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The HIF-1 Hypoxia-Inducible Factor Modulates Lifespan in C. elegans
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During normal development or during disease, animal cells experience hypoxic (low oxygen) conditions, and the hypoxia-inducible factor (HIF) transcription factors implement most of the critical changes in gene expression that enable animals to adapt to this stress. Here, we examine the roles of HIF-1 in post-mitotic aging. We examined the effects of HIF-1 over-expression and of hif-1 loss-of-function mutations on longevity in C. elegans, a powerful genetic system in which adult somatic cells are post-mitotic. We constructed transgenic lines that expressed varying levels of HIF-1 protein and discovered a positive correlation between HIF-1 expression levels and lifespan. The data further showed that HIF-1 acted in parallel to the SKN-1/NRF and DAF-16/FOXO transcription factors to promote longevity. HIF-1 over-expression also conferred increased resistance to heat and oxidative stress. We isolated and characterized additional hif-1 mutations, and we found that each of 3 loss-of-function mutations conferred increased longevity in normal lab culture conditions, but, unlike HIF-1 over-expression, a hif-1 deletion mutation did not extend the lifespan of daf-16 or skn-1 mutants. We conclude that HIF-1 over-expression and hif-1 loss-of-function mutations promote longevity by different pathways. These data establish HIF-1 as one of the key stress-responsive transcription factors that modulate longevity in C. elegans and advance our understanding of the regulatory networks that link oxygen homeostasis and aging.
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“Numerous reports have indicated that the HIF pathway has a role in life span of C. elegans (Chen et al., 2009; Zhang et al., 2009).”
From SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production (2011) · cites this paper as Zhang et al., 2009
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Cites
A C. elegans mutant that lives twice as long as wild type
Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387
Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.
Kaelin, W. G., & Ratcliffe, P. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.04.009 · Cited by 3,251 · cited 1×
“HIF stability and activity are influenced by reactive oxygen species, citric acid cycle intermediates, Fe(II) availability, and intracellular signaling events [1,3].”
BackgroundKimura, K. D., Tissenbaum, H. A., Liu, Y., & Ruvkun, G. (1997) · Science · doi:10.1126/science.277.5328.942 · Cited by 2,250
Ogg, S., Paradis, S., Gottlieb, S., Patterson, G. I., Lee, L., Tissenbaum, H. A., & Ruvkun, G. (1997) · Nature · doi:10.1038/40194 · Cited by 1,935
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
Tissenbaum, H. A., & Guarente, L. (2001) · Nature · doi:10.1038/35065638 · Cited by 1,603
Regulation of aging and age-related disease by DAF-16 and heat-shock factor
Hsu, A.-L., Murphy, C. T., & Kenyon, C. (2003) · Science · doi:10.1126/science.1083701 · Cited by 1,513
Hypoxia-inducible factor 1: master regulator of O2 homeostasis
Semenza, G. L. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80016-6 · Cited by 1,092
Lin, K., Hsin, H., Libina, N., & Kenyon, C. J. (2001) · Nature Genetics · doi:10.1038/88850 · Cited by 1,027
Henderson, S. T., & Johnson, T. E. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00594-2 · Cited by 949
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Items 101–200 of 211
Srivastava, V., Zelmanovich, V., Shukla, V., Abergel, R., Cohen, I., Ben‐Sasson, S. A., & Gross, E. (2022) · Autophagy · doi:10.1080/15548627.2022.2078069 · Cited by 24
Aging biology: a new frontier for drug discovery
Verdaguer, E., Junyent, F., Folch, J., Beas‐Zárate, C., Auladell, C., Pallàs, M., & Camins, A. (2012) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2012.660144 · Cited by 22
Liao, Y., Mo, G., Sun, J., Wei, F., & Liao, D. J. (2016) · Molecular Biology Reports · doi:10.1007/s11033-016-3976-0 · Cited by 22
Mitophagy during development and stress in C. elegans
Leboutet, R., Chen, Y., Legouis, R., & Culetto, E. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111266 · Cited by 22
Matera, D. L., Lee, A. T., Hiraki, H. L., & Baker, B. M. (2021) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-021-00698-5 · Cited by 23
Espinosa‐Ruíz, C., Manuguerra, S., Curcuraci, E., Santulli, A., & Messina, C. M. (2019) · Marine Environmental Research · doi:10.1016/j.marenvres.2019.104844 · Cited by 19
Mitophagy-promoting agents and their ability to promote healthy-aging
Srivastava, V., & Gross, E. (2023) · Biochemical Society Transactions · doi:10.1042/bst20221363 · Cited by 17
The Role of Hypoxia-Inducible Factor in the Mechanisms of Aging
Dzhalilova, D. S., & Makarova, O. V. (2022) · Biochemistry (Moscow) · doi:10.1134/s0006297922090115 · Cited by 17
Hypoxia extends lifespan of Brachionus manjavacas (Rotifera)
Snell, T. W., Johnston, R. K., & Jones, B. L. (2019) · Limnetica · doi:10.23818/limn.38.04 · Cited by 17
Ferritin is regulated by a neuro-intestinal axis in the nematode Caenorhabditis elegans
Romero, L., Zelmanovich, V., Abergel, Z., Zuckerman, B. M., Shaked, M., Abergel, R., Livshits, L., Smith, Y., & Gross, E. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101359 · Cited by 17
The Mitoscriptome in Aging and Disease.
Raju, R. P., Jian, B., Hubbard, W. J., & Chaudry, I. H. (2011) · Europe PMC (PubMed Central) · Cited by 17
Effects of dietary restriction on metabolic and cognitive health
Matos, M. S., Platt, B., & Delibegović, M. (2020) · Proceedings of The Nutrition Society · doi:10.1017/s0029665120007910 · Cited by 16
Gharbi, H., Fabretti, F., Bharill, P., Rinschen, M. M., Brinkkoetter, S., Frommolt, P., Burst, V. R., Schermer, B., Benzing, T. R., & Müller, R. (2013) · Aging Cell · doi:10.1111/acel.12081 · Cited by 16
Abergel, R., Livshits, L., Shaked, M., Chatterjee, A. K., & Gross, E. (2017) · Aging Cell · doi:10.1111/acel.12569 · Cited by 16
Fischer, F., Benner, C., Goyala, A., Grigolon, G., Vitiello, D., Wu, J. Y., Zarse, K., Ewald, C. Y., & Ristow, M. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102085 · Cited by 16
Wang, L., Cui, S., Ma, L., Kong, L., & Geng, X. (2015) · Insect Molecular Biology · doi:10.1111/imb.12189 · Cited by 14
Hearn, J., Clark, J., Wilson, P. J., & Little, T. J. (2020) · Molecular Ecology · doi:10.1111/mec.15557 · Cited by 13
Jones (2016) · doi:10.1016/j.lssr.2016.06.003 · Cited by 14
Self-citationSuppressing APOE4-induced neural pathologies by targeting the VHL–HIF axis
Jiang, W. I., Cao, Y., Xue, Y., Ji, Y., Winer, B. Y., Chandra, R., Zhang, X. F., Zhang, M., Singhal, N. S., Pierce-Shimomura, J. T., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2417515122 · Cited by 13
Zhao, L., Liu, Z., Yang, F., Zhang, Y., Xue, Y., Miao, H., Liao, X., Huang, H., & Li, G. (2019) · Scientific Reports · doi:10.1038/s41598-019-47891-1 · Cited by 13
Self-citationInteractions between oxygen homeostasis, food availability, and hydrogen sulfide signaling
Iranon, N. N., & Miller, D. L. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00257 · Cited by 14
Lack of oxygen aids cell survival
Powell‐Coffman, J. A., & Coffman, C. R. (2010) · Nature · doi:10.1038/465554a · Cited by 13
Self-citationMechanisms of defense against products of cysteine catabolism in the nematode Caenorhabditis elegans
Livshits, L., Chatterjee, A. K., Karbian, N., Abergel, R., Abergel, Z., & Gross, E. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.02.007 · Cited by 13
Dakik, P., Medkour, Y., Mohammad, K., & Titorenko, V. I. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00461 · Cited by 13
Mangu, J. C. K., Rai, N., Mandal, A., Olsson, P., & Jaß, J. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.155377 · Cited by 13
Roles of hypoxia-inducible factor-prolyl hydroxylases in aging and disease
Galkin, F., Pulous, F. E., Fu, Y., Zhang, M., Pun, F. W., Ren, F., & Zhavoronkov, A. A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102551 · Cited by 14
Mitochondria, Autophagy and Inflammation: Interconnected in Aging
Silva, R. C. M. C. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01231-x · Cited by 13
Müller, R., Zank, S., Fabretti, F., & Benzing, T. R. (2011) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e3283471a22 · Cited by 12
Zuckerman, B. M., Abergel, Z., Zelmanovich, V., Romero, L., Abergel, R., Livshits, L., Smith, Y., & Gross, E. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.05.007 · Cited by 12
Jones, L., Chen, Y., & van Oosten‐Hawle, P. (2020) · Biological Chemistry · doi:10.1515/hsz-2019-0385 · Cited by 13
Kruempel, J. C. P., Miller, H. A., Schaller, M. L., Fretz, A., Howington, M. B., Sarker, M. R., Huang, S., & Leiser, S. F. (2020) · GeroScience · doi:10.1007/s11357-020-00194-0 · Cited by 11
Lazaro-Pena, M. I., Cornwell, A. B., Diaz-Balzac, C. A., Das, R., Ward, Z. C., Macoretta, N., Thakar, J., & Samuelson, A. V. (2023) · eLife · doi:10.7554/elife.85792 · Cited by 11
Assessing Chronological Aging in Bacteria
Gonidakis, S., & Longo, V. D. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-239-1_28 · Cited by 12
Two sides of lifespan regulating genes: pro-longevity or anti-longevity?
Honjoh, S., & Nishida, E. (2011) · The Journal of Biochemistry · doi:10.1093/jb/mvr026 · Cited by 11
Phani, V., Somvanshi, V. S., Shukla, R. N., Davies, K. G., & Rao, U. (2018) · BMC Genomics · doi:10.1186/s12864-018-5230-8 · Cited by 11
Yu, Z., Tu, J., Ou, M., Cen, J., Xue, K., Li, S., Zhou, J., & Lu, G. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111963 · Cited by 11
Pede, A. D., Ko, B., AlOkda, A., González, A. A. T., Zhu, S., & Raamsdonk, J. M. V. (2025) · Open Biology · doi:10.1098/rsob.240358 · Cited by 12
Esmaillie, R., Ignarski, M., Bohl, K., Krüger, T., Ahmad, D., Seufert, L., Schermer, B., Benzing, T. R., Müller, R., & Fabretti, F. (2019) · iScience · doi:10.1016/j.isci.2019.11.039 · Cited by 10
Shilovsky, G. A., Putyatina, T. S., Lysenkov, S. N., Ashapkin, V. V., Luchkina, O. S., Markov, A. V., & Skulachev, V. P. (2016) · Biochemistry (Moscow) · doi:10.1134/s0006297916120075 · Cited by 10
Kamal, M., D'Amora, D. R., & Kubiseski, T. J. (2016) · BMC Cell Biology · doi:10.1186/s12860-016-0112-x · Cited by 9
Gonidakis, S., Finkel, S. E., & Longo, V. D. (2011) · Aging · doi:10.18632/aging.100301 · Cited by 9
Circadian Regulation of Hormesis for Health and Longevity
Jagota, A., Thummadi, N. B., & Kukkemane, K. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814253-0.00020-6 · Cited by 9
Hansen, M., & Kapahi, P. (2010) · The Enzymes · doi:10.1016/s1874-6047(10)28014-9 · Cited by 9
Kirmes, I., Hung, G. C. C., Hahn, A., Dai, C.-Y., Campbell, D., Ahier, A., Lee, R. S. Y., Palmer, A., & Zuryn, S. (2025) · Nature Communications · doi:10.1038/s41467-025-67198-2 · Cited by 7
Feng, D., Zhai, Z., Shao, Z., Zhang, Y., & Powell‐Coffman, J. A. (2021) · PLoS ONE · doi:10.1371/journal.pone.0249103 · Cited by 7
Self-citationFeng, D., Qu, L., & Powell‐Coffman, J. A. (2024) · PLoS ONE · doi:10.1371/journal.pone.0295094 · Cited by 7
Self-citationNeuropeptide signaling regulates the susceptibility of developing C. elegans to anoxia
Doshi, S., Price, E. L., Landis, J. T., Barot, U., Sabatella, M., Lans, H., & Kalb, R. G. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.12.006 · Cited by 7
Cornwell, A., Zhang, Y., Thondamal, M., Johnson, D. W., Thakar, J., & Samuelson, A. V. (2024) · GeroScience · doi:10.1007/s11357-024-01197-x · Cited by 6
Self-citationOne-day thermal regime extends the lifespan in Caenorhabditis elegans
Huang, J., Wang, K., Wang, M., Wu, Z., Xie, G., Peng, Y., Zhang, Y., Zhang, X., & Shao, Z. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.12.017 · Cited by 6
Self-citationShaposhnikov, M. V., Gorbunova, A. A., Zemskaya, N. V., Ulyasheva, N. S., Ришатовна, П. Н., Yakovleva, D. V., & Moskalev, A. (2023) · Biogerontology · doi:10.1007/s10522-023-10017-2 · Cited by 5
Searching for the elusive mitochondrial longevity signal in C. elegans
Bennett, C. F., Choi, H., & Kaeberlein, M. R. (2014) · Worm · doi:10.4161/21624046.2014.959404 · Cited by 5
HIF-1 as a Marker of Age-Related Diseases Associated with Tissue Hypoxia
Поправка, Е. С., Linkova, N. S., Trofimova, S., & Khavinson, V. K. (2018) · Biology Bulletin Reviews · doi:10.1134/s2079086418060075 · Cited by 5
Early Exposure is Necessary for the Lifespan Extension Effects of Cocoa in C. elegans
Munasinghe, M., Almotayri, A., Thomas, J., Heydarian, D., & Jois, M. (2021) · Nutrition and Metabolic Insights · doi:10.1177/11786388211029443 · Cited by 5
Long‐lived mitochondrial (Mit) mutants of Caenorhabditis elegans utilize a novel metabolism
Butler, J. A., Ventura, N., Johnson, T. E., & Rea, S. L. (2010) · The FASEB Journal · doi:10.1096/fj.10.162941 · Cited by 5
Dong, Q., Liu, C., Zhao, W. A. N. G., ZhuoRan, W. A. N. G., Liang, Y., & Wang, X. (2015) · Scientia Sinica Vitae · doi:10.1360/n052014-00281 · Cited by 4
Food touch limits lifespan through bioamine and neuroendocrine signalingPreprint
Kitto, E. S., Beydoun, S., & Leiser, S. F. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.19.590228 · Cited by 5
A transcription-independent role for HIF-1α in modulating microprocessor assembly
Li, J., Wang, M., Ruan, J., Lyu, Y.-J., Weng, Y.-H., Brindangnanam, P., Coumar, M. S., & Chen, P. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae792 · Cited by 5
Metabolic regulation of behavior by the intestinal enzyme FMO-2
Kitto, E. S., Beydoun, S., Henry, E., Schaller, M. L., Bhandari, M., Easow, S. A., Tuckowski, A. M., Howington, M. B., Bhat, A., Sridhar, A., et al. (2025) · Science Advances · doi:10.1126/sciadv.adx3018 · Cited by 6
Invertebrate models in translational research
Shukla, A. K., Wodrich, A. P. K., Sharma, A., & Giniger, E. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90042-3.00009-8 · Cited by 4
Lee, Y., Byeon, E., Lee, J.-S., Maszczyk, P., Kim, H. S., Sayed, A. E. H., Yang, Z., Lee, J., & Kim, D. (2024) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2024.117138 · Cited by 4
Saucedo, M. D. J. G., Camargo-Hernández, G., Castillo‐Romero, A., Ramírez-Herrera, M. A., Bañuelos‐Pineda, J., Pereira-Suárez, A. L., Hernández-Chávez, A., & Hernández-Hernández, L. (2020) · Neurotoxicity Research · doi:10.1007/s12640-020-00207-y · Cited by 6
Pitt, J. N., Leiser, S. F., & Kaeberlein, M. R. (2014) · Annual Review of Gerontology and Geriatrics · doi:10.1891/0198-8794.34.59 · Cited by 4
Longevity as a Complex Genetic Trait
Sutphin, G. L., & Korstanje, R. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-411596-5.00001-0 · Cited by 4
Zeidan, R. S., Ebea, P. O., Sykes, S., Evripidou, N., Pan, E., Markovich, Z., Sheng, Y., Han, S. M., Leeuwenburgh, C., & Xiao, R. (2025) · Experimental Gerontology · doi:10.1016/j.exger.2025.112826 · Cited by 3
Hypoxia signalling and regulation in chemosensory behaviour of Caenorhabditis elegans
Macnee, G., & Hejmadi, M. V. (2015) · Bioscience Horizons The International Journal of Student Research · doi:10.1093/biohorizons/hzv003 · Cited by 3
Feng, D., Qu, L., & Powell‐Coffman, J. A. (2024) · PLoS ONE · doi:10.1371/journal.pone.0295093 · Cited by 3
Self-citationWillett, J. D., Podugu, N., Sudama, G., Kopecký, J., & Isbister, J. D. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq036 · Cited by 3
Aging in the Nematode Caenorhabditis elegans
Daskalaki, I., Markaki, M., & Tavernarakis, N. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11376-5 · Cited by 4
Türkoğlu, S. A., Toprak, C., Poyrazlı, F., & Okuyan, D. (2026) · Cytotechnology · doi:10.1007/s10616-026-00972-2 · Cited by 2
Neuroprotective Effects of Cinnamon (Cinnamomum Verum) Via Modulation of Stress Response Signaling
Gomada, Y. (2012) · Cited by 2
Miller, D. L., Horsman, J. W., & Heinis, F. I. (2016) · Healthy ageing and longevity · doi:10.1007/978-3-319-44703-2_9 · Cited by 2
Cellular lifespan and senescence: a complex balance between multiple cellular pathways
Dolivo, D., Hernandez, S. J., & Dominko, T. (2015) · Inside the Cell · doi:10.1002/icl3.1036 · Cited by 3
The role of neurosensory systems in the modulation of aging
Yang, G., Sheng, Y., & Xiao, R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-815962-0.00013-5 · Cited by 1
Cao, Y., Ren, S., Li, X., Xiao, X., & Xiao, Y. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1816985 · Cited by 1
Kaeberlein, M. R., Kennedy, B. K., Liu, X., Suh, Y., & Zhou, Z. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.07.001 · Cited by 1
Diverse Roles for SIRT6 in Mammalian Healthspan and Longevity
Zwaans, B. M. M., Giblin, W., & Lombard, D. B. (2016) · Springer eBooks · doi:10.1007/978-94-024-0962-8_7 · Cited by 1
Network analysis in aged C. elegans reveals candidate regulatory genes of ageing
Aktypi, F. D., Papaevgeniou, N., Voutetakis, K., Chatziioannou, A. A., Grune, T., & Chondrogianni, N. (2021) · Biogerontology · doi:10.1007/s10522-021-09920-3 · Cited by 2
Searching for the elusive mitochondrial longevity signal in C. elegans
Bennett, C. F., Choi, H., & Kaeberlein, M. R. (2014) · Worm · doi:10.4161/worm.29868 · Cited by 1
Amin, M. (2015) · Nova Journal of Medical and Biological Sciences · doi:10.20286/nova-jmbs-040347 · Cited by 1
Impact of Caenorhabditis elegans in Cancer Drug Resistance Development
Shanmugam, G., Kannan, S., & Senthilkumar, K. (2022) · Springer eBooks · doi:10.1007/978-981-15-9411-3_16 · Cited by 1
New insights into cell non-autonomous mechanisms of theC. eleganshypoxic response
Leiser, S. F., Rossner, R., & Kaeberlein, M. R. (2016) · Worm · doi:10.1080/21624054.2016.1176823 · Cited by 1
Suppressing APOE4-induced mortality and cellular damage by targeting VHLPreprint
Jiang, W. I., Cao, Y., Xue, Y., Ji, Y., Winer, B. Y., Zhang, M., Singhal, N. S., Pierce-Shimomura, J. T., Chen, S., & Dengke, K. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.28.582664 · Cited by 1
The hypoxic response extends lifespan through a bioaminergic and peptidergic neural circuitPreprint
Kitto, E. S., Huang, S., Bhandari, M., Tian, C., Cox, R. L., Beydoun, S., Wang, E. Q., Shave, D., Miller, H. A., Easow, S. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.04.652087 · Cited by 1
The hypoxic response extends lifespan through a bioaminergic and peptidergic neural circuitPreprint
Kitto, E. S., Huang, S., Bhandari, M., Tian, C., Cox, R. L., Beydoun, S., Wang, E. Q., Shave, D., Miller, H. A., Easow, S. A., et al. (2025) · eLife · doi:10.7554/elife.107651 · Cited by 1
Vitale, M. (2013) · Università degli Studi di Napoli Federico II · doi:10.6092/unina/fedoa/9515
The regulation of hypoxia-inducible factor (HIF-1) and the role of HIF-1 in C. elegans longevity
Zhai, Z. (2010) · Iowa State University Digital Repository (Iowa State University) · doi:10.31274/etd-180810-2485
Self-citationLaRue, B. (2010) · University of North Texas Digital Library (University of North Texas) · doi:10.12794/metadc103350
Sartório, P. V. (2013) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.21.2013.tde-09042014-170635
Yanos, M. E. (2014) · ResearchWorks at the University of Washington (University of Washington)
Little, B. A. (2011) · University of North Texas Digital Library (University of North Texas) · doi:10.12794/metadc84241
Cervoni, M. S. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2019.tde-22072019-110323
Mechanisms underlying the functions of sleep in aging during starvation in Caenorhabditis elegans
Wu, Y. (2019) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-7601
Liontis, T. (2020) · eScholarship@McGill (McGill) · doi:10.82308/42346
Impact of Caenorhabditis elegans in Cancer Drug Resistance Development
Shanmugam, G., Kannan, S., & Senthilkumar, K. (2021) · Springer eBooks · doi:10.1007/978-981-15-4501-6_16-1
Gassmann, M. (2011) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.13360039.14730168
Machado, I. F., Teodoro, J. S., Castela, A. C., Palmeira, C. M., & Rolo, A. P. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821562-3.00035-6
Lee, S., & Park, H. H. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734291273.793555709
The Hypoxic Response and Aging
Leiser, S. F., Miller, H. A., & Kaeberlein, M. R. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-411596-5.00004-6
Schumacher, B. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734291273.793563332
Metadata
- Authors
- Zhang, Y., Shao, Z., Zhai, Z., Shen, C., & Powell-Coffman, J. A.
- Affiliations
- Iowa State University (US)
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2009-07-27
- Volume
- 4
- Issue
- 7
- Pages
- e6348
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC2711329
- OpenAlex
- W2076724288
- Cited by
- 211
- References
- 50
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 11 · 2023: 5 · 2022: 10 · 2021: 8 · 2020: 10 · 2019: 14 · 2018: 12 · 2017: 7 · 2016: 16 · 2015: 22 · 2014: 18 · 2013: 9 · 2012: 11
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Iowa State University Digital Repository (Iowa State University) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- Iowa State University
- National Institutes of Health
- National Institute of General Medical Sciences (R01GM078424)
- National Center for Research Resources
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- HIF-1, hypoxia-inducible factor, lifespan, longevity, Caenorhabditis elegans, DAF-16/FOXO, transcription factors, oxidative stress resistance, heat stress resistance, oxygen homeostasis, stress response, loss-of-function mutations
- MeSH terms
- Animals, Longevity, Mutation, Transcription Factors, Caenorhabditis elegans, Reverse Transcriptase Polymerase Chain Reaction, Caenorhabditis elegans Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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