Methamphetamine administration targets multiple immune subsets and induces phenotypic alterations suggestive of immunosuppression
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Methamphetamine (Meth) is a widely abused stimulant and its users are at increased risk for multiple infectious diseases. To determine the impact of meth on the immune system, we utilized a murine model that simulates the process of meth consumption in a typical addict. Our phenotypic analysis of leukocytes from this dose escalation model revealed that meth affected key immune subsets. Meth administration led to a decrease in abundance of natural killer (NK) cells and the remaining NK cells possessed a phenotype suggesting reduced responsiveness. Dendritic cells (DCs) and Gr-1(high) monocytes/macrophages were also decreased in abundance while Gr-1(low) monocytes/macrophages appear to show signs of perturbation. CD4 and CD8 T cell subsets were affected by methamphetamine, both showing a reduction in antigen-experienced subsets. CD4 T cells also exhibited signs of activation, with increased expression of CD150 on CD226-expressing cells and an expansion of KLRG1(+), FoxP3(-) cells. These results exhibit that meth has the ability to disrupt immune homeostasis and impact key subsets of leukocytes which may leave users more vulnerable to pathogens.
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Regular methamphetamine use is associated with various harms and symptoms including psychosis, mood swings, insomnia, skin lesions, depression, malnutrition, respiratory illness, gum disease, severe tooth decay, risky behaviours, and endocarditis.
“Regular methamphetamine use is associated with various harms and symptoms including psychosis, mood swings, insomnia, skin lesions, depression, malnutrition, respiratory illness, gum disease and severe tooth decay, risky behaviours (e.g., criminal behaviours, injection of other illicit substances, sexual practices that increase risk of sexually transmitted infections), and endocarditis [1, 7–18].”
From Psychosocial and pharmacologic interventions for problematic methamphetamine use: Findings from a scoping review of the literature (2023) · cites this paper as [7]
The Introduction (page unavailable) reports sleeplessness, reduced appetite, and increased infection risk linked to risky sexual practices and intravenous drug use. It does not establish several other listed harms, including psychosis, depression, dental disease, respiratory illness, and endocarditis; reduced appetite alone does not establish malnutrition. (LLM, conf=0.88)
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Cites
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,366 · see citing works
Nahrendorf, M., Swirski, F. K., Aikawa, E., Stangenberg, L., Wurdinger, T., Figueiredo, J.-L., Libby, P., Weissleder, R., & Pittet, M. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070885 · Cited by 2,300 · see citing works
Identification of splenic reservoir monocytes and their deployment to inflammatory sites
Swirski, F. K., Nahrendorf, M., Etzrodt, M., Wildgruber, M., Cortez-Retamozo, V., Panizzi, P., Figueiredo, J.-L., Kohler, R. H., Chudnovskiy, A., Waterman, P., et al. (2009) · Science · doi:10.1126/science.1175202 · Cited by 2,221 · see citing works
Butte, M. J., Keir, M. E., Phamduy, T. B., Sharpe, A. H., & Freeman, G. J. (2007) · Immunity · doi:10.1016/j.immuni.2007.05.016 · Cited by 1,733 · see citing works
Sharpe, A. H., & Freeman, G. J. (2002) · Nature reviews. Immunology · doi:10.1038/nri727 · Cited by 1,719 · see citing works
Regulatory T cells exert checks and balances on self tolerance and autoimmunity
Wing, K., & Sakaguchi, S. (2009) · Nature Immunology · doi:10.1038/ni.1818 · Cited by 1,110 · see citing works
Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice
Daley, J. M., Thomay, A. A., Connolly, M. D., Reichner, J. S., & Albina, J. E. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0407247 · Cited by 1,047 · see citing works
CD45: A Critical Regulator of Signaling Thresholds in Immune Cells
Hermiston, M. L., Xu, Z., & Weiss, A. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.140946 · Cited by 950 · see citing works
Maturation of mouse NK cells is a 4-stage developmental program
Chiossone, L., Chaix, J., Fuséri, N., Roth, C., Vivier, É., & Walzer, T. (2009) · Blood · doi:10.1182/blood-2008-10-187179 · Cited by 778 · see citing works
CD27 Dissects Mature NK Cells into Two Subsets with Distinct Responsiveness and Migratory Capacity
Hayakawa, Y., & Smyth, M. J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.3.1517 · Cited by 752 · see citing works
A review of the clinical pharmacology of methamphetamine.
Cruickshank, C., & Dyer, K. (2009) · Addiction · doi:10.1111/j.1360-0443.2009.02564.x · Cited by 747 · see citing works
NK cells and cancer immunosurveillance
Waldhauer, I., & Steinle, A. (2008) · Oncogene · doi:10.1038/onc.2008.267 · Cited by 682 · see citing works
Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates
Sarkar, S., Kalia, V., Haining, W. N., Konieczny, B. T., Subramaniam, S., & Ahmed, R. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071641 · Cited by 633 · see citing works
Natural killer cells act as rheostats modulating antiviral T cells
Waggoner, S. N., Cornberg, M., Selin, L. K., & Welsh, R. M. (2011) · Nature · doi:10.1038/nature10624 · Cited by 607 · see citing works
Methamphetamine toxicity and messengers of death
Krasnova, I. N., & Cadet, J. L. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.03.002 · Cited by 589 · see citing works
Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46
Walzer, T., Bléry, M., Chaix, J., Fuséri, N., Chasson, L., Robbins, S. H., Jaeger, S., André, P., Gauthier, L., Daniel, L., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609692104 · Cited by 476 · see citing works
NORDAHL, T. E., Salo, R. E., & Leamon, M. H. (2003) · Journal of Neuropsychiatry · doi:10.1176/jnp.15.3.317 · Cited by 370 · see citing works
The Methamphetamine Problem in the United States
Gonzales, R. E., Mooney, L. J., & Rawson, R. A. (2010) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.012809.103600 · Cited by 358 · see citing works
Monocyte subpopulations and their differentiation patterns during infection
Strauss‐Ayali, D., Conrad, S. M., & Mosser, D. M. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0307191 · Cited by 348 · see citing works
NK Cell Maturation and Peripheral Homeostasis Is Associated with KLRG1 Up-Regulation
Huntington, N. D., Tabarias, H. A., Fairfax, K. A., Brady, J., Hayakawa, Y., Degli‐Esposti, M. A., Smyth, M. J., Tarlinton, D. M., & Nutt, S. L. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.4764 · Cited by 340 · see citing works
B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance
Park, J., Omiya, R., Matsumura, Y., Sakoda, Y., Kuramasu, A., Augustine, M. M., Yao, S., Tsushima, F., Narazaki, H., Anand, S., et al. (2010) · Blood · doi:10.1182/blood-2010-01-265975 · Cited by 331 · see citing works
Thomas, D. M., Walker, P. D., Benjamins, J. A., Geddes, T. J., & Kuhn, D. M. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.070961 · Cited by 315 · see citing works
The immunological synapse and CD28-CD80 interactions
Bromley, S. K., Iaboni, A., Davis, S. J., Whitty, A., Green, J. M., Shaw, A. S., Weiss, A., & Dustin, M. L. (2001) · Nature Immunology · doi:10.1038/ni737 · Cited by 311 · see citing works
Tacke, F., Ginhoux, F., Jakubzick, C., van Rooijen, N., Mérad, M., & Randolph, G. J. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052119 · Cited by 282 · see citing works
Ito, M., Maruyama, T., Saito, N., Koganei, S., Yamamoto, K., & Matsumoto, N. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051986 · Cited by 260 · see citing works
Schif‐Zuck, S., Gross, N., Assi, S., Rostoker, R., Serhan, C. N., & Ariel, A. (2010) · European Journal of Immunology · doi:10.1002/eji.201040801 · Cited by 236 · see citing works
Interaction of human PD-L1 and B7-1
Butte, M. J., Peña‐Cruz, V., Kim, M., Freeman, G. J., & Sharpe, A. H. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2008.05.014 · Cited by 229 · see citing works
Ellis, R. J., Childers, M. E., Cherner, M., Lazzaretto, D., Letendre, S. L., & Grant, I. (2003) · The Journal of Infectious Diseases · doi:10.1086/379894 · Cited by 216 · see citing works
Role of CD27/CD70 pathway of activation in immunity and tolerance
Denoeud, J., & Moser, M. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0610351 · Cited by 197 · see citing works
Reiley, W. W., Shafiani, S., Wittmer, S. T., Tucker-Heard, G., Moon, J. J., Jenkins, M. K., Urdahl, K. B., Winslow, G. M., & Woodland, D. L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006298107 · Cited by 179 · see citing works
Trends in Production, Trafficking, and Consumption of Methamphetamine and Cocaine in Mexico
Brouwer, K. C., Case, P., Ramos, R. L., Magis-Rodríguez, C. L., Bucardo, J., Patterson, T. L., & Strathdee, S. A. (2006) · Substance Use & Misuse · doi:10.1080/10826080500411478 · Cited by 178 · see citing works
Distribution and Pharmacokinetics of Methamphetamine in the Human Body: Clinical Implications
Volkow, N. D., Fowler, J. S., Wang, G., Shumay, E., Telang, F., Thanos, P. K., & Alexoff, D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015269 · Cited by 167 · see citing works
Robbins, S. H., Nguyen, K. B., Takahashi, N., Mikayama, T., Biron, C. A., & Brossay, L. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.6.2585 · Cited by 159 · see citing works
Illicit Drug Use and Treatment in South Africa: A Review
Peltzer, K., Ramlagan, S., Johnson, B. D., & Phaswana-Mafuya, N. R. (2010) · Substance Use & Misuse · doi:10.3109/10826084.2010.481594 · Cited by 159 · see citing works
The rise of methamphetamine in Southeast and East Asia
McKetin, R., Kozel, N. J., Douglas, J., Ali, R. L., Vicknasingam, B. K., Lund, J., & Li, J. (2008) · Drug and Alcohol Review · doi:10.1080/09595230801923710 · Cited by 153 · see citing works
Rivière, G., Gentry, W., & Owens, S. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35387-x · Cited by 151 · see citing works
Methamphetamine Inhibits Antigen Processing, Presentation, and Phagocytosis
Tallóczy, Z., Martínez, J., Joset, D., Ray, Y., Gácser, A., Toussi, S., Mizushima, N., Nosanchuk, J., Goldstein, H., Loike, J., et al. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.0040028 · Cited by 147 · see citing works
Methamphetamine Enhances HIV Infection of Macrophages
Liang, H., Wang, X., Chen, H., Li, S., Ye, L., Wang, S.-H., Wang, Y., Zhou, L., & Ho, W. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070971 · Cited by 147 · see citing works
Potula, R., Hawkins, B., Cenna, J., Fan, S., Dykstra, H., Ramirez, S., Morsey, B., Brodie, M. R., & Persidsky, Y. (2010) · Journal of Immunology · doi:10.4049/jimmunol.0903691 · Cited by 115 · see citing works
Li, Y., Hofmann, M., Wang, Q., Teng, L., Chlewicki, L. K., Pircher, H., & Mariuzza, R. A. (2009) · Immunity · doi:10.1016/j.immuni.2009.04.019 · Cited by 115 · see citing works
Dardalhon, V., Schubart, A., Reddy, J., Meyers, J. H., Monney, L., Sabatos, C. A., Ahuja, R., Nguyen, K., Freeman, G., Greenfield, E., et al. (2005) · Journal of Immunology · doi:10.4049/jimmunol.175.3.1558 · Cited by 111 · see citing works
Marcondes, M. C. G., Flynn, C. T., Watry, D. D., Zandonatti, M. A., & Fox, H. S. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090953 · Cited by 98 · see citing works
Forrest, D. W., Metsch, L. R., LaLota, M., Cardenas, G. A., Beck, D. W., & Jeanty, Y. (2010) · Journal of Urban Health · doi:10.1007/s11524-009-9422-z · Cited by 94 · see citing works
Corsi, K. F., & Booth, R. (2008) · Current Drug Abuse Reviews · doi:10.2174/1874473710801030292 · Cited by 90 · see citing works
Characterization of mouse CD4 T cell subsets defined by expression of KLRG1
Beyersdorf, N., Ding, X., Tietze, J. K., & Hanke, T. (2007) · European Journal of Immunology · doi:10.1002/eji.200737126 · Cited by 81 · see citing works
The role of SAP in murine CD150 (SLAM)-mediated T-cell proliferation and interferon γ production
Howie, D., Okamoto, S., Rietdijk, S. T., Clarke, K., Wang, N., Gullo, C. A., Bruggeman, J. P., Manning, S., Coyle, A. J., Greenfield, E. A., et al. (2002) · Blood · doi:10.1182/blood-2002-02-0445 · Cited by 81 · see citing works
Multiple Modes of Hepatitis A Virus Transmission among Methamphetamine Users
Hutin, Y. J., Sabin, K. M., Hutwagner, L., Schaben, L., Shipp, G. M., Lord, D., Conner, J. S., Quinlisk, M. P., Shapiro, C. N., & Bell, B. P. (2000) · American Journal of Epidemiology · doi:10.1093/aje/152.2.186 · Cited by 80 · see citing works
Chronic methamphetamine exposure alters immune function in normal and retrovirus-infected mice
Yu, Q., Zhang, D., Walston, M., Zhang, J., Liu, Y., & WATSON, R. R. (2002) · International Immunopharmacology · doi:10.1016/s1567-5769(02)00047-4 · Cited by 79 · see citing works
Methamphetamine Enhances Histoplasmosis by Immunosuppression of the Host
Martinez, L. R., Mihu, M. R., Gácser, A., Santambrogio, L., & Nosanchuk, J. D. (2009) · The Journal of Infectious Diseases · doi:10.1086/599328 · Cited by 79 · see citing works
Methamphetamine Use and Risk for HIV Among Young Men Who Have Sex With Men in 8 US Cities
Freeman, P. (2011) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpediatrics.2011.118 · Cited by 72 · see citing works
The Economic Cost of Methamphetamine Use in the United States, 2005
Nicosia, N., Pacula, R., Kilmer, B., Lundberg, R., & Chiesa, J. (2009) · doi:10.7249/mg829 · Cited by 70 · see citing works
Hepatitis C virus infection among methamphetamine-dependent individuals in outpatient treatment
Gonzales, R. E., Marinelli‐Casey, P., SHOPTAW, S. J., Ang, A., & Rawson, R. A. (2006) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2006.04.006 · Cited by 68 · see citing works
House, R. V., Thomas, P. T., & Bhargava, H. N. (1994) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923979409029897 · Cited by 67 · see citing works
Methamphetamine Administration Produces Immunomodulation in Mice
In, S.-W., Son, E.-W., Rhee, D., & Pyo, S. (2005) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390500177156 · Cited by 64 · see citing works
Methamphetamine Use and Methicillin-Resistant Staphylococcus aureus Skin Infections
Cohen, A. L., Shuler, C. M., McAllister, S. K., Fosheim, G. E., Brown, M. G., Abercrombie, D., Anderson, K. F., McDougal, L. K., Drenzek, C. L., Arnold, K., et al. (2007) · Emerging infectious diseases · doi:10.3201/eid1311.070148 · Cited by 62 · see citing works
Ly6Clow Monocytes Differentiate into Dendritic Cells and Cross-Tolerize T Cells through PDL-1
Peng, Y., Latchman, Y. E., & Elkon, K. B. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803172 · Cited by 52 · see citing works
Detection of methamphetamine and amphetamine in a skeletonized body buried for 5 years
Kojima, T., Okamoto, I., Miyazaki, T., Chikasue, F., Yashiki, M., & Nakamura, K. (1986) · Forensic Science International · doi:10.1016/0379-0738(86)90193-3 · Cited by 51 · see citing works
Marshall, B. D. L., Wood, E., Shoveller, J., Patterson, T. L., Montaner, J. S. G., & Kerr, T. H. (2011) · BMC Public Health · doi:10.1186/1471-2458-11-20 · Cited by 50 · see citing works
Iwasa, M., Maeno, Y., Inoue, H., Koyama, H., & Matoba, R. (1996) · International Journal of Legal Medicine · doi:10.1007/bf01369597 · Cited by 48 · see citing works
Methamphetamine and amphetamine concentrations in postmortem rabbit tissues
Nagata, Τ., Kimura, K., Hara, K., & Kudo, K. (1990) · Forensic Science International · doi:10.1016/0379-0738(90)90270-9 · Cited by 47 · see citing works
Sheridan, J. L., Butler, R., & Wheeler, A. (2009) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2009.10400670 · Cited by 47 · see citing works
Characterization of murine CD160+ CD8+ T lymphocytes
Tsujimura, K., Obata, Y., Matsudaira, Y., Nishida, K., Akatsuka, Y., Ito, Y., Demachi‐Okamura, A., Kuzushima, K., & Takahashi, T. (2006) · Immunology Letters · doi:10.1016/j.imlet.2006.04.006 · Cited by 45 · see citing works
Methamphetamine enhances Hepatitis C virus replication in human hepatocytes
Ye, L., Peng, J. S., Wang, X., Wang, Y. J., Luo, G. G., & Ho, W. (2008) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2007.00940.x · Cited by 45 · see citing works
Effects of Single or Repeated Administrations of Methamphetamine on Immune Response in Mice
Saito, M., Terada, M., Kawata, T., Ito, H., Shigematsu, N., Kromkhun, P., Yokosuka, M., & Saito, T. R. (2008) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.57.35 · Cited by 40 · see citing works
Methamphetamine use among gay men across the UK
Bonell, C. P., Hickson, F. C. I., Weatherburn, P., & Reid, D. (2009) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2009.07.002 · Cited by 37 · see citing works
NK Cells and their Receptors during Viral Infections
Marcenaro, E., Carlomagno, S., Pesce, S., Chiesa, M. D., Parolini, S., Moretta, A., & Sivori, S. (2011) · Immunotherapy · doi:10.2217/imt.11.99 · Cited by 28 · see citing works
Wey, S., Wu, H., Chang, F., & Jan, T. (2008) · Toxicology Letters · doi:10.1016/j.toxlet.2008.07.015 · Cited by 27 · see citing works
Vogt, T. M., Perz, J. F., Houten, C. K. V., Harrington, R. D., Hansuld, T., Bialek, S. R., Johnston, R., Bratlie, R., & Williams, I. T. (2006) · Addiction · doi:10.1111/j.1360-0443.2006.01407.x · Cited by 27 · see citing works
MODULATION OF MURINE MACROPHAGE FUNCTION BY METHAMPHETAMINE
In, S.-W., Son, E.-W., Rhee, D., & Pyo, S. (2004) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390490514589 · Cited by 25 · see citing works
Degenhardt, L. J., Baker, A., & Maher, L. (2008) · Drug and Alcohol Review · doi:10.1080/09595230801956538 · Cited by 21 · see citing works
Housseau, F., Moorthy, A., Langer, D., Robbins, P. F., Gonzales, M. I., & Topalian, S. L. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(200109)31:9 · Cited by 20 · see citing works
Saito, M., YAMAGUCHI, T., Kawata, T., Ito, H., 金井, 孝., Terada, M., Yokosuka, M., & Saito, T. R. (2006) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.55.477 · Cited by 20 · see citing works
Mau, M. K. L. M., Mau, & Mau (2008) · Vascular Health and Risk Management · doi:10.2147/vhrm.s4138 · Cited by 13 · see citing works
The York Region Methamphetamine Strategy
Kirkos, W. C., Carrique, T., Griffen, K., & Barge, A. P. L. (2008) · Canadian Medical Association Journal · doi:10.1503/cmaj.071299 · Cited by 7 · see citing works
Age-dependent, polyclonal hyperactivation of T cells is reduced in TNF-negativegld/gldmice
Wiede, F., Roomberg, A., Cretney, E., Lechner, A., Fromm, P. D., Wren, L. H., Smyth, M. J., & Körner, H. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0107018 · Cited by 7 · see citing works
Gagnon, L., Lacroix, F., Chan, J., & Buttar, H. S. (1992) · Toxicology Letters · doi:10.1016/0378-4274(92)90093-y · Cited by 6 · see citing works
[Detection of methamphetamine in a severely burned cadaver--a case report].
Sato, Y., Kondo, T., Takayasu, T., & Ohshima, T. (2000) · PubMed · Cited by 3 · see citing works
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Methamphetamine: Effects on the brain, gut and immune system
Prakash, M. D., Tangalakis, K., Antonipillai, J., Stojanovska, L., Nurgali, K., & Apostolopoulos, V. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.03.009 · Cited by 220 · see citing works
Neuroimmune Basis of Methamphetamine Toxicity
Loftis, J. M., & Janowsky, A. J. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801284-0.00007-5 · Cited by 121 · see citing works
Victor, T. A., Khalsa, S. S., Simmons, W. K., Feinstein, J. S., Savitz, J. B., Aupperle, R. L., Yeh, H., Bodurka, J., & Paulus, M. P. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-016620 · Cited by 114 · see citing works
Impact of methamphetamine on infection and immunity
Salamanca, S. A., Sorrentino, E. E., Nosanchuk, J. D., & Martinez, L. R. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00445 · Cited by 116 · see citing works
Methamphetamine and its immune-modulating effects
Papageorgiou, M., Raza, A., Fraser, S. J., Nurgali, K., & Apostolopoulos, V. (2018) · Maturitas · doi:10.1016/j.maturitas.2018.12.003 · Cited by 89 · see citing works
The Complex Interaction Between Methamphetamine Abuse and HIV-1 Pathogenesis
Passaro, R. C., Pandhare, J., Qian, H.-Z., & Dash, C. (2015) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9604-2 · Cited by 66 · see citing works
Methamphetamine Dysregulation of the Central Nervous System and Peripheral Immunity
Miller, D. R., Bu, M., Gopinath, A., Martinez, L. R., & Khoshbouei, H. (2021) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.121.000767 · Cited by 72 · see citing works
Drugs and Bugs: The Gut-Brain Axis and Substance Use Disorders
Simpson, S., Mclellan, R., Wellmeyer, E., Matalon, F., & George, O. (2021) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-021-10022-7 · Cited by 61 · see citing works
Role of microglia in methamphetamine-induced neurotoxicity.
Xu, E., Liu, J., Liu, H., Wang, X., & Xiong, H. (2017) · Europe PMC (PubMed Central) · Cited by 52 · see citing works
Methamphetamine Induces Systemic Inflammation and Anxiety: The Role of the Gut–Immune–Brain Axis
Davidson, M., Mayer, M., Habib, A., Rashidi, N., Filippone, R. T., Fraser, S. J., Prakash, M. D., Sinnayah, P., Tangalakis, K., Mathai, M. L., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911224 · Cited by 47 · see citing works
Mata, M. M., Napier, T. C., Graves, S. M., Mahmood, F., Raeisi, S., & Baum, L. L. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.02.002 · Cited by 47 · see citing works
Reduced number of peripheral natural killer cells in schizophrenia but not in bipolar disorder
Karpiński, P., Frydecka, D., Sasiadek, M. M., & Misiak, B. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.02.005 · Cited by 41 · see citing works
Methamphetamine alters T cell cycle entry and progression: role in immune dysfunction
Potula, R., Haldar, B., Cenna, J. M., Sriram, U., & Fan, S. (2018) · Cell Death Discovery · doi:10.1038/s41420-018-0045-6 · Cited by 40 · see citing works
Methamphetamine Inhibits HIV-1 Replication in CD4+ T Cells by Modulating Anti–HIV-1 miRNA Expression
Mantri, C. K., Mantri, J. V., Pandhare, J., & Dash, C. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.09.011 · Cited by 39 · see citing works
Sriram, U., Cenna, J. M., Haldar, B., Fernandes, N. C., Razmpour, R., Fan, S., Ramirez, S. H., & Potula, R. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.4a0814-395rr · Cited by 37 · see citing works
Loh, Z., Fitzsimmons, R. L., Reid, R. C., Ramnath, D., Clouston, A. D., Gupta, P. K., Irvine, K. M., Powell, E. E., Schroder, K., Stow, J. L., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14768 · Cited by 34 · see citing works
Gao, B., Li, L., Zhu, P., Zhang, M., Hou, L., Sun, Y., Liu, X., Peng, X., & Gu, Y. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.09.001 · Cited by 34 · see citing works
Hernandez-Santini, A. C., Mitha, A. N., Chow, D., Hamed, M. F., Gucwa, A. L., Vaval, V., & Martinez, L. R. (2021) · Scientific Reports · doi:10.1038/s41598-021-87728-4 · Cited by 25 · see citing works
In vivo effects of methamphetamine on HIV-1 replication: A population-based study
Jiang, J., Wang, M., Liang, B., Shi, Y. Y., Su, Q.-J., Chen, H., Huang, J., Su, J., Pan, P., Yu, L., et al. (2016) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.12.027 · Cited by 27 · see citing works
Who Knew? Dopamine Transporter Activity Is Critical in Innate and Adaptive Immune Responses
Gopinath, A., Mackie, P. M., Phan, L. T., Mirabel, R., Smith, A. R., Miller, E., Franks, S., Syed, O., Riaz, T., Law, B. K., et al. (2023) · Cells · doi:10.3390/cells12020269 · Cited by 26 · see citing works
Immune System and Methamphetamine: Molecular Basis of a Relationship
Macur, K., & Ciborowski, P. S. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210428121632 · Cited by 23 · see citing works
Drugs of Abuse and Their Impact on Viral Pathogenesis
Blackard, J. T., & Sherman, K. E. (2021) · Viruses · doi:10.3390/v13122387 · Cited by 24 · see citing works
Methamphetamine mediates immune dysregulation in a murine model of chronic viral infection
Sriram, U., Haldar, B., Cenna, J. M., Gofman, L., & Potula, R. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00793 · Cited by 23 · see citing works
Kalayasiri, R., Dadwat, K., Thika, S., Sirivichayakul, S., & Maes, M. H. J. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02645-6 · Cited by 22 · see citing works
Huemer, H. P. (2015) · Mediators of Inflammation · doi:10.1155/2015/349176 · Cited by 22 · see citing works
Karpiński, P., Samochowiec, J., Frydecka, D., Sasiadek, M. M., & Misiak, B. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.04.026 · Cited by 22 · see citing works
Fattakhov, N. S., Torices, S., Stangis, M., Park, M., & Toborek, M. J. (2021) · Viruses · doi:10.3390/v13091883 · Cited by 22 · see citing works
Role of Autophagy in HIV Pathogenesis and Drug Abuse
Cao, L., Glazyrin, A. L., Kumar, S., & Kumar, A. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0118-6 · Cited by 19 · see citing works
Hamel, C., Corace, K., Hersi, M., Rice, D., Willows, M., Macpherson, P., Sproule, B., Flores-Aranda, J., Garber, G., Esmaeilisaraji, L., et al. (2020) · Systematic Reviews · doi:10.1186/s13643-020-01499-z · Cited by 17 · see citing works
The overexpression of Thioredoxin-1 suppressing inflammation induced by methamphetamine in spleen
Wu, X., Li, X., Li, Y., Kong, L., Fang, J.-L., Zhou, X., Li, M., Jia, J., & Bai, J. (2015) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.11.021 · Cited by 15 · see citing works
Oladapo, A., Kannan, M., Deshetty, U. M., Singh, S., Buch, S. J., & Periyasamy, P. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103517 · Cited by 14 · see citing works
Hersi, M., Corace, K., Hamel, C., Esmaeilisaraji, L., Rice, D., Dryburgh, N., Skidmore, B., Garber, G., Porath, A., Willows, M., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0292745 · Cited by 13 · see citing works
Wu, H., Zhang, Z., Ma, Y., Chen, F., Xiong, P., Xie, Z., Ding, G., Yu, J., & Wang, K. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.961131 · Cited by 13 · see citing works
Shi, S., Sun, Y., Zan, G., & Zhao, M. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03372-z · Cited by 14 · see citing works
Behavioral and Gene Regulatory Responses to Developmental Drug Exposures in Zebrafish
Mech, A. M., Merteroglu, M., Sealy, I., Teh, M., White, R. J., Havelange, W., Brennan, C., & Busch-Nentwich, E. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.795175 · Cited by 11 · see citing works
Kuo, S.-C., Yeh, Y., Chen, C., Huang, C., Ho, P., Liang, C., Lin, C., Yeh, T., Tsou, C., Yang, B., et al. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.06.023 · Cited by 11 · see citing works
Romero-Carramiñana, I., Domínguez-Zorita, S., Esparza‐Moltó, P. B., & Cuezva, J. M. (2024) · iScience · doi:10.1016/j.isci.2024.109863 · Cited by 10 · see citing works
Intestinal barrier damage caused by addictive substance use disorder
Gao, Y., Kong, D., Sun, J., Ma, Z.-X., Wang, G.-Q., Ma, X., Sun, L., Luo, H.-Y., Xu, Y., & Wang, K. (2025) · European journal of medical research · doi:10.1186/s40001-025-02446-1 · Cited by 9 · see citing works
Bacterial and fungal infections in persons who inject drugs
Masters, J., Goodman‐Meza, D., Russell, D. M., Marks, L. R., McCreary, E. K., Jacka, B. P., Seear, K., Davis, J. S., Matthews, G. V., Martinello, M., et al. (2025) · Clinical Microbiology Reviews · doi:10.1128/cmr.00162-23 · Cited by 9 · see citing works
Immunotherapeutic treatment of inflammation in mice exposed to methamphetamine
Loftis, J. M., Ramani, S., Firsick, E. J., Hudson, R., Le-Cook, A., Murnane, K. S., Vandenbark, A. A., & Shirley, R. L. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1259041 · Cited by 9 · see citing works
Glac, W., Dunacka, J., Grembecka, B., Świątek, G., Majkutewicz, I., & Wrona, D. (2021) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-021-09988-1 · Cited by 9 · see citing works
Wu, L., Liu, X., Jiang, Q., Li, M., Liang, M., Wang, R., Wang, R., Su, L., Ni, T., Dong, N., et al. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110175 · Cited by 8 · see citing works
Zhu, P., Li, L., Gao, B., Zhang, M., Wang, Y., Gu, Y., & Liqun, H. (2017) · Oncotarget · doi:10.18632/oncotarget.19020 · Cited by 8 · see citing works
Effects and associated transcriptomic landscape changes of methamphetamine on immune cells
Kong, D., Mao, J.-H., Li, H., Wang, J., Li, Y., Wu, X., Re, G.-F., Luo, H.-Y., Kuang, Y., & Wang, K. (2022) · BMC Medical Genomics · doi:10.1186/s12920-022-01295-9 · Cited by 8 · see citing works
Epigenetic clock analysis in methamphetamine dependence
Takemura, Y., Tanifuji, T., Okazaki, S., Shinko, Y., Otsuka, I., Horai, T., Shirai, T., Aso, K., Yamamoto, N., & Hishimoto, A. (2022) · Psychiatry Research · doi:10.1016/j.psychres.2022.114901 · Cited by 8 · see citing works
DiCaro, D., Lee, H. H., Belisario, C., Ramos, R. L., & Martinez, L. R. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.105751 · Cited by 7 · see citing works
Methamphetamine in Orthopaedics
Cornwell, D. Q., Thompson, A. R., Ivie, R. M. J., Working, Z. M., Friess, D., & Meeker, J. E. (2021) · JBJS Reviews · doi:10.2106/jbjs.rvw.20.00229 · Cited by 7 · see citing works
Case Report: Unusual oral cavity changes associated with methamphetamine abuse
Скрипник, М. І., Skrypnyk, R. І., Петрушанко, Т. О., Skikevych, M., Petrushanko, V., & Скрипник, І. М. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1473584 · Cited by 6 · see citing works
Ru, Q., Xiong, Q., Tian, X., Xu, C., Li, C., Chen, L., & Wu, Y. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.874080 · Cited by 6 · see citing works
Vision health perspectives on Breaking Bad: Ophthalmic sequelae of methamphetamine use disorder
Huang, Y., Nguyen, N. V., Mammo, D. A., Albini, T. A., Hayek, B., Timperley, B. D., Krueger, R. R., & Yeh, S. (2023) · Frontiers in Toxicology · doi:10.3389/ftox.2023.1135792 · Cited by 5 · see citing works
Jazbec, K., Jež, M., Švajger, U., Smrekar, B., Miceska, S., Rajčević, U., Justin, M., Završnik, J., Malovrh, T., Švara, T., et al. (2022) · Biomolecules · doi:10.3390/biom12040595 · Cited by 5 · see citing works
Immunity on ice: The impact of methamphetamine on peripheral immunity
Miller, E. J., & Khoshbouei, H. (2023) · Advances in pharmacology · doi:10.1016/bs.apha.2023.09.003 · Cited by 5 · see citing works
Secreted Metabolome of Human Macrophages Exposed to Methamphetamine
Pawlak, K., Lech, K., Vei, A., Burch, S., Zieschang, S., Jaquet, S., Yu, F., Harwood, E., Morsey, B., Fox, H. S., et al. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b01952 · Cited by 4 · see citing works
Pramanik, A., Das, S., & Khanna, G. L. (2020) · Pharmacological Reports · doi:10.1007/s43440-020-00066-6 · Cited by 4 · see citing works
Mekraksakit, P., Elmassry, M., Leelaviwat, N., & NUGENT, K. M. (2020) · BMJ Case Reports · doi:10.1136/bcr-2020-239718 · Cited by 3 · see citing works
Kumarnsit, E., Keawpradub, N., Sengnon, N., Wungsintaweekul, J., & Cheaha, D. (2021) · Sains Malaysiana · doi:10.17576/jsm-2021-5003-19 · Cited by 3 · see citing works
Huang, Y., Nguyen, N. V., Fashina, T., Kaftan, T., Lobo-Chan, A.-M., Conrady, C. D., & Yeh, S. (2025) · Eye · doi:10.1038/s41433-025-04034-3 · Cited by 2 · see citing works
Wood, E. K., Huang, E., Sano, E., & Loftis, J. M. (2025) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2025.578567 · Cited by 2 · see citing works
Methamphetamines and Acetabular Reoperation Rates: Poor Outcomes From the Front Lines.
Zusman, N. L., Woelber, E., McKibben, N. S., Gallacher, D. M., Thompson, A. R., Friess, D., & Working, Z. M. (2021) · PubMed · doi:10.1097/bot.0000000000002133 · Cited by 1 · see citing works
Immunotoxicology of Drugs of Abuse
Kaplan, B. L. F. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64180-6 · Cited by 1 · see citing works
Mosayebi, G., Moazzeni, S. M., Farahani, H., Solhi, H., Rafiei, M., & Ghazavi, A. (2025) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-025-00943-x · Cited by 1 · see citing works
Khalaji, N., Mohammadzadeh, A., Goosheh-derag, M. N., Naderi, R., & Hasanluyi, E. A. (2019) · Physiology and Pharmacology · doi:10.32598/ppj.24.1.50 · Cited by 1 · see citing works
Snider, S. E. (2014) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/wt5e-6716
Kuo, S.-C., Yeh, Y., Chen, C. Y., Huang, C. C., Shih, M.-C., Yen, C.-H., Ho, P. S., Liang, C., Tsou, C., Yang, B. Z., et al. (2018) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000448
Immunotoxicology of Drugs of Abuse
Kaplan, B. L. F. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00051-6
Lee, H., Kim, E., & Jeong, G. (2025) · PLoS ONE · doi:10.1371/journal.pone.0314054
Ahmed, S. Z., Amin, F., Farooqui, N., Omarova, Z., Mahmood, S. F., Khan, Q. U. A., Naqvi, H., Mumtaz, A., Baig, S., Khan, M. R., et al. (2025) · Viruses · doi:10.3390/v17091232
Kong, D., Mao, J.-H., Li, H., Wang, J.-Y., Li, Y.-Y., Wu, X.-C., Re, G.-F., Luo, H.-Y., Kuang, Y.-Q., & Wang, K.-H. (2022) · Figshare · doi:10.6084/m9.figshare.20175917
Hamel, C., Corace, K., Hersi, M., Rice, D., Willows, M., Macpherson, P., Sproule, B., Flores-Aranda, J., Garber, G., Esmaeilisaraji, L., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13141762
Kong, D., Mao, J.-H., Li, H., Wang, J.-Y., Li, Y.-Y., Wu, X.-C., Re, G.-F., Luo, H.-Y., Kuang, Y.-Q., & Wang, K.-H. (2022) · Figshare · doi:10.6084/m9.figshare.20175914
Kong, D., Mao, J.-H., Li, H., Wang, J.-Y., Li, Y.-Y., Wu, X.-C., Re, G.-F., Luo, H.-Y., Kuang, Y.-Q., & Wang, K.-H. (2022) · Figshare · doi:10.6084/m9.figshare.20175923
Kong, D., Mao, J.-H., Li, H., Wang, J.-Y., Li, Y.-Y., Wu, X.-C., Re, G.-F., Luo, H.-Y., Kuang, Y.-Q., & Wang, K.-H. (2022) · Figshare · doi:10.6084/m9.figshare.20175920
Kong, D., Mao, J.-H., Li, H., Wang, J.-Y., Li, Y.-Y., Wu, X.-C., Re, G.-F., Luo, H.-Y., Kuang, Y.-Q., & Wang, K.-H. (2022) · Figshare · doi:10.6084/m9.figshare.20175929
Hamel, C., Corace, K., Hersi, M., Rice, D., Willows, M., Macpherson, P., Sproule, B., Flores-Aranda, J., Garber, G., Esmaeilisaraji, L., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13141777
Hamel, C., Corace, K., Hersi, M., Rice, D., Willows, M., Macpherson, P., Sproule, B., Flores-Aranda, J., Garber, G., Esmaeilisaraji, L., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13141774
Kong, D., Mao, J.-H., Li, H., Wang, J.-Y., Li, Y.-Y., Wu, X.-C., Re, G.-F., Luo, H.-Y., Kuang, Y.-Q., & Wang, K.-H. (2022) · Figshare · doi:10.6084/m9.figshare.20175926
Hamel, C., Corace, K., Hersi, M., Rice, D., Willows, M., MacPherson, P., Sproule, B., Flores-Aranda, J., Garber, G., Esmaeilisaraji, L., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13141765
Hamel, C., Corace, K., Hersi, M., Rice, D., Willows, M., Macpherson, P., Sproule, B., Flores-Aranda, J., Garber, G., Esmaeilisaraji, L., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13141771
Li, T., Li, Z., Liu, H., Chen, J., Li, Y., Zhou, X., Zhang, S., Li, B., & Ren, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1775159
- Authors
- Harms, R., Morsey, B., Boyer, C. W., Fox, H. S., & Sarvetnick, N.
- Affiliations
- University of Nebraska Medical Center (US)
- Corresponding author
- Harms, Robert
- ORCID
- Fox, Howard S.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-12-05
- Volume
- 7
- Issue
- 12
- Pages
- e49897
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3515581
- OpenAlex
- W2016119405
- Cited by
- 81
- References
- 77
- Citations by year
- 2026: 1 · 2025: 10 · 2024: 3 · 2023: 7 · 2022: 13 · 2021: 11 · 2020: 8 · 2019: 4 · 2018: 6 · 2017: 4 · 2016: 3 · 2015: 8 · 2014: 2 · 2013: 1
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DigitalCommons@UNMC (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health
- U.S. Public Health Service (NIH RO1:345160-2058101)
- National Institute on Drug Abuse (R01DA032513)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Keywords
- methamphetamine, immunosuppression, natural killer cells, dendritic cells, CD4+ T cells, CD8+ T cells, CD150, CD226, immune homeostasis, drug abuse, infectious disease risk, leukocyte phenotyping
- MeSH terms
- Animals, Disease Susceptibility, Flow Cytometry, Lymphocytes, Macrophages, Male, Methamphetamine, Mice, Inbred C57BL, Monocytes, Immunophenotyping, Immunocompromised Host, Models, Animal, Mice
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