Cited by 128Hematopoietic Stem Cell TransplantationMesenchymal stem cell researchAcute Myeloid Leukemia Research

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Molecular Signatures of Quiescent, Mobilized and Leukemia-Initiating Hematopoietic Stem Cells

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Forsberg, E. Camilla, Passegué, Emmanuelle, Prohaska, Susan S., Wagers, Amy J., Koeva, Martina, Stuart, Joshua M., Weissman, Irving L.·2010·PLoS ONE

DOI 10.1371/journal.pone.0008785PMC PMC2808351

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Abstract

Hematopoietic stem cells (HSC) are rare, multipotent cells capable of generating all specialized cells of the blood system. Appropriate regulation of HSC quiescence is thought to be crucial to maintain their lifelong function; however, the molecular pathways controlling stem cell quiescence remain poorly characterized. Likewise, the molecular events driving leukemogenesis remain elusive. In this study, we compare the gene expression profiles of steady-state bone marrow HSC to non-self-renewing multipotent progenitors; to HSC treated with mobilizing drugs that expand the HSC pool and induce egress from the marrow; and to leukemic HSC in a mouse model of chronic myelogenous leukemia. By intersecting the resulting lists of differentially regulated genes we identify a subset of molecules that are downregulated in all three circumstances, and thus may be particularly important for the maintenance and function of normal, quiescent HSC. These results identify potential key regulators of HSC and give insights into the clinically important processes of HSC mobilization for transplantation and leukemic development from cancer stem cells.

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Figure 1 Significance Analysis of Microarray (SAM) plots. Pair-wise comparison of gene expression during HSC differentiation, mobilization, and leukemic transformation. Features colored green or red represent genes up- or downregulated, respectively, in each comparison.CC BY · PubMed Central

Figure 2 Heatmap representation of differential gene expression. Each of the 18 columns represents a pairwise comparison. Rows represent individual genes. Note that “nonLSC” and “nonMob” are the normal HSC counterparts to LSC and mobilized HSC.CC BY · PubMed Central

Figure 3 Venn diagram representation of differential gene expression. Lists of differentially expressed clones in each pairwise comparison were compared to identify clones that are shared or unique to different HSC fates. The numbers represent the number of up- or downregulated clones in each pairwise comparison and the number of clones shared between comparisons.CC BY · PubMed Central

Figure 4 Quantitative RT-PCR of HSC, MPP, D+2 mobilized HSC and LSC. The relative level of expression of genes identified by microarray analysis as downregulated upon HSC differentation, mobilization and leukemic transformation. Normal HSC levels were set to 100. Grey bars, HSC; red, MPP; blue, mobilized HSC; green, LSC.CC BY · PubMed Central

Figure 5 Gene ontology classification of genes selectively expressed by normal, quiescent HSC.CC BY · PubMed Central

Figure 6 Comparison between the findings in our study and six other reports on HSC gene expression. The 93 genes selectively expressed in normal HSC are indicated in the left column. Additional columns represent the same 93 genes in each study, named below the respective column. Black indicates that the gene was upregulated in HSC; white indicates that the gene was not upregulated; gray indicates that the gene was not tested.CC BY · PubMed Central

Figure 7 Putative transcription factor binding motifs enriched in upstream regulatory regions of genes selectively expressed by normal, quiescent HSC.CC BY · PubMed Central

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Authors: Forsberg, E. C., Passegué, E., Prohaska, S. S., Wagers, A. J., Koeva, M., Stuart, J. M., & Weissman, I. L.
Affiliations: University of California, Santa Cruz (US)
Stanford Medicine (US)
Joslin Diabetes Center (US)
Corresponding author: Forsberg, E. Camilla
ORCID: Forsberg, E. Camilla
Prohaska, Susan S.
Wagers, Amy J.
Stuart, Joshua M.
Weissman, Irving L.
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2010-01-20
Volume: 5
Issue: 1
Pages: e8785
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0008785
PMC: PMC2808351
OpenAlex: W2098528717
Cited by: 127
References: 88
Citations by year: 2026: 4 · 2025: 2 · 2024: 5 · 2023: 1 · 2022: 9 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 2 · 2017: 11 · 2016: 12 · 2015: 16 · 2014: 7 · 2013: 13 · 2012: 10
FWCI: 8.21
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS ONE (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
eScholarship (California Digital Library) (submittedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by)
Figshare (submittedVersion, cc-by)
Funders: National Science Foundation (0543197)
Burroughs Wellcome Fund
Alfred P. Sloan Foundation
California Institute for Regenerative Medicine
National Institutes of Health (5r01hl088582-05)
National Heart, Lung, and Blood Institute (R01HL058770, 1R01HL088582-01, R01HL092471, R01-HL088582)
National Cancer Institute (R01CA086065, R01CA086017)
National Institute of Diabetes and Digestive and Kidney Diseases (P01DK053074)
Division of Biological Infrastructure
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
Keywords: hematopoietic stem cells, HSC quiescence, hematopoietic stem cell mobilization, leukemia-initiating cells, chronic myeloid leukemia, gene expression profiling, bone marrow, cancer stem cells, stem cell self-renewal, HSC transplantation
MeSH terms: Animals, Cell Transformation, Neoplastic, Disease Models, Animal, Flow Cytometry, Gene Expression Regulation, Hematopoietic Stem Cells, Mice, Inbred C57BL, Nucleic Acid Hybridization, Transcription, Genetic, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Profiling, Mice

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Molecular Signatures of Quiescent, Mobilized and Leukemia-Initiating Hematopoietic Stem Cells

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