The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Exercise-Induced Splanchnic Hypoperfusion Results in Gut Dysfunction in Healthy Men
Open accessAbstract
BACKGROUND: Splanchnic hypoperfusion is common in various pathophysiological conditions and often considered to lead to gut dysfunction. While it is known that physiological situations such as physical exercise also result in splanchnic hypoperfusion, the consequences of flow redistribution at the expense of abdominal organs remained to be determined. This study focuses on the effects of splanchnic hypoperfusion on the gut, and the relationship between hypoperfusion, intestinal injury and permeability during physical exercise in healthy men. METHODS AND FINDINGS: Healthy men cycled for 60 minutes at 70% of maximum workload capacity. Splanchnic hypoperfusion was assessed using gastric tonometry. Blood, sampled every 10 minutes, was analyzed for enterocyte damage parameters (intestinal fatty acid binding protein (I-FABP) and ileal bile acid binding protein (I-BABP)). Changes in intestinal permeability were assessed using sugar probes. Furthermore, liver and renal parameters were assessed. Splanchnic perfusion rapidly decreased during exercise, reflected by increased gap(g-a)pCO(2) from -0.85±0.15 to 0.85±0.42 kPa (p<0.001). Hypoperfusion increased plasma I-FABP (615±118 vs. 309±46 pg/ml, p<0.001) and I-BABP (14.30±2.20 vs. 5.06±1.27 ng/ml, p<0.001), and hypoperfusion correlated significantly with this small intestinal damage (r(S) = 0.59; p<0.001). Last of all, plasma analysis revealed an increase in small intestinal permeability after exercise (p<0.001), which correlated with intestinal injury (r(S) = 0.50; p<0.001). Liver parameters, but not renal parameters were elevated. CONCLUSIONS: Exercise-induced splanchnic hypoperfusion results in quantifiable small intestinal injury. Importantly, the extent of intestinal injury correlates with transiently increased small intestinal permeability, indicating gut barrier dysfunction in healthy individuals. These physiological observations increase our knowledge of splanchnic hypoperfusion sequelae, and may help to understand and prevent these phenomena in patients.
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In the citing paper
“Exercise-induced redistribution of blood can result in splanchnic hypoperfusion as a possible mechanism for gut dysfunction [128, 129].”
From International Society of Sports Nutrition Position Stand: Probiotics (2019) · cites this paper as [129]
In the citing paper
“Symptoms such as nausea, cramping, bloating, and diarrhea most likely reflect redistribution of blood flow from the gut to the skin for cooling purposes.”
From International Society of Sports Nutrition Position Stand: Probiotics (2019) · cites this paper as [129]
In the citing paper
“It has been shown that exercise induced GI hypoperfusion may provoke transient damage to the gut epithelium [6]”
In the citing paper
“The pathophysiology of GI distress during ultra-marathon training and racing is multifactorial, but is likely the result of reduced mesenteric blood flow [131, 132], leading to relative GI hypoperfusion [133].”
From International Society of Sports Nutrition Position Stand: nutritional considerations for single-stage ultra-marathon training and racing (2019) · cites this paper as [133]
In the citing paper
“The pathophysiology of GI distress during ultra-marathon training and racing is multifactorial, but is likely the result of reduced mesenteric blood flow [131, 132], leading to relative GI hypoperfusion [133].”
From International Society of Sports Nutrition Position Stand: nutritional considerations for single-stage ultra-marathon training and racing (2019) · cites this paper as [133]
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Citations
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“Previous studies support the former, showing relatively unchanged renal flow after short-term splanchnic blood redistribution [28,29].”
Result
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Self-citationMedicine & science in sports & exercise
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“Exercise also can reduce intestinal blood flow by more than 50%, with significant gut ischemia occurring within 10 min of high-intensity exercise (69).”
Background
Metadata
- Authors
- van Wijck, K., Lenaerts, K., van Loon, L. J. C., Peters, W. H. M., Buurman, W. A., & Dejong, C. H. C.
- Affiliations
- Maastricht University Medical Centre (NL)
- Radboud University Nijmegen (NL)
- Corresponding author
- Lenaerts, Kaatje
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-07-21
- Volume
- 6
- Issue
- 7
- Pages
- e22366
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3141050
- OpenAlex
- W1986330043
- Cited by
- 359
- References
- 48
- Citations by year
- 2026: 26 · 2025: 28 · 2024: 21 · 2023: 32 · 2022: 32 · 2021: 33 · 2020: 30 · 2019: 24 · 2018: 24 · 2017: 27 · 2016: 18 · 2015: 12 · 2014: 17 · 2013: 18 · 2012: 15
- FWCI
- 16.54
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Research Bank (Australian Catholic University) (submittedVersion, cc-by)
- Research Publications (Maastricht University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Radboud Repository (Radboud University) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Funders
- GlaxoSmithKline
- Topics
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- splanchnic hypoperfusion, physical activity, gastrointestinal dysfunction, intestinal injury, intestinal permeability, intestinal barrier dysfunction, gastric tonometry, intestinal fatty acid binding protein, ileal bile acid binding protein, small intestine, healthy men
- MeSH terms
- Bacteria, Health, Humans, Inflammation, Kidney, Liver, Male, Perfusion, Permeability, Splanchnic Circulation, Exercise, Gastrointestinal Tract, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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