Waking action of ursodeoxycholic acid (UDCA) involves histamine and GABAA receptor block
Open accessAbstract
Since ancient times ursodeoxycholic acid (UDCA), a constituent of bile, is used against gallstone formation and cholestasis. A neuroprotective action of UDCA was demonstrated recently in models of Alzheimer's disease and retinal degeneration. The mechanisms of UDCA action in the nervous system are poorly understood. We show now that UDCA promotes wakefulness during the active period of the day, lacking this activity in histamine-deficient mice. In cultured hypothalamic neurons UDCA did not affect firing rate but synchronized the firing, an effect abolished by the GABA(A)R antagonist gabazine. In histaminergic neurons recorded in slices UDCA reduced amplitude and duration of spontaneous and evoked IPSCs. In acutely isolated histaminergic neurons UDCA inhibited GABA-evoked currents and sIPSCs starting at 10 µM (IC(50) = 70 µM) and did not affect NMDA- and AMPA-receptor mediated currents at 100 µM. Recombinant GABA(A) receptors composed of α1, β1-3 and γ2L subunits expressed in HEK293 cells displayed a sensitivity to UDCA similar to that of native GABA(A) receptors. The mutation α1V256S, known to reduce the inhibitory action of pregnenolone sulphate, reduced the potency of UDCA. The mutation α1Q241L, which abolishes GABA(A)R potentiation by several neurosteroids, had no effect on GABA(A)R inhibition by UDCA. In conclusion, UDCA enhances alertness through disinhibition, at least partially of the histaminergic system via GABA(A) receptors.
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Specific BAs demonstrate neuroprotective effects in cellular and animal models.
“Specific BAs demonstrate neuroprotective effects in cellular and animal models, with human clinical trials underway (306–308).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [306]
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Cites
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126 · see citing works
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
Watanabe, M., Houten, S. M., Mataki, C., Christoffolete, M. A., Kim, B. W., Sato, H., Messaddeq, N., Harney, J. W., Ezaki, O., Kodama, T., et al. (2006) · Nature · doi:10.1038/nature04330 · Cited by 2,220 · see citing works
A G Protein-coupled Receptor Responsive to Bile Acids
Kawamata, Y., Fujii, R., Hosoya, M., Harada, M., Yoshida, H., Miwa, M., Fukusumi, S., Habata, Y., Itoh, T., Shintani, Y., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209706200 · Cited by 1,628 · see citing works
Ionic Blockage of Sodium Channels in Nerve
Woodhull, A. M. (1973) · The Journal of General Physiology · doi:10.1085/jgp.61.6.687 · Cited by 1,581 · see citing works
General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal
Franks, N. P. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2372 · Cited by 1,266 · see citing works
Histamine in the Nervous System
Haas, H. L., Sergeeva, O. A., & Selbach, O. (2008) · Physiological Reviews · doi:10.1152/physrev.00043.2007 · Cited by 1,227 · see citing works
Self-citationOlsen, R. W., & Sieghart, W. (2008) · Pharmacological Reviews · doi:10.1124/pr.108.00505 · Cited by 1,064 · see citing works
Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites
Hosie, A. M., Wilkins, M. E., da Silva, H. M. A., & Smart, T. G. (2006) · Nature · doi:10.1038/nature05324 · Cited by 752 · see citing works
Bile acids as regulatory molecules
Hylemon, P. B., Zhou, H., Pandak, W. M., Ren, S., Gil, G., & Dent, P. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r900007-jlr200 · Cited by 694 · see citing works
The sedative component of anesthesia is mediated by GABAA receptors in an endogenous sleep pathway
Nelson, L. E., Guo, T. Z., Lu, J., Saper, C. B., Franks, N. P., & Maze, M. (2002) · Nature Neuroscience · doi:10.1038/nn913 · Cited by 568 · see citing works
Lin, J., Sakai, K., Vanni-Mercier, G., & Jouvet, M. (1989) · Brain Research · doi:10.1016/0006-8993(89)91623-5 · Cited by 318 · see citing works
Self-citationKeene, C. D., Rodrigues, C. M. P., Eich, T., Chhabra, M. S., Steer, C. J., & Low, W. C. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162362299 · Cited by 306 · see citing works
Anaclet, C., Parmentier, R., Ouk, K., Guidon, G., Buda, C., Sastre, J., Akaoka, H., Sergeeva, O. A., Yanagisawa, M., Ohtsu, H., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2604-09.2009 · Cited by 216 · see citing works
Self-citationAkk, G., Bracamontes, J., & Steinbach, J. H. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0673e.x · Cited by 137 · see citing works
Lin, J., Anaclet, C., Sergeeva, O. A., & Haas, H. L. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0631-8 · Cited by 130 · see citing works
Self-citationEndocrine and paracrine role of bile acids
Keitel, V., Kubitz, R., & Häussinger, D. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.5620 · Cited by 121 · see citing works
Hyperammonemia Increases GABAergic Tone in the Cerebellum but Decreases It in the Rat Cortex
Cauli, O., Mansouri, M. T., Agustí, A., & Felipo, V. (2009) · Gastroenterology · doi:10.1053/j.gastro.2008.12.057 · Cited by 120 · see citing works
Bile acids and apoptosis modulation: an emerging role in experimental Alzheimer's disease
Ramalho, R. M., Viana, R. J. S., Low, W. C., Steer, C. J., & Rodrigues, C. M. P. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.12.001 · Cited by 109 · see citing works
Oveson, B. C., Iwase, T., Hackett, S. F., Lee, S. Y., Usui, S., Sedlak, T. W., Snyder, S. H., Campochiaro, P. A., & Sung, J. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07092.x · Cited by 107 · see citing works
Shen, W., Mennerick, S. J., Covey, D. F., & Zorumski, C. F. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-10-03571.2000 · Cited by 97 · see citing works
Akk, G., Li, P., Bracamontes, J. R., Reichert, D. E. C., Covey, D. F., & Steinbach, J. H. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.048520 · Cited by 92 · see citing works
Tool from ancient pharmacopoeia prevents vision loss.
Boatright, J. H., Moring, A. G., McElroy, C., Phillips, M. J., Do, V. T., Chang, B., Hawes, N. L., Boyd, A. P., Sidney, S. S., Stewart, R. E., et al. (2006) · PubMed · Cited by 88 · see citing works
Effect of high-dose ursodeoxycholic acid on its biliary enrichment in primary sclerosing cholangitis
Rost, D., Rudolph, G., Kloeters-Plachky, P., & Stiehl, A. (2004) · Hepatology · doi:10.1002/hep.20370 · Cited by 84 · see citing works
The bile steroid chenodeoxycholate is a potent antagonist at NMDA and GABAA receptors
Schubring, S. R., Fleischer, W., Lin, J. S., Haas, H. L., & Sergeeva, O. A. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2011.11.036 · Cited by 81 · cited 6× · see citing works
“UDCA was co-applied with GABA, NMDA or kainate, see [12].”
BackgroundMethodInfluentialSelf-citationDalpiaz, A., Paganetto, G., Pavan, B., Fogagnolo, M., Medici, A., Beggiato, S., & Perrone, D. (2012) · Molecular Pharmaceutics · doi:10.1021/mp200565g · Cited by 78 · see citing works
Histamine Action on Vertebrate GABAA Receptors
Saras, A., Gisselmann, G., Vogt-Eisele, A. K., Erlkamp, K. S., Kletke, O., Pusch, H., & Hatt, H. H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709993200 · Cited by 76 · see citing works
Hatton, G. I., & Yang, Q. Z. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-09-02974.2001 · Cited by 74 · see citing works
Excitation of Histaminergic Tuberomamillary Neurons by Thyrotropin-Releasing Hormone
Parmentier, R., Kolbaev, S., Klyuch, B. P., Vandael, D. H. F., Lin, J., Selbach, O., Haas, H. L., & Sergeeva, O. A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2976-08.2009 · Cited by 70 · see citing works
Self-citationl ‐Dopa activates histaminergic neurons
Yanovsky, Y., Li, S., Klyuch, B. P., Yao, Q.-L., Blandina, P., Passani, M. B., Lin, J., Haas, H. L., & Sergeeva, O. A. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2010.203257 · Cited by 68 · see citing works
Self-citationA simple perfusion system for patch-clamp studies
Vorobjev, V. S., Sharonova, I. N., & Haas, H. L. (1996) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(96)00097-0 · Cited by 68 · see citing works
Self-citationCarbenoxolone impairs LTP and blocks NMDA receptors in murine hippocampus
Chepkova, A. N., Sergeeva, O. A., & Haas, H. L. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.05.001 · Cited by 67 · see citing works
Self-citationPharmacological Properties of GABAAReceptors in Rat Hypothalamic Neurons Expressing the ϵ-Subunit
Sergeeva, O. A., Andreeva, N., Garret, M., Scherer, A., & Haas, H. L. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3209-04.2005 · Cited by 66 · see citing works
Self-citationPerret, P. G., Sarda, X., Wolff, M. A., Wu, T.-T., Bushey, D. F., & Goeldner, M. P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.36.25350 · Cited by 64 · see citing works
Solá, S., Amaral, J. D., Castro, R. E., Ramalho, R. M., Borralho, P. M., Kren, B. T., Tanaka, H., Steer, C. J., & Rodrigues, C. M. P. (2005) · Hepatology · doi:10.1002/hep.20870 · Cited by 62 · see citing works
Clinical Efficacy and Effectiveness of Ursodeoxycholic Acid in Cholestatic Liver Diseases
Festi, D., Montagnani, M., Azzaroli, F., Lodato, F., Mazzella, G., Roda, A., Biase, A. R. D., Roda, E., Simoni, P., & Colecchia, A. (2007) · Current Clinical Pharmacology · doi:10.2174/157488407780598171 · Cited by 62 · see citing works
Solá, S., Amaral, J. D., Borralho, P. M., Ramalho, R. M., Castro, R. E., Aranha, M. M., Steer, C. J., & Rodrigues, C. M. P. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0063 · Cited by 61 · see citing works
Woo, S. J., Kim, J. H., & Yu, H. G. (2010) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2010.0012 · Cited by 49 · see citing works
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Sergeeva, O. A., Kletke, O., Kragler, A., Poppek, A., Fleischer, W., Schubring, S. R., Görg, B., Haas, H. L., Zhu, X., Lübbert, H., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.103309 · Cited by 47 · see citing works
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Yanovsky, Y., Schubring, S. R., Fleischer, W., Gisselmann, G., Zhu, X., Lübbert, H., Hatt, H. H., Rudolph, U., Haas, H. L., & Sergeeva, O. A. (2011) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-0988-4 · Cited by 46 · see citing works
Self-citationLu, J. W., Fenik, V. B., Branconi, J. L., Mann, G. L., Rukhadze, I., & Kubin, L. K. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.127613 · Cited by 36 · see citing works
Update on the Treatment of the Pruritus of Cholestasis
Bergasa, N. V. (2008) · Clinics in Liver Disease · doi:10.1016/j.cld.2007.11.009 · Cited by 33 · see citing works
Nobilis, M., Pour, M., Kuneš, J., Kopecký, J., Kvetina, J., Svoboda, Z., Sládková, K., & Vortel, J. (2001) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/s0731-7085(00)00563-x · Cited by 32 · see citing works
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Sergeeva, O. A., Klyuch, B. P., Fleischer, W., Eriksson, K. S., Korotkova, T. M., Siebler, M., & Haas, H. L. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05027.x · Cited by 28 · see citing works
Self-citationRoda, E., Azzaroli, F., Nigro, G., Piazza, F., Jaboli, F., Ferrara, F., Liva, S., Giovanelli, S., Miracolo, A., Colecchia, A., et al. (2002) · Digestive and Liver Disease · doi:10.1016/s1590-8658(02)80112-8 · Cited by 18 · see citing works
Modifcation of sleep architecture in an animal model ofexperimental cirrhosis
Jiménez‐Anguiano, A., Díaz-Medina, V., Farfán-Labonne, B. E., Giono-Chiang, G., Kersenobich, D., Lorenzana, M. G., Gutiérrez‐Ruíz, M. C., & Velázquez‐Moctezuma, J. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.5176 · Cited by 8 · see citing works
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- Authors
- Yanovsky, Y., Schubring, S. R., Yao, Q., Zhao, Y., Li, S., May, A., Haas, H. L., Lin, J.-S., & Sergeeva, O. A.
- Affiliations
- Heinrich Heine University Düsseldorf (DE)
- Lyon 1 Université (FR)
- Corresponding author
- Sergeeva, Olga A.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-08-06
- Volume
- 7
- Issue
- 8
- Pages
- e42512
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3412845
- OpenAlex
- W2026359448
- Cited by
- 34
- References
- 45
- Citations by year
- 2025: 1 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 3 · 2016: 5 · 2015: 1 · 2014: 1 · 2013: 3 · 2012: 1
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Deutsche Forschungsgemeinschaft (DFG SE 1767, SFB 575, SFB 575/3 and 8)
- Institut National de la Santé et de la Recherche Médicale
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- ursodeoxycholic acid, wakefulness, histamine, GABAA receptor, histaminergic neurons, disinhibition, neurosteroids, GABAergic inhibition, pregnenolone sulfate, hypothalamic neurons, alertness
- MeSH terms
- Action Potentials, Administration, Oral, Animals, Histamine, Hypothalamic Area, Lateral, Kinetics, Mutation, Neurons, Picrotoxin, Receptors, GABA-A, Recombinant Proteins, Steroids, Time Factors, Ursodeoxycholic Acid, Wakefulness, Mutant Proteins, Mice, Inhibitory Postsynaptic Potentials, GABA-A Receptor Antagonists
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