Cited by 275Microbial metabolism and enzyme functionMicrobial Fuel Cells and BioremediationAnaerobic Digestion and Biogas Production

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An Ancient Pathway Combining Carbon Dioxide Fixation with the Generation and Utilization of a Sodium Ion Gradient for ATP Synthesis

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Poehlein, Anja, Schmidt, Silke, Kaster, Anne-Kristin, Goenrich, Meike, Vollmers, John, Thürmer, Andrea, Bertsch, Johannes, Schuchmann, Kai, Voigt, Birgit, Hecker, Michael, Daniel, Rolf, Thauer, Rudolf K., Gottschalk, Gerhard, Müller, Volker·2012·PLoS ONE

DOI 10.1371/journal.pone.0033439PMC PMC3315566

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Abstract

Synthesis of acetate from carbon dioxide and molecular hydrogen is considered to be the first carbon assimilation pathway on earth. It combines carbon dioxide fixation into acetyl-CoA with the production of ATP via an energized cell membrane. How the pathway is coupled with the net synthesis of ATP has been an enigma. The anaerobic, acetogenic bacterium Acetobacterium woodii uses an ancient version of this pathway without cytochromes and quinones. It generates a sodium ion potential across the cell membrane by the sodium-motive ferredoxin:NAD oxidoreductase (Rnf). The genome sequence of A. woodii solves the enigma: it uncovers Rnf as the only ion-motive enzyme coupled to the pathway and unravels a metabolism designed to produce reduced ferredoxin and overcome energetic barriers by virtue of electron-bifurcating, soluble enzymes.

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Authors: Poehlein, A., Schmidt, S., Kaster, A.-K., Goenrich, M., Vollmers, J., Thürmer, A., Bertsch, J., Schuchmann, K., Voigt, B., Hecker, M., Daniel, R., Thauer, R. K., Gottschalk, G., & Müller, V.
Affiliations: University of Göttingen (DE)
Goethe University Frankfurt (DE)
Max Planck Institute for Terrestrial Microbiology (DE)
Universität Greifswald (DE)
Corresponding author: Müller, Volker
ORCID: Poehlein, Anja
Kaster, Anne-Kristin
Vollmers, John
Thürmer, Andrea
Voigt, Birgit
Daniel, Rolf
Thauer, Rudolf K.
Müller, Volker
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2012-03-29
Volume: 7
Issue: 3
Pages: e33439
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0033439
PMC: PMC3315566
OpenAlex: W2091506898
Cited by: 274
References: 46
Citations by year: 2026: 7 · 2025: 10 · 2024: 10 · 2023: 18 · 2022: 13 · 2021: 21 · 2020: 24 · 2019: 25 · 2018: 24 · 2017: 19 · 2016: 17 · 2015: 22 · 2014: 24 · 2013: 24 · 2012: 16
FWCI: 11.06
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS ONE (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Max Planck Institute for Plasma Physics (submittedVersion)
Figshare (submittedVersion, cc-by)
GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) (submittedVersion, cc-by)
MPG.PuRe (Max Planck Society) (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft
Max-Planck-Gesellschaft
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
Physical Sciences › Environmental Science › Environmental Engineering › Microbial Fuel Cells and Bioremediation
Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Anaerobic Digestion and Biogas Production
Keywords: acetate production, CO2 fixation, molecular hydrogen, Acetobacterium woodii, acetogenesis, ATP production, electron bifurcation, ferredoxin, acetyl-CoA, membrane potential, genome sequence
MeSH terms: Acetyl Coenzyme A, Adenosine Triphosphate, Bacterial Proteins, Carbon Dioxide, Cell Membrane, Energy Metabolism, Ferredoxins, Models, Biological, Oxidation-Reduction, Oxidoreductases, Sodium, Genome, Bacterial, Acetobacterium, Biosynthetic Pathways, Carbon Cycle

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An Ancient Pathway Combining Carbon Dioxide Fixation with the Generation and Utilization of a Sodium Ion Gradient for ATP Synthesis

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