Cited by 272Functional Brain Connectivity StudiesTraumatic Brain Injury ResearchAdvanced Neuroimaging Techniques and Applications

Resting State Networks and Consciousness

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Heine, Lizette, Soddu, Andrea, Gómez, Francisco, Vanhaudenhuyse, Audrey, Tshibanda, Luaba, Thonnard, Marie, Charland-Verville, Vanessa, Kirsch, Murielle +2 more·2012·Frontiers in Psychology

Abstract

In order to better understand the functional contribution of resting state activity to conscious cognition, we aimed to review increases and decreases in functional magnetic resonance imaging (fMRI) functional connectivity under physiological (sleep), pharmacological (anesthesia), and pathological altered states of consciousness, such as brain death, coma, vegetative state/unresponsive wakefulness syndrome, and minimally conscious state. The reviewed resting state networks were the DMN, left and right executive control, salience, sensorimotor, auditory, and visual networks. We highlight some methodological issues concerning resting state analyses in severely injured brains mainly in terms of hypothesis-driven seed-based correlation analysis and data-driven independent components analysis approaches. Finally, we attempt to contextualize our discussion within theoretical frameworks of conscious processes. We think that this "lesion" approach allows us to better determine the necessary conditions under which normal conscious cognition takes place. At the clinical level, we acknowledge the technical merits of the resting state paradigm. Indeed, fast and easy acquisitions are preferable to activation paradigms in clinical populations. Finally, we emphasize the need to validate the diagnostic and prognostic value of fMRI resting state measurements in non-communicating brain damaged patients.

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  1. Beckmann C. F. Smith S. M. (2004). Probabilistic independent component analysis for functional magnetic resonance imaging. IEEE Trans. Med. Imaging 23, 137– 152 10.1109/TMI.2003.822821 14964560 · DOI

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Authors
Heine, L., Soddu, A., Gómez, F., Vanhaudenhuyse, A., Tshibanda, L., Thonnard, M., Charland-Verville, V., Kirsch, M., Laureys, S., & Demertzi, A.
Affiliations
University of Liège (BE)
Venue
Frontiers in Psychology
Published
2012
Volume
3
Pages
295-295
ISSN
1664-1078 (ISSN-L)
OpenAlex
W1596614913
Cited by
272
References
107
Citations by year
2026: 3 · 2025: 8 · 2024: 15 · 2023: 17 · 2022: 13 · 2021: 19 · 2020: 24 · 2019: 22 · 2018: 24 · 2017: 27 · 2016: 19 · 2015: 35 · 2014: 18 · 2013: 23 · 2012: 4
FWCI
12.93
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Psychology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • ORBi (University of Liège) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • James S. McDonnell Foundation
  • Mind Science Foundation
  • European Commission
  • Fonds De La Recherche Scientifique - FNRS
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Keywords
resting-state networks, consciousness, altered states of consciousness, default mode network, frontoparietal network, salience network, sensorimotor network, anesthesia, sleep, brain death, coma, vegetative state, minimally conscious state, seed-based correlation analysis, independent component analysis, functional MRI, brain injury, prognostic value

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