Aging and reprogramming: a two-way street
Open accessAbstract
Aging is accompanied by the functional decline of cells, tissues, and organs, as well as a striking increase in a wide range of diseases. The reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) opens new avenues for the aging field and has important applications for therapeutic treatments of age-related diseases. Here we review emerging studies on how aging and age-related pathways influence iPSC generation and property. We discuss the exciting possibility that reverting to a pluripotent stem cell stage erases several deficits associated with aging and offers new strategies for rejuvenation. Finally, we argue that reprogramming provides a unique opportunity to model aging and perhaps exceptional longevity.
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Full expression of the Yamanaka factors (OCT4, SOX2, KLF4 and MYC (OSKM)) in differentiated cells results in induction of pluripotency and a resetting of cellular ageing characteristics.
“Full expression of the Yamanaka factors (OCT4, SOX2, KLF4 and MYC (OSKM)) in differentiated cells results in induction of pluripotency (induced pluripotent stem cells) and a resetting of cellular ageing characteristics223–225.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [225]
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- Authors
- Mahmoudi, S., & Brunet, A.
- Affiliations
- Stanford University (US)
- Corresponding author
- Brunet, Anne
- ORCID
- Brunet, Anne
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 24
- Issue
- 6
- Pages
- 744-756
- ISSN
- 0955-0674 (ISSN-L)
- PMC
- PMC3540161
- OpenAlex
- W1977789101
- Cited by
- 171
- References
- 116
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 10 · 2023: 17 · 2022: 18 · 2021: 17 · 2020: 11 · 2019: 11 · 2018: 18 · 2017: 11 · 2016: 15 · 2015: 10 · 2014: 9 · 2013: 5
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Current Opinion in Cell Biology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (P01 GM099130)
- Ellison Medical Foundation Senior Scholar Award
- Glenn Foundation for Medical Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- aging, cellular reprogramming, induced pluripotent stem cells, age-related diseases, rejuvenation, cellular senescence, pluripotency, aging models, exceptional longevity
- MeSH terms
- Aging, Animals, Humans, Longevity, Rejuvenation, Cellular Senescence, Epigenesis, Genetic, Induced Pluripotent Stem Cells, Cellular Reprogramming
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