorders
Lord, C., & Jones, R. M. (2012) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2012.02547.x · Cited by 290 · see citing works
The quantitative nature of autistic social impairment
CONSTANTINO, J. N. (2011) · Pediatric Research · doi:10.1203/pdr.0b013e318212ec6e · Cited by 282 · see citing works
Shining a light on CNTNAP2: Complex functions to complex disorders
Rodenas-Cuadrado, P., Ho, J., & Vernes, S. C. (2014) · European Journal of Human Genetics · doi:10.1038/ejhg.2013.100 · Cited by 272 · see citing works
Dysmaturation of the default mode network in autism
Washington, S. D., Gordon, E. M., Brar, J., Warburton, S., Sawyer, A. T., Wolfe, A., Mease‐Ference, E. R., Girton, L., Hailu, A., Mbwana, J., et al. (2014) · Human Brain Mapping · doi:10.1002/hbm.22252 · Cited by 269 · see citing works
Current Enlightenment About Etiology and Pharmacological Treatment of Autism Spectrum Disorder
Eissa, N., Al‐Houqani, M., Sadeq, A. S., Ojha, S. K., Sasse, A., & Sadek, B. S. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00304 · Cited by 263 · see citing works
Reward system dysfunction in autism spectrum disorders
Kohls, G., Schulte-Rüther, M., Nehrkorn, B., Müller, K., Fink, G. R., Kamp-Becker, I., Herpertz-Dahlmann, B., Schultz, R. T., & Konrad, K. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss033 · Cited by 259 · see citing works
Wang, P., Mokhtari, R., Pedrosa, E., Kirschenbaum, M. A., Bayrak, C., Zheng, D., & Lachman, H. M. (2017) · Molecular Autism · doi:10.1186/s13229-017-0124-1 · Cited by 255 · see citing works
The Emerging Picture of Autism Spectrum Disorder: Genetics and Pathology
Chen, J. A., Peñagarikano, O., Belgard, T. G., Swarup, V., & Geschwind, D. H. (2015) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040405 · Cited by 254 · see citing works
Self-citationHeterogeneity within Autism Spectrum Disorders: What have We Learned from Neuroimaging Studies?
Lenroot, R., & Yeung, P. K. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00733 · Cited by 230 · see citing works
Anderson, G. R., Galfin, T., Xu, W., Aoto, J. N., Malenka, R. C., & Südhof, T. C. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216398109 · Cited by 225 · see citing works
Dennis, E. L., Jahanshad, N., McMahon, K. L., de Zubicaray, G. I., Martin, N. G., Hickie, I. B., Toga, A. W., Wright, M. J., & Thompson, P. M. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2012.09.004 · Cited by 222 · see citing works
EEG hyper-connectivity in high-risk infants is associated with later autism
The BASIS Team, Orekhova, E. V., Elsabbagh, M., Jones, E. J., Dawson, G., Charman, T., & Johnson, M. H. (2014) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-6-40 · Cited by 210 · see citing works
Rudie, J. D., Shehzad, Z. E., Hernandez, L. M., Colich, N. L., Bookheimer, S. Y., Iacoboni, M., & Dapretto, M. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr171 · Cited by 193 · see citing works
Self-citationAutism genetics: searching for specificity and convergence
Berg, J. M., & Geschwind, D. H. (2012) · Genome Biology · doi:10.1186/gb-2012-13-7-247 · Cited by 192 · see citing works
Self-citationWhat does CNTNAP2 reveal about autism spectrum disorder?
Peñagarikano, O., & Geschwind, D. H. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.01.003 · Cited by 218 · see citing works
Self-citationLesca, G., Rudolf, G., Labalme, A., Hirsch, É., Arzimanoglou, A. A., Genton, P., Motte, J. E., Martin, A. D. S., Valenti, M., Boulay, C., et al. (2012) · Epilepsia · doi:10.1111/j.1528-1167.2012.03559.x · Cited by 180 · see citing works
The ontogenesis of language lateralization and its relation to handedness
Ocklenburg, S., Beste, C., Arning, L., Peterburs, J., & Güntürkün, O. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.04.008 · Cited by 172 · see citing works
Jack, A., & A. Pelphrey, K. (2017) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12687 · Cited by 159 · see citing works
Genetics of structural and functional brain changes in autism spectrum disorder
Hashem, S., Nisar, S., Bhat, A. A., Yadav, S. K., Azeem, M. W., Bagga, P., Fakhro, K. A., Reddy, R. D., Frenneaux, M. P., & Haris, M. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00921-3 · Cited by 161 · see citing works
Thompson, P. M., Ge, T., Glahn, D. C., Jahanshad, N., & Nichols, T. E. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.05.013 · Cited by 155 · see citing works
Autism-Associated Promoter Variant in MET Impacts Functional and Structural Brain Networks
Rudie, J. D., Hernandez, L. M., Brown, J. A., Beck-Pancer, D., Colich, N. L., Gorrindo, P., Thompson, P. M., Geschwind, D. H., Bookheimer, S. Y., Levitt, P., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.010 · Cited by 142 · see citing works
Self-citationNeural Signatures of Autism Spectrum Disorders: Insights into Brain Network Dynamics
Hernandez, L. M., Rudie, J. D., Green, S. A., Bookheimer, S. Y., & Dapretto, M. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.172 · Cited by 141 · see citing works
Self-citationVarea, O., Martin‐de‐Saavedra, M. D., Kopeikina, K. J., Schürmann, B., Fleming, H. J., Fawcett‐Patel, J. M., Bach, A. P., Jang, S., Peles, E., Kim, E., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1423205112 · Cited by 139 · see citing works
Candidate Biomarkers in Children with Autism Spectrum Disorder: A Review of MRI Studies
Li, D., Karnath, H., & Xu, X. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0118-1 · Cited by 139 · see citing works
Lazaro, M. T., Taxidis, J., Shuman, T., Bachmutsky, I., Ikrar, T., Santos, R., Marcello, G. M., Mylavarapu, A., Chandra, S., Foreman, A., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.006 · Cited by 125 · see citing works
Self-citationSuetterlin, P., Hurley, S., Mohan, C., Riegman, K. L. H., Pagani, M., Caruso, A., Ellegood, J., Galbusera, A., Crespo‐Enríquez, I., Michetti, C., et al. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy058 · Cited by 128 · see citing works
Dynamics of social representation in the mouse prefrontal cortex
Levy, D. R., Tamir, T., Kaufman, M., Parabucki, A., Weissbrod, A., Schneidman, E., & Yizhar, O. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0531-z · Cited by 127 · see citing works
Correspondence between Resting-State Activity and Brain Gene Expression
Wang, G.-Z., Belgard, T. G., Mao, D., Chen, L., Berto, S., Preuss, T. M., Lu, H., Geschwind, D. H., & Konopka, G. (2015) · Neuron · doi:10.1016/j.neuron.2015.10.022 · Cited by 131 · see citing works
Self-citationEpilepsy and Autism: Neurodevelopmental Perspective
Tuchman, R. F., & Cuccaro, M. L. (2011) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-011-0195-x · Cited by 131 · see citing works
Decoding the genetics of speech and language
Graham, S. A., & Fisher, S. E. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.11.006 · Cited by 130 · see citing works
Development of Patient-Specific Neurons in Schizophrenia Using Induced Pluripotent Stem Cells
Pedrosa, E., Sandler, V., Shah, A., Carroll, R., Chang, C.-J., Rockowitz, S., Guo, X.-Y., Zheng, D.-Y., & Lachman, H. (2011) · Journal of neurogenetics · doi:10.3109/01677063.2011.597908 · Cited by 123 · see citing works
Ornoy, A., Weinstein‐Fudim, L., & Ergaz, Z. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00316 · Cited by 130 · see citing works
Mascheretti, S., Luca, A. D., Trezzi, V., Peruzzo, D., Nordio, A., Marino, C., & Arrigoni, F. (2017) · Translational Psychiatry · doi:10.1038/tp.2016.240 · Cited by 127 · see citing works
Stamou, M., Streifel, K. M., Goines, P. E., & Lein, P. J. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2012.12.001 · Cited by 128 · see citing works
Regulation of neuronal migration, an emerging topic in autism spectrum disorders
Reiner, O., Karzbrun, E., Kshirsagar, A., & Kaibuchi, K. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13403 · Cited by 123 · see citing works
Bertero, A., Liska, A., Pagani, M., Parolisi, R., Masferrer, M. E., Gritti, M., Pedrazzoli, M., Galbusera, A., Sarica, A., Cerasa, A., et al. (2018) · Brain · doi:10.1093/brain/awy111 · Cited by 120 · see citing works
Genetic and non-genetic animal models for autism spectrum disorders (ASD)
Ergaz, Z., Weinstein‐Fudim, L., & Ornoy, A. (2016) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.04.024 · Cited by 116 · see citing works
Reduced multisensory facilitation in persons with autism
Collignon, O., Charbonneau, G., Peters, F., Nassim, M., Lassonde, M., Lepore, F., Mottron, L., & Bertone, A. (2013) · Cortex · doi:10.1016/j.cortex.2012.06.001 · Cited by 114 · see citing works
Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes
Zerbi, V., Pagani, M., Markicevic, M., Matteoli, M., Pozzi, D., Fagiolini, M., Bozzi, Y., Galbusera, A., Scattoni, M. L., Provenzano, G., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01245-4 · Cited by 102 · see citing works
Deletion of Autism Risk Gene Shank3 Disrupts Prefrontal Connectivity
Pagani, M., Bertero, A., Liska, A., Galbusera, A., Sabbioni, M., Barsotti, N., Colenbier, N., Marinazzo, D., Scattoni, M. L., Pasqualetti, M., et al. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.2529-18.2019 · Cited by 111 · see citing works
Genome‐wide association study of shared components of reading disability and language impairment
Eicher, J. D., Powers, N. R., Miller, L. L., Akshoomoff, N. A., Amaral, D. G., Bloss, C. S., Libiger, O., Schork, N. J., Darst, B. F., Casey, B. J., et al. (2013) · Genes Brain & Behavior · doi:10.1111/gbb.12085 · Cited by 108 · see citing works
Qiu, S., Anderson, C. T., Levitt, P., & Shepherd, G. M. G. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6569-10.2011 · Cited by 106 · see citing works
Bejjani, A. C., O’Neill, J., Kim, J. A., Frew, A. J., Yee, V. W., Ly, R., Ramirez, C. M., Salamon, N., McCracken, J. T., Toga, A. W., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038786 · Cited by 104 · see citing works
Whalley, H. C., O’Connell, G., Sussmann, J. E., Peel, A., Stanfield, A. C., Hayiou‐Thomas, M. E., Johnstone, E. C., Lawrie, S. M., McIntosh, A. M., & Hall, J. (2011) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31241 · Cited by 105 · see citing works
Shan, X., Uddin, L. Q., Xiao, J., He, C., Ling, Z., Li, L., Huang, X., Chen, H., & Duan, X. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.01.011 · Cited by 100 · see citing works
Altered Structural Brain Connectivity in Healthy Carriers of the Autism Risk Gene, CNTNAP2
Dennis, E. L., Jahanshad, N., Rudie, J. D., Brown, J. A., Johnson, K., McMahon, K. L., de Zubicaray, G. I., Montgomery, G. W., Martin, N. G., Wright, M. J., et al. (2011) · Brain Connectivity · doi:10.1089/brain.2011.0064 · Cited by 101 · see citing works
Self-citationLiska, A., Bertero, A., Gomolka, R. S., Sabbioni, M., Galbusera, A., Barsotti, N., Panzeri, S., Scattoni, M. L., Pasqualetti, M., & Gozzi, A. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx022 · Cited by 100 · see citing works
Neuroimaging in autism—from basic science to translational research
Ecker, C., & Murphy, D. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.276 · Cited by 98 · see citing works
Insula response and connectivity during social and non-social attention in children with autism
Odriozola, P., Uddin, L. Q., Lynch, C. J., Kochalka, J., Chen, T., & Menon, V. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv126 · Cited by 95 · see citing works
Translational approaches to the biology of Autism: false dawn or a new era?
Ecker, C., Spooren, W. P. J. M., & Murphy, D. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.102 · Cited by 93 · see citing works
Brain connectivity in normally developing children and adolescents
Khundrakpam, B. S., Lewis, J. D., Zhao, L., Chouinard-Decorte, F., & Evans, A. C. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.03.062 · Cited by 91 · see citing works
Scott, R. S., Sánchez-Aguilera, A., van Elst, K., Lim, L., Dehorter, N., Bae, S., Bartolini, G., Peles, E., Kas, M. J., Bruining, H., et al. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx341 · Cited by 91 · see citing works
Stein, M. B., Yang, B.-Z., Chavira, D. A., Hitchcock, C. A., Sung, S. C., Shipon-Blum, E., & Gelernter, J. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.11.008 · Cited by 89 · see citing works
Evidence for the role of EP HX2 gene variants in anorexia nervosa
Zeeland, A. A. S., Bloss, C. S., Tewhey, R., Bansal, V., Torkamani, A., Libiger, O., Duvvuri, V., Wineinger, N. E., Galvez, L., Darst, B. F., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.91 · Cited by 82 · see citing works
Saint‐Martin, M., Joubert, B., Pellier‐Monnin, V., Pascual, O., Noraz, N., & Honnorat, J. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14081 · Cited by 83 · see citing works
Zerbi, V., Ielacqua, G. D., Markicevic, M., Haberl, M. G., Ellisman, M. H., A-Bhaskaran, A., Frick, A., Rudin, M., & Wenderoth, N. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy046 · Cited by 81 · see citing works
Mapping connectivity in the developing brain
Dennis, E. L., & Thompson, P. M. (2013) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2013.05.007 · Cited by 79 · see citing works
Modeling the functional genomics of autism using human neurons
Konopka, G., Wexler, E., Rosen, E., Mukamel, Z., Osborn, G. E., Chen, L., Lu, D., Gao, F., Gao, K., Lowe, J. K., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.60 · Cited by 76 · see citing works
Self-citationAKAPs integrate genetic findings for autism spectrum disorders
Poelmans, G., Franke, B., Pauls, D. L., Glennon, J. C., & Buitelaar, J. K. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.48 · Cited by 72 · see citing works
Nakagawa, Y., & Chiba, K. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.234476 · Cited by 72 · see citing works
Dougnon, G., & Matsui, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147550 · Cited by 71 · see citing works
Thomas, M. S. C., Knowland, V. C. P., & Karmiloff‐Smith, A. (2011) · Psychological Review · doi:10.1037/a0025234 · Cited by 68 · see citing works
Singletary, W. M. (2015) · Neuropsychoanalysis · doi:10.1080/15294145.2015.1092334 · Cited by 71 · see citing works
Boeckx, C. A., & Benítez‐Burraco, A. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.01324 · Cited by 65 · see citing works
Voineskos, A. N., Lett, T. A. P., Lerch, J. P., Tiwari, A. K., Ameis, S. H., Rajji, T. K., Müller, D. J., Mulsant, B. H., & Kennedy, J. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020982 · Cited by 67 · see citing works
Peters, S. U., Horowitz, L. T., Barbieri‐Welge, R. L., Taylor, J. L., & Hundley, R. J. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2011.02455.x · Cited by 68 · see citing works
Language Impairments in ASD Resulting from a Failed Domestication of the Human Brain
Benítez‐Burraco, A., Lattanzi, W., & Murphy, E. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00373 · Cited by 61 · see citing works
Jouravlev, O., Kell, A. J. E., Mineroff, Z., Haskins, A. J., Ayyash, D., Kanwisher, N., & Fedorenko, E. G. (2020) · Autism Research · doi:10.1002/aur.2393 · Cited by 63 · see citing works
Harkin, L. F., Lindsay, S., Xu, Y., Alzu’bi, A., Ferrara, A., Gullon, E. A., James, O. G., & Clowry, G. J. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw394 · Cited by 64 · see citing works
Lu, Z., Reddy, M., Liu, J., Kalichava, A., Liu, J., Zhang, L., Chen, F., Wang, Y., Holthauzen, L. M. F., White, M. A., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.748236 · Cited by 61 · see citing works
The Oscillopathic Nature of Language Deficits in Autism: From Genes to Language Evolution
Benítez‐Burraco, A., & Murphy, E. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00120 · Cited by 61 · see citing works
Murphy, E., & Benítez‐Burraco, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.029 · Cited by 64 · see citing works
PTEN Regulation of Local and Long-Range Connections in Mouse Auditory Cortex
Xiong, Q., Oviedo, H. V., Trotman, L. C., & Zador, A. M. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4480-11.2012 · Cited by 60 · see citing works
Climbing Brain Levels of Organisation from Genes to Consciousness
Changeux, J.-P. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.01.004 · Cited by 61 · see citing works
Multivariate Neural Connectivity Patterns in Early Infancy Predict Later Autism Symptoms
Dickinson, A. H., Daniel, M., Marin, A., Gaonkar, B., Dapretto, M., McDonald, N. M., & Jeste, S. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.06.003 · Cited by 59 · see citing works
Self-citationNisar, S., & Haris, M. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02060-9 · Cited by 64 · see citing works
Blockwise Human Brain Network Visual Comparison Using NodeTrix Representation
Yang, X., Shi, L., Daianu, M., Tong, H., Liu, Q., & Thompson, P. M. (2016) · IEEE Transactions on Visualization and Computer Graphics · doi:10.1109/tvcg.2016.2598472 · Cited by 54 · see citing works
Inherited genetic variants in autism-related CNTNAP2 show perturbed trafficking and ATF6 activation
Falivelli, G., Jaco, A. D., Favaloro, F. L., Kim, H.-G., Wilson, J., Dubi, N., Ellisman, M. H., Abrahams, B. S., Taylor, P., & Comoletti, D. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds320 · Cited by 52 · see citing works
Self-citationLinks between genetics and pathophysiology in the autism spectrum disorders
Holt, R., & Monaco, A. P. (2011) · EMBO Molecular Medicine · doi:10.1002/emmm.201100157 · Cited by 52 · see citing works
Bridging the Gap between Genes and Language Deficits in Schizophrenia: An Oscillopathic Approach
Murphy, E., & Benítez‐Burraco, A. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00422 · Cited by 52 · see citing works
Liu, J., Okada, N. J., Cummings, K. K., Jung, J., Patterson, G., Bookheimer, S. Y., Jeste, S., & Dapretto, M. (2020) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2020.100814 · Cited by 51 · see citing works
Self-citationClaudio Toma, A., Pierce, K. D., Shaw, A. D., Heath, A., Mitchell, P. B., Schofield, P. R., & Fullerton, J. M. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007535 · Cited by 47 · see citing works
Thanseem, I., Anitha, A., Nakamura, K., Suda, S., Iwata, K., Matsuzaki, H., Ohtsubo, M., Ueki, T., Katayama, T., Iwata, Y., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.020 · Cited by 47 · see citing works
Eicher, J. D., & Gruen, J. R. (2013) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2013.07.001 · Cited by 48 · see citing works
Pivotal response treatment for autism spectrum disorder: current perspectives
Lei, J., & Ventola, P. E. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s120710 · Cited by 50 · see citing works
Imaging-Genetics in Autism Spectrum Disorder: Advances, Translational Impact, and Future Directions
Ameis, S. H., & Szatmári, P. (2012) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2012.00046 · Cited by 46 · see citing works
- Authors
- Scott-Van Zeeland, A. A., Abrahams, B. S., Alvarez-Retuerto, A. I., Sonnenblick, L. I., Rudie, J. D., Ghahremani, D., Mumford, J. A., Poldrack, R. A., Dapretto, M., Geschwind, D. H., & Bookheimer, S. Y.
- Affiliations
- Center for Cognitive Neuroscience, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
- University of California, Los Angeles (US)
- Corresponding author
- Abrahams, Brett S.
- Geschwind, Daniel H.
- Bookheimer, Susan Y.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2010-11-03
- Volume
- 2
- Issue
- 56
- Pages
- 56ra80-56ra80
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC3065863
- OpenAlex
- W2127753140
- Cited by
- 252
- References
- 41
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 4 · 2023: 12 · 2022: 16 · 2021: 11 · 2020: 13 · 2019: 14 · 2018: 12 · 2017: 23 · 2016: 24 · 2015: 19 · 2014: 10 · 2013: 29 · 2012: 31
- FWCI
- 16.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Autism Speaks (AS1626)
- National Institute of Mental Health (F31MH079645, R01MH081754, T32MH073526)
- National Center for Research Resources (P41RR013642, RR 13642, RR00865, M01RR000865, UL1RR025774, C06RR012169)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD035470, P50-HD055784-03S1, P50HD055784, R01HD065280)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- CNTNAP2, autism spectrum disorder, functional connectivity, genotype-phenotype correlation, neurexin, common genetic variants, neurodevelopmental disorders, specific language impairment, human brain imaging
- MeSH terms
- Autistic Disorder, Frontal Lobe, Humans, Magnetic Resonance Imaging, Membrane Proteins, Nerve Tissue Proteins, Neural Pathways, Risk Factors, Genetic Predisposition to Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
