Social defeat: Impact on fear extinction and amygdala-prefrontal cortical theta synchrony in 5-HTT deficient mice
Open accessAbstract
Emotions, such as fear and anxiety, can be modulated by both environmental and genetic factors. One genetic factor is for example the genetically encoded variation of the serotonin transporter (5-HTT) expression. In this context, the 5-HTT plays a key role in the regulation of central 5-HT neurotransmission, which is critically involved in the physiological regulation of emotions including fear and anxiety. However, a systematic study which examines the combined influence of environmental and genetic factors on fear-related behavior and the underlying neurophysiological basis is missing. Therefore, in this study we used the 5-HTT-deficient mouse model for studying emotional dysregulation to evaluate consequences of genotype specific disruption of 5-HTT function and repeated social defeat for fear-related behaviors and corresponding neurophysiological activities in the lateral amygdala (LA) and infralimbic region of the medial prefrontal cortex (mPFC) in male 5-HTT wild-type (+/+), homo- (-/-) and heterozygous (+/-) mice. Naive males and experienced losers (generated in a resident-intruder paradigm) of all three genotypes, unilaterally equipped with recording electrodes in LA and mPFC, underwent a Pavlovian fear conditioning. Fear memory and extinction of conditioned fear was examined while recording neuronal activity simultaneously with fear-related behavior. Compared to naive 5-HTT+/+ and +/- mice, 5-HTT-/- mice showed impaired recall of extinction. In addition, 5-HTT-/- and +/- experienced losers showed delayed extinction learning and impaired recall of extinction. Impaired behavioral responses were accompanied by increased theta synchronization between the LA and mPFC during extinction learning in 5-HTT-/- and +/- losers. Furthermore, impaired extinction recall was accompanied with increased theta synchronization in 5-HTT-/- naive and in 5-HTT-/- and +/- loser mice. In conclusion, extinction learning and memory of conditioned fear can be modulated by both the 5-HTT gene activity and social experiences in adulthood, accompanied by corresponding alterations of the theta activity in the amygdala-prefrontal cortex network.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Brain reward pathways, including the VTA and NAc, as well as the PFC and amygdala, have been implicated in the neural circuitry mediating individual differences in stress susceptibility.
“Brain reward pathways, including the ventral tegmental area (VTA) and the nucleus accumbens (NAc) (4) as well as the prefrontal cortex (PFC) and the amygdala (11,12), have been implicated in the neural circuitry mediating these differences in stress susceptibility.”
From Neuroanatomic differences associated with stress susceptibility and resilience (2016) · cites this paper as [11]
Social defeat-induced anxiety and depressive-like behaviors were previously associated with decreased neuronal activity in the medial PFC and increased VTA and amygdala activity.
“Social defeat–induced anxiety and depressive-like behaviors were previously associated with decreased neuronal activity in the medial PFC (46) as well as increased VTA and amygdala activity (10–12).”
From Neuroanatomic differences associated with stress susceptibility and resilience (2016) · cites this paper as [11]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859 · see citing works
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120 · see citing works
Neurophysiological investigation of the basis of the fMRI signal
Logothetis, N. K., Pauls, J., Augath, M., Trinath, T., & Oeltermann, A. (2001) · Nature · doi:10.1038/35084005 · Cited by 6,542 · see citing works
Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H., & Murphy, D. L. (1996) · Science · doi:10.1126/science.274.5292.1527 · Cited by 5,162 · see citing works
mouse brain in stereotaxic coordinates
Franklin, K. B. J., & Paxinos, G. (1997) · Cited by 3,258 · see citing works
Serotonin transporter genetic variation and the response of the human amygdala.
Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., Egan, M. F., & Weinberger, D. R. (2002) · Science · doi:10.1126/science.1071829 · Cited by 2,340 · see citing works
Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., Egan, M. F., Mattay, V. S., Hariri, A. R., & Weinberger, D. R. (2005) · Nature Neuroscience · doi:10.1038/nn1463 · Cited by 1,980 · see citing works
Neuronal signalling of fear memory
Maren, S., & Quirk, G. J. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1535 · Cited by 1,428 · see citing works
Cellular bases of hippocampal EEG in the behaving rat
Buzsáki, G., Leung Lai-Wo, S., & Vanderwolf, C. H. (1983) · Brain Research Reviews · doi:10.1016/0165-0173(83)90037-1 · Cited by 1,397 · see citing works
Gene–environment interactions in psychiatry: joining forces with neuroscience
Caspi, A., & Moffitt, T. E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1925 · Cited by 1,300 · see citing works
Sierra-Mercado, D., Padilla-Coreano, N., & Quirk, G. J. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.184 · Cited by 1,190 · see citing works
Pape, H.-C., & Pare, D. (2010) · Physiological Reviews · doi:10.1152/physrev.00037.2009 · Cited by 994 · see citing works
Self-citationPlasma membrane monoamine transporters: structure, regulation and function
Torres, G. E., Gainetdinov, R. R., & Caron, M. G. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1008 · Cited by 936 · see citing works
Memory processes, brain oscillations and EEG synchronization
Klimesch, W. (1996) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(96)00057-8 · Cited by 923 · see citing works
Cloning and expression of a functional serotonin transporter from rat brain
Blakely, R., Berson, H. E., Fremeau, R. T., Caron, M. G., Peek, M. M., Prince, H. K., & Bradley, C. C. (1991) · Nature · doi:10.1038/354066a0 · Cited by 831 · see citing works
Early-Life Blockade of the 5-HT Transporter Alters Emotional Behavior in Adult Mice
Ansorge, M. S., Zhou, M., Lira, A., Hen, R., & Gingrich, J. A. (2004) · Science · doi:10.1126/science.1101678 · Cited by 817 · see citing works
A Susceptibility Gene for Affective Disorders and the Response of the Human Amygdala
Hariri, A. R., Drabant, E. M., Munoz, K. E., Kolachana, B. S., Mattay, V. S., Egan, M. F., & Weinberger, D. R. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.2.146 · Cited by 815 · see citing works
Adhikari, A., Topiwala, M. A., & Gordon, J. A. (2010) · Neuron · doi:10.1016/j.neuron.2009.12.002 · Cited by 729 · see citing works
Amygdalar and Hippocampal Theta Rhythm Synchronization During Fear Memory Retrieval
Seidenbecher, T., Laxmi, T. R., Stork, O., & Pape, H.-C. (2003) · Science · doi:10.1126/science.1085818 · Cited by 728 · see citing works
Self-citationBengel, D., Murphy, D. L., Andrews, A. M., Wichems, C. H., Feltner, D. E., Heils, A., Mößner, R., Westphal, H., & Lesch, K. (1998) · Molecular Pharmacology · doi:10.1124/mol.53.4.649 · Cited by 719 · see citing works
Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter
Heinz, A., Braus, D. F., Smolka, M. N., Wrase, J., Puls, I., Hermann, D., Vollstädt‐Klein, S., Grüsser, S. M., Flor, H., Schumann, G., et al. (2004) · Nature Neuroscience · doi:10.1038/nn1366 · Cited by 700 · see citing works
5-HT1A receptor function in major depressive disorder
Savitz, J. B., Lucki, I., & Drevets, W. C. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.01.009 · Cited by 573 · see citing works
Celada, P., Puig, M. V., Casanovas, J. M., Guillazo, G., & Artigas, F. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-24-09917.2001 · Cited by 497 · see citing works
Malison, R. T., Price, L. H., Berman, R., van Dyck, C. H., Pelton, G. H., Carpenter, L., Sanacora, G., Owens, M. J., Nemeroff, C. B., Rajeevan, N., et al. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00272-8 · Cited by 496 · see citing works
Stress-induced prefrontal reorganization and executive dysfunction in rodents
Holmes, A., & Wellman, C. L. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.11.005 · Cited by 469 · see citing works
Serotonin Transporter: Gene, Genetic Disorders, and Pharmacogenetics
Murphy, D. L. (2004) · Molecular Interventions · doi:10.1124/mi.4.2.8 · Cited by 444 · see citing works
Disrupting Reconsolidation of Drug Memories Reduces Cocaine-Seeking Behavior
Lee, J. L. C., Ciano, P. D., Thomas, K. L., & Everitt, B. J. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.007 · Cited by 391 · see citing works
Arango, V (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00310-4 · Cited by 368 · see citing works
Wellman, C. L., Izquierdo, A., Garrett, J. E., Martin, K. P., Carroll, J., Millstein, R., Lesch, K.-P., Murphy, D. L., & Holmes, A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4595-06.2007 · Cited by 366 · see citing works
Holmes, A., Murphy, D. L., & Crawley, J. N. (2003) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.09.003 · Cited by 342 · see citing works
Lesch, K., & Mößner, R. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00121-8 · Cited by 334 · see citing works
A Specialized Subclass of Interneurons Mediates Dopaminergic Facilitation of Amygdala Function
Marowsky, A., Yanagawa, Y., Obata, K., & Vogt, K. E. (2005) · Neuron · doi:10.1016/j.neuron.2005.10.029 · Cited by 328 · see citing works
Zahniser, N. R., & Doolen, S. (2001) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(01)00158-9 · Cited by 311 · see citing works
Serotonergic Modulation of Neurotransmission in the Rat Basolateral Amygdala
Rainnie, D. G. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.1.69 · Cited by 310 · see citing works
Long-term effects of social stress on brain and behavior: a focus on hippocampal functioning
Buwalda, B., Kole, M. H. P., Veenema, A. H., Huininga, M., de Boer, S. F., Korte, S. M., & Koolhaas, J. M. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.05.005 · Cited by 304 · see citing works
Jüngling, K., Seidenbecher, T., Sosulina, L., Lesting, J., Sangha, S., Clark, S. D., Okamura, N., Duangdao, D. M., Xu, Y.-L., Reinscheid, R. K., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.002 · Cited by 299 · see citing works
Self-citationEvaluation of Antidepressant-related Behavioral Responses in Mice Lacking the Serotonin Transporter
Holmes, A. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00374-3 · Cited by 288 · see citing works
Gene–environment interaction and the genetics of depression
Lesch, K. (2004) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0420 · Cited by 284 · see citing works
Mathews, T. A., Fedele, D., Coppelli, F. M., Avila, A. M., Murphy, D. L., & Andrews, A. M. (2004) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.05.017 · Cited by 277 · see citing works
Lesting, J., Narayanan, R. T., Kluge, C., Sangha, S., Seidenbecher, T., & Pape, H.-C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021714 · Cited by 275 · see citing works
Self-citationFabre, V., Beaufour, C., Evrard, A., Bilan, A. R., Hanoun, N., Lesch, K., Murphy, D. L., Lanfumey, L., Hamon, M., & Martres, M. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00126.x · Cited by 274 · see citing works
Amygdala oscillations and the consolidation of emotional memories
Paré, D. (2002) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(02)01924-1 · Cited by 270 · see citing works
Dissecting the role of the serotonin system in neuropsychiatric disorders using knockout mice
Gingrich, J. A., & Hen, R. (2001) · Psychopharmacology · doi:10.1007/s002130000573 · Cited by 265 · see citing works
Veenema, A. H., Bredewold, R., & Neumann, I. D. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.02.008 · Cited by 263 · see citing works
Munafo, M. R., Clark, T. G., & Flint, J. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001627 · Cited by 250 · see citing works
Puig, M. V. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh104 · Cited by 232 · see citing works
Neumeister, A., Konstantinidis, A., Stastny, J., Schwarz, M. J., Vitouch, O., Willeit, M., Praschak-Rieder, N., Zach, J., de Zwaan, M., Bondy, B., et al. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.7.613 · Cited by 223 · see citing works
How social experiences influence the brain
Champagne, F. A., & Curley, J. P. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.10.001 · Cited by 217 · see citing works
Genetic perspectives on the serotonin transporter
Murphy, D. L., Li, Q., Engel, S. R., Wichems, C. H., Andrews, A. M., Lesch, K., & Uhl, G. R. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00622-0 · Cited by 214 · see citing works
Barr, C. S., Newman, T. K., Schwandt, M. L., Shannon, C., Dvoskin, R. L., Lindell, S. G., Taubman, J., Thompson, B., Champoux, M., Lesch, K., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403763101 · Cited by 205 · see citing works
The effects of prenatal social stress on behaviour: mechanisms and function
Kaiser, S., & Sachser, N. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.09.015 · Cited by 201 · see citing works
Self-citationTargeted gene mutation approaches to the study of anxiety-like behavior in mice
Holmes, A. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00012-4 · Cited by 198 · see citing works
Kim, D., Tolliver, T. J., Huang, S.-J., Martin, B. J., Andrews, A. M., Wichems, C. H., Holmes, A., Lesch, K., & Murphy, D. L. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.08.010 · Cited by 185 · see citing works
Willeit, M., Praschak-Rieder, N., Neumeister, A., Pirker, W., Asenbaum, S., Vitouch, O., Tauscher, J. T., Hilger, E., Stastny, J., Brücke, T., et al. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00293-0 · Cited by 178 · see citing works
Regulation of conditioned responses of basolateral amygdala neurons
GRACE, A., & ROSENKRANZ, J. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00909-5 · Cited by 172 · see citing works
Gobbi, G., Murphy, D. L., Lesch, K., & Blier, P. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38843-3 · Cited by 168 · see citing works
Steinbusch, H. W. M., Nieuwenhuys, R., Verhofstad, A. A. J., & Van der Kooy, D. (1981) · PubMed · Cited by 165 · see citing works
Genetic basis of anxiety-like behaviour: a critical review
Clément, Y., Calatayud, F., & Belzung, C. (2002) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00637-2 · Cited by 162 · see citing works
Kugaya, A., Seneca, N. M., Snyder, P. J., Williams, S. A., Malison, R. T., Baldwin, R. M., Seibyl, J. P., & Innis, R. B. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300036 · Cited by 161 · see citing works
Dynamics of central nervous 5-HT1A-receptors under psychosocial stress
Flügge, G. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07132.1995 · Cited by 155 · see citing works
Jennings, K. A., Loder, M. K., Sheward, W. J., Pei, Q., Deacon, R. M. J., Benson, M. A., Olverman, H. J., Hastie, N. D., Harmar, A. J., Shen, S., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5356-05.2006 · Cited by 153 · see citing works
Paré, D., Pape, H., & Dong, J. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.74.3.1179 · Cited by 147 · see citing works
Self-citationGlutamate and monoamine transporters: new visions of form and function
Torres, G. E., & Amara, S. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.05.002 · Cited by 144 · see citing works
Current treatments of the anxiety disorders in adults.
Ballenger, J. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00220-6 · Cited by 139 · see citing works
Rodent Models of Depression: Reexamining Validity Without Anthropomorphic Inference
Holmes, P. V. (2003) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v15.i2.30 · Cited by 132 · see citing works
Pinto, A., Jankowski, M. P., & Sesack, S. R. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10596 · Cited by 130 · see citing works
Serotonergic projections from the nucleus raphe dorsalis to the amygdala in the rat
Ma, Q., Yin, G. F., Ai, M. K., & Han, J. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90499-j · Cited by 122 · see citing works
Effects of median raphe nucleus lesions on hippocampal EEG in the freely moving rat
Maru, E., Takahashi, L. K., & Iwahara, S. (1979) · Brain Research · doi:10.1016/0006-8993(79)90351-2 · Cited by 118 · see citing works
Increased vulnerability to psychosocial stress in heterozygous serotonin transporter knockout mice
Bartolomucci, A., Carola, V., Pascucci, T., Puglisi‐Allegra, S., Cabib, S., Lesch, K., Parmigiani, S., Palanza, P., & Gross, C. T. (2010) · Disease Models & Mechanisms · doi:10.1242/dmm.004614 · Cited by 112 · see citing works
Narayanan, R. T., Seidenbecher, T., Kluge, C., Bergado, J. A., Stork, O., & Pape, H. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05437.x · Cited by 111 · see citing works
Self-citationVertes, R. P., Kinney, G. G., Kocsis, B., & Fortin, W. J. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90255-0 · Cited by 111 · see citing works
Adhikari, A., Sigurdsson, T., Topiwala, M. A., & Gordon, J. A. (2010) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2010.06.019 · Cited by 111 · see citing works
Koyama, S., Kubo, C., Rhee, J., & Akaike, N. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0525p.x · Cited by 108 · see citing works
Hajós, M. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00139-4 · Cited by 107 · see citing works
Pharmacotherapy for Post-Traumatic Stress Disorder
Sutherland, S. M., & Davidson, J. R. T. (1994) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(18)30122-9 · Cited by 105 · see citing works
Ionic Mechanisms of Intrinsic Oscillations in Neurons of the Basolateral Amygdaloid Complex
Pape, H., & Driesang, R. B. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.1.217 · Cited by 105 · see citing works
Self-citationHammack, S. E., Guo, J.-D., Hazra, R., Dabrowska, J., Myers, K. M., & Rainnie, D. G. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.05.013 · Cited by 103 · cited 1× · see citing works
“). Additionally, loss of 5-HTT gene function influenced normal activity in the LA and IL of mPFC in the theta frequency range and interaction between both regions. The serotonergic system, particularly the dorsal raphe nucleus, extensively innervates corticolimbic structures involved in the control of stress and anxie…”
BackgroundSangha, S., Narayanan, R. T., Bergado-Acosta, J. R., Stork, O., Seidenbecher, T., & Pape, H. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2620-09.2009 · Cited by 99 · see citing works
Self-citationEffects of Mild Early Life Stress on Abnormal Emotion-related Behaviors in 5-HTT Knockout Mice
Carroll, J. C., Boyce‐Rustay, J. M., Millstein, R. A., Yang, R. J., Wiedholz, L. M., Murphy, D. L., & Holmes, A. (2006) · Behavior Genetics · doi:10.1007/s10519-006-9129-9 · Cited by 97 · see citing works
Further studies on platelet serotonin transporter binding in depression
Nemeroff, C. B., Knight, D. L., Franks, J., Craighead, W. E., & Krishnan, K. R. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.11.1623 · Cited by 95 · see citing works
Jansen, F., Heiming, R. S., Lewejohann, L., Touma, C., Palme, R., Schmitt, A. G., Lesch, K., & Sachser, N. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.09.033 · Cited by 87 · see citing works
Self-citationPharmacotherapy for post traumatic stress disorder (PTSD)
Stein, D. J., Zungu‐Dirwayi, N., van der Linden, G. J., & Seedat, S. (2000) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002795 · Cited by 85 · see citing works
Ethanol Inhibits Clearance of Brain Serotonin by a Serotonin Transporter-Independent Mechanism
Daws, L. C., Montañez, S., Munn, J. L., Owens, W. A., Baganz, N. L., Boyce‐Rustay, J. M., Millstein, R. A., Wiedholz, L. M., Murphy, D. L., & Holmes, A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4050-05.2006 · Cited by 84 · see citing works
Li, X. B., Inoue, T., Hashimoto, S., & Koyama, T. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01159-1 · Cited by 76 · see citing works
Heiming, R. S. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.026.2009 · Cited by 72 · see citing works
Self-citationKoyama, S., Matsumoto, N., Murakami, N., Kubo, C., Nabekura, J., & Akaike, N. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02280-4 · Cited by 72 · see citing works
Lucki, I., & O'Leary, O. F. (2004) · PubMed · Cited by 71 · see citing works
Role of amygdala oscillations in the consolidation of emotional memories
Pelletier, J. G., & Paré, D. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.08.019 · Cited by 71 · see citing works
Molecular manipulations as tools for enhancing our understanding of 5-HT neurotransmission
Murphy, D. L., Wichems, C. H., Li, Q., & Heils, A. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01325-5 · Cited by 70 · see citing works
Line, S. J., Barkus, C., Coyle, C., Jennings, K. A., Deacon, R. M. J., Lesch, K., Sharp, T., & Bannerman, D. M. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.08.005 · Cited by 65 · see citing works
Theta resynchronization during reconsolidation of remote contextual fear memory
Narayanan, R. T., Seidenbecher, T., Sangha, S., Stork, O., & Pape, H. (2007) · Neuroreport · doi:10.1097/wnr.0b013e3282004992 · Cited by 63 · see citing works
Self-citationNietzer, S., Bonn, M., Jansen, F., Heiming, R. S., Lewejohann, L., Sachser, N., Asan, E., Lesch, K., & Schmitt, A. G. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.01.011 · Cited by 59 · see citing works
Self-citationGenetic and environmental factors interact to influence anxiety
Gross, C. T., & Hen, R. (2004) · Neurotoxicity Research · doi:10.1007/bf03033286 · Cited by 55 · see citing works
Nitz, D. A., & McNaughton, B. L. (1999) · Learning & Memory · doi:10.1101/lm.6.2.153 · Cited by 53 · see citing works
Marrosu, F., Fornal, C. A., Metzler, C. W., & Jacobs, B. L. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00826-8 · Cited by 48 · see citing works
Serotonin receptor knockouts: A moody subject
Julius, D. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15153 · Cited by 42 · see citing works
[3H]-Imipramine binding in human platelets: A new biochemical parameter in depression
Briley, M., Raisman‐Vozari, R., Sechter, D., Zarifian, E., & Langer, S. Z. (1980) · Neuropharmacology · doi:10.1016/0028-3908(80)90204-x · Cited by 38 · see citing works
GABAergic Neurons: Gate Masters of the Amygdala, Mastered by Dopamine
Pape, H. (2005) · Neuron · doi:10.1016/j.neuron.2005.12.002 · Cited by 37 · see citing works
Self-citationLesting, J., Geiger, M., Narayanan, R. T., Pape, H., & Seidenbecher, T. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2010.02758.x · Cited by 36 · see citing works
Self-citationPharmacotherapy of post-traumatic stress disorder
Opler, L. A., GRENNAN, M. S., & Opler, M. G. (2006) · Drugs of today · doi:10.1358/dot.2006.42.12.1025704 · Cited by 25 · see citing works
Knockout mice in neuropsychopharmacology: present and future
Mößner, R., & Lesch, K. (1998) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145798001114 · Cited by 7 · see citing works
Flagged first, then by citations
2 of the 104 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
50 years of hurdles and hope in anxiolytic drug discovery
Griebel, G., & Holmes, A. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4075 · Cited by 414 · see citing works
Deslauriers, J., Tóth, M., Der‐Avakian, A., & Risbrough, V. B. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.11.019 · Cited by 253 · see citing works
Rodent models of post-traumatic stress disorder: behavioral assessment
Verbitsky, A., Dopfel, D., & Zhang, N. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0806-x · Cited by 250 · see citing works
Serotonin, Amygdala and Fear: Assembling the Puzzle
Bocchio, M., McHugh, S. B., Bannerman, D. M., Sharp, T., & Capogna, M. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2016.00024 · Cited by 207 · see citing works
Harvey, C., Gehrman, P., & Espie, C. A. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2013.11.004 · Cited by 201 · see citing works
Neuroanatomic differences associated with stress susceptibility and resilience
Anacker, C., Scholz, J., O’Donnell, K. J., Allemang-Grand, R., Diorio, J., Bagot, R. C., Nestler, E. J., Hen, R., Lerch, J. P., & Meaney, M. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.08.009 · Cited by 167 · see citing works
Emotion regulation by cognitive reappraisal - The role of frontal theta oscillations
Ertl, M., Hildebrandt, M., Ourina, K., Leicht, G., & Mulert, C. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.05.044 · Cited by 159 · see citing works
Long-Range Neural Synchrony in Behavior
Harris, A. Z., & Gordon, J. A. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-034111 · Cited by 165 · see citing works
Animal models of post-traumatic stress disorder: face validity
Goswami, S., Rodríguez-Sierra, O. E., Cascardi, M. A., & Paré, D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00089 · Cited by 151 · see citing works
Are We Getting Closer to Valid Translational Models for Major Depression?
Berton, O., Hahn, C.-G., & Thase, M. E. (2012) · Science · doi:10.1126/science.1222940 · Cited by 148 · see citing works
Asan, E., Steinke, M. R., & Lesch, K. (2013) · Histochemistry and Cell Biology · doi:10.1007/s00418-013-1081-1 · Cited by 137 · see citing works
Hultman, R. C., Mague, S. D., Li, Q., Katz, B. M., Michel, N., Lin, L., Wang, J., David, L. K., Blount, C., Chandy, R., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.05.038 · Cited by 137 · see citing works
Prefrontal cortex reactivity underlies trait vulnerability to chronic social defeat stress
Kumar, S., Hultman, R. C., Hughes, D. N., Michel, N., Katz, B. M., & Dzirasa, K. (2014) · Nature Communications · doi:10.1038/ncomms5537 · Cited by 130 · see citing works
Serotonin in fear conditioning processes
Bauer, E. P. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.028 · Cited by 127 · see citing works
Homberg, J. R., Schubert, D., Asan, E., & Aron, E. N. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.029 · Cited by 121 · see citing works
Animal models for posttraumatic stress disorder: An overview of what is used in research
Borghans, B. (2015) · World Journal of Psychiatry · doi:10.5498/wjp.v5.i4.387 · Cited by 120 · see citing works
A Discrete Dorsal Raphe to Basal Amygdala 5-HT Circuit Calibrates Aversive Memory
Sengupta, A., & Holmes, A. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.029 · Cited by 113 · see citing works
Lesting, J., Daldrup, T., Narayanan, V., Himpe, C., Seidenbecher, T., & Pape, H.-C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077707 · Cited by 105 · see citing works
Self-citationNocjar, C., Zhang, J., Feng, P., & Panksepp, J. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.05.033 · Cited by 105 · see citing works
Rodent models of social stress and neuronal plasticity: Relevance to depressive-like disorders
Patel, D., Kas, M. J., Chattarji, S., & Buwalda, B. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.111900 · Cited by 105 · see citing works
Refining the Role of 5-HT in Postnatal Development of Brain Circuits
Teissier, A., Soiza‐Reilly, M., & Gaspar, P. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00139 · Cited by 101 · see citing works
Bazzari, A. H., & Parri, H. R. (2019) · Brain Sciences · doi:10.3390/brainsci9110300 · Cited by 99 · see citing works
Persistent prelimbic cortex activity contributes to enhanced learned fear expression in femalesPreprint
Fenton, G. E., Pollard, A. K., Halliday, D. M., Mason, R., Bredy, T. W., & Stevenson, C. W. (2014) · Learning & Memory · doi:10.1101/lm.033514.113 · Cited by 101 · see citing works
Social stress models in depression research: what do they tell us?
Chaouloff, F. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1606-x · Cited by 99 · see citing works
Medial prefrontal cortex neuronal circuits in fear behavior
Courtin, J., Bienvenu, T., Einarsson, E. Ö., & Herry, C. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.03.001 · Cited by 97 · see citing works
Prefrontal oscillations during recall of conditioned and extinguished fear in humans
Mueller, E. M., Panitz, C., Hermann, C., & Pizzagalli, D. A. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3427-13.2014 · Cited by 89 · see citing works
Amygdala-Prefrontal Synchronization Underlies Resistance to Extinction of Aversive Memories
Livneh, U., & Paz, R. (2012) · Neuron · doi:10.1016/j.neuron.2012.05.016 · Cited by 87 · see citing works
Aizawa, H., Yanagihara, S., Kobayashi, M. S., Niisato, K., Takekawa, T., Harukuni, R., McHugh, T. J., Fukai, T., Isomura, Y., & Okamoto, H. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4369-12.2013 · Cited by 86 · see citing works
Serotonin transporter polyadenylation polymorphism modulates the retention of fear extinction memory
Hartley, C. A., McKenna, M. C., Salman, R., Holmes, A., Casey, B. J., Phelps, E. A., & Glatt, C. E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202044109 · Cited by 82 · see citing works
Serotonin-related pathways and developmental plasticity: relevance for psychiatric disorders
Dayer, A. G. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.1/adayer · Cited by 71 · see citing works
Prefrontal single-unit firing associated with deficient extinction in mice
Fitzgerald, P. J., Whittle, N., Flynn, S., Graybeal, C., Pinard, C. R., Gunduz‐Cinar, O., Kravitz, A. V., Singewald, N., & Holmes, A. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.11.002 · Cited by 71 · see citing works
Bukalo, O., Pinard, C. R., & Holmes, A. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12779 · Cited by 67 · see citing works
Interindividual Variability in Stress Susceptibility: A Role for Epigenetic Mechanisms in PTSD
Zovkic, I. B., Meadows, J. P., Kaas, G. A., & Sweatt, J. D. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00060 · Cited by 62 · see citing works
Raber, J., Arzy, S., Bertolus, J. B., Depue, B., Haas, H. E., Hofmann, S. G., Kangas, M., Kensinger, E., Lowry, C. A., Marusak, H. A., et al. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.03.015 · Cited by 62 · see citing works
“Studies also support a role for serotonergic signaling in control of fear extinction (Narayanan et al., 2011).”
Stress‐Induced Depression: Is Social Rank a Predictive Risk Factor?
Larrieu, T., & Sandi, C. (2018) · BioEssays · doi:10.1002/bies.201800012 · Cited by 61 · see citing works
Olivier, J. D. A., Vinkers, C. H., & Olivier, B. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00074 · Cited by 57 · see citing works
Lebrón‐Milad, K., Tsareva, A., Ahmed, N., & Milad, M. R. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.07.024 · Cited by 58 · see citing works
Karabeg, M. M., Grauthoff, S., Kollert, S. Y., Weidner, M., Heiming, R. S., Jansen, F., Popp, S., Kaiser, S., Lesch, K.-P., Sachser, N., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078238 · Cited by 56 · see citing works
Self-citationKinast, K., Peeters, D., Kolk, S. M., Schubert, D., & Homberg, J. R. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00072 · Cited by 57 · see citing works
Serotonin Modulation of Prefronto-Hippocampal Rhythms in Health and Disease
Puig, M. V., & Gener, T. (2015) · ACS Chemical Neuroscience · doi:10.1021/cn500350e · Cited by 55 · see citing works
Bocchio, M., Fucsina, G., Oikonomidis, L., McHugh, S. B., Bannerman, D. M., Sharp, T., & Capogna, M. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.157 · Cited by 54 · see citing works
Brain hyperserotonemia causes autism-relevant social deficits in mice
Tanaka, M., Sato, A., Kasai, S., Hagino, Y., Kotajima‐Murakami, H., Kashii, H., Takamatsu, Y., Nishito, Y., Inagaki, M., Mizuguchi, M., et al. (2018) · Molecular Autism · doi:10.1186/s13229-018-0243-3 · Cited by 57 · see citing works
Fear Extinction Recall Modulates Human Frontomedial Theta and Amygdala Activity
Sperl, M. F. J., Panitz, C., Rosso, I. M., Dillon, D. G., Kumar, P., Hermann, A., Whitton, A. E., Hermann, C., Pizzagalli, D. A., & Mueller, E. M. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx353 · Cited by 56 · see citing works
Homberg, J. R., & van den Hove, D. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.08.003 · Cited by 51 · see citing works
Hill, J. L., Hardy, N. F., Jimenez, D. V., Maynard, K. R., Kardian, A., Pollock, C. J., Schloesser, R. J., & Martinowich, K. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.153 · Cited by 50 · see citing works
Serotonergic Modulation of Conditioned Fear
Homberg, J. (2012) · Scientifica · doi:10.6064/2012/821549 · Cited by 49 · see citing works
Theta-Range Oscillations in Stress-Induced Mental Disorders as an Oscillotherapeutic Target
Okonogi, T., & Sasaki, T. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.698753 · Cited by 40 · see citing works
Cortical–Amygdalar Circuit Dysfunction in a Genetic Mouse Model of Serotonin Deficiency
Dzirasa, K., Kumar, S., Sachs, B. D., Caron, M. G., & Nicolelis, M. A. L. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4891-12.2013 · Cited by 39 · see citing works
Activity-dependent signaling: influence on plasticity in circuits controlling fear-related behavior
Hill, J. L., & Martinowich, K. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2015.10.001 · Cited by 39 · see citing works
van der Doelen, R. H. A., Calabrese, F., Guidotti, G., Geenen, B., Riva, M. A., Kozicz, T., & Homberg, J. R. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00355 · Cited by 39 · see citing works
Cerina, M., Narayanan, V., Göbel, K., Bittner, S., Ruck, T., Meuth, P., Herrmann, A. M., Stangel, M., Gudi, V., Skripuletz, T., et al. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.08.014 · Cited by 35 · see citing works
Self-citationShoji, H., Ikeda, K., & Miyakawa, T. (2023) · Molecular Brain · doi:10.1186/s13041-023-01020-2 · Cited by 34 · see citing works
A unified circuit for social behavior
Modi, M. E., & Şahin, M. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.08.010 · Cited by 34 · see citing works
Electrolytic lesion of the nucleus incertus retards extinction of auditory conditioned fear
Pereira, C. W., Santos, F. N., Sánchez‐Pérez, A. M., Otero‐García, M., Marchioro, M., Ma, S., Gundlach, A. L., & Olucha-Bordonau, F. E. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.03.025 · Cited by 32 · see citing works
Endocannabinoid-serotonin systems interaction in health and disease
Colangeli, R., Teskey, G. C., & Giovanni, G. D. (2021) · Progress in brain research · doi:10.1016/bs.pbr.2021.01.003 · Cited by 30 · see citing works
Shan, L., Schipper, P., Nonkes, L. J. P., & Homberg, J. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091472 · Cited by 30 · see citing works
A Role for Serotonin in Modulating Opposing Drive and Brake Circuits of Impulsivity
Desrochers, S. S., Spring, M. G., & Nautiyal, K. M. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.791749 · Cited by 29 · see citing works
Meduri, J. D., Farnbauch, L. A., & Jasnow, A. M. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.09.009 · Cited by 28 · see citing works
Bodden, C., van den Hove, D., Lesch, K., & Sachser, N. (2017) · Scientific Reports · doi:10.1038/s41598-017-09292-0 · Cited by 26 · see citing works
Self-citationMyelination- and immune-mediated MR-based brain network correlates
Cerina, M., Muthuraman, M., Gallus, M., Koirala, N., Dik, A., Wachsmuth, L., Hundehege, P., Schiffler, P., Tenberge, J., Fleischer, V., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01827-z · Cited by 24 · see citing works
Self-citationSivamaruthi, B. S., Madhumita, R., Balamurugan, K., & Rajan, K. E. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00188 · Cited by 22 · see citing works
Protective potential of dimethyl fumarate in a mouse model of thalamocortical demyelination
Cerina, M., Narayanan, V., Delank, A., Meuth, P., Graebenitz, S., Göbel, K., Herrmann, A. M., Albrecht, S., Daldrup, T., Seidenbecher, T., et al. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1680-7 · Cited by 22 · see citing works
Self-citationLi, H., Ohta, H., Izumi, H., Matsuda, Y., Seki, M., Toda, T., Akiyama, M., Matsushima, Y., Goto, Y., Kaga, M., et al. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.09.051 · Cited by 22 · see citing works
Suzuki, T., Gu, P., Grove, T. B., Hammond, T., Collins, K. M., Pamidighantam, P., Arnold, P. D., Taylor, S. F., Liu, Y., Gehring, W. J., et al. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.10.020 · Cited by 20 · see citing works
Enhanced discriminative aversive learning and amygdala responsivity in 5-HT transporter mutant mice
Lima, J., Sharp, T., Bannerman, D. M., & McHugh, S. B. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0476-8 · Cited by 20 · see citing works
Hartley, C. A., & Casey, B. J. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12287 · Cited by 19 · see citing works
Decreased kynurenine pathway potentiate resilience to social defeat effect on cocaine reward
Giménez‐Gómez, P., Ballestín, R., de Biedma‐Elduayen, L. G., Vidal, R., Perez, C. F., Reguilón, M. D., O’Shea, E., Miñarro, J., Colado, M. I., & Rodríguez‐Arias, M. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108753 · Cited by 18 · see citing works
Gilbert, J. R., Gerner, J. L., Burton, C. R., Nugent, A. C., Zarate, C. A., & Ballard, E. D. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.06.025 · Cited by 18 · see citing works
Ródenas-González, F., Arenas, M. C., Blanco-Gandía, M. C., Manzanedo, C., & Rodríguez‐Arias, M. (2023) · Biomedicines · doi:10.3390/biomedicines11020502 · Cited by 18 · see citing works
Wannemueller, A., Moser, D., Kumsta, R., Jöhren, H.-P., Adolph, D., & Margraf, J. (2018) · Behaviour Research and Therapy · doi:10.1016/j.brat.2018.06.003 · Cited by 18 · see citing works
Bierhansl, L., Gola, L., Narayanan, V., Dik, A., Meuth, S. G., Wiendl, H., & Kovac, S. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04148-x · Cited by 17 · see citing works
Self-citationSchipper, P., Brivio, P., de Leest, D., Madder, L., Asrar, B., Rebuglio, F., Verheij, M. M. M., Kozicz, T., Riva, M. A., Calabrese, F., et al. (2019) · Brain Sciences · doi:10.3390/brainsci9050118 · Cited by 16 · see citing works
Bierwirth, P., Antov, M. I., & Stockhorst, U. (2023) · Psychophysiology · doi:10.1111/psyp.14283 · Cited by 16 · see citing works
Namkung, H., Thomas, K. L., Hall, J., & Sawa, A. (2021) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.12.025 · Cited by 12 · see citing works
Role of murine models in psychiatric illness drug discovery: a dimensional view
Hoffman, K. L. (2013) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2013.797959 · Cited by 14 · see citing works
Nonkes, L. J. P., & Homberg, J. R. (2012) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.12.004 · Cited by 15 · see citing works
Carlson, H. N., & Weiner, J. L. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.09.006 · Cited by 14 · see citing works
Impact of Life History on Fear Memory and Extinction
Remmes, J., Bodden, C., Richter, S. H., Lesting, J., Sachser, N., Pape, H., & Seidenbecher, T. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00185 · Cited by 15 · see citing works
Self-citationResilience to fear: The role of individual factors in amygdala response to stressors
Fonseca, R., Madeira, N., & Simões, C. R. B. (2020) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2020.103582 · Cited by 16 · see citing works
Hallock, H. L., Quillian, H. M., Mai, Y., Maynard, K. R., Hill, J. L., & Martinowich, K. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0429-1 · Cited by 14 · see citing works
Ferrara, N. C., Mrackova, E., Loh, M. K., Padival, M., & Rosenkranz, J. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21083008 · Cited by 14 · see citing works
Brivio, P., Gallo, M. T., Karel, P., Cogi, G., Fumagalli, F., Homberg, J. R., & Calabrese, F. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.957702 · Cited by 13 · see citing works
Caffino, L., Mottarlini, F., van Reijmersdal, B., Telese, F., Verheij, M. M. M., Fumagalli, F., & Homberg, J. R. (2020) · Addiction Biology · doi:10.1111/adb.12896 · Cited by 13 · see citing works
Progesterone modulates theta oscillations in the frontal‐parietal network
Riddle, J., Ahn, S., McPherson, T., Girdler, S. S., & Frӧhlich, F. (2020) · Psychophysiology · doi:10.1111/psyp.13632 · Cited by 13 · see citing works
Riga, D., Schmitz, L. J. M., van Mourik, Y., Hoogendijk, W. J. G., Vries, T. J. D., Smit, A. B., & Spijker, S. (2018) · Addiction Biology · doi:10.1111/adb.12701 · Cited by 12 · see citing works
Plant-Derived Extracts in the Neuroscience of Anxietyon Animal Models: Biases and Comments
Chirumbolo, S. (2011) · International Journal of Neuroscience · doi:10.3109/00207454.2011.635829 · Cited by 11 · see citing works
Temporal profiling of depression vulnerability in a preclinical model of sustained depression
Riga, D., Schmitz, L. J. M., Hoogendijk, W. J. G., Smit, A. B., & Spijker, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-06984-5 · Cited by 11 · see citing works
Schipper, P., Lopresto, D., Reintjes, R. J., Joosten, J., Henckens, M. J. A. G., Kozicz, T., & Homberg, J. R. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00126 · Cited by 10 · see citing works
Kroes, M. C. W., Henckens, M. J. A. G., & Homberg, J. R. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.09.018 · Cited by 7 · see citing works
Multi-regional control of amygdalar dynamics reliably reflects fear memory age
Makino, Y., Wang, Y., & McHugh, T. J. (2024) · Nature Communications · doi:10.1038/s41467-024-54273-3 · Cited by 6 · see citing works
Béopoulos, A., Géa, M., Fasano, A., & Iris, F. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1101422 · Cited by 6 · see citing works
Andersen, E. H., Campbell, A. M., Girdler, S., Duffy, K., & Belger, A. (2018) · Clinical Neurophysiology · doi:10.1016/j.clinph.2018.10.019 · Cited by 4 · see citing works
Meta-analysis of the effect of 5HTTLPR polymorphism in fear learning
Miño, V., Martín, C. S., Alfaro, F., Míguez, G., Laborda, M. A., Bacigalupo, F., & Quezada-Scholz, V. E. (2023) · Learning and Motivation · doi:10.1016/j.lmot.2023.101889 · Cited by 3 · see citing works
More and Less Fear in Serotonin Transporter Knockout Mice
Lima, J., Panayi, M. C., Sharp, T., McHugh, S. B., & Bannerman, D. M. (2025) · Genes Brain & Behavior · doi:10.1111/gbb.70016 · Cited by 2 · see citing works
Yawata, Y., Tashima, R., Aritomi, H., Shimada, S., Onodera, T., Taishi, T., Takasu, K., & Ogawa, K. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1404603 · Cited by 2 · see citing works
Boillot, M., ter Horst, J., López, J. R., Fazio, I. D., Steens, I. L. M., Cohen, M. X., & Homberg, J. R. (2024) · Cerebral Cortex · doi:10.1093/cercor/bhae334 · Cited by 1 · see citing works
The interplay of genotype and environment in the development of fear and anxiety
Sachser, N., & Lesch, K. (2013) · e-Neuroforum · doi:10.1007/s13295-013-0045-1 · Cited by 1 · see citing works
Self-citationPietropaolo, S., Sluyter, F., & Crusio, W. E. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107360556.021
Lima, J., Sharp, T., Taylor, A. M., Bannerman, D. M., & McHugh, S. B. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/154690
- Authors
- Narayanan, V., Heiming, R. S., Jansen, F., Lesting, J., Sachser, N., Pape, H.-C., & Seidenbecher, T.
- Affiliations
- University of Münster (DE)
- Corresponding author
- Seidenbecher, Thomas
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-07-27
- Volume
- 6
- Issue
- 7
- Pages
- e22600
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3144906
- OpenAlex
- W2051845141
- Cited by
- 103
- References
- 104
- Citations by year
- 2025: 1 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 9 · 2018: 8 · 2017: 6 · 2016: 6 · 2015: 8 · 2014: 9 · 2013: 22 · 2012: 8
- FWCI
- 6.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Deutsche Forschungsgemeinschaft (TRR‐58, TP A01, SFB TRR 58)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- social defeat, fear extinction, serotonin transporter, 5-HTT knockout mice, lateral amygdala, medial prefrontal cortex, infralimbic cortex, theta synchronization, fear conditioning, fear memory, resident-intruder paradigm, emotional dysregulation, extinction recall
- MeSH terms
- Action Potentials, Amygdala, Animals, Cortical Synchronization, Extinction, Psychological, Fear, Genotype, Male, Nerve Net, Mental Recall, Social Behavior, Prefrontal Cortex, Mice, Knockout, Freezing Reaction, Cataleptic, Serotonin Plasma Membrane Transport Proteins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review