Effects of Genetic Variants in ADCY5, GIPR, GCKR and VPS13C on Early Impairment of Glucose and Insulin Metabolism in Children

Windholz, Jan; Kovacs, Peter; Tönjes, Anke; Dittrich, Kathrin; Blüher, Susann; Kiess, Wieland; Stumvoll, Michael; Körner, Antje

doi:10.1371/journal.pone.0022101

Effects of Genetic Variants in ADCY5, GIPR, GCKR and VPS13C on Early Impairment of Glucose and Insulin Metabolism in Children

Objective Recent genome-wide association studies identified novel candidate genes for fasting and 2 h blood glucose and insulin levels in adults. We investigated the role of four of these loci (ADCY5, GIPR, GCKR and VPS13C) in early impairment of glucose and insulin metabolism in children. Resear…