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Cited by 260

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Gene Expression Commons: An Open Platform for Absolute Gene Expression Profiling

Open access
Seita, Jun, Sahoo, Debashis, Rossi, Derrick J., Bhattacharya, Deepta, Serwold, Thomas, Inlay, Matthew A., Ehrlich, Lauren I. R., Fathman, John W., Dill, David L., Weissman, Irving L.·2012·PLoS ONE

Abstract

Gene expression profiling using microarrays has been limited to comparisons of gene expression between small numbers of samples within individual experiments. However, the unknown and variable sensitivities of each probeset have rendered the absolute expression of any given gene nearly impossible to estimate. We have overcome this limitation by using a very large number (>10,000) of varied microarray data as a common reference, so that statistical attributes of each probeset, such as the dynamic range and threshold between low and high expression, can be reliably discovered through meta-analysis. This strategy is implemented in a web-based platform named "Gene Expression Commons" (https://gexc.stanford.edu/) which contains data of 39 distinct highly purified mouse hematopoietic stem/progenitor/differentiated cell populations covering almost the entire hematopoietic system. Since the Gene Expression Commons is designed as an open platform, investigators can explore the expression level of any gene, search by expression patterns of interest, submit their own microarray data, and design their own working models representing biological relationship among samples.

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Metadata

Authors
Seita, J., Sahoo, D., Rossi, D. J., Bhattacharya, D., Serwold, T., Inlay, M. A., Ehrlich, L. I. R., Fathman, J. W., Dill, D. L., & Weissman, I. L.
Venue
PLoS ONE
Published
2012-07-18
Volume
7
Issue
7
Pages
e40321
ISSN
1932-6203 (ISSN-L)
OpenAlex
W2052670712
Cited by
260
References
27
FWCI
6.97
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Gene Expression Commons: An Open Platform for Absolute Gene Expression Profiling. https://app.cochat.ai/papers/10.1371/journal.pone.0040321
The paper
Seita, J., Sahoo, D., Rossi, D. J., Bhattacharya, D., Serwold, T., Inlay, M. A., Ehrlich, L. I. R., Fathman, J. W., Dill, D. L., & Weissman, I. L. (2012). Gene Expression Commons: An Open Platform for Absolute Gene Expression Profiling. PLoS ONE. https://doi.org/10.1371/journal.pone.0040321

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