The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Population Genetic Analysis of Propionibacterium acnes Identifies a Subpopulation and Epidemic Clones Associated with Acne
Open accessAbstract
The involvement of Propionibacterium acnes in the pathogenesis of acne is controversial, mainly owing to its dominance as an inhabitant of healthy skin. This study tested the hypothesis that specific evolutionary lineages of the species are associated with acne while others are compatible with health. Phylogenetic reconstruction based on nine housekeeping genes was performed on 210 isolates of P. acnes from well-characterized patients with acne, various opportunistic infections, and from healthy carriers. Although evidence of recombination was observed, the results showed a basically clonal population structure correlated with allelic variation in the virulence genes tly and camp5, with pulsed field gel electrophoresis (PFGE)- and biotype, and with expressed putative virulence factors. An unexpected geographically and temporal widespread dissemination of some clones was demonstrated. The population comprised three major divisions, one of which, including an epidemic clone, was strongly associated with moderate to severe acne while others were associated with health and opportunistic infections. This dichotomy correlated with previously observed differences in in vitro inflammation-inducing properties. Comparison of five genomes representing acne- and health-associated clones revealed multiple both cluster- and strain-specific genes that suggest major differences in ecological preferences and redefines the spectrum of disease-associated virulence factors. The results of the study indicate that particular clones of P. acnes play an etiologic role in acne while others are associated with health.
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MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) Software Version 4.0
Tamura, K., Dudley, J., Nei, M., & Kumar, S. (2007) · Molecular Biology and Evolution · doi:10.1093/molbev/msm092 · Cited by 28,730
Application of Phylogenetic Networks in Evolutionary Studies
Huson, D. H., & Bryant, D. (2006) · Molecular Biology and Evolution · doi:10.1093/molbev/msj030 · Cited by 8,830
Mauve: Multiple alignment of conserved genomic sequence with rearrangements
Darling, A. C. E., Mau, B., Blattner, F. R., & Perna, N. T. (2004) · Genome Research · doi:10.1101/gr.2289704 · Cited by 4,949
Maiden, M. C. J., Bygraves, J. A., Feil, E., Morelli, G., Russell, J. E., Urwin, R., Zhang, Q., Zhou, J., Zurth, K., Caugant, D. A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3140 · Cited by 3,833
Enright, M. C., Day, N. P. J., Davies, C. E., Peacock, S. J., & Spratt, B. G. (2000) · Journal of Clinical Microbiology · doi:10.1128/jcm.38.3.1008-1015.2000 · Cited by 3,063
Topographical and Temporal Diversity of the Human Skin Microbiome
Grice, E. A., Kong, H. H., Conlan, S., Deming, C. B., Davis, J., Young, A. C., Program, N. C. S., Bouffard, G. G., Blakesley, R. W., Murray, P. R., et al. (2009) · Science · doi:10.1126/science.1171700 · Cited by 2,953
Tettelin, H., Masignani, V., Cieslewicz, M. J., Donati, C., Medini, D., Ward, N. L., Angiuoli, S. V., Crabtree, J., Jones, A. L., Durkin, A. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506758102 · Cited by 2,631
Sex and virulence in Escherichia coli: an evolutionary perspective
Wirth, T., Falush, D., Lan, R., Colles, F., Mensa, P., Wieler, L. H., Karch, H., Reeves, P. R., Maiden, M. C. J., Ochman, H., et al. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05172.x · Cited by 2,025
Feil, E. J., Li, B. C., Aanensen, D. M., Hanage, W. P., & Spratt, B. G. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.5.1518-1530.2004 · Cited by 1,861
Escherichia coli and Salmonella.
Neidhart, F. C. (1996) · Cited by 1,577
Cited by
Byrd, A. L., Belkaid, Y., & Segre, J. A. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.157 · Cited by 2,806
Guidelines of care for the management of acne vulgaris
Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., Bowe, W. P., Graber, E. M., Harper, J. C., Kang, S., et al. (2016) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2015.12.037 · Cited by 1,597
Host-microbiome interactions and recent progress into understanding the biology of acne vulgaris
O’Neill, A. M., & Gallo, R. L. (2018) · Microbiome · doi:10.1186/s40168-018-0558-5 · Cited by 334
Potential Role of the Microbiome in Acne: A Comprehensive Review
Lee, Y. B., Byun, E. J., & Kim, H. S. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8070987 · Cited by 316
Cutibacterium acnes as an Opportunistic Pathogen: An Update of Its Virulence-Associated Factors
Mayslich, C., Grange, P. A., & Dupin, N. (2021) · Microorganisms · doi:10.3390/microorganisms9020303 · Cited by 304
Metadata
- Authors
- Lomholt, H. B., & Kilian, M.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-08-19
- Volume
- 5
- Issue
- 8
- Pages
- e12277
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2042861376
- Cited by
- 279
- References
- 47
- FWCI
- 19.27
- Type
- journal article
- Language
- en
- Open access
- gold
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