Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet-induced systemic inflammation, microglial activation, and reduced neuroplasticity
Open accessAbstract
The goal of this study was to identify the intrinsic links that explain the effect of a Western diet (WD) on cognitive dysfunction. Specific pathogen-free, wild-type mice were fed either a control diet (CD) or a high-fat, high-sucrose WD after weaning and were euthanized at 10 mo of age to study the pathways that affect cognitive health. The results showed that long-term WD intake reduced hippocampal synaptic plasticity and the level of brain-derived neurotrophic factor mRNA in the brain and isolated microglia. A WD also activated ERK1/2 and reduced postsynaptic density-95 in the brain, suggesting postsynaptic damage. Moreover, WD-fed mice had increased inflammatory signaling in the brain, ileum, liver, adipose tissue, and spleen, which was accompanied by microglia activation. In the brain, as well as in the digestive tract, a WD reduced signaling regulated by retinoic acid and bile acids (BAs), whose receptors form heterodimers to control metabolism and inflammation. Furthermore, a WD intake caused dysbiosis and dysregulated BA synthesis with reduced endogenous ligands for BA receptors, i.e., farnesoid X receptor and G-protein-coupled bile acid receptor in the liver and brain. Together, dysregulated BA synthesis and dysbiosis were accompanied by systemic inflammation, microglial activation, and reduced neuroplasticity induced by WD.-Jena, P. K., Sheng, L., Di Lucente, J., Jin, L.-W., Maezawa, I., Wan, Y.-J. Y. Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet-induced systemic inflammation, microglial activation, and reduced neuroplasticity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Bile acids, generated by hepatic and bacterial enzymes to aid lipid digestion, may be involved in the fat-microbiota interaction effect on brain function.
“Bile acids, which are generated by hepatic and bacterial enzymes to aid in lipid digestion, may be involved in the fat-microbiota interaction effect on brain function (406).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [406]
Shifts in the gut microbiota induced by a Western diet resulted in neuroinflammation and reduced synaptic plasticity via dysregulation of bile acid synthesis and disruption of TGR5 signaling.
“recent experimental data suggested that shifts in the gut microbiota induced by a Western diet resulted in neuroinflammation and reduced synaptic plasticity via dysregulation of bile acid synthesis, and disruption of TGR5 signaling (406).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [406]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Analyzing real-time PCR data by the comparative CT method
Schmittgen, T. D., & Livak, K. J. (2008) · Nature Protocols · doi:10.1038/nprot.2008.73 · Cited by 26,190 · see citing works
Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
Wang, Q., Garrity, G. M., Tiedje, J. M., & Cole, J. R. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00062-07 · Cited by 19,770 · see citing works
Proteobacteria: Microbial signature of dysbiosis in gut microbiota
Shin, N.-R., Whon, T. W., & Bae, J.-W. (2015) · Trends in Biotechnology · doi:10.1016/j.tibtech.2015.06.011 · Cited by 3,954 · see citing works
Mechanisms underlying inflammation in neurodegeneration
Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580 · see citing works
Altered fecal microbiota composition in patients with major depressive disorder
Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., Wang, W., Tang, W., Tan, Z., Shi, J., et al. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.016 · Cited by 2,275 · see citing works
The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon
Donohoe, D. R., Garge, N., Zhang, X., Sun, W., O'Connell, T. M., Bunger, M. K., & Bultman, S. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.018 · Cited by 2,003 · cited 1× · see citing works
“Butyrate is a major energy source for colonic health (105) and also stimulates gut peptide PYY production (106).”
BackgroundTGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis
Thomas, C., Gioiello, A., Noriega, L., Strehle, A., Oury, J., Rizzo, G., Macchiarulo, A., Yamamoto, H., Mataki, C., Pruzanski, M., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.001 · Cited by 1,885 · see citing works
A G Protein-coupled Receptor Responsive to Bile Acids
Kawamata, Y., Fujii, R., Hosoya, M., Harada, M., Yoshida, H., Miwa, M., Fukusumi, S., Habata, Y., Itoh, T., Shintani, Y., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209706200 · Cited by 1,628 · see citing works
Bile Acid Metabolism and Signaling
Chiang, J. Y. L. (2013) · Comprehensive physiology · doi:10.1002/cphy.c120023 · Cited by 1,390 · see citing works
Correlation between the human fecal microbiota and depression
Naseribafrouei, A., Hestad, K., Avershina, E., Sekelja, M., Linløkken, A., Wilson, R., & Rudi, K. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12378 · Cited by 1,044 · see citing works
Bile salt transporters: molecular characterization, function, and regulation
Trauner, M., & Boyer, J. L. (2003) · Physiological Reviews · doi:10.1152/physrev.00027.2002 · Cited by 999 · see citing works
The Gut Microbiota and Alzheimer’s Disease
Jiang, C., Li, G., Huang, P., Liu, Z., & Zhao, B. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-161141 · Cited by 852 · see citing works
Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome
Guo, C., Xie, S., Chi, Z., Zhang, J., Liu, Y., Zhang, L., Zheng, M., Zhang, X., Xia, D., Ke, Y., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.09.008 · Cited by 838 · see citing works
An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota
Jeffery, I. B., O'Toole, P. W., Öhman, L., Claesson, M. J., Deane, J., Quigley, E. M. M., & Simrén, M. (2012) · Gut · doi:10.1136/gutjnl-2011-301501 · Cited by 835 · see citing works
Pinto-Sanchez, M. I., Hall, G. B., Ghajar, K., Nardelli, A., Bolino, C., Lau, J. T., Martin, F.-P., Cominetti, O., Welsh, C., Rieder, A., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.05.003 · Cited by 821 · see citing works
Parracho, H. M., Bingham, M. O., Gibson, G. R., & McCartney, A. L. (2005) · Journal of Medical Microbiology · doi:10.1099/jmm.0.46101-0 · Cited by 784 · see citing works
BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases
Lu, B., Nagappan, G., Guan, X.-M., Nathan, P. J., & Wren, P. B. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3505 · Cited by 747 · see citing works
Systemic gut microbial modulation of bile acid metabolism in host tissue compartments
Swann, J. R., Want, E. J., Geier, F. M., Spagou, K., Wilson, I. D., Sidaway, J. E., Nicholson, J. K., & Holmes, E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006734107 · Cited by 726 · see citing works
Liu, S.-Y., Aliyari, R., Chikere, K., Li, G., Marsden, M. D., Smith, J. K., Pernet, O., Guo, H., Nusbaum, R., Zack, J. A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.11.005 · Cited by 678 · see citing works
The bile acid receptor FXR is a modulator of intestinal innate immunity
Vavassori, P., Mencarelli, A., Renga, B., Distrutti, E., & Fiorucci, S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803978 · Cited by 655 · see citing works
Quantitative estimation of the hydrophilic-hydrophobic balance of mixed bile salt solutions.
Heuman, D. M. (1989) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38331-0 · Cited by 555 · see citing works
Cali, J. J., Hsieh, C., Francke, U., & Russell, D. W. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)89518-0 · Cited by 509 · see citing works
Bile Acids Induce Inflammatory Genes in Hepatocytes
Allen, K., Jaeschke, H., & Copple, B. L. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2010.11.026 · Cited by 501 · see citing works
Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease
Pistollato, F., Sumalla Cano, S., Elio, I., Masias Vergara, M., Giampieri, F., & Battino, M. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw023 · Cited by 496 · see citing works
Yang, F., Huang, X., Yi, T., Yen, Y., Moore, D. D., & Huang, W. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-1078 · Cited by 488 · see citing works
The bile acid TGR5 membrane receptor: from basic research to clinical application
Duboc, H., Taché, Y., & Hofmann, A. F. (2014) · Digestive and Liver Disease · doi:10.1016/j.dld.2013.10.021 · Cited by 473 · see citing works
Bonfili, L., Cecarini, V., Berardi, S., Scarpona, S., Suchodolski, J. S., Nasuti, C., Fiorini, D., Boarelli, M. C., Rossi, G., & Eleuteri, A. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-02587-2 · Cited by 453 · see citing works
25-Hydroxycholesterols in innate and adaptive immunity
Cyster, J. G., Dang, E. V., Reboldi, A., & Yi, T. (2014) · Nature Reviews Immunology · doi:10.1038/nri3755 · Cited by 388 · see citing works
Gut Hormones and Appetite Control: A Focus on PYY and GLP-1 as Therapeutic Targets in Obesity
Silva, A. D., & Bloom, S. R. (2012) · Gut and Liver · doi:10.5009/gnl.2012.6.1.10 · Cited by 373 · see citing works
Evidence That Hydrogen Sulfide Is a Genotoxic Agent
Attene‐Ramos, M. S., Wagner, E. D., Plewa, M. J., & Gaskins, H. R. (2006) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0126 · Cited by 363 · see citing works
Mechanisms of Molecular Mimicry Involving the Microbiota in Neurodegeneration
Friedland, R. P. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-142841 · Cited by 338 · see citing works
Diversity, biogenesis and function of microbial amyloids
Blanco, L. P., Evans, M. L., Smith, D. R., Badtke, M. P., & Chapman, M. R. (2012) · Trends in Microbiology · doi:10.1016/j.tim.2011.11.005 · Cited by 320 · see citing works
Brain aging, Alzheimer's disease, and mitochondria
Swerdlow, R. H. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.08.012 · Cited by 306 · cited 1× · see citing works
“Aging is by far the major risk factor for dementia; however, recent studies suggest that life style, including food habits, have a critical role in theonset of dementia (1).”
BackgroundRett Syndrome Astrocytes Are Abnormal and Spread MeCP2 Deficiency through Gap Junctions
Maezawa, I., Swanberg, S. E., Harvey, D. J., LaSalle, J. M., & Jin, L. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0324-09.2009 · Cited by 283 · see citing works
Self-citationGarcía‐Cañaveras, J. C., Donato, M. T., Castell, J. V., & Lahoz, A. (2012) · Journal of Lipid Research · doi:10.1194/jlr.d028803 · Cited by 276 · see citing works
The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain
Keitel, V., Görg, B., Bidmon, H. J., Zemtsova, I., Spomer, L., Zilles, K., & Häussinger, D. (2010) · Glia · doi:10.1002/glia.21049 · Cited by 274 · see citing works
Ding, Y., Qiao, A., Wang, Z., Goodwin, J. S., Lee, E.-S., Block, M. L., Allsbrook, M., McDonald, M. P., & Fan, G.-H. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3153-08.2008 · Cited by 269 · see citing works
Differential Expression of Cholesterol Hydroxylases in Alzheimer's Disease
Brown, J. A., Theisler, C. M., Silberman, S., Magnuson, D. J., Gottardi-Littell, N. R., Lee, J. M., Yager, D., Crowley, J., Sambamurti, K., Rahman, M. M., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402324200 · Cited by 268 · see citing works
Barger, S. W., & Basile, A. S. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00075.x · Cited by 264 · see citing works
Retinoic acid is required early during adult neurogenesis in the dentate gyrus
Jacobs, S. G. P. M., Lie, D. C., DeCicco-Skinner, K. L., Shi, Y., DeLuca, L. M., Gage, F. H., & Evans, R. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511294103 · Cited by 259 · see citing works
Pathak, P., Liu, H., Boehme, S., Xie, C., Krausz, K. W., Gonzalez, F. J., & Chiang, J. Y. L. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.784322 · Cited by 254 · see citing works
Dysregulated hepatic bile acids collaboratively promote liver carcinogenesis
Xie, G., Wang, X., Huang, F., Zhao, A., Chen, W., Yan, J., Zhang, Y., Lei, S., Ge, K., Zheng, X., et al. (2016) · International Journal of Cancer · doi:10.1002/ijc.30219 · Cited by 252 · see citing works
Human and Rat Hepatic Stellate Cells Express Neurotrophins and Neurotrophin Receptors
Cassiman, D. M., Denef, C., Desmet, V. J., & Roskams, T. (2001) · Hepatology · doi:10.1053/jhep.2001.20793 · Cited by 250 · see citing works
Recent advances in the development of farnesoid X receptor agonists.
Ali, A. H., Carey, E. J., & Lindor, K. D. (2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2305-5839.2014.12.06 · Cited by 223 · see citing works
Djelti, F., Braudeau, J., Hudry, E., Dhenain, M., Varin, J., Bièche, I., Marquer, C., Chali, F., Ayciriex, S., Auzeil, N., et al. (2015) · Brain · doi:10.1093/brain/awv166 · Cited by 223 · see citing works
Yanguas‐Casás, N., Barreda‐Manso, M. A., Nieto‐Sampedro, M., & Romero‐Ramírez, L. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25742 · Cited by 223 · see citing works
Shao, C. Y., Mirra, S. S., Sait, H. B. R., Sacktor, T. C., & Sigurdsson, E. M. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0843-x · Cited by 219 · see citing works
Lipid metabolism in mammalian tissues and its control by retinoic acid
Bonet, M. L., Ribot, J., & Palou, A. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.06.001 · Cited by 212 · see citing works
Nutrition and the Risk of Alzheimer's Disease
Hu, N., Yu, J., Tan, L., Wang, Y., Sun, L., & Tan, L. (2013) · BioMed Research International · doi:10.1155/2013/524820 · Cited by 212 · see citing works
Glucose and Insulin Induction of Bile Acid Synthesis
Li, T., Ferrell, J. M., Boehme, S., Ochoa, A., Zhang, Y., Klaassen, C. D., Erickson, S. K., & Chiang, J. Y. L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.305789 · Cited by 211 · see citing works
Lorbek, G., Lewińska, M., & Rozman, D. (2011) · FEBS Journal · doi:10.1111/j.1742-4658.2011.08432.x · Cited by 196 · see citing works
Neuronal expression and subcellular localization of cholesterol 24‐hydroxylase in the mouse brain
Ramirez, D. M. O., Andersson, S., & Russell, D. W. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21605 · Cited by 189 · see citing works
Peptide YY and Proglucagon mRNA Expression Patterns and Regulation in the Gut
Zhou, J. F., Hegsted, M., McCutcheon, K. L., Keenan, M. J., Xi, X., Raggio, A. M., & Martin, R. J. (2006) · Obesity · doi:10.1038/oby.2006.77 · Cited by 187 · see citing works
Williams, J. E., Carrothers, J. M., Lackey, K. A., Beatty, N. F., York, M. A., Brooker, S. L., Shafii, B., Price, W. J., Settles, M. L., McGuire, M. A., et al. (2017) · Journal of Nutrition · doi:10.3945/jn.117.248864 · Cited by 186 · see citing works
Alzheimer’s Disease and Type 2 Diabetes: Multiple Mechanisms Contribute to Interactions
Jayaraman, A., & Pike, C. J. (2014) · Current Diabetes Reports · doi:10.1007/s11892-014-0476-2 · Cited by 181 · see citing works
Nguyen, H. M., Grössinger, E. M., Horiuchi, M., Davis, K. W., Jin, L., Maezawa, I., & Wulff, H. (2017) · Glia · doi:10.1002/glia.23078 · Cited by 178 · see citing works
Self-citationBile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome
Guo, C., Xie, S., Chi, Z., Zhang, J., Liu, Y., Zhang, L., Zheng, M., Zhang, X., Xia, D., Ke, Y., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.10.009 · Cited by 175 · see citing works
Chong, Y. H., Shin, Y. J., Lee, E. O., Kayed, R., Glabe, C. G., & Tenner, A. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601016200 · Cited by 164 · see citing works
Cyphert, H. A., Ge, X., Kohan, A. B., Salati, L. M., Zhang, Y., & Hillgartner, F. B. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.375907 · Cited by 162 · see citing works
Wang, Q., Yuan, J., Yu, Z., Lin, L., Jiang, Y., Cao, Z., Zhuang, P., Whalen, M. J., Song, B., Wang, X., et al. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0663-7 · Cited by 157 · see citing works
Schilderink, R., Verseijden, C., Seppen, J., Muncan, V., BRINK, G. R. V. D., Lambers, T. T., van Tol, E. A. F., & de Jonge, W. J. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00411.2015 · Cited by 153 · see citing works
Sheng, L., Jena, P. K., Liu, H., Kalanetra, K. M., Gonzalez, F. J., French, S. W., Krishnan, V. V., Mills, D. A., & Wan, Y. Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-01576-9 · Cited by 153 · see citing works
Self-citationNutrient patterns and brain biomarkers of Alzheimer's disease in cognitively normal individuals
Berti, V., Murray, J., Davies, M., Spector, N. C., Tsui, W. H., Li, Y., Williams, S. K., Pirraglia, E., Vallabhajosula, S., McHugh, P. F., et al. (2014) · The journal of nutrition health & aging · doi:10.1007/s12603-014-0534-0 · Cited by 152 · see citing works
Significance of vitamin A to brain function, behavior and learning
Olson, C. R., & Mello, C. V. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900246 · Cited by 144 · see citing works
Ligand-dependent dynamics of retinoic acid receptor binding during early neurogenesis
Mahony, S., Mazzoni, E. O., McCuine, S., Young, R. A., Wichterle, H., & Gifford, D. K. (2011) · Genome Biology · doi:10.1186/gb-2011-12-1-r2 · Cited by 142 · see citing works
Glinghammar, B. (2002) · Carcinogenesis · doi:10.1093/carcin/23.5.839 · Cited by 133 · see citing works
Sheng, L., Jena, P. K., Hu, Y. C., Liu, H., Nagar, N., Kalanetra, K. M., French, S. W., French, S. W., Mills, D. A., & Wan, Y. Y. (2017) · The Journal of Pathology · doi:10.1002/path.4983 · Cited by 131 · see citing works
Self-citationTGR 5 signaling reduces neuroinflammation during hepatic encephalopathy
McMillin, M., Frampton, G. A., Tobin, R. P., Dusio, G. F., Smith, J., Shin, H. D., Newell‐Rogers, K., Grant, S. M., & DeMorrow, S. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13243 · Cited by 129 · see citing works
9-Cis-retinoic acid suppresses inflammatory responses of microglia and astrocytes
Xu, J., & Drew, P. D. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.10.004 · Cited by 124 · see citing works
Effect of endogenous GLP-1 on insulin secretion in type 2 diabetes
Salehi, M., Aulinger, B., Prigeon, R. L., & D'Alessio, D. A. (2010) · Diabetes · doi:10.2337/db09-1253 · Cited by 124 · see citing works
Bala, V., Rajagopal, S., Kumar, D. P., Nalli, A. D., Mahavadi, S., Sanyal, A. J., Grider, J. R., & Murthy, K. S. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00420 · Cited by 124 · see citing works
Sa‐nguanmoo, P., Tanajak, P., Kerdphoo, S., Satjaritanun, P., Wang, X., Liang, G., Li, X., Jiang, C., Pratchayasakul, W., Chattipakorn, N., et al. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.08.006 · Cited by 122 · see citing works
Yau, J. L. W., Rasmuson, S., Andrew, R., Graham, M., Noble, J., Olsson, T., Fuchs, E., Lathe, R., & Seckl, J. R. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00438-x · Cited by 118 · see citing works
Bile acid dysregulation, gut dysbiosis, and gastrointestinal cancer
Tsuei, J., Chau, T., Mills, D. A., & Wan, Y. Y. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370214538743 · Cited by 118 · see citing works
Self-citationA Blood-Based, 7-Metabolite Signature for the Early Diagnosis of Alzheimer's Disease
Olazarán, J., Gil‐de‐Gómez, L., Rodríguez‐Martín, A., Valentí, M., Payo, B. F., Marín-Muñoz, J., Antúnez, C., Frank, A., Acedo, C., Gracia, L. M., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142925 · Cited by 116 · see citing works
Jena, P. K., Sheng, L., Liu, H., Kalanetra, K. M., Mirsoian, A., Murphy, W. J., French, S. W., Krishnan, V. V., Mills, D. A., & Wan, Y. Y. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.04.019 · Cited by 112 · see citing works
Self-citationDeletion of mouse FXR gene disturbs multiple neurotransmitter systems and alters neurobehavior
Huang, F., Wang, T., Lan, Y., Yang, L., Pan, W., Zhu, Y., Lv, B., Wei, Y., Shi, H., Wu, H., et al. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00070 · Cited by 109 · see citing works
Association of Alzheimer disease pathology with abnormal lipid metabolism
Matsuzaki, T., Sasaki, K., Hata, J., Hirakawa, Y., Fujimi, K., Ninomiya, T., Suzuki, S. O., Kanba, S., Kiyohara, Y., & Iwaki, T. (2011) · Neurology · doi:10.1212/wnl.0b013e31822e145d · Cited by 108 · see citing works
GLP-1 secretion by microglial cells and decreased CNS expression in obesity
Kappe, C., Tracy, L. M., Patrone, C., Iverfeldt, K., & Sjöholm, Å. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-276 · Cited by 107 · see citing works
Longitudinal Inflammation, Cognitive Decline, and Alzheimer’s Disease: A Mini-Review
Bettcher, B. M., & Kramer, J. H. (2014) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2014.147 · Cited by 107 · see citing works
la Fuente, M. D., Bernaez, I., Rio, M. D., & Hernánz, Á. (1993) · PubMed Central · Cited by 106 · see citing works
Regulation of FGF21 Expression and Secretion by Retinoic Acid Receptor-related Orphan Receptor α
Wang, Y., Solt, L. A., & Burris, T. P. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.102160 · Cited by 106 · see citing works
Ion Channels as Drug Targets in Central Nervous System Disorders
Waszkielewicz, A. M., Gunia‐Krzyżak, A., Szkaradek, N., Słoczyńska, K., Krupinska, S., & Marona, H. (2013) · Current Medicinal Chemistry · doi:10.2174/0929867311320100005 · Cited by 100 · see citing works
The gut hormone glucagon-like peptide-1 produced in brain: is this physiologically relevant?
Trapp, S., & Richards, J. E. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.09.006 · Cited by 93 · see citing works
Jin, L.-W., Horiuchi, M., Wulff, H., Liu, X.-B., Cortopassi, G. A., Erickson, J. D., & Maezawa, I. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2778-14.2015 · Cited by 88 · cited 1× · see citing works
“Using this method, 94% of isolated cells are microglial cells, as determined by flow cytometry (26).”
MethodSelf-citationIL-17A Synergistically Enhances Bile Acid–Induced Inflammation during Obstructive Cholestasis
O'Brien, K. M., Allen, K. M., Rockwell, C. E., Towery, K., Luyendyk, J. P., & Copple, B. L. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.07.019 · Cited by 82 · see citing works
The bile steroid chenodeoxycholate is a potent antagonist at NMDA and GABAA receptors
Schubring, S. R., Fleischer, W., Lin, J. S., Haas, H. L., & Sergeeva, O. A. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2011.11.036 · Cited by 81 · cited 1× · see citing works
“Both CDCA, the endogenous ligand for FXR (84), and UDCA have neuroprotective properties and are used as Nmethyl-D-aspartate receptor and g-aminobutyric receptor antagonists to treat AD (85, 86).”
Insulin Sensitivity and Glucose Tolerance Are Altered by Maintenance on a Ketogenic Diet
Kinzig, K. P., Honors, M. A., & Hargrave, S. L. (2010) · Endocrinology · doi:10.1210/en.2010-0175 · Cited by 78 · see citing works
Gong, Y., & Lippa, C. F. (2010) · American Journal of Alzheimer's Disease & Other Dementias® · doi:10.1177/1533317510382893 · Cited by 76 · see citing works
Fader, K. A., Nault, R., Zhang, C., Kumagai, K., Harkema, J. R., & Zacharewski, T. R. (2017) · Scientific Reports · doi:10.1038/s41598-017-05656-8 · Cited by 74 · see citing works
Nuclear Receptors and Inflammatory Diseases
Wang, K., & Wan, Y. Y. (2008) · Experimental Biology and Medicine · doi:10.3181/0708-mr-231 · Cited by 72 · see citing works
Self-citationHe, Y., Gong, L., Fang, Y., Qi, Z., Liu, H., Lu, Y., Guo, G. L., Lehman‐McKeeman, L. D., Fang, J., & Wan, Y. Y. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-575 · Cited by 70 · see citing works
Self-citationMicroglial KCa3.1 Channels as a Potential Therapeutic Target for Alzheimer’s Disease
Maezawa, I., Jenkins, D. P., Jin, B. E., & Wulff, H. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/868972 · Cited by 65 · see citing works
Self-citationZhan, L., Liu, H.-X., Fang, Y., Kong, B., He, Y.-Q., Zhong, X.-B., Fang, J.-W., Wan, Y., & Guo, G. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105930 · Cited by 62 · see citing works
Self-citationChenodeoxycholic acid, an endogenous FXR ligand alters adipokines and reverses insulin resistance
Shihabudeen, M. S., Roy, D., James, J., & Thirumurugan, K. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.07.012 · Cited by 60 · see citing works
Holland, A. M., Kephart, W. C., Mumford, P. W., Mobley, C. B., Lowery, R. P., Shake, J. J., Patel, R. K., Healy, J. C., McCullough, D. J., Kluess, H. A., et al. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00156.2016 · Cited by 59 · see citing works
Lavrnja, I., Smiljanic, K., Savic, D., Mladenovic-Djordjevic, A., Tesovic, K., Kanazir, S., & Pekovic, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-02638-8 · Cited by 54 · see citing works
Guay, V., Lamarche, B., Charest, A., Tremblay, A. J., & Couture, P. (2012) · Metabolism · doi:10.1016/j.metabol.2011.06.002 · Cited by 48 · see citing works
All-trans retinoic acid regulates hepatic bile acid homeostasis
Yang, F., He, Y., Liu, H., Tsuei, J., Jiang, X., Yang, L., Wang, Z., & Wan, Y. Y. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.08.018 · Cited by 46 · see citing works
Self-citationApolipoprotein Serum Amyloid A in Alzheimer's Disease
Kindy, M., Yu, J., Guo, J.-T., & Zhu, H. (1999) · Journal of Alzheimer's Disease · doi:10.3233/jad-1999-1303 · Cited by 44 · see citing works
Ayciriex, S., Djelti, F., Alves, S., Regazzetti, A., Gaudin, M., Varin, J., Langui, D., Bièche, I., Hudry, E., Dargère, D., et al. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00211 · Cited by 37 · see citing works
Serum Amyloid A Differentially Activates Microglia and Astrocytes via the PI3K Pathway
Yu, Y., Liu, J., Li, S.-Q., Lei, P., & Ye, R. D. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130818 · Cited by 35 · see citing works
Amyloid precursor protein modulates macrophage phenotype and diet-dependent weight gain
Puig, K. L., Brose, S. A., Zhou, X.-D., Sens, M., Combs, G., Jensen, M., Golovko, M., & Combs, C. (2017) · Scientific Reports · doi:10.1038/srep43725 · Cited by 35 · see citing works
Waking action of ursodeoxycholic acid (UDCA) involves histamine and GABAA receptor block
Yanovsky, Y., Schubring, S. R., Yao, Q., Zhao, Y., Li, S., May, A., Haas, H. L., Lin, J.-S., & Sergeeva, O. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042512 · Cited by 34 · see citing works
Adipose tissue and skeletal muscle plasticity modulates metabolic health
Ukropec, J., Ukropcová, B., Kurdiová, T., Gašperíková, D., & Klimeś, I. (2008) · Archives of Physiology and Biochemistry · doi:10.1080/13813450802535812 · Cited by 33 · see citing works
Mamoon, A. M., Subauste, A. R., Subauste, M. C., & Subauste, J. S. (2014) · Gene · doi:10.1016/j.gene.2014.07.017 · Cited by 29 · see citing works
Sodium deoxycholate causes nitric oxide mediated DNA damage in oesophageal cells
Jolly, A. J., Wild, C. P., & Hardie, L. J. (2009) · Free Radical Research · doi:10.1080/10715760802684211 · Cited by 25 · see citing works
Biphasic Regulation of Cell Death and Survival by Hydrophobic Bile Acids in HCT116 Cells
Yui, S., Kanamoto, R., & SAEKI, T. (2009) · Nutrition and Cancer · doi:10.1080/01635580802582744 · Cited by 22 · see citing works
Keshava, H. B., Mowla, A., Heinberg, L. J., Schauer, P. R., Brethauer, S. A., & Aminian, A. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.05.002 · Cited by 21 · see citing works
Poša, M., & Popović, K. J. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00375 · Cited by 14 · see citing works
The effect of high fat diet and dehydroepiandrosterone (DHEA) administration in the rhesus monkey.
Christopher‐Hennings, J., Kurzman, I. D., Haffa, A. L., Kemnitz, J. W., & MacEwen, E. G. (1995) · PubMed · Cited by 12 · see citing works
He, Y., Tsuei, J., & Wan, Y. Y. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00105.2014 · Cited by 6 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [76]McMillin M., Frampton G., Tobin R., Dusio G., Smith J., Shin H., Newell-Rogers K., Grant S., DeMorrow S. (2015) TGR5 signaling reduces neuroinflammation during hepatic encephalopathy. J. Neurochem. 135, 565–576 [DOI] [PMC free article] [PubMed] [Google Scholar]
Cited by
Sorted by citations
Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment
Liu, Z., Dai, X., Zhang, H., Shi, R., Hui, Y., Jin, X., Zhang, W., Wang, L., Wang, Q., Wang, D., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14676-4 · Cited by 549 · see citing works
Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function
Tan, B. L., & Norhaizan, M. E. (2019) · Nutrients · doi:10.3390/nu11112579 · Cited by 525 · see citing works
Gut barrier disruption and chronic disease
Martel, J., Chang, S.-H., Ko, Y.-F., Hwang, T.-L., Young, J. D., & Ojcius, D. M. (2022) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2022.01.002 · Cited by 514 · see citing works
Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
Berding, K., Vlckova, K., Marx, W., Schellekens, H., Stanton, C., Clarke, G., Jacka, F., Dinan, T. G., & Cryan, J. F. (2021) · Advances in Nutrition · doi:10.1093/advances/nmaa181 · Cited by 451 · see citing works
Więckowska-Gacek, A., Mietelska-Porowska, A., Wydrych, M., & Wojda, U. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101397 · Cited by 343 · see citing works
Excessive intake of sugar: An accomplice of inflammation
Ma, X., Nan, F., Liang, H., Shu, P., Fan, X., Song, X., Hou, Y., & Zhang, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.988481 · Cited by 338 · see citing works
Feeding gut microbes to nourish the brain: unravelling the diet–microbiota–gut–brain axis
Schneider, E., O'Riordan, K. J., Clarke, G., & Cryan, J. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01108-6 · Cited by 258 · see citing works
Bhargava, P., Smith, M. D., Mische, L., Harrington, E., Fitzgerald, K. C., Martin, K. A., Kim, S., Reyes, A. A., Cardona, J. G., Volsko, C. M., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci129401 · Cited by 236 · see citing works
Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia
Connell, E., Le Gall, G., Pontifex, M. G., Sami, S., Cryan, J. F., Clarke, G., Müller, M., & Vauzour, D. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00548-6 · Cited by 208 · see citing works
Effect of ultra-processed diet on gut microbiota and thus its role in neurodegenerative diseases
Leo, E. E. M., & Campos, M. R. S. (2019) · Nutrition · doi:10.1016/j.nut.2019.110609 · Cited by 188 · see citing works
Xiao, H., Yan, J., Huang, L., Araujo, C., Peng, J., Gao, L., Liu, S., Tang, J., Zuo, G., & Zhang, J. H. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.09.016 · Cited by 180 · see citing works
Liu, T., Kern, J. T., Jain, U., Sonnek, N. M., Xiong, S., Simpson, K. F., VanDussen, K. L., Winkler, E. S., Haritunians, T., Malique, A., et al. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.04.004 · Cited by 173 · see citing works
Extracellular vesicle‐mediated delivery of circDYM alleviates CUS‐induced depressive‐like behaviours
Yu, X., Bai, Y., Han, B., Ju, M., Tang, T., Shen, L., Li, M., Yang, L., Zhang, Z., Hu, G., et al. (2022) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12185 · Cited by 164 · see citing works
High-fat or high-sugar diets as trigger inflammation in the microbiota-gut-brain axis
Jamar, G., Ribeiro, D. A., & Pisani, L. P. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1747046 · Cited by 163 · see citing works
Inflammatory pathways in Alzheimer’s disease mediated by gut microbiota
Qian, X.-H., Song, X.-X., Liu, X.-L., Chen, S.-D., & Tang, H.-D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101317 · Cited by 153 · see citing works
Diet in Parkinson’s Disease: Critical Role for the Microbiome
Jackson, A., Forsyth, C. B., Shaikh, M., Voigt, R. M., Engen, P. A., Ramirez, V., & Keshavarzian, A. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01245 · Cited by 145 · see citing works
Neuroinflammation: The central enabler of postoperative cognitive dysfunction
Liu, Y., Yang, W., Xue, J., Chen, J., Liu, S., Zhang, S., Zhang, X., Gu, X., Dong, Y., & Qiu, P. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115582 · Cited by 136 · see citing works
Effects of ultra-processed foods on the microbiota-gut-brain axis: The bread-and-butter issue
Song, Z., Song, R., Liu, Y., Wu, Z., & Zhang, X. (2023) · Food Research International · doi:10.1016/j.foodres.2023.112730 · Cited by 132 · see citing works
Planetary Health: From the Wellspring of Holistic Medicine to Personal and Public Health Imperative
Prescott, S. L., & Logan, A. C. (2019) · EXPLORE · doi:10.1016/j.explore.2018.09.002 · Cited by 118 · see citing works
Bile acids as key modulators of the brain-Gut-Microbiota axis in alzheimer’s disease
Mulak, A. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210608 · Cited by 114 · see citing works
Bazzari, A. H., & Parri, H. R. (2019) · Brain Sciences · doi:10.3390/brainsci9110300 · Cited by 99 · see citing works
Cai, L., Zhu, H., Mou, Q., Wong, P. Y., Lan, L., Ng, C. W. K., Pu, L., Cheung, M. K., Wang, D., Wong, E. W. Y., et al. (2024) · npj Biofilms and Microbiomes · doi:10.1038/s41522-024-00511-x · Cited by 89 · see citing works
The microbiome-driven impact of western diet in the development of noncommunicable chronic disorders
Severino, A., Tohumcu, E., Tamai, L., D’Argenio, P., Porcari, S., Rondinella, D., Venturini, I., Maida, M. F., Gasbarrini, A., Cammarota, G., et al. (2024) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2024.101923 · Cited by 97 · see citing works
Chen, Y., Li, Y., Fan, Y., Chen, S., Chen, L., Chen, Y., & Chen, Y. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2302310 · Cited by 90 · see citing works
Role of brain-gut-muscle axis in human health and energy homeostasis
Yin, Y., Guo, Q., Zhou, X., Duan, Y., Yang, Y., Gong, S., Han, M., Liu, Y., Yang, Z., Chen, Q., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.947033 · Cited by 80 · see citing works
Focus on the gut-brain axis: Multiple sclerosis, the intestinal barrier and the microbiome
Camara-Lemarroy, C. R., Metz, L. M., & Yong, V. W. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i37.4217 · Cited by 75 · see citing works
Regulation of bile acid receptor activity
Wan, Y. Y., & Sheng, L. (2018) · Liver Research · doi:10.1016/j.livres.2018.09.008 · Cited by 76 · see citing works
Self-citationDaruich, A., Picard, É., Boatright, J. H., & Béhar‐Cohen, F. (2019) · PubMed Central · Cited by 73 · see citing works
Shi, Z., Wu, X., Yu, S., Huynh, M., Jena, P. K., Nguyen, M., Wan, Y. Y., & Hwang, S. T. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.01.020 · Cited by 73 · see citing works
Self-citationAlzheimer’s Disease and Diabetes: Role of Diet, Microbiota and Inflammation in Preclinical Models
Carranza-Naval, M. J., Vargas-Soria, M., Hierro‐Bujalance, C., Baena‐Nieto, G., Garcı́a-Alloza, M., Infante‐Garcia, C., & del Marco, À. (2021) · Biomolecules · doi:10.3390/biom11020262 · Cited by 73 · see citing works
Więckowska‐Gacek, A., Mietelska‐Porowska, A., Chutorański, D., Wydrych, M., Długosz, J., & Wojda, U. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.654509 · Cited by 69 · see citing works
Meng, F., Li, N., Li, D., Song, B., & Li, L. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.111902 · Cited by 67 · see citing works
Jena, P. K., Sheng, L., McNeil, K. D., Chau, T., Yu, S., Kiuru, M. H., Fung, M. A., Hwang, S. T., & Wan, Y. Y. (2019) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2019.05.007 · Cited by 67 · see citing works
Self-citationMicrobiota impacts on chronic inflammation and metabolic syndrome - related cognitive dysfunction
Arnoriaga‐Rodríguez, M., & Fernández‐Real, J. M. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09537-5 · Cited by 67 · see citing works
Metformin, Cognitive Function, and Changes in the Gut Microbiome
Rosell-Díaz, M., & Fernández‐Real, J. M. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad029 · Cited by 68 · see citing works
Zhang, F., Deng, Y., Wang, H., Fu, J., Wu, G., Duan, Z., Zhang, X., Cai, Y., Zhou, H., Yin, J., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.11.021 · Cited by 68 · see citing works
Probiotics VSL#3 are effective in reversing non-alcoholic steatohepatitis in a mouse model
Jena, P. K., Sheng, L., Li, Y., & Wan, Y.-J. Y. (2020) · HepatoBiliary Surgery and Nutrition · doi:10.21037/hbsn.2019.09.07 · Cited by 60 · see citing works
Self-citationShi, Z., Wu, X., Rocha, C. S., Rolston, M. R., Melchor, E. G., Huynh, M., Nguyen, M., Law, T., Haas, K. N., Yamada, D., et al. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.11.032 · Cited by 60 · see citing works
Self-citationJena, P. K., Sheng, L., Nagar, N., Wu, C., Barile, D., Mills, D. A., & Wan, Y.-J. Y. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.04.007 · Cited by 60 · see citing works
Self-citationThe gut microbiota promotes pain in fibromyalgia
Cai, W., Haddad, M., Haddad, R., Kesten, I., Hoffman, T., Laan, R., Westfall, S., Defaye, M., Abdullah, N. S., Wong, C., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.03.032 · Cited by 59 · see citing works
The role of bile acid receptor TGR5 in regulating inflammatory signalling
Ye, D., He, J., & He, X. (2024) · Scandinavian Journal of Immunology · doi:10.1111/sji.13361 · Cited by 57 · see citing works
Warren, A., Nyavor, Y., Zarabian, N., Mahoney, A., & Frame, L. A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1365673 · Cited by 62 · see citing works
Jena, P., Sheng, L., Nguyen, M. M., di Lucente, J., Hu, Y., Li, Y.-C., Maezawa, I., Jin, L.-W., & Wan, Y. (2020) · Biomarker Research · doi:10.1186/s40364-020-00239-8 · Cited by 46 · see citing works
Self-citationWu, H., Lv, W., Pan, Q., Kalavagunta, P. K., Liu, Q., Qin, G., Cai, M., Zhou, L., Wang, T., Xia, Z., et al. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.09.022 · Cited by 54 · see citing works
Olmo, N. D., & Ruiz‐Gayo, M. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00439 · Cited by 53 · see citing works
Shi, Z., Wu, X., Wu, C., Singh, S. P., Law, T., Yamada, D., Huynh, M., Liakos, W., Yang, G., Farber, J. M., et al. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2021.10.027 · Cited by 52 · see citing works
Self-citationMa, J., Li, M., Bao, Y., Huang, W., He, X., Hong, Y., Wei, W., Liu, Z., Gao, X., Yang, Y., et al. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107361 · Cited by 52 · see citing works
Self-citationDirect and indirect effects of lipids on microglia function
Leyrolle, Q., Layé, S., & Nadjar, A. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134348 · Cited by 50 · see citing works
Inflammatory bowel disease: A potential pathogenic factor of Alzheimer's disease
Wang, D., Zhang, X., & Du, H. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110610 · Cited by 49 · see citing works
TGR5 Receptor Activation Attenuates Diabetic Retinopathy Through Suppression of RhoA/ROCK Signaling
Zhu, L., Wang, W., Xie, T., Zou, J., Nie, X., Wang, X., Zhang, M., Wang, Z., Gu, S., Zhuang, M., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201902496rr · Cited by 47 · see citing works
Psychosis spectrum illnesses as disorders of prefrontal critical period plasticity
Vinogradov, S., Chafee, M. V., Lee, E. G., & Morishita, H. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01451-w · Cited by 44 · see citing works
Huang, R., Gao, Y., Chen, J., Duan, Q., He, P., Zhang, J., Huang, H., Zhang, Q., Ma, G., Zhang, Y., et al. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.02.028 · Cited by 40 · see citing works
Hayes, A., Lauer, L. T., Kao, A. E., Sun, S., Klug, M. E., Tsan, L., Rea, J. J., Subramanian, K. S., Gu, C., Tanios, N., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.03.015 · Cited by 38 · see citing works
The Effect of a High-Fat Diet on the Fatty Acid Composition in the Hearts of Mice
Pakiet, A., Jakubiak, A. A., Mierzejewska, P., Zwara, A., Liakh, I., Śledziński, T., & Mika, A. (2020) · Nutrients · doi:10.3390/nu12030824 · Cited by 37 · see citing works
Bile acids and salt-sensitive hypertension: a role of the gut-liver axis
Ishimwe, J., Dola, T., Ertuğlu, L. A., & Kirabo, A. (2022) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00027.2022 · Cited by 36 · see citing works
The Pathological Effects of Circulating Hydrophobic Bile Acids in Alzheimer’s Disease
Ehtezazi, T., Rahman, K., Davies, R., & Leach, A. G. (2023) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-220071 · Cited by 35 · see citing works
Jamar, G., Santamarina, A. B., Dias, G. C., Masquio, D. C. L., de Rosso, V. V., & Pisani, L. P. (2018) · Food Research International · doi:10.1016/j.foodres.2018.07.002 · Cited by 34 · see citing works
Ma, J., Sheng, L., Hong, Y., Xi, C., Gu, Y., Zheng, N., Li, M., Chen, L., Wu, G., Li, Y., et al. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00972 · Cited by 33 · see citing works
Self-citationMetabolic Diffusion in Neuropathologies: The Relevance of Brain-Liver Axis
Vegas‐Suárez, S., Simón, J., Martínez‐Chantar, M. L., & Moratalla, R. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.864263 · Cited by 33 · see citing works
The influence of genetic and acquired factors on the vulnerability to develop depression: a review
Zhang, X., Qiao, Y., Wang, M., Liang, X., Zhang, M., Li, C., Cairang, J., Wang, J., Bi, H., & Gao, T. (2023) · Bioscience Reports · doi:10.1042/bsr20222644 · Cited by 31 · see citing works
Jena, P. K., Setayesh, T., Sheng, L., Lucente, J. D., Jin, L. W., & Wan, Y. Y. (2022) · Cells · doi:10.3390/cells11030504 · Cited by 28 · see citing works
Self-citationLiu, R., Bai, L., Liu, M., Wang, R., Wu, Y., Li, Q., Ba, Y., Zhang, H., Zhou, G., Yu, F., et al. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.119200 · Cited by 28 · see citing works
Fiaschini, N., Mancuso, M., Tanori, M., Colantoni, E., Vitali, R., Diretto, G., Lorenzo-Rebenaque, L., Stronati, L., & Negroni, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214254 · Cited by 27 · see citing works
Interplay between microglia and environmental risk factors in Alzheimer's disease
Zhang, M., Liang, C.-M., Chen, X., Cai, Y.-J., & Cui, L. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.389745 · Cited by 18 · see citing works
Western Diet Accelerates the Impairment of Odor-Related Learning and Olfactory Memory in the Mouse
Lietzau, G., Nyström, T., Wang, Z., Darsalia, V., & Patrone, C. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00466 · Cited by 26 · see citing works
Beverages in Rheumatoid Arthritis: What to Prefer or to Avoid
Dey, M., Cutolo, M., & Nikiphorou, E. (2020) · Nutrients · doi:10.3390/nu12103155 · Cited by 25 · see citing works
Ultraprocessed Foods and Neuropsychiatric Outcomes: Putative Mechanisms
Mariane Lutz, R., Marcelo Arancibia, M., Morán, J., & Manterola, M. (2025) · Nutrients · doi:10.3390/nu17071215 · Cited by 24 · see citing works
He, X., Gao, X., Hong, Y., Zhong, J., Li, Y., Zhu, W., Ma, J., Huang, W., Li, Y., Li, Y., et al. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c02909 · Cited by 23 · see citing works
Self-citationOverview of the Gut–Brain Axis: From Gut to Brain and Back Again
Post, Z., Manfready, R. A., & Keshavarzian, A. (2023) · Seminars in Neurology · doi:10.1055/s-0043-1771464 · Cited by 23 · see citing works
Chen, L., Wang, B., Liu, J., Wu, X., Xu, X., Cao, H., Ji, X., Zhang, P., Li, X., Hou, Z., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.974694 · Cited by 22 · see citing works
Darmanto, A. G., Yen, T., Jan, J., Linh, T. T. D., Taliyan, R., Yang, C. H., & Sheu, J. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107564 · Cited by 21 · see citing works
Poon, K. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.591559 · Cited by 20 · see citing works
Brain-Gut and Microbiota-Gut-Brain Communication in Type-2 Diabetes Linked Alzheimer’s Disease
Momen, Y. S., Mishra, J., & Kumar, N. (2024) · Nutrients · doi:10.3390/nu16152558 · Cited by 24 · see citing works
Saieva, S., & Taglialatela, G. (2022) · Scientific Reports · doi:10.1038/s41598-022-14812-8 · Cited by 19 · see citing works
Warren, A. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1395825 · Cited by 18 · see citing works
Bile acid modulation by gut microbiota: a bridge to understanding cognitive health
Sabahat, S. E., Saqib, M., Talib, M., Shaikh, T. G., Khan, T., & Kailash, S. J. (2024) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000002433 · Cited by 18 · see citing works
Cinquina, V., Keimpema, E., Pollak, D. D., & Harkany, T. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13320 · Cited by 15 · see citing works
Huang, F., Mariani, N., Pariante, C. M., & Borsini, A. (2023) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2023.100674 · Cited by 15 · see citing works
Western diet components that increase intestinal permeability with implications on health
Jaquez-Durán, G., & Arellano-Ortiz, A. L. (2023) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000801 · Cited by 14 · see citing works
Wu, Y., Shao, Y., Shao, X., Yu, H., Wang, M., Wang, J., She, Y., Liu, J., Zhang, T., Li, Z., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.145427 · Cited by 14 · see citing works
Boziki, M. K., Grigoriadis, N., Papaefthymiou, A., Doulberis, M., Pοlyzos, S. A., Gavalas, E., Deretzi, G., Karafoulidou, E., Kesidou, E., Taloumtzis, C., et al. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2020.104938 · Cited by 16 · see citing works
Mezhibovsky, E., Tveter, K. M., Villa-Rodríguez, J. A., Bacalia, K. M. A., Kshatriya, D., Desai, N., Cabales, A., Wu, Y., Sui, K., Duran, R. M., et al. (2023) · Journal of the Endocrine Society · doi:10.1210/jendso/bvad095 · Cited by 12 · see citing works
Wang, R., Sun, Y., Wang, M., Li, H., Liu, S., & Liu, Z. (2023) · Phytotherapy Research · doi:10.1002/ptr.7947 · Cited by 14 · see citing works
Uncovering the Gut–Liver Axis Biomarkers for Predicting Metabolic Burden in Mice
Yang, G., Liu, R., Rezaei, S., Liu, X., & Wan, Y. Y. (2023) · Nutrients · doi:10.3390/nu15153406 · Cited by 13 · see citing works
Self-citationThe contributions of bacteria metabolites to the development of hepatic encephalopathy
Gilbert, M. C., Setayesh, T., & Wan, Y. Y. (2022) · Liver Research · doi:10.1016/j.livres.2022.11.005 · Cited by 11 · see citing works
Self-citationRetinoic Acid Signaling Is Compromised in DSS-Induced Dysbiosis
Li, Y., Sheng, L., Jena, P. K., Gilbert, M. C., Wan, Y. Y., & Mao, H. (2022) · Nutrients · doi:10.3390/nu14142788 · Cited by 11 · see citing works
Self-citationThe emerging roles of the gut microbiome in allogeneic hematopoietic stem cell transplantation
Khuat, L. T., Dave, M., & Murphy, W. J. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1966262 · Cited by 11 · see citing works
Decoding TGR5: A comprehensive review of its impact on cerebral diseases
Zhang, Z., Zhang, Y., Peng, H., Yu, Q., Kang, X., Liu, Y., Zheng, Y., Cheng, F., Wang, X., & Li, F. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107671 · Cited by 10 · see citing works
Prebiotics and the Modulation on the Microbiota-GALT-Brain Axis
Franco‐Robles, E., Ramı́rez-Emiliano, J., López-Briones, J. S., & Balcón-Pacheco, C. D. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.89690 · Cited by 9 · see citing works
Braden-Kuhle, P. N., Lacy, V. A., Brice, K. N., Bertrand, M. E., Uras, H. B., Shoffner, C., Fischer, B. E., Rana, A., Willis, J. L., Boehm, G. W., et al. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251319467 · Cited by 8 · see citing works
Environmental Stressors and Neuroinflammation: Linking Climate Change to Alzheimer’s Disease
Caldarelli, M., Rio, P., Gasbarrini, A., Gambassi, G., & Cianci, R. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47110959 · Cited by 8 · see citing works
Ding, S., Lyu, X.-Y., Zhou, S.-Y., Fang, Y.-W., Ji, H.-H., Li, J.-Y., & Lü, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1633486 · Cited by 8 · see citing works
Asbjornsdottir, B., Miranda-Ribera, A., Fiorentino, M. R., Konno, T., Çetinbaş, M., Lan, J., Sadreyev, R. I., Gudmundsson, L. S., Gottfreðsson, M., Lauth, B., et al. (2022) · Biomedicines · doi:10.3390/biomedicines11010091 · Cited by 7 · see citing works
Diet as a Modulator of Gut Microbiota May Reduce Alzheimer’s Disease Risk
Ochocińska, A., Podstawka, I., Kępka, A., & Waszkiewicz, N. (2025) · Nutrients · doi:10.3390/nu17193053 · Cited by 6 · see citing works
Circulatory dietary and gut-derived metabolites predict early cognitive decline
Connell, E., Sami, S. A. K., Khondoker, M. R., Minihane, A. M., Pontifex, M. G., Müller, M. M., McArthur, S., Gall, G. L., & Vauzour, D. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2649487 · Cited by 6 · see citing works
Multi-pathway targeted therapy of MASH-HCC using miR-22
Hu, Y., Setayesh, T., Wei, D., Testerman, T. J. E., Ji, Y. S., & Wan, Y. Y. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01352-7 · Cited by 6 · see citing works
Self-citationGlucosinolates and their bioactive metabolites as functional compounds modulating inflammation
García-Ibáñez, P., Ben-Romdhane, O., & Moreno, D. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823482-2.00017-0 · Cited by 6 · see citing works
Elocalcitol mitigates high-fat diet-induced microglial senescence via miR-146a modulation
Chithanathan, K., Jürgenson, M., Ducena, K., Remm, A., Kask, K., Rebane, A., Li, T., & Zharkovsky, A. (2024) · Immunity & Ageing · doi:10.1186/s12979-024-00485-6 · Cited by 5 · see citing works
Industrialized diets modulate host eating behavior via the microbiome–gut–brain axis
Liow, Y. J., Sarkar, A., & Carmody, R. N. (2025) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2025.06.002 · Cited by 5 · see citing works
Liu, R., Durbin-Johnson, B. P., Paciotti, B. M., Liu, A. T., Weakley, A. M., Liu, X., & Wan, Y. Y. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14101 · Cited by 5 · see citing works
Self-citation
- Authors
- Jena, P. K., Sheng, L., Di Lucente, J., Jin, L., Maezawa, I., & Wan, Y. Y.
- Affiliations
- University of California, Davis (US)
- Medical Investigation of Neurodevelopmental Disorders Institute University of California Davis Sacramento, California USA
- Corresponding author
- Wan, Yu‐Jui Yvonne
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2018-01-10
- Volume
- 32
- Issue
- 5
- Pages
- 2866-2877
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- PMC
- PMC5901391
- OpenAlex
- W2793463729
- Cited by
- 134
- References
- 112
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 22 · 2023: 19 · 2022: 19 · 2021: 14 · 2020: 17 · 2019: 11 · 2018: 7
- FWCI
- 4.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- The FASEB Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (U01CA179582)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- Western diet, bile acid synthesis, gut dysbiosis, systemic inflammation, microglial activation, neuroplasticity, cognitive impairment, hippocampal synaptic plasticity, brain-derived neurotrophic factor, ERK signaling, PSD-95, retinoic acid signaling, farnesoid X receptor, G protein-coupled bile acid receptor, high-fat high-sugar diet, gut-brain axis
- MeSH terms
- Receptor, Farnesoid X-Activated, Animals, Bile Acids and Salts, Hippocampus, Inflammation, Male, Neuronal Plasticity, Tretinoin, Microglia, Receptors, Cytoplasmic and Nuclear, Mitogen-Activated Protein Kinase 1, MAP Kinase Signaling System, Mitogen-Activated Protein Kinase 3, Mice, Dysbiosis, Diet, Western
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
