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The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Telomere Dynamics in Human Cells Reprogrammed to Pluripotency

Suhr, Steven T., Chang, Eun Ah, Rodriguez, Ramon M., Wang, Kai, Ross, Pablo J., Beyhan, Zeki, Murthy, Shashanka, Cibelli, Jose B.·2009·PLoS ONE
DOI 10.1371/journal.pone.0008124PMC PMC2780312
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Crossref · 10.1371/journal.pone.0008124

Cites

6 of 6 references verified0 citation errors · 0 not checkable

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  • Early human cell reprogramming protocols relied upon rejuvenation through re-differentiation after iPS cell formation.

    “but protocols relied upon rejuvenation through re-differentiation after iPS cell formation 20,26,28 .”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [28]

    The Introduction and Results describe forming human iPSCs and then re-differentiating them, so the sequence in the claim is supported. But the paper reports telomere elongation during iPSC conversion and shortening after re-differentiation; it does not say that early protocols relied on re-differentiation itself to produce rejuvenation. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • Early experiments in human cells provided evidence that some biomarkers of aging (telomere lengths) were responding to epigenetic reprogramming.

    “Early experiments in human cells were somewhat encouraging as they provide evidence that some of the biomarkers of aging (that is telomere lengths) were responding to the epigenetic reprogramming”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [28]

  • Early reports using cells derived from old donors to generate iPS cells demonstrated beneficial effects on senescence phenotypes and telomere length.

    “Early reports using cells derived from old donors to generate iPS cells demonstrated beneficial effects on senescence phenotypes and telomere length [26][27][28] .”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [28]

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Citations

Cites

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Research works printed but not linked: 19

  1. [1]Blackburn EH 2005 Telomeres and telomerase: their mechanisms of action and the effects of altering their functions. FEBS Lett 579 859 862 15680963
  2. [2]Hug N Lingner J 2006 Telomere length homeostasis. Chromosoma 115 413 425 16741708
  3. [3]Riethman H 2008 Human telomere structure and biology. Annu Rev Genomics Hum Genet 9 1 19 18466090
  4. [4]Harrington L 2004 Does the reservoir for self-renewal stem from the ends? Oncogene 23 7283 7289 15378088
  5. [7]Wakayama T Shinkai Y Tamashiro KL Niida H Blanchard DC 2000 Cloning of mice to six generations. Nature 407 318 319 11014179
  6. [8]Kubota C Tian XC Yang X 2004 Serial bull cloning by somatic cell nuclear transfer. Nat Biotechnol 22 693 694 15156155
  7. [9]Marion RM Strati K Li H Tejera A Schoeftner S 2009 Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells. Cell Stem Cell 4 141 154 19200803
  8. [10]Shiels PG Kind AJ Campbell KH Waddington D Wilmut I 1999 Analysis of telomere lengths in cloned sheep. Nature 399 316 317 10360570
  9. [11]Amit M Carpenter MK Inokuma MS Chiu CP Harris CP 2000 Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture. Dev Biol 227 271 278 11071754
  10. [12]Niida H Shinkai Y Hande MP Matsumoto T Takehara S 2000 Telomere maintenance in telomerase-deficient mouse embryonic stem cells: characterization of an amplified telomeric DNA. Mol Cell Biol 20 4115 4127 10805753 PMC85781
  11. [13]Rosler ES Fisk GJ Ares X Irving J Miura T 2004 Long-term culture of human embryonic stem cells in feeder-free conditions. Dev Dyn. 229 259 274 14745951
  12. [14]Yu J Vodyanik MA Smuga-Otto K Antosiewicz-Bourget J Frane JL 2007 Induced pluripotent stem cell lines derived from human somatic cells. Science 318 1917 1920 18029452
  13. [15]Takahashi K Tanabe K Ohnuki M Narita M Ichisaka T 2007 Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131 861 872 18035408
  14. [16]Park IH Zhao R West JA Yabuuchi A Huo H 2008 Reprogramming of human somatic cells to pluripotency with defined factors. Nature 451 141 146 18157115
  15. [17]Greenberg RA O'Hagan RC Deng H Xiao Q Hann SR 1999 Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation. Oncogene 18 1219 1226 10022128
  16. [18]Wu KJ Grandori C Amacker M Simon-Vermot N Polack A 1999 Direct activation of TERT transcription by c-MYC. Nat Genet 21 220 224 9988278
  17. [19]Moyzis RK Buckingham JM Cram LS Dani M Deaven LL 1988 A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc Natl Acad Sci U S A 85 6622 6626 3413114 PMC282029
  18. [20]Lansdorp PM Verwoerd NP van de Rijke FM Dragowska V Little MT 1996 Heterogeneity in telomere length of human chromosomes. Hum Mol Genet 5 685 691 8733138
  19. [24]Cheung AL Deng W 2008 Telomere dysfunction, genome instability and cancer. Front Biosci 13 2075 2090 17981693

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Metadata

Authors
Suhr, S. T., Chang, E. A., Rodriguez, R. M., Wang, K., Ross, P. J., Beyhan, Z., Murthy, S., & Cibelli, J. B.
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2009-12-02
Volume
4
Issue
12
Pages
e8124
ISSN
1932-6203
DOI
10.1371/journal.pone.0008124
PMC
PMC2780312
Cited by
107
References
6
Language
en
Update notices
correction (2010-03-19)
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)

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