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Cited by 17Regulation of Appetite and ObesityOlfactory and Sensory Function StudiesHypothalamic control of reproductive hormones

Effects of Chemosignals from Sad Tears and Postprandial Plasma on Appetite and Food Intake in Humans

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Oh, Tae Jung, Kim, Min Young, Park, Kyong Soo, Cho, Young Min·2012·PLoS ONE
DOI 10.1371/journal.pone.0042352PMC PMC3411620
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Abstract

Chemosignals from human body fluids may modulate biological functions in humans. The objective of this study was to examine whether chemosignals from human sad tears and postprandial plasma modulate appetite. We obtained fasting and postprandial plasma from male participants and sad tears and saline, which was trickled below the eyelids, from female volunteers. These samples were then randomly distributed to male participants to sniff with a band-aid containing 100 µl of each fluid on four consecutive days in a double-blind fashion. We checked appetite by a visual analogue scale (VAS) and food intake by measuring the consumption of a test meal. In addition, the serum levels of total testosterone and LH were measured. Twenty men (mean age 26.3±4.6 years) were enrolled in this study. They could not discriminate between the smell of fasting and postprandial plasma and the smell of sad tears and trickled saline. Appetite and the amount of food intake were not different between the groups. Although the VAS ratings of appetite correlated with the food intake upon sniffing fasting plasma, postprandial plasma, and trickled saline, there was no such correlation upon sniffing sad tears. In addition, the decrease in serum testosterone levels from the baseline was greater with sad tears than with the trickled saline (-28.6±3.3% vs. -14.0±5.2%; P = 0.019). These data suggest that chemosignals from human sad tears and postprandial plasma do not appear to reduce appetite and food intake. However, further studies are necessary to examine whether sad tears may alter the appetite-eating behavior relation.

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  1. [3]Yanovski SZ, Yanovski JA (2002) Obesity. N Engl J Med 346: 591– 602. 11856799
  2. [8]McClintock MK (1971) Menstrual synchorony and suppression. Nature 229: 244– 245. 4994256

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Authors
Oh, T. J., Kim, M. Y., Park, K. S., & Cho, Y. M.
Affiliations
Seoul National University (KR)
Corresponding author
Cho, Young Min
ORCID
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2012-08-01
Volume
7
Issue
8
Pages
e42352
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0042352
PMC
PMC3411620
OpenAlex
W2004491270
Cited by
17
References
35
Citations by year
2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 1 · 2016: 3 · 2014: 2 · 2013: 2
FWCI
0.57
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Research Foundation
  • National Research Foundation of Korea (2011-0009127)
  • Ministry of Education, Science and Technology
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
chemosignals, appetite, dietary intake, olfactory cues, testosterone, luteinizing hormone, sex differences
MeSH terms
Adolescent, Adult, Appetite, Double-Blind Method, Eating, Emotions, Female, Humans, Plasma, Tears, Postprandial Period

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