Urinary bisphenol A and hypertension in a multiethnic sample of US adults
Open accessAbstract
Background. Bisphenol A (BPA) is a common chemical used in the manufacture of polycarbonate plastics and epoxy resins, with >93% of US adults having detectable BPA levels in urine. Recent animal studies have suggested that BPA exposure may have a role in several mechanisms involved in the development of hypertension, including weight gain, insulin resistance, thyroid dysfunction, endothelial dysfunction, and oxidative stress. However, no previous human study has examined the association between markers of BPA exposure and hypertension.Methods. We examined urinary BPA levels in 1380 subjects from the National Health and Nutritional Examination Survey 2003-2004. Main outcome-of-interest was hypertension, defined as blood pressure-reducing medication use and/or blood pressures >140/90 mm of Hg (n=580).Results. We observed a positive association between increasing levels of urinary BPA and hypertension independent of confounding factors such as age, gender, race/ethnicity, smoking, body mass index (BMI), diabetes mellitus and total serum cholesterol levels. Compared to tertile 1 (referent), the multivariate-adjusted odds ratio (95% confidence interval) of hypertension associated with tertile 3 was 1.50 (1.12−2.00);P-trend = 0.007. The association was consistently present in subgroup analyses by race/ethnicity, smoking status, BMI, and diabetes mellitus.Conclusions. Urinary BPA levels are associated with hypertension, independent of traditional risk factors.
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BPA may cause homeostatic disruptions including cardiovascular effects and hypertension, and by extension other EDCs may do so.
“This would suggest an avenue for homeostatic disruptions including cardiovascular effects and hypertension associated with BPA and, by extension, other EDCs (142, 143).”
From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [142]
The Discussion reports an association between higher urinary BPA and hypertension and describes biologically plausible mechanisms; the Introduction also notes studies linking BPA to self-reported cardiovascular disease. The paper does not establish that BPA causes these effects—the Discussion says its cross-sectional design precludes causal conclusions—and it does not extend its findings to other endocrine-disrupting chemicals. (LLM, conf=0.84)
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- Authors
- Shankar, A., & Teppala, S.
- Affiliations
- West Virginia University (US)
- Corresponding author
- Shankar, Anoop
- ORCID
- Teppala, Srinivas
- Venue
- Journal of Environmental and Public Health
- Publisher
- Wiley
- Published
- 2012
- Volume
- 2012
- Pages
- 1-5
- ISSN
- 1687-9805 (ISSN-L)
- 1687-9813
- PMC
- PMC3272835
- OpenAlex
- W2051419233
- Cited by
- 162
- References
- 31
- Citations by year
- 2026: 2 · 2025: 12 · 2024: 9 · 2023: 8 · 2022: 7 · 2021: 16 · 2020: 11 · 2019: 10 · 2018: 19 · 2017: 11 · 2016: 13 · 2015: 14 · 2014: 11 · 2013: 13 · 2012: 6
- FWCI
- 9.77
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Environmental and Public Health (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institute of Environmental Health Sciences (1R03ES018888-01)
- American Heart Association (1R03ES018888-01)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- bisphenol A, urinary BPA, hypertension, endocrine disruptors, environmental chemical exposure, blood pressure, race and ethnicity, smoking, body mass index, diabetes mellitus
- MeSH terms
- Bisphenol A Compounds, Benzhydryl Compounds, Diabetes Mellitus, Environmental Exposure, Estrogens, Non-Steroidal, Ethnicity, Female, Humans, Hypertension, Insulin Resistance, Male, Middle Aged, Obesity, Phenols, Risk Factors, Thyroid Diseases, United States, Odds Ratio, Oxidative Stress
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