The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Changes in Resting Neural Connectivity during Propofol Sedation
Open accessAbstract
BACKGROUND: The default mode network consists of a set of functionally connected brain regions (posterior cingulate, medial prefrontal cortex and bilateral parietal cortex) maximally active in functional imaging studies under "no task" conditions. It has been argued that the posterior cingulate is important in consciousness/awareness, but previous investigations of resting interactions between the posterior cingulate cortex and other brain regions during sedation and anesthesia have produced inconsistent results. METHODOLOGY/PRINCIPAL FINDINGS: We examined the connectivity of the posterior cingulate at different levels of consciousness. "No task" fMRI (BOLD) data were collected from healthy volunteers while awake and at low and moderate levels of sedation, induced by the anesthetic agent propofol. Our data show that connectivity of the posterior cingulate changes during sedation to include areas that are not traditionally considered to be part of the default mode network, such as the motor/somatosensory cortices, the anterior thalamic nuclei, and the reticular activating system. CONCLUSIONS/SIGNIFICANCE: This neuroanatomical signature resembles that of non-REM sleep, and may be evidence for a system that reduces its discriminable states and switches into more stereotypic patterns of firing under sedation.
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Cites
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An information integration theory of consciousness
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“Given this concordance between propofol levels and fMRI findings, what might be the relationship between consciousness and the connectivity changes that we observe? Interpreted in the context of the information integration theory, which stipulates that consciousness increases in proportion to a system’s repertoire of…”
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Cited by
Grandjean, J., Schroeter, A., Batata, I., & Rudin, M. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.08.043 · Cited by 339
Default Mode Dynamics for Global Functional Integration
Vatansever, D., Menon, D. K., Manktelow, A. E., Sahakian, B. J., & Stamatakis, E. A. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2135-15.2015 · Cited by 333
Self-citationThe amplitude of the resting-state fMRI global signal is related to EEG vigilance measures
Wong, C. W., Olafsson, V., Tal, O., & Liu, T. T. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.07.057 · Cited by 318
Resting State Networks and Consciousness
Heine, L., Soddu, A., Gómez, F., Vanhaudenhuyse, A., Tshibanda, L., Thonnard, M., Charland-Verville, V., Kirsch, M., Laureys, S., & Demertzi, A. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00295 · Cited by 272
General Anesthesia and Human Brain Connectivity
Hudetz, A. G. (2012) · Brain Connectivity · doi:10.1089/brain.2012.0107 · Cited by 271
Metadata
- Authors
- Stamatakis, E. A., Adapa, R. M., Absalom, A. R., & Menon, D. K.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-12-02
- Volume
- 5
- Issue
- 12
- Pages
- e14224
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2072827698
- Cited by
- 188
- References
- 25
- FWCI
- 8.87
- Type
- journal article
- Language
- en
- Open access
- gold
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