Sequence Variants of Toll Like Receptor 4 and Late-Onset Alzheimer's Disease
Open accessAbstract
BACKGROUND: Toll like receptor 4 (TLR4) has been related to inflammation and beta-amyloid deposition in Alzheimer's disease (AD) brain. No study has explored the association between haplotype-tagging single nucleotide polymorphisms (htSNPs) of TLR4 and AD risk previously and ApoE e4 status alone showed low sensitivity in identifying late-onset AD (LOAD) patients. METHODS: A total of 269 LOAD patients were recruited from three hospitals in northern Taiwan (2007-2010). Controls (n = 449) were recruited from elderly health checkup and volunteers of the hospital during the same period of time. Five common (frequency≥5%) TLR4 htSNPs were selected to assess the association between TLR4 polymorphisms and the risk of LOAD in the Chinese ethnic population. RESULTS: Homozygosity of TLR4 rs1927907 was significantly associated with an increased risk of LOAD [TT vs. CC: adjusted odds ratio (AOR) = 2.45, 95% confidence interval (CI) = 1.30-4.64]. After stratification, the association increased further in ApoE e4 non-carriers (AOR = 3.07) and in hypertensive patients (AOR = 3.60). Haplotype GACGG was associated with a decreased risk of LOAD (1 vs. 0 copies: AOR = 0.59, 95% CI = 0.36-0.96; 2 vs. 0 copies: AOR = 0.31, 95% CI = 0.14-0.67) in ApoE e4 non-carriers. ApoE e4 status significantly modified this association (p(interaction) = 0.01). These associations remained significant after correction for multiple tests. CONCLUSIONS: Sequence variants of TLR4 were associated with an increased risk of LOAD, especially in ApoE e4 non-carriers and in hypertensive patients. The combination of TLR4 rs1927907 and ApoE e4 significantly increased the screening sensitivity in identifying LOAD patients from 0.4 to 0.7.
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Sequence variants of the LPS-receptor TLR4 and the LPS-binding receptor TREM2 are associated with an increased risk of Alzheimer's disease.
“Sequence variants of the LPS-receptor TLR4 [84] and the LPS-binding receptor TREM2 [22] are also associated with an increased risk of AD, indicating additional genetic links between AD and endotoxin.”
From The endotoxin hypothesis of neurodegeneration (2019) · cites this paper as [84]
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Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
A Simple Sequentially Rejective Multiple Test Procedure
(1979) · Scandinavian Journal of Statistics · doi:10.2307/4615733 · Cited by 21,526 · see citing works
Pathogen Recognition and Innate Immunity
Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 11,974 · see citing works
Diagnostic and Statistical Manual of Mental Disorders
Siegel, L. J., & Fletcher‐Janzen, E. (2008) · Wiley eBooks · doi:10.1002/9780470373699.speced0655 · Cited by 8,468 · see citing works
The Structure of Haplotype Blocks in the Human Genome
Gabriel, S. B., Schaffner, S. F., Nguyen, H., Moore, J. M., Roy, J., Blumenstiel, B., Higgins, J., DeFelice, M., Lochner, A., Faggart, M., et al. (2002) · Science · doi:10.1126/science.1069424 · Cited by 5,863 · see citing works
Pfeiffer, E. A. (1975) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1975.tb00927.x · Cited by 5,320 · see citing works
Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569 · see citing works
Harold, D., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Hamshere, M. L., Pahwa, J. S., Moskvina, V., Dowzell, K., Williams, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.440 · Cited by 3,326 · see citing works
TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
Arbour, N. C., Lorenz, E., Schutte, B. C., Zabner, J., Kline, J. N., Jones, M., Frees, K., Watt, J. L., & Schwartz, D. A. (2000) · Nature Genetics · doi:10.1038/76048 · Cited by 2,024 · see citing works
Deaths: preliminary data for 2003.
Hoyert, D. L., Kung, H.-C., & Smith, B. L. (2005) · PubMed · Cited by 1,649 · see citing works
The Clinical Diagnosis of Alzheimer's Disease
Wade, J. P. H., Mirsen, T. R., Hachinski, V. C., Fisman, M., Lau, C. S., & Merskey, H. (1987) · Archives of Neurology · doi:10.1001/archneur.1987.00520130016010 · Cited by 1,416 · see citing works
Okura, Y., Urban, L. H., Mahoney, D. W., Jacobsen, S. J., & Rodeheffer, R. J. (2004) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2004.04.005 · Cited by 1,237 · see citing works
Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease
Seshadri, S. (2010) · JAMA · doi:10.1001/jama.2010.574 · Cited by 1,219 · see citing works
Deaths: preliminary data for 2002.
Kochanek, K. D., & Smith, B. L. (2004) · PubMed · Cited by 700 · see citing works
Role of the Toll-Like Receptor 4 in Neuroinflammation in Alzheimer’s Disease
Walter, S., Letiembre, M., Liu, Y., Heine, H., Penke, B., Hao, W., Bode, B., Manietta, N., Walter, J., Schulz-Schüffer, W., et al. (2007) · Cellular Physiology and Biochemistry · doi:10.1159/000110455 · Cited by 543 · see citing works
Role of toll-like receptor signalling in A uptake and clearance
Tahara, K., Kim, H.-D., Jin, J.-J., Maxwell, J. A., Li, L., & Fukuchi, K.-I. (2006) · Brain · doi:10.1093/brain/awl249 · Cited by 493 · see citing works
Li, N.-C., Lee, A., Whitmer, R. A., Kivipelto, M., Lawler, E., Kazis, L. E., & Wolozin, B. (2010) · BMJ · doi:10.1136/bmj.b5465 · Cited by 486 · see citing works
Annual Incidence of Alzheimer Disease in the United States Projected to the Years 2000 Through 2050
Hebert, L. E., Beckett, L. A., Scherr, P. A., & Evans, D. A. (2001) · Alzheimer Disease and Associated Disorders · doi:10.1097/00002093-200110000-00002 · Cited by 467 · see citing works
Viña, J., & Lloret, A. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-100501 · Cited by 447 · see citing works
Microglia and Alzheimer's disease pathogenesis
Streit, W. J. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20093 · Cited by 335 · see citing works
TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans
Ferwerda, B., McCall, M. B. B., Alonso, S., Giamarellos‐Bourboulis, E. J., Mouktaroudi, M., Izagirre, N., Syafruddin, D., Kibiki, G. S., Cristea, T., Hijmans, A., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704828104 · Cited by 319 · see citing works
Deaths: preliminary data for 2009.
Kochanek, K. D., Xu, J., Murphy, S. L., Miniño, A., & Kung, H.-C. (2011) · PubMed · Cited by 282 · see citing works
Jin, J.-J., Kim, H.-D., Maxwell, J. A., Li, L., & Fukuchi, K. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-23 · Cited by 272 · see citing works
Genome-wide Association Study Implicates a Chromosome 12 Risk Locus for Late-Onset Alzheimer Disease
Beecham, G. W., Martin, E. R., Li, Y.-J., Slifer, M. A., Gilbert, J. R., Haines, J. L., & Pericak-Vance, M. A. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.12.008 · Cited by 260 · see citing works
Stram, D. O., Pearce, C. L., Bretsky, P., Freedman, M. L., Hirschhorn, J. N., Altshuler, D., Kolonel, L. N., Henderson, B. E., & Thomas, D. C. (2003) · Human Heredity · doi:10.1159/000073202 · Cited by 249 · see citing works
Genome-wide association study of Alzheimer's disease
Kamboh, M. I., Demirci, F. Y., Wang, X., Minster, R. L., Carrasquillo, M. M., Pankratz, V. S., Younkin, S. G., Saykin, A. J., Initiative, A. D. N., Jun, G., et al. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.45 · Cited by 242 · see citing works
Cardiovascular risk factors and dementia
Fillit, H., Nash, D. T., Rundek, T., & Zuckerman, A. (2008) · The American Journal of Geriatric Pharmacotherapy · doi:10.1016/j.amjopharm.2008.06.004 · Cited by 225 · see citing works
Bomfim, G. F., Eichler, R. A. D. S., Oliveira, M. A., Giachini, F. R. C., Akamine, E. H., Tostes, R. C., Fortes, Z. B., Webb, R. C., & de Carvalho, M. H. C. (2012) · Clinical Science · doi:10.1042/cs20110523 · Cited by 201 · see citing works
A genome-wide association study for late-onset Alzheimer's disease using DNA pooling
Abraham, R., Moskvina, V., Sims, R., Hollingworth, P., Morgan, A., Georgieva, L., Dowzell, K., Cichon, S., Hillmer, A. M., O'Donovan, M. C., et al. (2008) · BMC Medical Genomics · doi:10.1186/1755-8794-1-44 · Cited by 195 · see citing works
Udan, M. L. D., Ajit, D., Crouse, N. R., & Nichols, M. R. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05001.x · Cited by 175 · see citing works
Sequence Variants of Toll-Like Receptor 4 and Susceptibility to Prostate Cancer
Chen, Y., Giovannucci, E. L., Lazarus, R. M., Kraft, P., Ketkar, S., & Hunter, D. J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-2078 · Cited by 167 · see citing works
Self-citationMinoretti, P., Gazzaruso, C., Vito, C. D., Emanuele, E., Bianchi, M., Coen, E., Reino, M., & Geroldi, D. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.08.047 · Cited by 164 · see citing works
Microglial degeneration in the aging brain - bad news for neurons?
Streit, W. (2008) · Frontiers in Bioscience · doi:10.2741/2937 · Cited by 150 · see citing works
Vascular Dementia Prevention: A Risk Factor Analysis
Román, G. C. (2005) · Cerebrovascular Diseases · doi:10.1159/000089361 · Cited by 150 · see citing works
TLR4 Polymorphisms and Ageing: Implications for the Pathophysiology of Age-Related Diseases
Balistreri, C., Colonna-Romano, G., Lio, D., Candore, G., & Caruso, C. (2009) · Journal of Clinical Immunology · doi:10.1007/s10875-009-9297-5 · Cited by 124 · see citing works
Agreement Between Patient Reports of Cardiovascular Disease and Patient Medical Records
Sauver, J. L. S., Hagen, P. T., Cha, S. S., Bagniewski, S. M., Mandrekar, J. N., Curoe, A. M., Rodeheffer, R. J., Roger, V. L., & Jacobsen, S. J. (2005) · Mayo Clinic Proceedings · doi:10.4065/80.2.203 · Cited by 124 · see citing works
Hypertension augments cardiac Toll-like receptor 4 expression and activity
Eißler, R., Schmaderer, C., Rusai, K., Kühne, L., Sollinger, D., Lahmer, T., Witzke, O., Lutz, J., Heemann, U. W., & Baumann, M. (2011) · Hypertension Research · doi:10.1038/hr.2010.270 · Cited by 95 · see citing works
From SNPs to functional polymorphism: The insight into biotechnology applications
Liao, P.-Y., & Lee, K. H. (2010) · Biochemical Engineering Journal · doi:10.1016/j.bej.2009.12.021 · Cited by 89 · see citing works
A simple and efficient method for apolipoprotein E genotype determination
Chapman, J., Estupiñan, J., Asherou, A., & Goldfarb, L. G. (1996) · Neurology · doi:10.1212/wnl.46.5.1484-a · Cited by 82 · see citing works
Association between the Polymorphisms of TLR4 and CD14 Genes and Alzheimers Disease
Balistreri, C. R., Grimaldi, M., Chiappelli, M., Licastro, F., Castiglia, L., Listı̀, F., Vasto, S., Lio, D., Caruso, C., & Candore, G. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208786264089 · Cited by 65 · see citing works
Harold, D. H., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Hamshere, M. L., Pahwa, J. S., Moskvina, V., Dowzell, K., Williams, A., et al. (2009) · Nature Genetics · doi:10.1038/ng1009-1156d · Cited by 64 · see citing works
Dementia in Taiwan: past, present, and future.
Fuh, J., & Wang, S. (2008) · PubMed · Cited by 62 · see citing works
Fakiri, F. E., Bruijnzeels, M. A., & Hoes, A. W. (2007) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2007.02.014 · Cited by 55 · see citing works
Risk and protective factors for sporadic Alzheimer's disease.
Stožická, Z., Žilka, N., & Novák, M. (2007) · PubMed · Cited by 55 · see citing works
Zheng, S. L., Liu, W., Wiklund, F. E., Dimitrov, L. M., Bälter, K. A., Sun, J., Adami, H., Johansson, J., Sun, J., Chang, B., et al. (2006) · The Prostate · doi:10.1002/pros.20496 · Cited by 52 · see citing works
Hajjar, I. M., Keown, M., Lewis, P., & Almor, A. (2008) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317507309803 · Cited by 52 · see citing works
TLR4 Asp299Gly and Thr399Ile polymorphisms are very rare in the Chinese population
Hang, J., Zhou, W., Zhang, H., Sun, B., Dai, H., Su, L., & Christiani, D. C. (2004) · Journal of Endotoxin Research · doi:10.1177/09680519040100040601 · Cited by 38 · see citing works
TLR4 Asp299Gly and Thr399Ile polymorphisms are very rare in the Chinese population
Hang, J., Zhou, W., Zhang, H., Sun, B., Dai, H., Su, L., & Christiani, D. C. (2004) · Journal of Endotoxin Research · doi:10.1179/096805104225005841 · Cited by 36 · see citing works
The interleukin-6 gene −572C/G promoter polymorphism modifies Alzheimer's risk in APOE ɛ4 carriers
Wang, M., & Jia, J. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.07.051 · Cited by 33 · see citing works
Wang, L., Yu, J., Miao, D., Wu, Z., Zong, Y., Wen, C.-Q., & Tan, L. (2011) · Brain Research · doi:10.1016/j.brainres.2011.01.007 · Cited by 32 · see citing works
Balistreri, C. R., Caruso, C., Listı̀, F., Colonna‐Romano, G., Lio, D., & Candore, G. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.12.005 · Cited by 28 · see citing works
Flagged first, then by citations
1 of the 53 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Cao, X. (2015) · Nature reviews. Immunology · doi:10.1038/nri.2015.8 · Cited by 661 · see citing works
The endotoxin hypothesis of neurodegeneration
Brown, G. C. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1564-7 · Cited by 457 · see citing works
The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease
Minter, M. R., Taylor, J. M., & Crack, P. J. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13411 · Cited by 451 · see citing works
TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease
Yang, J., Wise, L., & Fukuchi, K.-I. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00724 · Cited by 387 · see citing works
Zhan, X.-H., Stamova, B., & Sharp, F. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00042 · Cited by 335 · see citing works
Innate Immunity in the CNS: Redefining the Relationship between the CNS and Its Environment
Lampron, A., ElAli, A., & Rivest, S. (2013) · Neuron · doi:10.1016/j.neuron.2013.04.005 · Cited by 282 · see citing works
How Do Immune Cells Support and Shape the Brain in Health, Disease, and Aging?
Schwartz, M., Kipnis, J., Rivest, S., & Prat, A. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3241-13.2013 · Cited by 256 · see citing works
Leszek, J., E. Barreto, G., G|siorowski, K., Koutsouraki, E., Ávila-Rodrigues, M., & Aliev, G. (2016) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527315666160202125914 · Cited by 206 · see citing works
Fontes-Dantas, F. L., Fernandes, G. G., Gutman, E. G., de Lima, E. V., Antonio, L. S., Hämmerle, M. B., Mota-Araujo, H. P., Colodeti, L. C., Araújo, S. M. B., Froz, G. M., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112189 · Cited by 177 · see citing works
Zhou, J., Yu, W., Zhang, M., Tian, X., Li, Y., & Lü, Y. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02748-x · Cited by 139 · see citing works
TLR4 Targeting as a Promising Therapeutic Strategy for Alzheimer Disease Treatment
Zhou, Y., Chen, Y., Xu, C., Zhang, H., & Lin, C. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.602508 · Cited by 119 · see citing works
Self-citationGarbuz, D. G., Zatsepina, O. G., & Evgen’ev, M. B. (2021) · Molecular Biology · doi:10.1134/s002689332104004x · Cited by 95 · see citing works
Hopperton, K. E., Trépanier, M., Giuliano, V., & Bazinet, R. P. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0721-5 · Cited by 78 · see citing works
Toll-like receptors in Alzheimer's disease
Momtazmanesh, S., Perry, G. L., & Rezaei, N. (2020) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2020.577362 · Cited by 71 · see citing works
Microglial toll-like receptors and Alzheimer’s disease
Su, F., Bai, F., Zhou, H., & Zhang, Z. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.10.010 · Cited by 67 · see citing works
Yang, J., Malone, F., Go, M., Kou, J., Lim, J.-E., Caughey, R. C., & Fukuchi, K.-I. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01750-1 · Cited by 46 · see citing works
TLR4 genetic variation is associated with inflammatory responses in Gram-positive sepsis
Chantratita, N., Tandhavanant, S., Seal, S., Wikraiphat, C., Wongsuvan, G., Ariyaprasert, P., Suntornsut, P., Teerawattanasook, N., Jutrakul, Y., Srisurat, N., et al. (2016) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2016.08.028 · Cited by 37 · see citing works
Sutinen, E. M., Korolainen, M. A., Häyrinen, J., Alafuzoff, I., Petratos, S., Salminen, A., Soininen, H., Pirttilä, T., & Ojala, J. O. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00214 · Cited by 34 · see citing works
Hopperton, K. E., Trépanier, M., James, N. C. E., Chouinard‐Watkins, R., & Bazinet, R. P. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.11.002 · Cited by 34 · see citing works
A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice
Balu, D., Valencia‐Olvera, A. C., Nguyen, A. Q., Patnam, M., York, J. M., Peri, F., Neumann, F., LaDu, M. J., & Tai, L. M. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01330-6 · Cited by 32 · see citing works
Association of TLR4 gene polymorphisms with sporadic Parkinson’s disease in a Han Chinese population
Zhao, J., Han, X., Li, X., Zhu, K., Liu, H., & Xie, A. (2015) · Neurological Sciences · doi:10.1007/s10072-015-2227-9 · Cited by 32 · see citing works
Performance Metrics for Selecting Single Nucleotide Polymorphisms in Late-onset Alzheimer’s Disease
Chen, Y., Hsiao, C.-J., Jung, C.-C., Hu, H., Chen, J.-H., Lee, W., Chiou, J., Chen, T., Sun, Y., Wen, L.-L., et al. (2016) · Scientific Reports · doi:10.1038/srep36155 · Cited by 21 · see citing works
Self-citationReprint of: Microglial toll-like receptors and Alzheimer’s disease
Su, F., Bai, F., Zhou, H., & Zhang, Z. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.05.016 · Cited by 19 · see citing works
Wang, Z., Wu, S., Chen, D., Guo, F., Zhong, L., Fan, J., & Peng, Z. (2014) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-014-1673-2 · Cited by 18 · see citing works
Garbuz, D. G., Zatsepina, O. G., & Evgen’ev, M. B. (2019) · Molecular Biology · doi:10.1134/s0026893319020055 · Cited by 18 · see citing works
Too, L. K., Yau, B., Baxter, A. G., McGregor, I. S., & Hunt, N. H. (2019) · Scientific Reports · doi:10.1038/s41598-019-52212-7 · Cited by 17 · see citing works
Zhou, X., Kumar, P., Bhuyan, D. J., Jensen, S. O., Roberts, T. L., & Münch, G. W. (2023) · Biomolecules · doi:10.3390/biom13111568 · Cited by 15 · see citing works
Kurakin, A. V., & Bredesen, D. E. (2020) · Aging · doi:10.18632/aging.103883 · Cited by 14 · see citing works
Chen, J., Hsieh, C.-J., Huang, Y., Chen, Y., Chen, T., Sun, Y., Wen, L., Yip, P., & Chu, Y. (2015) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2015.01.008 · Cited by 10 · see citing works
Self-citationToll-Like Receptor Signaling in Alzheimer?s Disease Progression
Downer, E. J. (2012) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.s10-006 · Cited by 9 · see citing works
Garbuz, D. G., Zatsepina, O. G., & Evgen’ev, M. B. (2019) · Molecular Biology · doi:10.1134/s0026898419020058 · Cited by 8 · see citing works
Crammond, P., Hastak, P., Delaney, A. P., & Sasson, S. C. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1761361 · Cited by 8 · see citing works
Zhou, L., Zheng, D., Wang, S., Zhu, J. H., Jia, Y., Sun, D., Xu, J., Wang, Q., Chen, H., Xu, F., et al. (2016) · SpringerPlus · doi:10.1186/s40064-016-3177-2 · Cited by 7 · see citing works
Li, Z., Song, A., & Yu, H. (2018) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2018.12.002 · Cited by 7 · see citing works
Apolipoprotein E3 and E4 isoforms exhibit differing effects in countering endotoxins
Puthia, M., Marzinek, J. K., Veselá, K., Larsson, A., Schmidtchen, A., Bond, P. J., & Petrlová, J. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108236 · Cited by 5 · see citing works
The many connections of UFMylation with Alzheimer’s disease: a comprehensive review
Yan, T., Clarkson, B. D. S., Lou, Z., Springer, W., & Fiesel, F. C. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00855-8 · Cited by 4 · see citing works
Inflammation in Alzheimer's Disease: Cross-talk between Lipids and Innate Immune Cells of the Brain
Ai, L., & Me, C. (2015) · Cited by 2 · see citing works
Phf15 - a novel transcriptional repressor regulating inflammation in a mouse microglial cell line
Muroy, S. E., Timblin, G. A., Preininger, M. K., Cedillo, P., & Saijo, K. (2020) · Neuroimmunology and Neuroinflammation · doi:10.20517/2347-8659.2020.16
- Authors
- Chen, Y.-C., Yip, P.-K., Huang, Y.-L., Sun, Y., Wen, L.-L., Chu, Y.-M., & Chen, T.-F.
- Affiliations
- National Taiwan University (TW)
- Fu Jen Catholic University (TW)
- En Chu Kong Hospital (TW)
- National Taiwan University Hospital (TW)
- Corresponding author
- Chen, Yen-Ching
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-12-18
- Volume
- 7
- Issue
- 12
- Pages
- e50771
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3525588
- OpenAlex
- W2012612081
- Cited by
- 38
- References
- 53
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- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
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- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
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- Figshare (submittedVersion, cc-by)
- Funders
- National Science Council (97‐2314‐B‐002‐168‐MY3, 96-2314-B-002-197)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- TLR4, late-onset Alzheimer's disease, single nucleotide polymorphisms, haplotype tagging, APOE ε4, genetic susceptibility, hypertension, Chinese population
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Dementia, Female, Genotype, Haplotypes, Heterozygote, Homozygote, Humans, Hypertension, Inflammation, Genetic Linkage, Male, Models, Genetic, Surveys and Questionnaires, Risk, Taiwan, Odds Ratio, Case-Control Studies, Age of Onset, Polymorphism, Single Nucleotide, Toll-Like Receptor 4, Apolipoprotein E4
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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