Effects of bile acids on neurological function and disease

The amyloid hypothesis of Alzheimer's disease at 25 years

Selkoe, D. J., & Hardy, J. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201606210 · Cited by 6,164 · see citing works

The Enzymes, Regulation, and Genetics of Bile Acid Synthesis

Russell, D. W. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161712 · Cited by 2,069 · see citing works

Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR

Wang, H., Chen, J., Hollister, K., Sowers, L. C., & Forman, B. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80348-2 · Cited by 1,636 · see citing works

A G Protein-coupled Receptor Responsive to Bile Acids

Kawamata, Y., Fujii, R., Hosoya, M., Harada, M., Yoshida, H., Miwa, M., Fukusumi, S., Habata, Y., Itoh, T., Shintani, Y., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209706200 · Cited by 1,628 · see citing works

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

Lehmann, J., McKee, D. D., Watson, M. A., Willson, T. M., Moore, J. T., & Kliewer, S. A. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3703 · Cited by 1,577 · see citing works

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

Staudinger, J. L., Goodwin, B. J., Jones, S. A., Hawkins‐Brown, D., MacKenzie, K. I., Latour, A. M., Liu, Y., Klaassen, C. D., Brown, K. K., Reinhard, J. F., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051551698 · Cited by 1,378 · see citing works

Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network

Bookout, A. L., Jeong, Y., Downes, M., Yu, R. T., Evans, R. M., & Mangelsdorf, D. J. (2006) · Cell · doi:10.1016/j.cell.2006.06.049 · Cited by 1,015 · see citing works

Identification of membrane-type receptor for bile acids (M-BAR)

Maruyama, T., Miyamoto, Y., Nakamura, T., Tamai, Y., Okada, H., Sugiyama, E., Nakamura, T., Itadani, H., & Tanaka, K. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02550-0 · Cited by 993 · see citing works

The Continuing Importance of Bile Acids in Liver and Intestinal Disease

Hofmann, A. F. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.22.2647 · Cited by 972 · see citing works

Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR

Calkin, A. C., & Tontonoz, P. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3312 · Cited by 779 · see citing works

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

Greggio, E., Jain, S., Kingsbury, A. E., Bandopadhyay, R., Lewis, P. A., Kaganovich, A., van der Brug, M. P., Beilina, A. G., Blackinton, J. G., Craig, K. J. T., et al. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.04.001 · Cited by 731 · see citing works

Bile acid transporters

Dawson, P. A., Lan, T., & Rao, A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r900012-jlr200 · Cited by 683 · see citing works

cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain

Lund, E. G., Guileyardo, J. M., & Russell, D. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7238 · Cited by 668 · see citing works

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

Pols, T. W. H., Nomura, M., Harach, T., Sasso, G. L., Oosterveer, M. H., Thomas, C., Rizzo, G., Gioiello, A., Adorini, L., Pellicciari, R., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.11.006 · Cited by 622 · see citing works

Kinase activity of mutant LRRK2 mediates neuronal toxicity

Smith, W. W., Pei, Z., Jiang, H., Dawson, V. L., Dawson, T. M., & Ross, C. A. (2006) · Nature Neuroscience · doi:10.1038/nn1776 · Cited by 619 · see citing works

Vitamin D Receptor: New Assignments for an Already Busy Receptor

Norman, A. W. (2006) · Endocrinology · doi:10.1210/en.2006-0946 · Cited by 583 · see citing works

Bile acid nuclear receptor FXR and digestive system diseases

Ding, L., Yang, L., Wang, Z., & Huang, W. (2015) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2015.01.004 · Cited by 477 · see citing works

Human cholesterol 7α-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype

Pullinger, C. R., Eng, C. S., Salen, G., Shefer, S., BATTA, A. K., Erickson, S. K., Verhagen, A., Rivera, C. R., Mulvihill, S. J., Malloy, M. J., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15387 · Cited by 468 · see citing works

Human cholesterol 7α-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype

Pullinger, C. R., Eng, C. S., Salen, G., Shefer, S., BATTA, A. K., Erickson, S. K., Verhagen, A., Rivera, C. R., Mulvihill, S. J., Malloy, M. J., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215387 · Cited by 456 · see citing works

Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover

Lund, E. G., Xie, C., Kotti, T., Turley, S. D., Dietschy, J. M., & Russell, D. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303415200 · Cited by 421 · see citing works

Apoptosis After Traumatic Brain Injury

Raghupathi, R., GRAHAM, D. I., & McIntosh, T. K. (2000) · Journal of Neurotrauma · doi:10.1089/neu.2000.17.927 · Cited by 417 · see citing works

Cerebrotendinous xanthomatosis: a comprehensive review of pathogenesis, clinical manifestations, diagnosis, and management

Nie, S., Chen, G., Cao, X., & Zhang, Y. (2014) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-014-0179-4 · Cited by 320 · see citing works

Conjugated Bile Acids Activate the Sphingosine–1–Phosphate Receptor 2 in Primary Rodent Hepatocytes

Studer, E. J., Zhou, X., Zhao, R., Wang, Y., Takabe, K., Nagahashi, M., Pandak, W. M., Dent, P., Spiegel, S., Shi, R., et al. (2011) · Hepatology · doi:10.1002/hep.24681 · Cited by 319 · see citing works

Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation

Vassileva, G., Golovko, A., Markowitz, L., Abbondanzo, S. J., Zeng, M., Yang, S., Hoos, L. M., Tetzloff, G. G., Levitan, D. J., Murgolo, N., et al. (2006) · Biochemical Journal · doi:10.1042/bj20060537 · Cited by 277 · see citing works

The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain

Keitel, V., Görg, B., Bidmon, H. J., Zemtsova, I., Spomer, L., Zilles, K., & Häussinger, D. (2010) · Glia · doi:10.1002/glia.21049 · Cited by 274 · see citing works

Disruption of Cholesterol 7α-Hydroxylase Gene in Mice

Schwarz, M., Lund, E. G., Setchell, K. D. R., Kayden, H. J., Zerwekh, J. E., Björkhem, I., Herz, J., & Russell, D. W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.18024 · Cited by 270 · see citing works

Markedly Reduced Bile Acid Synthesis but Maintained Levels of Cholesterol and Vitamin D Metabolites in Mice with Disrupted Sterol 27-Hydroxylase Gene

Rosen, H., Reshef, A., Maeda, N., Lippoldt, A., Shpizen, S., Triger, L., Eggertsen, G., Björkhem, I., & Leitersdorf, E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.24.14805 · Cited by 267 · see citing works

Brain cholesterol turnover required for geranylgeraniol production and learning in mice

Kotti, T. J., Ramirez, D. M. O., Pfeiffer, B. E., Huber, K. M., & Russell, D. W. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600316103 · Cited by 259 · see citing works

Bile acids permeabilize the blood brain barrier after bile duct ligation in rats via Rac1-dependent mechanisms

Quinn, M., McMillin, M., Galindo, C., Frampton, G., Pae, H. Y., & DeMorrow, S. (2014) · Digestive and Liver Disease · doi:10.1016/j.dld.2014.01.159 · Cited by 259 · see citing works

Similar Patterns of Mitochondrial Vulnerability and Rescue Induced by Genetic Modification of α-Synuclein, Parkin, and DJ-1 in Caenorhabditis elegans

Ved, R., Saha, S., Westlund, B., Perier, C., Griffin, L. B., Sluder, A. E., Hoener, M. C., Rodrigues, C. M. P., Alfonso, A., Steer, C. J., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505910200 · Cited by 256 · see citing works

Disruption of Cholesterol 7α-Hydroxylase Gene in Mice

Ishibashi, S., Schwarz, M., Frykman, P. K., Herz, J., & Russell, D. W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.18017 · Cited by 233 · see citing works

Role of the Intestinal Bile Acid Transporters in Bile Acid and Drug Disposition

Dawson, P. A. (2010) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-14541-4_4 · Cited by 227 · see citing works

Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis

Elia, A. E., Lalli, S., Monsurrò, M. R., Sagnelli, A., Taiello, A. C., Reggiori, B., Bella, V. L., Tedeschi, G., & Albanese, A. (2015) · European Journal of Neurology · doi:10.1111/ene.12664 · Cited by 225 · see citing works

The liver–brain axis in liver failure: neuroinflammation and encephalopathy

Butterworth, R. F. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.99 · Cited by 220 · see citing works

Regulation of Bile Acid Synthesis by Fat-soluble Vitamins A and D

Schmidt, D. R., Holmstrom, S. R., Tacer, K. F., Bookout, A. L., Kliewer, S. A., & Mangelsdorf, D. J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.116004 · Cited by 211 · see citing works

Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats

Rodrigues, C. M. P., Solá, S., Nan, Z., Castro, R. E., Ribeiro, P. S., Low, W. C., & Steer, C. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1031632100 · Cited by 210 · see citing works

Disruption of the Sterol 27-Hydroxylase Gene in Mice Results in Hepatomegaly and Hypertriglyceridemia

Repa, J. J., Lund, E. G., Horton, J. D., Leitersdorf, E., Russell, D. W., Dietschy, J. M., & Turley, S. D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007653200 · Cited by 202 · see citing works

Cytochrome P450s in the synthesis of cholesterol and bile acids – from mouse models to human diseases

Lorbek, G., Lewińska, M., & Rozman, D. (2011) · FEBS Journal · doi:10.1111/j.1742-4658.2011.08432.x · Cited by 196 · see citing works

TUDCA, a Bile Acid, Attenuates Amyloid Precursor Protein Processing and Amyloid-β Deposition in APP/PS1 Mice

Nunes, A. F., Amaral, J. D., Lo, A. C., Fonseca, M. B., Viana, R. J. S., Callaerts-Vegh, Z., D’Hooge, R., & Rodrigues, C. M. P. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8256-y · Cited by 192 · see citing works

An essential role for the H218/AGR16/Edg‐5/LPB2 sphingosine 1‐phosphate receptor in neuronal excitability

MacLennan, A. J., Carney, P. R., Zhu, W., Chaves, A. H., Garcia, J., Grimes, J. R., Anderson, K. J., Roper, S. N., & Lee, N. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01634.x · Cited by 187 · see citing works

Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension

Toman, R. E., Payne, S. G., Watterson, K. R., Maceyka, M. W., Lee, N. H., Milstien, S., Bigbee, J. W., & Spiegel, S. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200402016 · Cited by 173 · see citing works

Neuroprotection by a Bile Acid in an Acute Stroke Model in the Rat

Rodrigues, C. M. P., Spellman, S. R., Solá, S., Grande, A. W., Linehan-Stieers, C., Low, W. C., & Steer, C. J. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200204000-00010 · Cited by 160 · see citing works

1α,25-Dihydroxyvitamin D 3 Reduces Cerebral Amyloid-β Accumulation and Improves Cognition in Mouse Models of Alzheimer's Disease

Durk, M. R., Han, K., Chow, E. C. Y., Ahrens, R., Henderson, J. T., Fraser, P. E., & Pang, K. S. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2711-13.2014 · Cited by 154 · see citing works

Current concepts in the assessment and treatment of Hepatic Encephalopathy

Cash, W. J., McConville, P., McDermott, E., McCormick, P. A., Callender, M. E., & McDougall, N. (2009) · QJM · doi:10.1093/qjmed/hcp152 · Cited by 142 · see citing works

Cerebrotendinous xanthomatosis in Spain: clinical, prognostic, and genetic survey

Pilo‐de‐la‐Fuente, B., Jiménez‐Escrig, A., Lorenzo, J. R., Pardo, J., Arias, M., Arés-Luque, A., Duarte, J., Muñiz‐Pérez, S., & Sobrido, M. J. (2011) · European Journal of Neurology · doi:10.1111/j.1468-1331.2011.03439.x · Cited by 141 · see citing works

Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis

Theofilopoulos, S., Wang, Y., Kitambi, S. S., Sacchetti, P., Sousa, K. M., Bodin, K., Kirk, J. M., Saltó, C., Gustafsson, M., Toledo, E. M., et al. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.1156 · Cited by 132 · see citing works

Bilirubin and Amyloid-β Peptide Induce Cytochrome c Release Through Mitochondrial Membrane Permeabilization

Rodrigues, C. M. P., Solá, S., Silva, R. F. M., & Brites, D. M. T. O. (2000) · Molecular Medicine · doi:10.1007/bf03401828 · Cited by 131 · see citing works

UDCA exerts beneficial effect on mitochondrial dysfunction in <i>LRRK2</i> ^{<i>G2019S</i>} carriers and in vivo

Mortiboys, H., Furmston, R., Bronstad, G., Aasly, J., Elliott, C., & Bandmann, O. (2015) · Neurology · doi:10.1212/wnl.0000000000001905 · Cited by 131 · see citing works

TGR 5 signaling reduces neuroinflammation during hepatic encephalopathy

McMillin, M., Frampton, G. A., Tobin, R. P., Dusio, G. F., Smith, J., Shin, H. D., Newell‐Rogers, K., Grant, S. M., & DeMorrow, S. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13243 · Cited by 129 · see citing works

Amyloid-β pathology is attenuated by tauroursodeoxycholic acid treatment in APP/PS1 mice after disease onset

Dionísio, P. A., Amaral, J. D., Ribeiro, M. F., Lo, A. C., D'Hooge, R., & Rodrigues, C. M. P. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.08.034 · Cited by 127 · see citing works

Presence of protein-bound unconjugated bile acids in the cytoplasmic fraction of rat brain

Mano, N., Goto, T., Uchida, M., Nishimura, K., Ando, M., Kobayashi, N., & Goto, J. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300369-jlr200 · Cited by 123 · see citing works

Cerebrotendinous Xanthomatosis

Lorincz, M. T., Rainier, S. R., Thomas, D., & Fink, J. K. (2005) · Archives of Neurology · doi:10.1001/archneur.62.9.1459 · Cited by 116 · see citing works

Expression of Constitutive Androstane Receptor Splice Variants in Human Tissues and Their Functional Consequences

Lamba, J. K., Lamba, V., Yasuda, K., Lin, Y. S., Assem, M., Thompson, E. E., Strom, S. C., & Schuetz, E. G. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.069310 · Cited by 114 · see citing works

Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice

Erickson, S. K., Lear, S. R., Deane, S., Dubrac, S., Huling, S. L., Nguyen, L., Bollineni, J. S., Shefer, S., Hyogo, H., Cohen, D. E., et al. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200489-jlr200 · Cited by 113 · see citing works

Deletion of mouse FXR gene disturbs multiple neurotransmitter systems and alters neurobehavior

Huang, F., Wang, T., Lan, Y., Yang, L., Pan, W., Zhu, Y., Lv, B., Wei, Y., Shi, H., Wu, H., et al. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00070 · Cited by 109 · see citing works

In vivo roles of lysophospholipid receptors revealed by gene targeting studies in mice

Yang, A. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(02)00172-5 · Cited by 108 · see citing works

Activation of Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) by Herbal Medicines

Chang, T. K. H. (2009) · The AAPS Journal · doi:10.1208/s12248-009-9135-y · Cited by 108 · see citing works

Bile Acid Signaling Is Involved in the Neurological Decline in a Murine Model of Acute Liver Failure

McMillin, M., Frampton, G. A., Quinn, M. A., Ashfaq, S., Santos, M. D. L., Grant, S. M., & DeMorrow, S. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.10.005 · Cited by 106 · see citing works

Cerebrotendinous xanthomatosis: An inborn error in bile acid synthesis with defined mutations but still a challenge

Björkhem, I., & Hansson, M. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.140 · Cited by 92 · see citing works

Treatment of cerebrotendinous xanthomatosis: effects of chenodeoxycholic acid, pravastatin, and combined use

Kuriyama, M., Tokimura, Y., Fujiyama, J., Utatsu, Y., & Osame, M. (1994) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(94)90237-2 · Cited by 91 · see citing works

Suppression of hypothalamic-pituitary-adrenal axis responsiveness to stress in a rat model of acute cholestasis.

Swain, M. G., Patchev, V. K., Vergalla, J., Chrousos, G. P., & Jones, E. A. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116408 · Cited by 91 · see citing works

Bile acids modulate glucocorticoid metabolism and the hypothalamic–pituitary–adrenal axis in obstructive jaundice

McNeilly, A. D., Macfarlane, D. P., O’Flaherty, E., Livingstone, D. E. W., Mitić, T., McConnell, K. M. M., MacKenzie, S. M., Davies, E., Reynolds, R. M., Thiesson, H. C., et al. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2009.10.037 · Cited by 90 · see citing works

Mechanisms of Glucocorticoids in the Control of Neuroinflammation

Schweingruber, N., Reichardt, S. D., Lühder, F., & Reichardt, H. M. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02161.x · Cited by 89 · see citing works

Molecular and functional comparison of 1,25‐dihydroxyvitamin D3 and the novel vitamin D receptor ligand, lithocholic acid, in activating transcription of cytochrome P450 3A4

Jurutka, P. W., Thompson, P. D., Whitfield, G. K., Eichhorst, K. R., Hall, N., Dominguez, C. E., Hsieh, J., Haussler, C. A., & Haussler, M. R. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20359 · Cited by 86 · see citing works

Obeticholic acid, a synthetic bile acid agonist of the farnesoid X receptor, attenuates experimental autoimmune encephalomyelitis

Ho, P. P.-K., & Steinman, L. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1524890113 · Cited by 85 · see citing works

A GPBAR1 (TGR5) Small Molecule Agonist Shows Specific Inhibitory Effects on Myeloid Cell Activation In Vitro and Reduces Experimental Autoimmune Encephalitis (EAE) In Vivo

Lewis, N. D., Patnaude, L. A., Pelletier, J., Souza, D. J., Lukas, S., King, J., Hill, J. D., Stefanopoulos, D. E., Ryan, K. R., Desai, S. N., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100883 · Cited by 84 · see citing works

Inhibition of the E2F‐1/p53/Bax pathway by tauroursodeoxycholic acid in amyloid β‐peptide‐induced apoptosis of PC12 Cells

Ramalho, R. M., Ribeiro, P. S., Solá, S., Castro, R. E., Steer, C. J., & Rodrigues, C. M. P. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02517.x · Cited by 83 · see citing works

Suppression of the HPA axis during cholestasis can be attributed to hypothalamic bile acid signaling

McMillin, M., Frampton, G., Quinn, M., Divan, A., Grant, S., Patel, N., Newell-Rogers, K., & DeMorrow, S. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1087 · Cited by 82 · see citing works

The bile steroid chenodeoxycholate is a potent antagonist at NMDA and GABAA receptors

Schubring, S. R., Fleischer, W., Lin, J. S., Haas, H. L., & Sergeeva, O. A. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2011.11.036 · Cited by 81 · cited 1× · see citing works

Fibronectin supports neurite outgrowth and axonal regeneration of adult brain neurons in vitro

Tonge, D. A., de Burgh, H. T., Docherty, R. J., Humphries, M. J., Craig, S. E., & Pizzey, J. A. (2012) · Brain Research · doi:10.1016/j.brainres.2012.03.024 · Cited by 78 · see citing works

Tauroursodeoxycholic acid protects retinal neural cells from cell death induced by prolonged exposure to elevated glucose

Gaspar, J. M., Martins, A., Cruz, R., Rodrigues, C. M. P., Ambrósio, A. F., & Santiago, A. R. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.053 · Cited by 78 · see citing works

α5β1-integrins are sensors for tauroursodeoxycholic acid in hepatocytes

Gohlke, H., Schmitz, B., Sommerfeld, A., Reinehr, R., & Häussinger, D. (2013) · Hepatology · doi:10.1002/hep.25992 · Cited by 77 · see citing works

Constitutive Androstane Receptor-Mediated Changes in Bile Acid Composition Contributes to Hepatoprotection from Lithocholic Acid-Induced Liver Injury in Mice

Beilke, L. D., Aleksunes, L. M., Holland, R. D., Besselsen, D. G., Beger, R. D., Klaassen, C. D., & Cherrington, N. J. (2009) · Drug Metabolism and Disposition · doi:10.1124/dmd.108.023317 · Cited by 73 · see citing works

Tauroursodeoxycholic acid modulates p53‐mediated apoptosis in Alzheimer's disease mutant neuroblastoma cells

Ramalho, R. M., Borralho, P. M., Castro, R. E., Solá, S., Steer, C. J., & Rodrigues, C. M. P. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04007.x · Cited by 71 · see citing works

Structural Determinants for Vitamin D Receptor Response to Endocrine and Xenobiotic Signals

Adachi, R., Shulman, A. I., Yamamoto, K., Shimomura, I., Yamada, S., Mangelsdorf, D. J., & Makishima, M. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0244 · Cited by 71 · see citing works

Parkinson's Disease: The LRRK2-G2019S mutation: opening a novel era in Parkinson's disease genetics

Bonifati, V. (2006) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201695 · Cited by 60 · see citing works

On the mechanism of accumulation of cholestanol in the brain of mice with a disruption of sterol 27-hydroxylase

Båvner, A., Shafaati, M., Hansson, M. E. A., Olin, M., Shpitzen, S., Meiner, V., Leitersdorf, E., & Björkhem, I. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m008326 · Cited by 60 · see citing works

Glycoursodeoxycholic Acid Reduces Matrix Metalloproteinase-9 and Caspase-9 Activation in a Cellular Model of Superoxide Dismutase-1 Neurodegeneration

Vaz, A. R., Cunha, C., Gomes, C., Schmucki, N., Barbosa, M., & Brites, D. M. T. O. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8731-8 · Cited by 57 · see citing works

Common CYP7A1 promoter polymorphism associated with risk of neuromyelitis optica

Kim, H. J., Park, H., Kim, E., Lee, K.-S., Kim, K., Choi, B., Kim, S. M., Bae, J. S., Lee, S. O., Chun, J. Y., et al. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.10.013 · Cited by 54 · see citing works

Mice deficient in endothelial α5 integrin are profoundly resistant to experimental ischemic stroke

Roberts, J., de Hoog, L., & Bix, G. J. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15616979 · Cited by 54 · see citing works

Glucocorticoid receptor is involved in the neuroprotective effect of ginsenoside Rg1 against inflammation-induced dopaminergic neuronal degeneration in substantia nigra

Sun, X., Ren, X., Chen, L., Gao, X.-Q., Xie, J., & Chen, W. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.09.040 · Cited by 53 · see citing works

Integrin α5β1 is necessary for regulation of radial migration of cortical neurons during mouse brain development

Marchetti, G., Escuin, S., van der Flier, A., Arcangelis, A. D., Hynes, R. O., & Georges‐Labouesse, E. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.07072.x · Cited by 50 · see citing works

Serum, cerebrospinal fluid, and brain levels of bile acids in patients with fulminant hepatic failure.

Bron, B., Waldram, R., Silk, D. B. A., & Williams, R. L. (1977) · Gut · doi:10.1136/gut.18.9.692 · Cited by 49 · see citing works

Antagonism of sphingosine 1-phosphate receptor 2 causes a selective reduction of portal vein pressure in bile duct-ligated rodents

Kageyama, Y., Ikeda, H., Watanabe, N., Nagamine, M., Kusumoto, Y., Yashiro, M., Satoh, Y., Shimosawa, T., Shinozaki, K., Tomiya, T., et al. (2012) · Hepatology · doi:10.1002/hep.25780 · Cited by 48 · see citing works

Polyneuropathy in cerebrotendinous xanthomatosis and response to treatment with chenodeoxycholic acid

Ginanneschi, F., Mignarri, A., Mondelli, M., Gallus, G. N., Puppo, M. D., Giorgi, S., Federico, A., Rossi, A., & Dotti, M. T. (2012) · Journal of Neurology · doi:10.1007/s00415-012-6630-3 · Cited by 47 · see citing works

Constitutive androstane receptor upregulates Abcb1 and Abcg2 at the blood–brain barrier after CITCO activation

Lemmen, J., Tozakidis, I. E. P., Bele, P., & Galla, H. (2013) · Brain Research · doi:10.1016/j.brainres.2013.01.025 · Cited by 47 · see citing works

RXRα, PXR and CAR xenobiotic receptors mediate the apoptotic and neurotoxic actions of nonylphenol in mouse hippocampal cells

Litwa, E., Rzemieniec, J., Wnuk, A., Lasoń, W., Krzeptowski, W., & Kajta, M. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.11.018 · Cited by 43 · see citing works

Differential Effects of Traumatic Brain Injury on the Cytochrome P450 System: A Perspective into Hepatic and Renal Drug Metabolism

Kalsotra, A., Turman, C. M., Dash, P. K., & Strobel, H. W. (2003) · Journal of Neurotrauma · doi:10.1089/089771503322686139 · Cited by 40 · see citing works

Bile acids content in brain of common duct ligated rats

Tripodi, V. P., Contin, M. D., Fernández, M. A., & Lemberg, A. (2012) · Annals of Hepatology · doi:10.1016/s1665-2681(19)31420-6 · Cited by 40 · see citing works

1,25-dyhydroxyvitamin D3 Attenuates l-DOPA-Induced Neurotoxicity in Neural Stem Cells

Jang, W., Park, H.-H., Lee, K. Y., Lee, Y. J., Kim, H.-T., & Koh, S. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8835-1 · Cited by 35 · see citing works

Waking action of ursodeoxycholic acid (UDCA) involves histamine and GABAA receptor block

Yanovsky, Y., Schubring, S. R., Yao, Q., Zhao, Y., Li, S., May, A., Haas, H. L., Lin, J.-S., & Sergeeva, O. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042512 · Cited by 34 · see citing works

Suppression of the HPA axis during extrahepatic biliary obstruction induces cholangiocyte proliferation in the rat

Quinn, M. A., Ueno, Y., Pae, H. Y., Huang, L., Frampton, G. A., Galindo, C., Francis, H., Horvat, D., McMillin, M., & DeMorrow, S. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00205.2011 · Cited by 33 · see citing works

Glucocorticoid receptor-dependent immunomodulatory effect of ursodeoxycholic acid on liver lymphocytes in mice

Takigawa, T., Miyazaki, H., Kinoshita, M., Kawarabayashi, N., Nishiyama, K., Hatsuse, K., Ono, S., Saitoh, D., Seki, S., & Yamamoto, J. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00205.2012 · Cited by 31 · see citing works

Ameliorative Effects of a Combination of Baicalin, Jasminoidin and Cholic Acid on Ibotenic Acid-Induced Dementia Model in Rats

Zhang, J., Li, P., Wang, Y., Liu, J., Zhang, Z., Cheng, W., & Wang, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056658 · Cited by 27 · see citing works

Detection of monohydroxy “bile” acids in the brains of guinea pigs afflicted with experimental allergic encephalomyelitis

Naqvi, S. H. M., Herndon, B., Kelley, M. T., Bleisch, V. R., Aexel, R. T., & Nicholas, H. J. (1969) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42655-0 · Cited by 24 · see citing works

One-Year Mortality after Traumatic Brain Injury in Liver Cirrhosis Patients—A Ten-Year Population-Based Study

Cheng, C.-Y., Ho, C., Wang, C.-C., Liang, F., Wang, J., Chio, C., Chang, C.-H., & Kuo, J. (2015) · Medicine · doi:10.1097/md.0000000000001468 · Cited by 23 · see citing works

Effects of Bile Acids and the Bile Acid Receptor FXR Agonist on the Respiratory Rhythm in the In Vitro Brainstem Medulla Slice of Neonatal Sprague-Dawley Rats

Zhao, C., Wang, X., Cong, Y.-L., Deng, Y., Xu, Y., Chen, A., & Yin, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112212 · Cited by 21 · see citing works

Identification and Analysis of CYP7A1, CYP17A1, CYP20A1, CYP27A1 and CYP51A1 in Cynomolgus Macaques

Uno, Y., Hosaka, S., & Yamazaki, H. (2014) · Journal of Veterinary Medical Science · doi:10.1292/jvms.14-0313 · Cited by 21 · see citing works

Detection of lithocholic acid in multiple sclerosis brain tissue

Naqvi, S. H. M., Ramsey, R. B., & Nicholas, H. J. (1970) · Lipids · doi:10.1007/bf02532752 · Cited by 18 · see citing works

The pregnane xenobiotic receptor, a prominent liver factor, has actions in the midbrain for neurosteroid synthesis and behavioral/neural plasticity of female rats

Frye, C. A., Koonce, C. J., & Walf, A. A. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00060 · Cited by 18 · see citing works

Conversion of 3-keto-5β-cholanoic acid to lithocholic acid by guinea pig brain tissue, in vitro

Naqvi, S. H. M., & Nicholas, H. J. (1970) · Steroids · doi:10.1016/s0039-128x(70)80115-5 · Cited by 11 · see citing works

Glucocorticoid receptor-dependent immunomodulatory effect of ursodeoxycholic acid on liver lymphocytes in mice

Kinoshita, M., Miyazaki, H., Nakashima, H., & Seki, S. (2013) · Frontiers in Immunology · doi:10.3389/conf.fimmu.2013.02.00677 · Cited by 1 · see citing works

Functions of Gut Microbiota Metabolites, Current Status and Future Perspectives

Liu, J., Tan, Y., Cheng, H., Zhang, D., Feng, W., & Peng, C. (2022) · Aging and disease · doi:10.14336/ad.2022.0104 · Cited by 529 · see citing works

Bile Acids as Metabolic Regulators and Nutrient Sensors

Chiang, J. Y. L., & Ferrell, J. M. (2019) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082018-124344 · Cited by 440 · see citing works

Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis

Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works

Gut microbial molecules in behavioural and neurodegenerative conditions

Needham, B. D., Kaddurah-Daouk, R., & Mazmanian, S. K. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-00381-0 · Cited by 379 · see citing works

Bile acid signaling pathways from the enterohepatic circulation to the central nervous system

Mertens, K. L., Kalsbeek, A., Soeters, M. R., & Eggink, H. M. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00617 · Cited by 287 · see citing works

Tauroursodeoxycholate—Bile Acid with Chaperoning Activity: Molecular and Cellular Effects and Therapeutic Perspectives

Kusaczuk, M. (2019) · Cells · doi:10.3390/cells8121471 · Cited by 244 · see citing works

Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation

Bhargava, P., Smith, M. D., Mische, L., Harrington, E., Fitzgerald, K. C., Martin, K. A., Kim, S., Reyes, A. A., Cardona, J. G., Volsko, C. M., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci129401 · Cited by 236 · see citing works

Gut Microbiota-Derived Components and Metabolites in the Progression of Non-Alcoholic Fatty Liver Disease (NAFLD)

Ji, Y. S., Yin, Y., Li, Z., & Zhang, W. (2019) · Nutrients · doi:10.3390/nu11081712 · Cited by 230 · see citing works

Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer’s Disease

Baloni, P., Funk, C. C., Yan, J., Yurkovich, J. T., Kueider-Paisley, A., Nho, K., Heinken, A., Jia, W., Mahmoudiandehkordi, S., Louie, G., et al. (2020) · Cell Reports Medicine · doi:10.1016/j.xcrm.2020.100138 · Cited by 211 · see citing works

X‐linked adrenoleukodystrophy: Pathology, pathophysiology, diagnostic testing, newborn screening and therapies

Turk, B. R., Theda, C., Fatemi, A. S., & Moser, A. B. (2020) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10003 · Cited by 206 · see citing works

Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia

Connell, E., Le Gall, G., Pontifex, M. G., Sami, S., Cryan, J. F., Clarke, G., Müller, M., & Vauzour, D. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00548-6 · Cited by 208 · see citing works

Gut Microbiome–Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders

Sasso, J. M., Ammar, R. M., Tenchov, R., Lemmel, S. A., Kelber, O., Grieswelle, M., & Zhou, Q. A. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00127 · Cited by 217 · see citing works

Central anorexigenic actions of bile acids are mediated by TGR5

Perino, A., Velázquez‐Villegas, L. A., Bresciani, N., Sun, Y., Huang, Q. D., Fénelon, V. S., Castellanos-Jankiewicz, A., Zizzari, P., Bruschetta, G., Jin, S., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00398-4 · Cited by 152 · see citing works

Gut Microbiota Dysbiosis Is Associated with Elevated Bile Acids in Parkinson’s Disease

Li, P., Killinger, B. A., Ensink, E., Beddows, I., Yilmaz, A., Lubben, N., Lamp, J., Schilthuis, M., Vega, I. E., Woltjer, R., et al. (2021) · Metabolites · doi:10.3390/metabo11010029 · Cited by 146 · see citing works

Metagenomic analysis of the human microbiome reveals the association between the abundance of gut bile salt hydrolases and host health

Jia, B., Park, D., Hahn, Y., & Jeon, C. O. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1748261 · Cited by 135 · see citing works

The bile acid TUDCA and neurodegenerative disorders: An overview

Zangerolamo, L., Vettorazzi, J. F., Rosa, L. R. D. O., Carneiro, E. M., & Barbosa, H. C. L. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119252 · Cited by 127 · see citing works

From dried bear bile to molecular investigation: A systematic review of the effect of bile acids on cell apoptosis, oxidative stress and inflammation in the brain, across pre-clinical models of neurological, neurodegenerative and neuropsychiatric disorders

Huang, F., Pariante, C. M., & Borsini, A. (2022) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2021.09.021 · Cited by 117 · see citing works

Gut microbiota dysbiosis in functional gastrointestinal disorders: Underpinning the symptoms and pathophysiology

Wei, L., Singh, R., Ro, S., & Ghoshal, U. C. (2021) · JGH Open · doi:10.1002/jgh3.12528 · Cited by 127 · see citing works

Bile acids as key modulators of the brain-Gut-Microbiota axis in alzheimer’s disease

Mulak, A. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210608 · Cited by 114 · see citing works

Probiotics ameliorate intestinal pathophysiology in a mouse model of Alzheimer’s disease

Kaur, H., Nagamoto‐Combs, K., Golovko, S. A., Golovko, M. Y., Klug, M. G., & Combs, C. K. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.04.009 · Cited by 112 · see citing works

Mangiferin alleviated poststroke cognitive impairment by modulating lipid metabolism in cerebral ischemia/reperfusion rats

Zhang, H., Wang, L., Wang, X., Deng, L., He, B., Xia, Y., & Li, J. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176724 · Cited by 109 · see citing works

Pathogenesis of Hepatic Encephalopathy in Chronic Liver Disease

Ochoa‐Sanchez, R., & Rose, C. F. (2018) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2018.08.001 · Cited by 89 · see citing works

Nigral overexpression of α-synuclein in a rat Parkinson's disease model indicates alterations in the enteric nervous system and the gut microbiome

O’Donovan, S. M., Crowley, E. K., Brown, J. R. ‐., O’Sullivan, O., O’Leary, O. F., Timmons, S., Nolan, Y. M., Clarke, D. J., Hyland, N. P., Joyce, S. A., et al. (2020) · Neurogastroenterology &amp; Motility · doi:10.1111/nmo.13726 · Cited by 86 · see citing works

Takeda G Protein–Coupled Receptor 5 Modulates Depression-like Behaviors via Hippocampal CA3 Pyramidal Neurons Afferent to Dorsolateral Septum

Wang, H., Tan, Y.-Z., Mu, R.-H., Tang, S., Liu, X., Xing, S.-Y., Long, Y., Yuan, D.-H., & Hong, H. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.11.018 · Cited by 81 · see citing works

Carotenoids Diet: Digestion, Gut Microbiota Modulation, and Inflammatory Diseases

Rocha, H. R., Coelho, M. C., Gomes, A., & Pintado, M. (2023) · Nutrients · doi:10.3390/nu15102265 · Cited by 78 · see citing works

Tauroursodeoxycholic acid alleviates secondary injury in spinal cord injury mice by reducing oxidative stress, apoptosis, and inflammatory response

Hou, Y., Luan, J., Huang, T., Deng, T., Li, X., Xiao, Z., Zhan, J., Luo, D., Hou, Y., Xu, L., et al. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02248-2 · Cited by 77 · see citing works

Probiotic bacteria and bile acid profile are modulated by prebiotic diet and associate with facilitated diurnal clock/sleep realignment after chronic disruption of rhythms

Thompson, R. S., Gaffney, M., Hopkins, S., Kelley, T., González, A., Bowers, S. J., Vitaterna, M. H., Turek, F. W., Foxx, C. L., Lowry, C. A., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.07.006 · Cited by 80 · see citing works

Gut microbiome structure and adrenocortical activity in dogs with aggressive and phobic behavioral disorders

Mondo, E., Barone, M., Soverini, M., D’Amico, F., Cocchi, M., Petrulli, C. A., Mattioli, M., Marliani, G., Candela, M., & Accorsi, P. A. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e03311 · Cited by 76 · see citing works

Unraveling the Role of the Human Gut Microbiome in Health and Diseases

Khalil, M., Ciaula, A. D., Mahdi, L., Jaber, N., Palo, D. M. D., Graziani, A., Baffy, G., & Portincasa, P. (2024) · Microorganisms · doi:10.3390/microorganisms12112333 · Cited by 98 · see citing works

Review: The bile acids urso- and tauroursodeoxycholic acid as neuroprotective therapies in retinal disease.

Daruich, A., Picard, É., Boatright, J. H., & Béhar‐Cohen, F. (2019) · PubMed Central · Cited by 73 · see citing works

Nutritional Modulation of Immune and Central Nervous System Homeostasis: The Role of Diet in Development of Neuroinflammation and Neurological Disease

Estrada, J. A., & Contreras, I. (2019) · Nutrients · doi:10.3390/nu11051076 · Cited by 65 · see citing works

Choroid Plexus Blood-CSF Barrier: Major Player in Brain Disease Modeling and Neuromedicine

Johanson, C. E. (2018) · Journal of Neurology and Neuromedicine · doi:10.29245/2572.942x/2018/4.1194 · Cited by 62 · see citing works

Enterochromaffin Cells–Gut Microbiota Crosstalk: Underpinning the Symptoms, Pathogenesis, and Pharmacotherapy in Disorders of Gut-Brain Interaction

Wei, L., Singh, R., & Ghoshal, U. C. (2022) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm22008 · Cited by 65 · see citing works

Gut-Brain Axis a Key Player to Control Gut Dysbiosis in Neurological Diseases

Pan, I., Issac, P. K., Rahman, M. M., Guru, A., & Arockiaraj, J. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03691-3 · Cited by 60 · see citing works

Gut microbiome: An intermediary to neurotoxicity

Dempsey, J. L., Little, M., & Cui, J. Y. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.08.005 · Cited by 62 · see citing works

The gut microbiota-bile acid axis: a crucial regulator of immune function and metabolic health

Tyagi, A., & Kumar, V. (2025) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-025-04395-7 · Cited by 60 · see citing works

The contribution of age-related changes in the gut-brain axis to neurological disorders

Khan, R., Gesù, C. M. D., Lee, J., & McCullough, L. D. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2302801 · Cited by 60 · see citing works

Reduced bile acid excretion is an independent risk factor for stroke and mortality: A prospective follow-up study

Charach, G., Karniel, E., Novikov, I., Galin, L., Vons, S., Grosskopf, I., & Charach, L. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.12.010 · Cited by 56 · see citing works

The pathophysiological function of non-gastrointestinal farnesoid X receptor

Yan, N., Yan, T., Xia, Y., Hao, H., Wang, G., & Gonzalez, F. J. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107867 · Cited by 54 · see citing works

Nutrition and Gastrointestinal Microbiota, Microbial-Derived Secondary Bile Acids, and Cardiovascular Disease

Rodríguez-Morató, J., & Matthan, N. R. (2020) · Current Atherosclerosis Reports · doi:10.1007/s11883-020-00863-7 · Cited by 53 · see citing works

Organ cross-talk: molecular mechanisms, biological functions, and therapeutic interventions for diseases

Che, H., Gao, Y., Xu, Y., Xu, H., Eils, R., & Tian, M. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02329-1 · Cited by 55 · see citing works

Implications of glial metabolic dysregulation in the pathophysiology of neurodegenerative diseases

Afridi, R., Rahman, M. H., & Suk, K. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105874 · Cited by 53 · see citing works

Therapeutic targeting of nuclear receptors, liver X and retinoid X receptors, for Alzheimer's disease

Fitz, N. F., Nam, K. N., Koldamova, R. P., & Lefterov, I. M. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14668 · Cited by 50 · see citing works

Maternal high-fat diet in mice induces cerebrovascular, microglial and long-term behavioural alterations in offspring

Bordeleau, M., Comin, C. H., de Cossío, L. F., Lacabanne, C., Freitas-Andrade, M., Ibáñez, F. G., Raman-Nair, J., Wakem, M., Chakravarty, M., Costa, L. D. F., et al. (2022) · Communications Biology · doi:10.1038/s42003-021-02947-9 · Cited by 51 · see citing works

Gut Biofactory—Neurocompetent Metabolites within the Gastrointestinal Tract. A Scoping Review

Skonieczna‐Żydecka, K., Jakubczyk, K., Maciejewska, D., Janda, K., Kaźmierczak-Siedlecka, K., Kaczmarczyk, M., Łoniewski, I., & Marlicz, W. M. (2020) · Nutrients · doi:10.3390/nu12113369 · Cited by 50 · see citing works

Structural and biochemical investigation of MARK4 inhibitory potential of cholic acid: Towards therapeutic implications in neurodegenerative diseases

Anwar, S., Shamsi, A., Kar, R. K., Queen, A., Islam, A., Ahmad, F., & Hassan, M. I. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.06.078 · Cited by 49 · see citing works

Coconut oil as a therapeutic treatment for alzheimer's disease: a review

Sandupama, P., Munasinghe, D., & Jayasinghe, M. A. (2022) · Journal of Future Foods · doi:10.1016/j.jfutfo.2022.03.016 · Cited by 47 · see citing works

Donor-recipient intermicrobial interactions impact transfer of subspecies and fecal microbiota transplantation outcome

Chen, Q., Wu, C., Xu, J., Ye, C., Chen, X., Tian, H., Zong, N., Zhang, S., Li, L., Gao, Y., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.01.013 · Cited by 48 · see citing works

Redox‐Dependent Effects in the Physiopathological Role of Bile Acids

Orozco-Aguilar, J., Simón, F., & Cabello‐Verrugio, C. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/4847941 · Cited by 43 · see citing works

Molecular mechanisms and therapeutic possibilities of short-chain fatty acids in posttraumatic stress disorder patients: a mini-review

Petakh, P., Duve, K. V., Oksenych, V., Behzadi, P., & Kamyshnyi, O. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1394953 · Cited by 45 · see citing works

TGR5 Agonist INT-777 Alleviates Inflammatory Neurodegeneration in Parkinson’s Disease Mouse Model by Modulating Mitochondrial Dynamics in Microglia

Huang, R., Gao, Y., Chen, J., Duan, Q., He, P., Zhang, J., Huang, H., Zhang, Q., Ma, G., Zhang, Y., et al. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.02.028 · Cited by 40 · see citing works

The Role of Bile Acids in the Human Body and in the Development of Diseases

Shulpekova, Y. O., Жаркова, М. С., Tkachenko, P. E., Тихонов, И. Н., Stepanov, A. A., Sinitsyna, A. A., Izotov, A., Butkova, T. V., Shulpekova, N. V., Лапина, Н. В., et al. (2022) · Molecules · doi:10.3390/molecules27113401 · Cited by 44 · see citing works

Molecular mechanism and therapeutic strategy of bile acids in Alzheimer’s disease from the emerging perspective of the microbiota–gut–brain axis

Wu, M., Cheng, Y., Zhang, R., Han, W., Jiang, H., Bi, C., Zhang, Z., Ye, M., Lin, X., & Liu, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117228 · Cited by 38 · see citing works

FXR-Mediated Cortical Cholesterol Accumulation Contributes to the Pathogenesis of Type A Hepatic Encephalopathy

McMillin, M., Grant, S. M., Frampton, G. A., Petrescu, A. D., Kain, J., Williams, E., Haines, R., Canady, L., & DeMorrow, S. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.02.008 · Cited by 38 · see citing works

Peripheral neuronal activation shapes the microbiome and alters gut physiology

Griffiths, J. A., Yoo, B. B., Thuy-Boun, P. S., Cantu, V., Weldon, K. C., Challis, C., Sweredoski, M. J., Chan, K. Y., Thron, T., Sharon, G., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113953 · Cited by 37 · see citing works

Hypothalamus-Pituitary-Adrenal Dysfunction in Cholestatic Liver Disease

Petrescu, A. D., Kain, J., Liere, V., Heavener, T. E., & DeMorrow, S. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00660 · Cited by 37 · see citing works

Liver Bile Acid Changes in Mouse Models of Alzheimer’s Disease

Kaur, H., Seeger, D. R., Golovko, S. A., Golovko, M. Y., & Combs, C. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147451 · Cited by 36 · see citing works

Role of Microglia in Regulating Cholesterol and Tau Pathology in Alzheimer’s Disease

Nanjundaiah, S., Chidambaram, H., Chandrashekar, M., & Chinnathambi, S. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00883-6 · Cited by 36 · see citing works

Metabolic Diffusion in Neuropathologies: The Relevance of Brain-Liver Axis

Vegas‐Suárez, S., Simón, J., Martínez‐Chantar, M. L., & Moratalla, R. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.864263 · Cited by 33 · see citing works

Gut–Brain Axis and Bile Acid Signaling: Linking Microbial Metabolism to Brain Function and Metabolic Regulation

Stanimirov, B., Đanić, M., Pavlović, N., Zaklan, D., Lazarević, S., Mikov, M., & Stankov, K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262412167 · Cited by 37 · see citing works

Linking Nonalcoholic Fatty Liver Disease and Brain Disease: Focusing on Bile Acid Signaling

Ren, Z., Li, C.-X., Ma, C., Chen, D., Chen, J., Xu, W., Chen, C.-A., Cheng, F., & Wang, X. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113045 · Cited by 32 · see citing works

Xanthohumol ameliorates Diet-Induced Liver Dysfunction via Farnesoid X Receptor-Dependent and Independent Signaling

Paraiso, I. L., Tran, T. Q., Magaña, A. A., Kundu, P., Choi, J., Maier, C. S., Bobe, G., Raber, J., Kioussi, C., & Stevens, J. F. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.643857 · Cited by 31 · see citing works

Liver’s influence on the brain through the action of bile acids

Yeo, X. Y., Tan, L. Y., Chae, W. R., Lee, D., Lee, Y., Wüestefeld, T., & Jung, S. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1123967 · Cited by 33 · see citing works

Effects of dietary restriction on gut microbiota and CNS autoimmunity

Cantoni, C., Dorsett, Y., Fontana, L., Zhou, Y., & Piccio, L. M. (2020) · Clinical Immunology · doi:10.1016/j.clim.2020.108575 · Cited by 31 · see citing works

Fecal Microbiota Transplantation in Gastrointestinal and Extraintestinal Disorders

Ianiro, G., Segal, J. P., Mullish, B. H., Quraishi, M. N., Porcari, S., Fabiani, G., Gasbarrini, A., & Cammarota, G. (2020) · Future Microbiology · doi:10.2217/fmb-2020-0061 · Cited by 31 · see citing works

A critical review of bile acids and their receptors in hepatic encephalopathy

Williams, E., Chu, C. S., & DeMorrow, S. (2021) · Analytical Biochemistry · doi:10.1016/j.ab.2021.114436 · Cited by 31 · see citing works

Pharmacological and Metabolic Significance of Bile Acids in Retinal Diseases

Win, A. S., Delgado, A. M., Jadeja, R. N., Martin, P. M., Bartoli, M., & Thounaojam, M. C. (2021) · Biomolecules · doi:10.3390/biom11020292 · Cited by 30 · see citing works

Gut-microbiota-directed strategies to treat epilepsy: clinical and experimental evidence

Granados, D. M. M., Villasana‐Salazar, B., Lozano‐García, L., Cavalheiro, É. A., & Striano, P. (2021) · Seizure · doi:10.1016/j.seizure.2021.03.009 · Cited by 30 · see citing works

Serum bile acids profiling by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and its application on pediatric liver and intestinal diseases

Fu, X., Xiao, Y., Golden, J. M., Niu, S., & Gayer, C. P. (2019) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2019-0354 · Cited by 29 · see citing works

Bile acid signalling and its role in anxiety disorders

Chen, S., Shao, Q., Chen, J., Lv, X., Ji, J., Liu, Y., & Song, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1268865 · Cited by 29 · see citing works

Liver Steatosis and Steatohepatitis Alter Bile Acid Receptors in Brain and Induce Neuroinflammation: A Contribution of Circulating Bile Acids and Blood-Brain Barrier

Fiaschini, N., Mancuso, M., Tanori, M., Colantoni, E., Vitali, R., Diretto, G., Lorenzo-Rebenaque, L., Stronati, L., & Negroni, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214254 · Cited by 27 · see citing works

Ursodeoxycholic acid as a potential alternative therapeutic approach for neurodegenerative disorders: Effects on cell apoptosis, oxidative stress and inflammation in the brain

Huang, F. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100348 · Cited by 27 · see citing works

Genetically personalised organ-specific metabolic models in health and disease

Foguet, C., Xu, Y., Ritchie, S. C., Lambert, S. A., Persyn, E., Nath, A. P., Davenport, E. E., Roberts, D. J., Paul, D. S., Angelantonio, E. D., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35017-7 · Cited by 27 · see citing works

Metabolomic signature of the Dravet syndrome: A genetic mouse model study

Miljanovic, N., van Dijk, R. M., Buchecker, V., & Potschka, H. (2021) · Epilepsia · doi:10.1111/epi.16976 · Cited by 26 · see citing works

Collaborative Metabolism: Gut Microbes Play a Key Role in Canine and Feline Bile Acid Metabolism

Rowe, J. C., & Winston, J. A. (2024) · Veterinary Sciences · doi:10.3390/vetsci11020094 · Cited by 26 · see citing works

Identification of amniotic fluid metabolomic and placental transcriptomic changes associated with abnormal development of cloned pig fetuses

Ao, Z., Li, Z., Wang, X., Zhao, C., Gan, Y., Wu, X. F., Zeng, F., Shi, J., Gu, T., Hong, L., et al. (2019) · Molecular Reproduction and Development · doi:10.1002/mrd.23102 · Cited by 23 · see citing works

The role of the gut microbiome in disorders of gut–brain interaction

Gawey, B. J., Mars, R. A. T., & Kashyap, P. (2024) · FEBS Journal · doi:10.1111/febs.17200 · Cited by 28 · see citing works

Research Progress on the Mechanism of Bile Acids and Their Receptors in Depression

Zhao, X., Zheng, I., Huang, W., Tang, D., Zhao, M., Hou, R., Huang, Y., Shi, Y., Zhu, W., & Wang, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094023 · Cited by 24 · see citing works

Role of Microbiota-Modified Bile Acids in the Regulation of Intracellular Organelles and Neurodegenerative Diseases

Kiriyama, Y., & Nochi, H. (2023) · Genes · doi:10.3390/genes14040825 · Cited by 22 · see citing works

Beyond metabolic messengers: Bile acids and TGR5 as pharmacotherapeutic intervention for psychiatric disorders

Darmanto, A. G., Yen, T., Jan, J., Linh, T. T. D., Taliyan, R., Yang, C. H., & Sheu, J. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107564 · Cited by 21 · see citing works

Microbiome influences on neuro-immune interactions in neurodegenerative disease

Menees, K. B., Otero, B. A., & Tansey, M. G. (2022) · International review of neurobiology · doi:10.1016/bs.irn.2022.07.006 · Cited by 23 · see citing works

Uncovering the behaviour of ions in the gas-phase to predict the ion mobility separation of isomeric steroid compounds

Hadavi, D., Borzova, M., Siegel, T. P., & Honing, M. (2022) · Analytica Chimica Acta · doi:10.1016/j.aca.2022.339617 · Cited by 20 · see citing works

Emerging Anti-Diabetic Drugs for Beta-Cell Protection in Type 1 Diabetes

Ajmal, N., Bogart, M. C., Khan, P., Max-Harry, I. M., & Nunemaker, C. S. (2023) · Cells · doi:10.3390/cells12111472 · Cited by 20 · see citing works

Neuroprotective effects of mesenchymal stromal cells in mouse models of Alzheimer’s Disease: The Mediating role of gut microbes and their metabolites via the Microbiome-Gut-Brain axis

Xing, C., Zhang, X., Wang, D., Chen, H., Gao, X., Sun, C., Guo, W., Roshan, S., Li, Y., Hang, Z., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.08.047 · Cited by 20 · see citing works

Diabetic cognitive dysfunction is associated with increased bile acids in liver and activation of bile acid signaling in intestine

Wang, X., Wang, F., Zhang, Y., Xiong, H., Zhang, Y., Zhuang, P., & Zhang, Y. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.01.006 · Cited by 20 · see citing works

Methylated Cytochrome P450 and the Solute Carrier Family of Genes Correlate With Perturbations in Bile Acid Metabolism in Parkinson’s Disease

Vishweswaraiah, S., Akyol, S., Yılmaz, A., Ugur, Z., Gordevičius, J., Oh, K. J., Brundin, P., Radhakrishna, U., Labrie, V., & Graham, S. F. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.804261 · Cited by 18 · see citing works

Bile acid modulation by gut microbiota: a bridge to understanding cognitive health

Sabahat, S. E., Saqib, M., Talib, M., Shaikh, T. G., Khan, T., & Kailash, S. J. (2024) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000002433 · Cited by 18 · see citing works

Late-Stage Glioma Is Associated with Deleterious Alteration of Gut Bacterial Metabolites in Mice

Herbreteau, A., Aubert, P., Croyal, M., Naveilhan, P., Billon‐Crossouard, S., Neunlist, M., Delneste, Y., Couez, D., & Aymeric, L. (2022) · Metabolites · doi:10.3390/metabo12040290 · Cited by 18 · see citing works

Bile acids as novel enhancers of CNS targeting antitumor drugs: a comprehensive review

Gvoic, M., Vukmirović, S., Al‐Salami, H., Mooranian, A., Mikov, M., & Stankov, K. (2021) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2021.1916032 · Cited by 17 · see citing works

Enhanced Activation of the S1PR2-IL-1β-Src-BDNF-TrkB Pathway Mediates Neuroinflammation in the Hippocampus and Cognitive Impairment in Hyperammonemic Rats

Sancho-Alonso, M., Arenas, Y. M., Izquierdo-Altarejos, P., Martínez-García, M., Llansola, M., & Felipo, V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417251 · Cited by 18 · see citing works

Glucocorticoid receptor-dependent therapeutic efficacy of tauroursodeoxycholic acid in preclinical models of spinocerebellar ataxia type 3

Duarte‐Silva, S., Silva, J. D. D., Monteiro‐Fernandes, D., Costa, M. D., Neves‐Carvalho, A., Raposo, M., Soares‐Cunha, C., Correia, J. S., Nogueira-Goncalves, G., Fernandes, H. S., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci162246 · Cited by 17 · see citing works

Metabolic and histopathological changes in the brain and plasma of rats exposed to fractionated whole-brain irradiation

Bálentová, S., Hnilicová, P., Kalenská, D., Baranovičová, E., Muríň, P., Bittšanský, M., Hajtmanová, E., Lehotský, J., & Adamkov, M. (2018) · Brain Research · doi:10.1016/j.brainres.2018.12.022 · Cited by 17 · see citing works

Untargeted Metabolomics of Slc13a5 Deficiency Reveal Critical Liver–Brain Axis for Lipid Homeostasis

Milosavljevic, S., Glinton, K. E., Li, X., Medeiros, C., Gillespie, P. J., Seavitt, J. R., Graham, B. H., & Elsea, S. H. (2022) · Metabolites · doi:10.3390/metabo12040351 · Cited by 17 · see citing works

Postbiotics and the gut–brain axis: A mechanistic review on modulating neuroinflammation and cognitive aging

Lahariya, R., Anand, G., Kumari, B., & Priyadarshi, K. (2026) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2026.578870 · Cited by 17 · see citing works

ApoE isoform-dependent effects of xanthohumol on high fat diet-induced cognitive impairments and hippocampal metabolic pathways

Kundu, P., Holden, S. J., Paraiso, I. L., Sudhakar, R., McQuesten, C., Choi, J., Miranda, C. L., Maier, C. S., Bobe, G., Stevens, J. F., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.954980 · Cited by 15 · see citing works

Hepatic interoception in health and disease

Berthoud, H., Münzberg, H., Morrison, C. D., & Neuhuber, W. (2024) · Autonomic Neuroscience · doi:10.1016/j.autneu.2024.103174 · Cited by 17 · see citing works

X-linked Adrenoleukodystrophy: Pathology, Pathophysiology, Diagnostic Testing, Newborn Screening, and Therapies

Turk, B. R., Theda, C., Fatemi, A. S., & Moser, A. B. (2019) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2019.11.002 · Cited by 17 · see citing works

TUDCA receptors and their role on pancreatic beta cells

Rosa, L. R. D. O., Vettorazzi, J. F., Zangerolamo, L., Carneiro, E. M., & Barbosa, H. C. L. (2021) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2021.09.003 · Cited by 15 · see citing works

Research progress on intranasal treatment for Parkinson's disease

Wen, P., & Ren, C. (2024) · Neuroprotection/Neuroprotection (Chichester, England. Print) · doi:10.1002/nep3.42 · Cited by 15 · see citing works

Bile Acids in Pancreatic Carcinogenesis

Sharma, B., Twelker, K., Nguyen, C., Ellis, S., Bhatia, N. D., Kuschner, Z. D., Agriantonis, A., Agriantonis, G., Arnold, M., Dave, J., et al. (2024) · Metabolites · doi:10.3390/metabo14070348 · Cited by 14 · see citing works

The biosynthesis, signaling, and neurological functions of bile acids

Kiriyama, Y., & Nochi, H. (2019) · Biomolecules · doi:10.3390/biom9060232 · Cited by 204 · see citing works

Bile acid signaling in neurodegenerative and neurological disorders

Grant, S. M., & DeMorrow, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21175982 · Cited by 185 · see citing works

Bile Acids and Their Value for Central Nervous System

Shulpekova, Y. O., Tkachenko, P. E., Shirokova, E. N., & Damulin, I. V. (2022) · Russian Journal of Gastroenterology Hepatology Coloproctology · doi:10.22416/1382-4376-2021-31-5-7-15 · Cited by 2 · see citing works

Bile Acid Metabolism and Signaling

Chiang, J. Y. L. (2013) · Comprehensive physiology · doi:10.1002/j.2040-4603.2013.tb00517.x · Cited by 286 · see citing works

Roles of bile acids signaling in neuromodulation under physiological and pathological conditions

Chen, X., Huang, X., Wang, D., Yu, D., Hou, S., Cui, H., & Song, L. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01053-z · Cited by 120 · see citing works