The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Joint Genome-Wide Profiling of miRNA and mRNA Expression in Alzheimer's Disease Cortex Reveals Altered miRNA Regulation
Open accessAbstract
Although microRNAs are being extensively studied for their involvement in cancer and development, little is known about their roles in Alzheimer's disease (AD). In this study, we used microarrays for the first joint profiling and analysis of miRNAs and mRNAs expression in brain cortex from AD and age-matched control subjects. These data provided the unique opportunity to study the relationship between miRNA and mRNA expression in normal and AD brains. Using a non-parametric analysis, we showed that the levels of many miRNAs can be either positively or negatively correlated with those of their target mRNAs. Comparative analysis with independent cancer datasets showed that such miRNA-mRNA expression correlations are not static, but rather context-dependent. Subsequently, we identified a large set of miRNA-mRNA associations that are changed in AD versus control, highlighting AD-specific changes in the miRNA regulatory system. Our results demonstrate a robust relationship between the levels of miRNAs and those of their targets in the brain. This has implications in the study of the molecular pathology of AD, as well as miRNA biology in general.
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“Because two recent studies [13,21] found that, for some miRNAs, miRNA levels affect target mRNA levels only for high-prevalence mRNAs, we repeated the analysis, but using only mRNAs with relatively high average expression values.”
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“Results on differentially expressed miRNAs in AD [9,23,24] appear to be more robust and reproducible than those of differentially expressed mRNAs [5].”
Background
Cited by
Identifying miRNAs, targets and functions
Liu, B., Li, J., & Cairns, M. J. (2014) · Briefings in Bioinformatics · doi:10.1093/bib/bbs075 · Cited by 563
Alteration of the microRNA network during the progression of Alzheimer's disease
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Finnerty, J. R., Wang, W.-X., Hébert, S. S., Wilfred, B. R., Mao, G., & Nelson, P. T. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.07.051 · Cited by 371
Metadata
- Authors
- Nunez-Iglesias, J., Liu, C.-C., Morgan, T. E., Finch, C. E., & Zhou, X. J.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-02-01
- Volume
- 5
- Issue
- 2
- Pages
- e8898
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2091934374
- Cited by
- 321
- References
- 11
- FWCI
- 9.30
- Type
- journal article
- Language
- en
- Open access
- gold
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