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Cutibacterium acnes as an Opportunistic Pathogen: An Update of Its Virulence-Associated Factors

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Mayslich, Constance, Grange, Philippe Alain, Dupin, Nicolas·2021·Microorganisms
DOI 10.3390/microorganisms9020303
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Abstract

Cutibacterium acnes is a member of the skin microbiota found predominantly in regions rich in sebaceous glands. It is involved in maintaining healthy skin and has long been considered a commensal bacterium. Its involvement in various infections has led to its emergence as an opportunist pathogen. Interactions between C. acnes and the human host, including the human skin microbiota, promote the selection of C. acnes strains capable of producing several virulence factors that increase inflammatory capability. This pathogenic property may be related to many infectious mechanisms, such as an ability to form biofilms and the expression of putative virulence factors capable of triggering host immune responses or enabling C. acnes to adapt to its environment. During the past decade, many studies have identified and characterized several putative virulence factors potentially involved in the pathogenicity of this bacterium. These virulence factors are involved in bacterial attachment to target cells, polysaccharide-based biofilm synthesis, molecular structures mediating inflammation, and the enzymatic degradation of host tissues. C. acnes, like other skin-associated bacteria, can colonize various ecological niches other than skin. It produces several proteins or glycoproteins that could be considered to be active virulence factors, enabling the bacterium to adapt to the lipophilic environment of the pilosebaceous unit of the skin, but also to the various organs it colonizes. In this review, we summarize current knowledge concerning characterized C. acnes virulence factors and their possible implication in the pathogenicity of C. acnes.

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Research works printed but not linked: 37

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Metadata

Authors
Mayslich, C., Grange, P. A., & Dupin, N.
Venue
Microorganisms
Publisher
MDPI AG
Published
2021-02-02
Volume
9
Issue
2
Pages
303
ISSN
2076-2607 (ISSN-L)
DOI
10.3390/microorganisms9020303
OpenAlex
W3128206046
Cited by
304
References
131
FWCI
29.09
Type
journal article
Language
en
Open access
gold
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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Mayslich, C., Grange, P. A., & Dupin, N. (2021). Cutibacterium acnes as an Opportunistic Pathogen: An Update of Its Virulence-Associated Factors. Microorganisms. https://doi.org/10.3390/microorganisms9020303

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