The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
Human Cancer Long Non-Coding RNA Transcriptomes
Open accessAbstract
Once thought to be a part of the 'dark matter' of the genome, long non-coding RNAs (lncRNAs) are emerging as an integral functional component of the mammalian transcriptome. LncRNAs are a novel class of mRNA-like transcripts which, despite no known protein-coding potential, demonstrate a wide range of structural and functional roles in cellular biology. However, the magnitude of the contribution of lncRNA expression to normal human tissues and cancers has not been investigated in a comprehensive manner. In this study, we compiled 272 human serial analysis of gene expression (SAGE) libraries to delineate lncRNA transcription patterns across a broad spectrum of normal human tissues and cancers. Using a novel lncRNA discovery pipeline we parsed over 24 million SAGE tags and report lncRNA expression profiles across a panel of 26 different normal human tissues and 19 human cancers. Our findings show extensive, tissue-specific lncRNA expression in normal tissues and highly aberrant lncRNA expression in human cancers. Here, we present a first generation atlas for lncRNA profiling in cancer.
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Cites
Hallmarks of Cancer: The Next Generation
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Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
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The Transcriptional Landscape of the Mammalian Genome
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Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
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“The known repertoire of lncRNA functions is rapidly expanding – with demonstrated roles as mediators of mRNA decay [13], structural scaffolds for nuclear substructures [14,15], as host genes for miRNAs [16,17], and as regulators of chromatin remodeling [18,19,20,21] – even though the functional identities of many lncR…”
BackgroundTripathi, V., Ellis, J. D., Shen, Z., Song, D. Y., Pan, Q., Watt, A. T., Freier, S. M., Bennett, C. F., Sharma, A., Bubulya, P. A., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.08.011 · Cited by 2,219
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A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response
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Cited by
Roles, Functions, and Mechanisms of Long Non-Coding RNAs in Cancer
Fang, Y., & Fullwood, M. J. (2016) · Genomics, Proteomics & Bioinformatics · doi:10.1016/j.gpb.2015.09.006 · Cited by 1,069
The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer
Chakravarty, D., Sboner, A., Nair, S. S., Giannopoulou, E., Li, R., Hennig, S., Mosquera, J. M., Pauwels, J., Park, K., Kossai, M., et al. (2014) · Nature Communications · doi:10.1038/ncomms6383 · Cited by 621
Vitamin D receptor, a tumor suppressor in skin
Bikle, D. D. (2015) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2014-0367 · Cited by 101
Expanding the p53 regulatory network: LncRNAs take up the challenge
Grossi, E., Sánchez, Y., & Huarte, M. (2016) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2015.07.011 · Cited by 78
Metadata
- Authors
- Gibb, E. A., Vucic, E. A., Enfield, K. S. S., Stewart, G. L., Lonergan, K. M., Kennett, J. Y., Becker-Santos, D. D., MacAulay, C. E., Lam, S., Brown, C. J., & Lam, W. L.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-10-03
- Volume
- 6
- Issue
- 10
- Pages
- e25915
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2060772907
- Cited by
- 364
- References
- 69
- FWCI
- 9.42
- Type
- journal article
- Language
- en
- Open access
- gold
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- Gibb, E. A., Vucic, E. A., Enfield, K. S. S., Stewart, G. L., Lonergan, K. M., Kennett, J. Y., Becker-Santos, D. D., MacAulay, C. E., Lam, S., Brown, C. J., & Lam, W. L. (2011). Human Cancer Long Non-Coding RNA Transcriptomes. PLoS ONE. https://doi.org/10.1371/journal.pone.0025915
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