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An Ancient Pathway Combining Carbon Dioxide Fixation with the Generation and Utilization of a Sodium Ion Gradient for ATP Synthesis
Open accessAbstract
Synthesis of acetate from carbon dioxide and molecular hydrogen is considered to be the first carbon assimilation pathway on earth. It combines carbon dioxide fixation into acetyl-CoA with the production of ATP via an energized cell membrane. How the pathway is coupled with the net synthesis of ATP has been an enigma. The anaerobic, acetogenic bacterium Acetobacterium woodii uses an ancient version of this pathway without cytochromes and quinones. It generates a sodium ion potential across the cell membrane by the sodium-motive ferredoxin:NAD oxidoreductase (Rnf). The genome sequence of A. woodii solves the enigma: it uncovers Rnf as the only ion-motive enzyme coupled to the pathway and unravels a metabolism designed to produce reduced ferredoxin and overcome energetic barriers by virtue of electron-bifurcating, soluble enzymes.
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“Acetogens that lack cytochromes use their version of the WL-pathway to make methyl-H4F, as sketched in figure 3b, which is modified from Pohlein et al. [146] and Buckel & Thauer [143] for Acetobacterium woodii.”
From Early bioenergetic evolution (2013) · cites this paper as [146]
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Citations
Cites
Energy conservation in chemotrophic anaerobic bacteria
Thauer, R. K., Jungermann, K., & Decker, K. (1977) · Bacteriological Reviews · doi:10.1128/br.41.1.100-180.1977 · Cited by 4,146
Self-citationCDD: a conserved domain database for interactive domain family analysis
Marchler‐Bauer, A., Anderson, J. B., Derbyshire, M. K., DeWeese-Scott, C., Gonzales, N. R., Gwadz, M., Hao, L., He, S., Hurwitz, D. I., Jackson, J. D., et al. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl951 · Cited by 851
On the origin of biochemistry at an alkaline hydrothermal vent
Martin, W., & Russell, M. J. (2007) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1881 · Cited by 771
Clostridium ljungdahlii represents a microbial production platform based on syngas
Köpke, M., Held, C., Hujer, S., Liesegang, H., Wiezer, A., Wollherr, A., Ehrenreich, A., Liebl, W., Gottschalk, G., & Dürre, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004716107 · Cited by 660
Self-citationThe Autotrophic Pathway of Acetate Synthesis in Acetogenic Bacteria
Ljungdhal, L. G. (1986) · Annual Review of Microbiology · doi:10.1146/annurev.mi.40.100186.002215 · Cited by 575
Cord-Ruwisch, R., Seitz, H.-J., & Conrad, R. (1988) · Archives of Microbiology · doi:10.1007/bf00411655 · Cited by 549
Schut, G. J., & Adams, M. W. W. (2009) · Journal of Bacteriology · doi:10.1128/jb.01582-08 · Cited by 447
Li, F., Hinderberger, J., Seedorf, H., Zhang, J., Buckel, W., & Thauer, R. K. (2008) · Journal of Bacteriology · doi:10.1128/jb.01417-07 · Cited by 420
Self-citationEnergy conservation via electron-transferring flavoprotein in anaerobic bacteria
Herrmann, G., Jayamani, E., Mai, G., & Buckel, W. (2008) · Journal of Bacteriology · doi:10.1128/jb.01422-07 · Cited by 407
Enzymology of the Wood–Ljungdahl Pathway of Acetogenesis
Ragsdale, S. W. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1419.015 · Cited by 405
Kaster, A.-K., Moll, J., Parey, K., & Thauer, R. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016761108 · Cited by 389
Self-citationBiegel, E., Schmidt, S., Gónzalez, J. M., & Müller, V. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0555-8 · Cited by 354
Self-citationEnergy conservation in Acetogenic Bacteria
Müller, V. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.11.6345-6353.2003 · Cited by 335
Self-citationCO2 fixation in acetogenic bacteria: Variations on a theme
Fuchs, G. (1986) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1986.tb01859.x · Cited by 294
The complete genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum )
Pierce, E., Xie, G. G., Barabote, R. D., Saunders, E. H., Han, C. S., Detter, J. C., Richardson, P., Brettin, T. S., Das, A., Ljungdahl, L. G., et al. (2008) · Environmental Microbiology · doi:10.1111/j.1462-2920.2008.01679.x · Cited by 267
Bacterial Na + -translocating ferredoxin:NAD + oxidoreductase
Biegel, E., & Müller, V. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010318107 · Cited by 262
Self-citationWang, S., Huang, H., Moll, J., & Thauer, R. K. (2010) · Journal of Bacteriology · doi:10.1128/jb.00612-10 · Cited by 230
Self-citationThe acetyl-CoA pathway of autotrophic growth
Wood, H. G., Ragsdale, S. W., & Pezacka, E. H. (1986) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1986.tb01865.x · Cited by 214
The Na+-translocating methyltransferase complex from methanogenic archaea
Gottschalk, G., & Thauer, R. K. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00274-7 · Cited by 193
Self-citationvan de Vossenberg, J. L. C. M., Ubbink-Kok, T., Elferink, M. G. L., Driessen, A. J. M., & Konings, W. N. (1995) · Molecular Microbiology · doi:10.1111/j.1365-2958.1995.18050925.x · Cited by 166
Evolutionary primacy of sodium bioenergetics
Mulkidjanian, A. Y., Galperin, M. Y., Makarova, K. S., Wolf, Y. I., & Koonin, E. V. (2008) · Biology Direct · doi:10.1186/1745-6150-3-13 · Cited by 163
The past and present of sodium energetics: May the sodium-motive force be with you
Mulkidjanian, A. Y., Dibrov, P. A., & Galperin, M. Y. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.04.028 · Cited by 157
Sodium dependence of acetate formation by the acetogenic bacterium Acetobacterium woodii
Heise, R., Müller, V., & Gottschalk, G. (1989) · Journal of Bacteriology · doi:10.1128/jb.171.10.5473-5478.1989 · Cited by 137
Self-citationEnergy-Converting [NiFe] Hydrogenases: More than Just H2 Activation
Hedderich, R., & Forzi, L. (2005) · Microbial Physiology · doi:10.1159/000091557 · Cited by 133
Takami, H., Noguchi, H., Takaki, Y., Uchiyama, I., Toyoda, A., Nishi, S., Chee, G.-J., Arai, W., Nunoura, T., Itoh, T., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030559 · Cited by 115
Voigt, B., Schweder, T., Sibbald, M. J. J. B., Albrecht, D., Ehrenreich, A., Bernhardt, J., Feesche, J., Maurer, K., Gottschalk, G., van Dijl, J. M., et al. (2005) · PROTEOMICS · doi:10.1002/pmic.200500091 · Cited by 115
Self-citationVerhagen, M. F. J. M., O’Rourke, T., & Adams, M. W. W. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00062-6 · Cited by 109
Martin, W. F. (2012) · FEBS Letters · doi:10.1016/j.febslet.2011.09.031 · Cited by 108
Wait, R., Gianazza, E., Eberini, I., Sironi, L., Dunn, M. J., Gemeiner, M., & Miller, I. (2001) · Electrophoresis · doi:10.1002/1522-2683(200108)22:14 · Cited by 91
Clark, J. E., & Ljungdahl, L. G. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)90590-9 · Cited by 87
Biegel, E., Schmidt, S., & Müller, V. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.01871.x · Cited by 84
Self-citationGraentzdoerffer, A., Rauh, D., Pich, A., & Andreesen, J. R. (2003) · Archives of Microbiology · doi:10.1007/s00203-002-0508-1 · Cited by 83
Soils contain two different activities for oxidation of hydrogen
Schuler, S., & Conrad, R. (1990) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1990.tb03927.x · Cited by 78
Carbon monoxide-driven electron transport in Clostridium thermoautotrophicum membranes
Hugenholtz, J., Ivey, D. M., & Ljungdahl, L. G. (1987) · Journal of Bacteriology · doi:10.1128/jb.169.12.5845-5847.1987 · Cited by 71
Imkamp, F., Biegel, E., Jayamani, E., Buckel, W., & Müller, V. (2007) · Journal of Bacteriology · doi:10.1128/jb.01017-07 · Cited by 68
Self-citationProton-translocating transhydrogenase: an update of unsolved and controversial issues
Pedersen, A., Karlsson, G., & Rydström, J. (2008) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-008-9170-x · Cited by 67
Occurrence of corrinoid-containing membrane proteins in anaerobic bacteria
Dangel, W., Schulz, H., Diekert, G. B., K�nig, H., & Fuchs, G. (1987) · Archives of Microbiology · doi:10.1007/bf00429647 · Cited by 66
The ins and outs of Na+ bioenergetics in Acetobacterium woodii
Schmidt, S., Biegel, E., & Müller, V. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.12.015 · Cited by 64
Self-citationWohlfarth, G., Geerligs, G., & Diekert, G. B. (1990) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1990.tb19242.x · Cited by 58
Wohlfarth, G., & Diekert, G. B. (1991) · Archives of Microbiology · doi:10.1007/bf00243458 · Cited by 57
Metabolism and energy generation in homoacetogenic clostridia
Hugenholtz, J., & Ljungdahl, L. G. (1990) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1990.tb04941.x · Cited by 55
Fritz, M., & Müller, V. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05874.x · Cited by 42
Self-citationMatson, E. G., Zhang, X., & Leadbetter, J. R. (2010) · Environmental Microbiology · doi:10.1111/j.1462-2920.2010.02188.x · Cited by 28
Hess, V., Vitt, S., & Müller, V. (2010) · Journal of Bacteriology · doi:10.1128/jb.01126-10 · Cited by 22
Self-citationClark, J. E., & Ljungdahl, L. G. (1986) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(86)22199-0 · Cited by 5
Voigt, B., Schweder, T., Sibbald, M. J. J. B., Albrecht, D., Ehrenreich, A., Bernhardt, J., Feesche, J., Maurer, K., Gottschalk, G., van Dijl, J. M., et al. (2006) · PROTEOMICS · doi:10.1002/pmic.200690025 · Cited by 3
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- F Li, 2008, Coupled ferredoxin and crotonyl coenzyme A (CoA) reduction with NADH catalyzed by the butyryl-CoA dehydrogenase/Etf complex from Clostridium kluyveri., J Bacteriol, 190, 843, 10.1128/JB.01417-07 · DOI · Paper page
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Self-citationBuckel, W., & Thauer, R. K. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2012.07.002 · Cited by 797
Self-citationKracke, F., Vassilev, I., & Krömer, J. O. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00575 · Cited by 748
Cross-feeding in the gut microbiome: Ecology and mechanisms
Culp, E. J., & Goodman, A. L. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.03.016 · Cited by 562
Liew, F., Martin, M. E., Tappel, R. C., Heijstra, B. D., Mihalcea, C., & Köpke, M. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00694 · Cited by 485
Metadata
- Authors
- Poehlein, A., Schmidt, S., Kaster, A.-K., Goenrich, M., Vollmers, J., Thürmer, A., Bertsch, J., Schuchmann, K., Voigt, B., Hecker, M., Daniel, R., Thauer, R. K., Gottschalk, G., & Müller, V.
- Affiliations
- University of Göttingen (DE)
- Goethe University Frankfurt (DE)
- Max Planck Institute for Terrestrial Microbiology (DE)
- Universität Greifswald (DE)
- Corresponding author
- Müller, Volker
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-03-29
- Volume
- 7
- Issue
- 3
- Pages
- e33439
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3315566
- OpenAlex
- W2091506898
- Cited by
- 274
- References
- 46
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 10 · 2023: 18 · 2022: 13 · 2021: 21 · 2020: 24 · 2019: 25 · 2018: 24 · 2017: 19 · 2016: 17 · 2015: 22 · 2014: 24 · 2013: 24 · 2012: 16
- FWCI
- 11.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Figshare (submittedVersion, cc-by)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
- Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) (submittedVersion, cc-by)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Max-Planck-Gesellschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
- Physical Sciences › Environmental Science › Environmental Engineering › Microbial Fuel Cells and Bioremediation
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Anaerobic Digestion and Biogas Production
- Keywords
- acetate production, CO2 fixation, molecular hydrogen, Acetobacterium woodii, acetogenesis, ATP production, electron bifurcation, ferredoxin, acetyl-CoA, membrane potential, genome sequence
- MeSH terms
- Acetyl Coenzyme A, Adenosine Triphosphate, Bacterial Proteins, Carbon Dioxide, Cell Membrane, Energy Metabolism, Ferredoxins, Models, Biological, Oxidation-Reduction, Oxidoreductases, Sodium, Genome, Bacterial, Acetobacterium, Biosynthetic Pathways, Carbon Cycle
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