Sensory symptom profiles and co-morbidities in painful radiculopathy
Open accessAbstract
Painful radiculopathies (RAD) and classical neuropathic pain syndromes (painful diabetic polyneuropathy, postherpetic neuralgia) show differences how the patients express their sensory perceptions. Furthermore, several clinical trials with neuropathic pain medications failed in painful radiculopathy. Epidemiological and clinical data of 2094 patients with painful radiculopathy were collected within a cross sectional survey (painDETECT) to describe demographic data and co-morbidities and to detect characteristic sensory abnormalities in patients with RAD and compare them with other neuropathic pain syndromes. Common co-morbidities in neuropathic pain (depression, sleep disturbance, anxiety) do not differ considerably between the three conditions. Compared to other neuropathic pain syndromes touch-evoked allodynia and thermal hyperalgesia are relatively uncommon in RAD. One distinct sensory symptom pattern (sensory profile), i.e., severe painful attacks and pressure induced pain in combination with mild spontaneous pain, mild mechanical allodynia and thermal hyperalgesia, was found to be characteristic for RAD. Despite similarities in sensory symptoms there are two important differences between RAD and other neuropathic pain disorders: (1) The paucity of mechanical allodynia and thermal hyperalgesia might be explained by the fact that the site of the nerve lesion in RAD is often located proximal to the dorsal root ganglion. (2) The distinct sensory profile found in RAD might be explained by compression-induced ectopic discharges from a dorsal root and not necessarily by nerve damage. These differences in pathogenesis might explain why medications effective in DPN and PHN failed to demonstrate efficacy in RAD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The greater refractoriness of HIV-related neuropathy and radiculopathy may be due to large placebo responses, a distinct clinical phenotype, or neglected psychosocial comorbidities.
“This may be due to large placebo responses in HIV-related neuropathy trials,45 a distinct clinical phenotype in subgroups of patients with radiculopathy,46 or psychological/psychosocial comorbidites, often neglected in large trials.”
From Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis (2015) · cites this paper as [45]
Placebo response is higher in HIV-related neuropathies and in patients with low or variable baseline pain scores, and lower in postherpetic neuralgia.
“Placebo response has been found to be higher in HIV-related neuropathies,45 and in patients with low or variable pain scores at inclusion.52 Conversely it seems to be lower in postherpetic neuralgia.45”
From Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis (2015) · cites this paper as [45]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Classification of Chronic Pain: Descriptions of Chronic Pain Syndromes and Definitions of Pain Terms
Merskey, H. (1994) · Medical Entomology and Zoology · Cited by 3,362 · see citing works
Treede (2008) · doi:10.1212/01.wnl.0000282763.29778.59 · Cited by 2,746 · see citing works
Freynhagen, R., Baron, R., Gockel, U., & Tölle, T. R. (2006) · Current Medical Research and Opinion · doi:10.1185/030079906x132488 · Cited by 2,280 · cited 2× · see citing works
“In addition to standard demographic questions the following validated questionnaires were used to assess co-morbidities and sensory abnormalities: for sleep disturbances the Medical Outcomes Study sleep scale (MOS; [6]), for depressive disorders and panic and anxiety disorders the German-language Patient Health Questi…”
MethodSelf-citationA review of psychological risk factors in back and neck pain
Linton, S. J. (2000) · Spine · doi:10.1097/00007632-200005010-00017 · Cited by 1,776 · cited 1× · see citing works
“The literature indicates a clear link between psychological variables and back pain [11,12].”
BackgroundLöwe, B., Kroenke, K., Herzog, W., & Gräfe, K. (2004) · Journal of Affective Disorders · doi:10.1016/s0165-0327(03)00198-8 · Cited by 1,558 · cited 1× · see citing works
“In addition to standard demographic questions the following validated questionnaires were used to assess co-morbidities and sensory abnormalities: for sleep disturbances the Medical Outcomes Study sleep scale (MOS; [6]), for depressive disorders and panic and anxiety disorders the German-language Patient Health Questi…”
MethodPsychometric properties of the Medical Outcomes Study Sleep measure
Hays, R. D., Martin, S. A., Sesti, A. M., & Spritzer, K. L. (2005) · Sleep Medicine · doi:10.1016/j.sleep.2004.07.006 · Cited by 557 · see citing works
Howe, J. F., Loeser, J. D., & Calvin, W. H. (1977) · Pain · doi:10.1016/0304-3959(77)90033-1 · Cited by 488 · see citing works
On the definitions and physiology of back pain, referred pain, and radicular pain
Bogduk, N. (2009) · Pain · doi:10.1016/j.pain.2009.08.020 · Cited by 344 · see citing works
Baron, R., Tölle, T. R., Gockel, U., Brosz, M., & Freynhagen, R. (2009) · Pain · doi:10.1016/j.pain.2009.06.001 · Cited by 317 · see citing works
Self-citationWu, G., Ringkamp, M., Murinson, B. B., Pogatzki, E. M., Hartke, T. V., Weerahandi, H. M., Campbell, J. N., Griffin, J. W., & Meyer, R. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-17-07746.2002 · Cited by 279 · see citing works
Sciatica and the Intervertebral Disc
SMYTH, M. J., & WRIGHT, V. (1958) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-195840060-00016 · Cited by 271 · see citing works
The treatment of depression in chronic low back pain: review and recommendations
Sullivan, M. J. L., Reesor, K., Mikail, S. F., & Fisher, R. (1992) · Pain · doi:10.1016/0304-3959(92)90107-m · Cited by 246 · see citing works
Morphine, nortriptyline and their combination vs. placebo in patients with chronic lumbar root pain
Khoromi, S., Cui, L., Nackers, L. M., & Max, M. B. (2006) · Pain · doi:10.1016/j.pain.2006.10.029 · Cited by 216 · see citing works
Freynhagen, R., Rolke, R., Baron, R., Tölle, T. R., Rutjes, A.-K., Schu, S., & Treede, R. (2007) · Pain · doi:10.1016/j.pain.2007.05.004 · Cited by 189 · see citing works
Self-citationBaron, R., Freynhagen, R., Tölle, T. R., Cloutier, C., Leon, T., Murphy, K. T., & Phillips, K. (2010) · Pain · doi:10.1016/j.pain.2010.04.013 · Cited by 163 · see citing works
Self-citationTopiramate in Chronic Lumbar Radicular Pain
Khoromi, S., Patsalides, A. T., Parada, S., Salehi, V., Meegan, J. M., & Max, M. B. (2005) · Journal of Pain · doi:10.1016/j.jpain.2005.08.002 · Cited by 160 · see citing works
Daniel, H. C., Narewska, J., Serpell, M. G., Hoggart, B., Johnson, R. W., & Rice, A. S. C. (2008) · European Journal of Pain · doi:10.1016/j.ejpain.2007.11.006 · Cited by 101 · see citing works
Meyer, T., Cooper, J., & Raspe, H. (2007) · Spine · doi:10.1097/brs.0b013e3181557955 · Cited by 100 · see citing works
Palmgren, T., Grönblad, M., Virri, J., et al. (1996) · Spine · doi:10.1097/00007632-199606010-00004 · Cited by 86 · see citing works
Differential Spinal Cord Gene Expression in Rodent Models of Radicular and Neuropathic Pain
LaCroix‐Fralish, M. L., Tawfik, V. L., Tanga, F. Y., et al. (2006) · Anesthesiology · doi:10.1097/00000542-200606000-00025 · Cited by 72 · see citing works
Motor axon excitability during Wallerian degeneration
Moldovan, M., Alvarez, S., & Krarup, C. (2008) · Brain · doi:10.1093/brain/awn332 · Cited by 71 · see citing works
Evaluation of the Psychological Status in Chronic Low Back Pain: Comparison with General Population
Manchikanti, L. (2002) · Pain Physician · doi:10.36076/ppj.2002/5/149 · Cited by 68 · see citing works
Shamji, M. F., Allen, K. D., So, S., Jing, L., Adams, S. B., Schuh, R., Huebner, J. L., Kraus, V. B., Friedman, A. H., Setton, L. A., et al. (2009) · Spine · doi:10.1097/brs.0b013e318197f013 · Cited by 64 · see citing works
JUNKER, U., Freynhagen, R., Längler, K., Gockel, U., Schmidt, U., Tölle, T. R., Baron, R., & Kohlmann, T. (2008) · Current Medical Research and Opinion · doi:10.1185/03007990802121059 · Cited by 48 · see citing works
Self-citationNakata, M., Baba, H., Kanai, K., et al. (2008) · Muscle & Nerve · doi:10.1002/mus.21031 · Cited by 21 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis
Finnerup, N. B., Attal, N., Haroutounian, S., McNicol, E., Baron, R., Dworkin, R. H., Gilron, I., Haanpää, M., Hansson, P., Jensen, T. S., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70251-0 · Cited by 3,980 · see citing works
Self-citationAllodynia and hyperalgesia in neuropathic pain: clinical manifestations and mechanisms
Jensen, T. S., & Finnerup, N. B. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70102-4 · Cited by 976 · see citing works
Pain and Depression: A Systematic Review
IsHak, W. W., Wen, R. Y., Naghdechi, L., Vanle, B., Dang, J., Knosp, M., Dascal, J., Marcia, L., Gohar, Y., Eskander, L., et al. (2018) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000198 · Cited by 498 · see citing works
Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations
Edwards, R. R., Dworkin, R. H., Turk, D. C., Angst, M. S., Dionne, R., Freeman, R., Hansson, P., Haroutounian, S., Arendt-Nielsen, L., Attal, N., et al. (2016) · Pain · doi:10.1097/j.pain.0000000000000602 · Cited by 403 · see citing works
Self-citation
- Authors
- Mahn, F., Hüllemann, P., Gockel, U., Brosz, M., Freynhagen, R., Tölle, T. R., & Baron, R.
- Affiliations
- University Hospital Schleswig-Holstein (DE)
- Technical University of Munich (DE)
- Corresponding author
- Baron, Ralf
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-05-09
- Volume
- 6
- Issue
- 5
- Pages
- e18018
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3090397
- OpenAlex
- W2158273944
- Cited by
- 84
- References
- 25
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 2 · 2023: 6 · 2022: 6 · 2021: 7 · 2020: 8 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 11 · 2015: 5 · 2014: 8 · 2013: 5 · 2012: 4
- FWCI
- 4.36
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- mediaTUM (Technical University of Munich) (submittedVersion)
- Funders
- Eli Lilly and Company
- Pfizer
- Sanofi
- Eisai
- Astellas Pharma
- Allergan
- UCB US
- Sanofi Pasteur
- UCB Pharma
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Keywords
- neuropathic pain, diabetic polyneuropathy, postherpetic neuralgia, mechanical allodynia, thermal hyperalgesia, depression, sleep disorders, anxiety, comorbidities, dorsal root ganglia, ectopic discharges, painDETECT
- MeSH terms
- Aged, Female, Humans, Male, Middle Aged, Neuralgia, Radiculopathy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
