Cited by 103Memory and Neural MechanismsNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Social defeat: Impact on fear extinction and amygdala-prefrontal cortical theta synchrony in 5-HTT deficient mice

Open access
Narayanan, Venu, Heiming, Rebecca S., Jansen, Friederike, Lesting, Jörg, Sachser, Norbert, Pape, Hans-Christian, Seidenbecher, Thomas·2011·PLoS ONE

Abstract

Emotions, such as fear and anxiety, can be modulated by both environmental and genetic factors. One genetic factor is for example the genetically encoded variation of the serotonin transporter (5-HTT) expression. In this context, the 5-HTT plays a key role in the regulation of central 5-HT neurotransmission, which is critically involved in the physiological regulation of emotions including fear and anxiety. However, a systematic study which examines the combined influence of environmental and genetic factors on fear-related behavior and the underlying neurophysiological basis is missing. Therefore, in this study we used the 5-HTT-deficient mouse model for studying emotional dysregulation to evaluate consequences of genotype specific disruption of 5-HTT function and repeated social defeat for fear-related behaviors and corresponding neurophysiological activities in the lateral amygdala (LA) and infralimbic region of the medial prefrontal cortex (mPFC) in male 5-HTT wild-type (+/+), homo- (-/-) and heterozygous (+/-) mice. Naive males and experienced losers (generated in a resident-intruder paradigm) of all three genotypes, unilaterally equipped with recording electrodes in LA and mPFC, underwent a Pavlovian fear conditioning. Fear memory and extinction of conditioned fear was examined while recording neuronal activity simultaneously with fear-related behavior. Compared to naive 5-HTT+/+ and +/- mice, 5-HTT-/- mice showed impaired recall of extinction. In addition, 5-HTT-/- and +/- experienced losers showed delayed extinction learning and impaired recall of extinction. Impaired behavioral responses were accompanied by increased theta synchronization between the LA and mPFC during extinction learning in 5-HTT-/- and +/- losers. Furthermore, impaired extinction recall was accompanied with increased theta synchronization in 5-HTT-/- naive and in 5-HTT-/- and +/- loser mice. In conclusion, extinction learning and memory of conditioned fear can be modulated by both the 5-HTT gene activity and social experiences in adulthood, accompanied by corresponding alterations of the theta activity in the amygdala-prefrontal cortex network.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1371/journal.pone.0022600

Cites

102 of 102 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Brain reward pathways, including the VTA and NAc, as well as the PFC and amygdala, have been implicated in the neural circuitry mediating individual differences in stress susceptibility.

    “Brain reward pathways, including the ventral tegmental area (VTA) and the nucleus accumbens (NAc) (4) as well as the prefrontal cortex (PFC) and the amygdala (11,12), have been implicated in the neural circuitry mediating these differences in stress susceptibility.”
  • Social defeat-induced anxiety and depressive-like behaviors were previously associated with decreased neuronal activity in the medial PFC and increased VTA and amygdala activity.

    “Social defeat–induced anxiety and depressive-like behaviors were previously associated with decreased neuronal activity in the medial PFC (46) as well as increased VTA and amygdala activity (10–12).”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

2 of the 104 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Narayanan, V., Heiming, R. S., Jansen, F., Lesting, J., Sachser, N., Pape, H.-C., & Seidenbecher, T.
Affiliations
University of Münster (DE)
Corresponding author
Seidenbecher, Thomas
Venue
PLoS ONE
Published
2011-07-27
Volume
6
Issue
7
Pages
e22600
ISSN
1932-6203 (ISSN-L)
OpenAlex
W2051845141
Cited by
103
References
104
Citations by year
2025: 1 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 9 · 2018: 8 · 2017: 6 · 2016: 6 · 2015: 8 · 2014: 9 · 2013: 22 · 2012: 8
FWCI
6.49
Type
journal article
Language
en
Open access
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (submittedVersion, cc-by)
Funders
Deutsche Forschungsgemeinschaft (TRR‐58, TP A01, SFB TRR 58)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
social defeat, fear extinction, serotonin transporter, 5-HTT knockout mice, lateral amygdala, medial prefrontal cortex, infralimbic cortex, theta synchronization, fear conditioning, fear memory, resident-intruder paradigm, emotional dysregulation, extinction recall
MeSH terms
Action Potentials, Amygdala, Animals, Cortical Synchronization, Extinction, Psychological, Fear, Genotype, Male, Nerve Net, Mental Recall, Social Behavior, Prefrontal Cortex, Mice, Knockout, Freezing Reaction, Cataleptic, Serotonin Plasma Membrane Transport Proteins, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review