The DOI matches its Crossref record; 87 of the 88 references it cites were found in a registry or an index.
Molecular Signatures of Quiescent, Mobilized and Leukemia-Initiating Hematopoietic Stem Cells
Open accessAbstract
Hematopoietic stem cells (HSC) are rare, multipotent cells capable of generating all specialized cells of the blood system. Appropriate regulation of HSC quiescence is thought to be crucial to maintain their lifelong function; however, the molecular pathways controlling stem cell quiescence remain poorly characterized. Likewise, the molecular events driving leukemogenesis remain elusive. In this study, we compare the gene expression profiles of steady-state bone marrow HSC to non-self-renewing multipotent progenitors; to HSC treated with mobilizing drugs that expand the HSC pool and induce egress from the marrow; and to leukemic HSC in a mouse model of chronic myelogenous leukemia. By intersecting the resulting lists of differentially regulated genes we identify a subset of molecules that are downregulated in all three circumstances, and thus may be particularly important for the maintenance and function of normal, quiescent HSC. These results identify potential key regulators of HSC and give insights into the clinically important processes of HSC mobilization for transplantation and leukemic development from cancer stem cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“a comparison of gene expression profiles of different types of quiescent stem cells, including HSCs45, MuSCs15 and HFSCs43, reveals a gene signature that is common to these quiescent stem cells (TABLE 1).”
From Molecular regulation of stem cell quiescence (2013) · cites this paper as [45]
In the citing paper
“Examples of genes that are downregulated in all three quiescent cell types (HSCs, MuSCs and HFSCs) include genes encoding cyclin A2, cyclin B1, cyclin E2 and survivin”
From Molecular regulation of stem cell quiescence (2013) · cites this paper as [45]
In the citing paper
“the signature reveals the downregulation of genes that are involved in DNA replication and cell cycle progression.”
From Molecular regulation of stem cell quiescence (2013) · cites this paper as [45]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Basic local alignment search tool
Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990) · Journal of Molecular Biology · doi:10.1006/jmbi.1990.9999 · Cited by 98,669
Gene Ontology: tool for the unification of biology
Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics · doi:10.1038/75556 · Cited by 43,206
In silico prediction of protein-protein interactions in human macrophages
Souiai, O., Guerfali, F. Z., Miled, S. B., Brun, C., & Benkahla, A. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-157 · Cited by 10,785
Significance analysis of microarrays applied to the ionizing radiation response
Tusher, V. G., Tibshirani, R., & Chu, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091062498 · Cited by 10,568
Kiel, M. J., Yilmaz, Ö. H., Iwashita, T., Yilmaz, O. H., Terhorst, C., & Morrison, S. J. (2005) · Cell · doi:10.1016/j.cell.2005.05.026 · Cited by 3,168
Wnt proteins are lipid-modified and can act as stem cell growth factors
Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., & Nusse, R. (2003) · Nature · doi:10.1038/nature01611 · Cited by 2,257
Self-citationA role for Wnt signalling in self-renewal of haematopoietic stem cells
Reya, T., Duncan, A. W., Ailles, L., Domen, J., Scherer, D. C., Willert, K., Hintz, L., Nusse, R., & Weissman, I. L. (2003) · Nature · doi:10.1038/nature01593 · Cited by 2,159
Self-citationTie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche
Arai, F., Hirao, A., Ohmura, M., Sato, H., Matsuoka, S., Takubo, K., Ito, K., Koh, G. Y., & Suda, T. (2004) · Cell · doi:10.1016/j.cell.2004.07.004 · Cited by 1,958
Weissman, I. L. (2000) · Cell · doi:10.1016/s0092-8674(00)81692-x · Cited by 1,827
Self-citation"Stemness": Transcriptional Profiling of Embryonic and Adult Stem Cells
Ramalho‐Santos, M., Yoon, S., Matsuzaki, Y., Mulligan, R. C., & Melton, D. A. (2002) · Science · doi:10.1126/science.1072530 · Cited by 1,711
A Stem Cell Molecular Signature
Ivanova, N. B., Dimos, J. T., Schaniel, C., Hackney, J. A., Moore, K. A., & Lemischka, I. R. (2002) · Science · doi:10.1126/science.1073823 · Cited by 1,543
Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9
Krivtsov, A. V., Twomey, D., Feng, Z., Stubbs, M. C., Wang, Y., Faber, J., Levine, J. E., Wang, J., Hahn, W. C., Gilliland, D. G., et al. (2006) · Nature · doi:10.1038/nature04980 · Cited by 1,513 · cited 1×
“and as a translocation partner with Mll causes leukemia via a leukemic stem cell mechanism. Thus, Mllt3 plays roles in normal cell growth and maintenance and in oncogenesis”
BackgroundGranulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
Jamieson, C. H. M., Ailles, L. E., Dylla, S. J., Muijtjens, M., Jones, C., Zehnder, J. L., Gotlib, J., Li, K., Manz, M. G., Keating, A., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040258 · Cited by 1,485 · cited 1×
“or from transformed progenitor cells that have re-acquired the stem cell property of self-renewal”
BackgroundSelf-citationLittle Evidence for Developmental Plasticity of Adult Hematopoietic Stem Cells
Wagers, A. J., Sherwood, R. I., Christensen, J. L., & Weissman, I. L. (2002) · Science · doi:10.1126/science.1074807 · Cited by 1,460
Self-citationMorrison, S. J., & Weissman, I. L. (1994) · Immunity · doi:10.1016/1074-7613(94)90037-x · Cited by 1,116
Self-citationPhysiological Migration of Hematopoietic Stem and Progenitor Cells
Wright, D. E., Wagers, A. J., Gulati, A. P., Johnson, F. L., & Weissman, I. L. (2001) · Science · doi:10.1126/science.1064081 · Cited by 933
Self-citationIn vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells
Cheshier, S. H., Morrison, S. J., Liao, X., & Weissman, I. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3120 · Cited by 858
Self-citationLymphocyte Sequestration Through S1P Lyase Inhibition and Disruption of S1P Gradients
Schwab, S. R., Pereira, J. P., Matloubian, M., Xu, Y., Huang, Y., & Cyster, J. G. (2005) · Science · doi:10.1126/science.1113640 · Cited by 814
Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation
Chambers, S. M., Shaw, C. A., Gatza, C. E., Fisk, C. J., Donehower, L. A., & Goodell, M. A. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050201 · Cited by 799
Christensen, J. L., & Weissman, I. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261562798 · Cited by 786
Self-citationMaßberg, S., Schaerli, P., Maramica, I. K., Köllnberger, M., Tubo, N. J., Moseman, E. A., Huff, I. V., Junt, T., Wagers, A. J., Mazo, I. B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.047 · Cited by 711
Self-citationHOXB4-Induced Expansion of Adult Hematopoietic Stem Cells Ex Vivo
Antonchuk, J., Sauvageau, G., & Humphries, R. K. (2002) · Cell · doi:10.1016/s0092-8674(02)00697-9 · Cited by 700
Passegué, E., Wagers, A. J., Giuriato, S., Anderson, W. C., & Weissman, I. L. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050967 · Cited by 646
Self-citationUncertainty in the niches that maintain haematopoietic stem cells
Kiel, M. J., & Morrison, S. J. (2008) · Nature reviews. Immunology · doi:10.1038/nri2279 · Cited by 608
Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia
Somervaille, T. C. P., & Cleary, M. L. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.08.020 · Cited by 582
Identification of a lineage of multipotent hematopoietic progenitors
Morrison, S. J., Wandycz, A. M., Hemmati, H. D., Wright, D. E., & Weissman, I. L. (1997) · Development · doi:10.1242/dev.124.10.1929 · Cited by 482
Self-citationJunB Deficiency Leads to a Myeloproliferative Disorder Arising from Hematopoietic Stem Cells
Passegue, E. A., Wagner, E. F., & Weissman, I. L. (2004) · Cell · doi:10.1016/j.cell.2004.10.010 · Cited by 442
Self-citationAmeye, L., & Young, M. F. (2002) · Glycobiology · doi:10.1093/glycob/cwf065 · Cited by 440
Yarilina, A., Park‐Min, K., Antoniv, T. T., Hu, X., & Ivashkiv, L. B. (2008) · Nature Immunology · doi:10.1038/ni1576 · Cited by 437
Molecular Signatures of Proliferation and Quiescence in Hematopoietic Stem Cells
Bowman, T. V., Merchant, A. A., Ramos, C. A., Whitehouse, N. L., Young, A., Shaw, C. A., & Goodell, M. A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020301 · Cited by 378
Akashi, K., He, X., Chen, J., Iwasaki, H., Niu, C. S., Steenhard, B. M., Zhang, J., Haug, J., & Li, L. (2002) · Blood · doi:10.1182/blood-2002-06-1780 · Cited by 368
Min, I. M., Pietramaggiori, G., Kim, F. S., Passegue, E. A., Stevenson, K. E., & Wagers, A. J. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.01.015 · Cited by 347
Self-citationShifting foci of hematopoiesis during reconstitution from single stem cells
Cao, Y., Wagers, A. J., Beilhack, A., Dusich, J., Bachmann, M. H., Negrin, R. S., Weissman, I. L., & Contag, C. H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2637010100 · Cited by 337
Self-citationBalazs, A. B., Fabian, A. J., Esmon, C. T., & Mulligan, R. C. (2005) · Blood · doi:10.1182/blood-2005-06-2249 · Cited by 329
Morrison, S. J., Wright, D. E., & Weissman, I. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.5.1908 · Cited by 314
Self-citationDifferential Expression of Novel Potential Regulators in Hematopoietic Stem Cells
Forsberg, E. C., Prohaska, S. S., Katzman, S. J., Heffner, G. C., Stuart, J. M., & Weissman, I. L. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010028 · Cited by 296
Self-citationDysregulated gene expression networks in human acute myelogenous leukemia stem cells
Majeti, R., Becker, M. W., Tian, Q., Lee, T.-L. M., Yan, X., Liu, R., Chiang, J.-H., Hood, L., Clarke, M. F., & Weissman, I. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900089106 · Cited by 281
Self-citationMaintenance of Quiescent Hematopoietic Stem Cells in the Osteoblastic Niche
Arai, F., & Suda, T. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1392.005 · Cited by 253
Zhang, C. C., Steele, A. D., Lindquist, S. L., & Lodish, H. F. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510577103 · Cited by 251
Passegue, E. A., Jochum, W., Schorpp‐Kistner, M., Möhle-Steinlein, U., & Wagner, E. F. (2001) · Cell · doi:10.1016/s0092-8674(01)00188-x · Cited by 236
Pbx1 Regulates Self-Renewal of Long-Term Hematopoietic Stem Cells by Maintaining Their Quiescence
Ficara, F., Murphy, M., Lin, M., & Cleary, M. L. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.03.004 · Cited by 235
Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism
Kabashima, K., Haynes, N. M., Xu, Y., Nutt, S. L., Allende, M. L., Proia, R. L., & Cyster, J. G. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061289 · Cited by 232
Masuoka, H. C., & Townes, T. M. (2002) · Blood · doi:10.1182/blood.v99.3.736 · Cited by 226
Antonchuk, J., Sauvageau, G., & Humphries, R. K. (2001) · Experimental Hematology · doi:10.1016/s0301-472x(01)00681-6 · Cited by 221
Forsberg, E. C., Serwold, T. F., Kogan, S. C., Weissman, I. L., & Passegue, E. A. (2006) · Cell · doi:10.1016/j.cell.2006.06.037 · Cited by 215
Self-citationWright, D. E., Cheshier, S. H., Wagers, A. J., Randall, T. D., Christensen, J. L., & Weissman, I. L. (2001) · Blood · doi:10.1182/blood.v97.8.2278 · Cited by 208
Self-citationGene expression analysis of purified hematopoietic stem cells and committed progenitors
Terskikh, A. V., Miyamoto, T., Chang, C. C., Diatchenko, L. B., & Weissman, I. L. (2003) · Blood · doi:10.1182/blood-2002-08-2509 · Cited by 194
Self-citationDiMartino, J. F., Selleri, L., Traver, D. J., Firpo, M. T., Rhee, J. W., Warnke, R. A., O’Gorman, S., Weissman, I. L., & Cleary, M. L. (2001) · Blood · doi:10.1182/blood.v98.3.618 · Cited by 172
Self-citationFusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma
Storlazzi, C. T. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg237 · Cited by 170
Santaguida, M. A., Schepers, K., King, B., Sabnis, A. J., Forsberg, E. C., Attema, J. L., Braun, B. S., & Passegue, E. A. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.02.016 · Cited by 159
Self-citationLiu, K., Luo, Y., Lin, F., & Lin, W.-C. (2004) · Genes & Development · doi:10.1101/gad.1180204 · Cited by 151
Weissman, I. L. (2005) · JAMA · doi:10.1001/jama.294.11.1359 · Cited by 150
Self-citationNeben, S., Marcus, K. J., & Mauch, P. (1993) · Blood · doi:10.1182/blood.v81.7.1960.1960 · Cited by 148
Nishikata, I., Sasaki, H., Iga, M., Tateno, Y., Imayoshi, S., Asou, N., Nakamura, T., & Morishita, K. (2003) · Blood · doi:10.1182/blood-2002-12-3944 · Cited by 145
Cleavage of the Wnt Receptor Ryk Regulates Neuronal Differentiation during Cortical Neurogenesis
Lyu, J., Yamamoto, V. N., & Lu, W. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.10.004 · Cited by 138
Attema, J. L., Papathanasiou, P., Forsberg, E. C., Xu, J., Smale, S. T., & Weissman, I. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704468104 · Cited by 134
Self-citationJordan, C. T. (2007) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2006.10.005 · Cited by 124
The Histone-Like NF-Y Is a Bifunctional Transcription Factor
Ceribelli, M., Dolfini, D., Merico, D., Gatta, R. P., Viganò, M., Pavesi, G., & Mantovani, R. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01861-07 · Cited by 117
Biology of Normal and Acute Myeloid Leukemia Stem Cells
Dick, J. E., & Lapidot, T. (2005) · International Journal of Hematology · doi:10.1532/ijh97.05144 · Cited by 112
Vilar, M., Murillo‐Carretero, M., Mira, H., Magnusson, K., Besset, V., & Ibáñez, C. F. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601017 · Cited by 109
Muchardt, C., Bourachot, B., Reyes, J. C., & Yaniv, M. (1998) · The EMBO Journal · doi:10.1093/emboj/17.1.223 · Cited by 101
Zhu, J., Zhang, Y., Joe, G. J., Pompetti, R., & Emerson, S. G. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503405102 · Cited by 101
Bone marrow homing: the players, the playfield, and their evolving roles
Papayannopoulou, T. (2003) · Current Opinion in Hematology · doi:10.1097/00062752-200305000-00004 · Cited by 99
The Competitive Nature of HOXB4-Transduced HSC Is Limited by PBX1
Krošl, J., Beslu, N., Mayotte, N., Humphries, R. K., & Sauvageau, G. (2003) · Immunity · doi:10.1016/s1074-7613(03)00090-6 · Cited by 82
Considerations for Targeting Malignant Stem Cells in Leukemia
Guzmán, M. L., & Jordan, C. T. (2004) · Cancer Control · doi:10.1177/107327480401100216 · Cited by 81
NF-Y cooperates with USF1/2 to induce the hematopoietic expression of HOXB4
Zhu, J., Giannola, D. M., Zhang, Y., Rivera, A. J., & Emerson, S. G. (2003) · Blood · doi:10.1182/blood-2003-01-0251 · Cited by 78
MLLT3 regulates early human erythroid and megakaryocytic cell fate.
Pina, C., May, G., Soneji, S., Hong, D., & Enver, T. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.01.013 · Cited by 77
Wang, G.-L., Shi, X., Salisbury, E. A., Sun, Y., Albrecht, J. H., Smith, R. G., & Timchenko, N. A. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.7.2570-2582.2006 · Cited by 73
Laricchia‐Robbio, L., Fazzina, R., Li, D., Rinaldi, C. R., Sinha, K. K., Chakraborty, S., & Nucifora, G. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00363-06 · Cited by 71
The Adhesion Molecule Esam1 Is a Novel Hematopoietic Stem Cell Marker
Ooi, A. G. L., Karsunky, H., Majeti, R., Butz, S., Vestweber, D., Ishida, T., Quertermous, T., Weissman, I. L., & Forsberg, E. C. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0824 · Cited by 69
Self-citationB-cell development fails in the absence of the Pbx1 proto-oncogene
Sanyal, M., Tung, J. W., Karsunky, H., Zeng, H., Selleri, L., Weissman, I. L., Herzenberg, L. A., & Cleary, M. L. (2007) · Blood · doi:10.1182/blood-2006-10-054213 · Cited by 68
Self-citationIkaros and chromatin regulation in early hematopoiesis
Ng, S. Y., Yoshida, T., & Georgopoulos, K. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.02.014 · Cited by 67
Sugano, Y., Takeuchi, M., Hirata, A., Matsushita, H., Kitamura, T., Tanaka, M., & Miyajima, A. (2007) · Blood · doi:10.1182/blood-2007-03-081554 · Cited by 58
Impaired myelopoiesis in mice devoid of interferon regulatory factor 1
Testa, U., Stellacci, E., Pelosi, E., Sestili, P., Venditti, M., Orsatti, R., Fragale, A., Petrucci, E., Pasquini, L., Belardelli, F., et al. (2004) · Leukemia · doi:10.1038/sj.leu.2403472 · Cited by 48
Sato, T., Goyama, S., Nitta, E., Takeshita, M., Yoshimi, M., Nakagawa, M. M., Kawazu, M., Ichikawa, M., & Kurokawa, M. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2008.00842.x · Cited by 43
Gitler, A. D., Kong, Y., Choi, J. K., Zhu, Y., Pear, W. S., & Epstein, J. A. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000113462.98851.2e · Cited by 42
Genetic deletion of JAM-C reveals a role in myeloid progenitor generation
Praetor, A., McBride, J., Chiu, H. H., Rangell, L. K., Cabote, L., Lee, W. P., Cupp, J. E., Danilenko, D. M., & Fong, S. (2008) · Blood · doi:10.1182/blood-2008-06-159574 · Cited by 42
The Role of IRF1 and IRF2 Transcription Factors in Leukaemogenesis
Choo, A., Palladinetti, P., Passioura, T., Shen, S., Lock, R. B., Symonds, G. P., & Dolnikov, A. (2006) · Current Gene Therapy · doi:10.2174/156652306778520683 · Cited by 29
Uchida, K., Yoshimura, A., Inazawa, J., Yanagisawa, K., Osada, H., Masuda, A., Saito, T., Takahashi, T., Miyajima, A., & Takahashi, T. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000134658 · Cited by 27
β common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice
Kim, A., Morgan, K. J., Hasz, D. E., Wiesner, S. M., Lauchle, J., Geurts, J. L., Diers, M. D., Le, D., Kogan, S. C., Parada, L. F., et al. (2006) · Blood · doi:10.1182/blood-2006-05-025395 · Cited by 25
Expression of BEX1 in acute myeloid leukemia with MLL rearrangements
Quentmeier, H., Tonelli, R., Geffers, R., Pession, A., Uphoff, C. C., & Drexler, H. G. (2005) · Leukemia · doi:10.1038/sj.leu.2403820 · Cited by 23
The Wilms' Tumor Gene 1 (WT1) Induces Expression of the N-myc Downstream Regulated Gene 2 (NDRG2)
Svensson, E., Vidovic, K., Olofsson, T., Vallon‐Christersson, J., Borg, Å., & Gullberg, U. (2007) · DNA and Cell Biology · doi:10.1089/dna.2007.0586 · Cited by 20
Alterations in IRF1/IRF2 expression in acute myelogenous leukemia
Preisler, H. D., Perambakam, S. M., Li, Y., Hsu, W.-T., Venugopal, P., Creech, S., Sivaraman, S., & Tanaka, N. (2001) · American Journal of Hematology · doi:10.1002/ajh.1144 · Cited by 20
Neben, S., Marcus, K. J., & Mauch, P. (1993) · Blood · doi:10.1182/blood.v81.7.1960.bloodjournal8171960 · Cited by 13
Ficara, F., Murphy, M., Lin, M., & Cleary, M. L. (2007) · Blood · doi:10.1182/blood.v110.11.94.94 · Cited by 7
Stem cell research: paths to cancer therapies and regenerative medicine
(2007) · Nature reports. Stem cells · doi:10.1038/stemcells.2007.63 · Cited by 6
ESAM: adding to the hematopoietic toolbox
Mikkola, H. K. A. (2009) · Blood · doi:10.1182/blood-2009-01-199794 · Cited by 2
Cited by
Sorted by citations
Molecular regulation of stem cell quiescence
Cheung, T. H., & Rando, T. A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3591 · Cited by 1,148
Codega, P., Silva-Vargas, V., Paul, A., Maldonado-Soto, A. R., DeLeo, A. M., Pastrana, E., & Doetsch, F. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.039 · Cited by 634
Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals
Sawai, C. M., Babovic, S., Upadhaya, S., Knapp, D. J. H. F., Lavin, Y., Lau, C. M., Goloborodko, A., Feng, J., Fujisaki, J., Ding, L., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.08.007 · Cited by 381
“Pdzk1ip1 (also known as Map17) is expressed in the murine HSC population but is strongly reduced in more differentiated cells or in mobilized HSCs (Cabezas-Wallscheid et al., 2014; Forsberg et al., 2010; Wilson et al., 2015).”
Moore, N., & Lyle, S. R. (2010) · Journal of Oncology · doi:10.1155/2011/396076 · Cited by 378
Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche
Chen, J. Y., Miyanishi, M., Wang, S. K., Yamazaki, S., Sinha, R., Kao, K. S., Seita, J., Sahoo, D., Nakauchi, H., & Weissman, I. L. (2016) · Nature · doi:10.1038/nature16943 · Cited by 345
Self-citation
Metadata
- Authors
- Forsberg, E. C., Passegué, E., Prohaska, S. S., Wagers, A. J., Koeva, M., Stuart, J. M., & Weissman, I. L.
- Affiliations
- University of California, Santa Cruz (US)
- Stanford Medicine (US)
- Joslin Diabetes Center (US)
- Corresponding author
- Forsberg, E. Camilla
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-01-20
- Volume
- 5
- Issue
- 1
- Pages
- e8785
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC2808351
- OpenAlex
- W2098528717
- Cited by
- 127
- References
- 88
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 5 · 2023: 1 · 2022: 9 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 2 · 2017: 11 · 2016: 12 · 2015: 16 · 2014: 7 · 2013: 13 · 2012: 10
- FWCI
- 8.21
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Figshare (submittedVersion, cc-by)
- Funders
- National Science Foundation (0543197)
- Burroughs Wellcome Fund
- Alfred P. Sloan Foundation
- California Institute for Regenerative Medicine
- National Institutes of Health (5r01hl088582-05)
- National Heart, Lung, and Blood Institute (R01HL058770, 1R01HL088582-01, R01HL092471, R01-HL088582)
- National Cancer Institute (R01CA086065, R01CA086017)
- National Institute of Diabetes and Digestive and Kidney Diseases (P01DK053074)
- Division of Biological Infrastructure
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Keywords
- hematopoietic stem cells, HSC quiescence, hematopoietic stem cell mobilization, leukemia-initiating cells, chronic myeloid leukemia, gene expression profiling, bone marrow, cancer stem cells, stem cell self-renewal, HSC transplantation
- MeSH terms
- Animals, Cell Transformation, Neoplastic, Disease Models, Animal, Flow Cytometry, Gene Expression Regulation, Hematopoietic Stem Cells, Mice, Inbred C57BL, Nucleic Acid Hybridization, Transcription, Genetic, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Profiling, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
