Inflammatory mechanisms and oxidative stress as key factors responsible for progression of neurodegeneration: role of brain innate immune system
Abstract
Chronic inflammation is characterized by longstanding microglial activation followed by sustained release of inflammatory mediators, which aid in enhanced nitrosative and oxidative stress. The sustained release of inflammatory mediators propels the inflammatory cycle by increased microglial activation, promoting their proliferation and thus stimulating enhanced release of inflammatory factors. Elevated levels of several cytokines and chronic neuroinflammation have been associated with many neurodegenerative disorders of central nervous system like age-related macular degeneration, Alzheimer disease, multiple sclerosis, Parkinson's disease, Huntington' disease, and tauopathies. This review highlights the basic mechanisms of neuroinflammation, the characteristics of neurodegenerative diseases, and the main immunologic responses in CNS neurodegenerative disorders. A comprehensive outline for the crucial role of microglia in neuroinflammation and neurodegeneration and the role of Toll-like receptor signalling in coexistence of inflammatory mechanisms and oxidative stress as major factors responsible for progression of neurodegeneration have also been presented.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Increased biomarkers of oxidative stress, inflammation and chronic neuroinflammation are associated with many neurodegenerative disorders of the central nervous system, including Alzheimer's disease.
“Increased biomarkers of oxidative stress (Furman et al., 2016), inflammation and chronic neuroinflammation are reported to be associated with many neurodegenerative disorders of central nervous system (CNS) including AD (Leszek et al., 2016).”
From Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial (2016) · cites this paper as Leszek et al., 2016
Cites
The Classical Complement Cascade Mediates CNS Synapse Elimination
Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., Micheva, K. D., Mehalow, A. K., Huberman, A. D., Stafford, B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.036 · Cited by 3,313 · see citing works
Brain energy metabolism: focus on Astrocyte-neuron metabolic cooperation
Bélanger, M., Allaman, I., & Magistretti, P. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.016 · Cited by 2,313 · see citing works
Chronic inflammation and cytokines in the tumor microenvironment
Landskron, G., De la Fuente, M., Thuwajit, P., Thuwajit, C., & Hermoso, M. A. (2014) · Journal of Immunology Research · doi:10.1155/2014/149185 · Cited by 1,765 · see citing works
The roles of intracellular protein-degradation pathways in neurodegeneration
Rubinsztein, D. C. (2006) · Nature · doi:10.1038/nature05291 · Cited by 1,625 · see citing works
Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism
Block, M. L., & Hong, J.-S. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.004 · Cited by 1,557 · see citing works
Oxidative stress and mitochondrial dysfunction in Alzheimer’s disease
Wang, X., Wang, W., Li, L., Perry, G., Lee, H.-G., & Zhu, X. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.10.015 · Cited by 1,357 · see citing works
Oxidative stress, mitochondrial damage and neurodegenerative diseases.
Guo, C., Sun, L., Chen, X., & Zhang, D. (2013) · PubMed Central · doi:10.3969/j.issn.1673-5374.2013.21.009 · Cited by 1,308 · see citing works
Toll‐like Receptor and RIG‐1‐like Receptor Signaling
Kawai, T., & Akira, S. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1443.020 · Cited by 985 · see citing works
Regulation of innate immune responses in the brain
Rivest, S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2565 · Cited by 843 · see citing works
Role of Microglia in Central Nervous System Infections
Rock, R. B., Gekker, G., Hu, S., Sheng, W. S., Cheeran, M., Lokensgard, J. R., & Peterson, P. K. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.4.942-964.2004 · Cited by 723 · see citing works
Immune activation in brain aging and neurodegeneration: too much or too little?
Lucin, K. M., & Wyss-Coray, T. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.039 · Cited by 679 · see citing works
Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits
Tang, S.-C., Arumugam, T. V., Xu, X., Cheng, A., Mughal, M. R., Jo, D. G., Lathia, J. D., Siler, D. A., Chigurupati, S., Ouyang, X., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702553104 · Cited by 672 · see citing works
Ramesh, G., MacLean, A. G., & Philipp, M. T. (2013) · Mediators of Inflammation · doi:10.1155/2013/480739 · Cited by 639 · see citing works
Cell death in the nervous system
Bredesen, D. E., Rao, R. V., & Mehlen, P. (2006) · Nature · doi:10.1038/nature05293 · Cited by 638 · see citing works
Toll-Like Receptor 4 Is Involved in Brain Damage and Inflammation After Experimental Stroke
Caso, J. R., Pradillo, J. M., Hurtado, O., Lorenzo, P. L., Moro, M. Á., & Lizasoaín, I. (2007) · Circulation · doi:10.1161/circulationaha.106.603431 · Cited by 606 · see citing works
Lehnardt, S. (2009) · Glia · doi:10.1002/glia.20928 · Cited by 596 · see citing works
Glia and their cytokines in progression of neurodegeneration
Mrak, R. E., & Griffin, W. S. T. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.05.010 · Cited by 592 · see citing works
Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.
Goldgaber, D., Harris, H. W., Hla, T., Maciag, T., DONNELLY, R. J., Jacobsen, J. S., Vitek, M. P., & Gajdusek, D. C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7606 · Cited by 591 · see citing works
CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar Aβ-Stimulated Microglial Activation
Reed-Geaghan, E. G., Savage, J. C., Hise, A. G., & Landreth, G. E. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3158-09.2009 · Cited by 591 · see citing works
Tansey, M. G., McCoy, M. K., & Frank-Cannon, T. C. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.07.004 · Cited by 580 · see citing works
Immune proteins in brain development and synaptic plasticity
Boulanger, L. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.001 · Cited by 555 · see citing works
Role of the Toll-Like Receptor 4 in Neuroinflammation in Alzheimer’s Disease
Walter, S., Letiembre, M., Liu, Y., Heine, H., Penke, B., Hao, W., Bode, B., Manietta, N., Walter, J., Schulz-Schüffer, W., et al. (2007) · Cellular Physiology and Biochemistry · doi:10.1159/000110455 · Cited by 543 · see citing works
Microglia during development and aging
Harry, G. J. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.04.013 · Cited by 524 · see citing works
A Cell Surface Receptor Complex for Fibrillar β-Amyloid Mediates Microglial Activation
Bamberger, M. E., Harris, M. E., McDonald, D. R., Husemann, J., & Landreth, G. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02665.2003 · Cited by 501 · see citing works
Neurosteroidogenesis in Astrocytes, Oligodendrocytes, and Neurons of Cerebral Cortex of Rat Brain
Zwain, I. H., & Yen, S. S. C. (1999) · Endocrinology · doi:10.1210/endo.140.8.6907 · Cited by 473 · see citing works
Brain metabolic dysfunction at the core of Alzheimer's disease
de la Monte, S. M., & Tong, M. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.12.012 · Cited by 462 · see citing works
Toll-Like Receptors in Neurodegeneration
Okun, E., Griffioen, K., Lathia, J., Tang, S.-C., Mattson, M., & Arumugam, T. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.09.001 · Cited by 459 · see citing works
Astrocytic modulation of blood brain barrier: perspectives on Parkinson’s disease
Cabezas, R., Ávila, M. F., González, J., El-Bachá, R. D. S., Báez-Jurado, E., García‐Segura, L. M., Jurado-Coronel, J. C., Capani, F., Cardona‐Gómez, G. P., & Barreto, G. E. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00211 · Cited by 453 · see citing works
Yan, S. D., Yan, S. F., Chen, X., Fu, J., Chen, M., Kuppusamy, P., Smith, M. A., Perry, G., Godman, G. C., Nawroth, P., et al. (1995) · Nature Medicine · doi:10.1038/nm0795-693 · Cited by 406 · see citing works
Oxidative Stress and Neurodegeneration
Moreira, P. I., Smith, M. A., Zhu, X., Nunomura, A., Castellani, R. J., & Perry, G. L. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1333.062 · Cited by 366 · see citing works
Protecting the mitochondrial powerhouse
Scheibye‐Knudsen, M., Fang, E. F., Croteau, D. L., Wilson, D. M., & Bohr, V. A. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.11.002 · Cited by 330 · see citing works
Misonou, H., Morishima-Kawashima, M., & Ihara, Y. (2000) · Biochemistry · doi:10.1021/bi000169p · Cited by 304 · see citing works
Lehnardt, S., Schott, E., Trimbuch, T., Laubisch, D., Krueger, C., Wulczyn, G., Nitsch, R., & Weber, J. R. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4760-07.2008 · Cited by 287 · see citing works
Can the immune system be harnessed to repair the CNS?
Popovich, P. G., & Longbrake, E. E. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2398 · Cited by 287 · see citing works
Song, M., Jin, J., Lim, J.-E., Kou, J., Pattanayak, A., Rehman, J. A., Kim, H.-D., Tahara, K., Lalonde, R., & Fukuchi, K.-I. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-92 · Cited by 273 · see citing works
Effects of natural antioxidants in neurodegenerative disease
Albarracín, S. L., Stab, B., Casas, Z., Sutachan, J. J., Samudio, I. J., González, J., Gonzalo, L., Capani, F., Morales, L., & Barreto, G. E. (2012) · Nutritional Neuroscience · doi:10.1179/1476830511y.0000000028 · Cited by 273 · see citing works
Role of ICAM-1 in persisting inflammation in Parkinson disease and MPTP monkeys
Judith Miklossy, A., Doudet, D., Schwab, C., Yu, S. Y., McGeer, E. G., & McGeer, P. L. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.10.034 · Cited by 255 · see citing works
Protein misfolding and aggregation in Alzheimer’s disease and type 2 diabetes mellitus
Ashraf, G., Greig, N., Khan, T., Hassan, I., Tabrez, S., Shakil, S., Sheikh, I., Zaidi, S., Akram, M., Jabir, N., et al. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666140917095514 · Cited by 236 · see citing works
Tang, S.-C., Lathia, J. D., Selvaraj, P. K., Jo, D.-G., Mughal, M. R., Cheng, A., Siler, D. A., Markesbery, W. R., Arumugam, T. V., & Mattson, M. P. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.05.014 · Cited by 232 · see citing works
Biological role of Toll-like receptor-4 in the brain
Trotta, T., Porro, C., Calvello, R., & Panaro, M. A. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.01.014 · Cited by 204 · see citing works
Xiong, X., Barreto, G. E., Xu, L., Ouyang, Y., Xie, X., & Giffard, R. G. (2011) · Stroke · doi:10.1161/strokeaha.110.593772 · Cited by 198 · see citing works
Shared Mechanisms of Neurodegeneration in Alzheimer’s Disease and Parkinson’s Disease
Xie, A., Gao, J., Xu, L., & Meng, D.-M. (2014) · BioMed Research International · doi:10.1155/2014/648740 · Cited by 196 · see citing works
Astrocytic-neuronal crosstalk: Implications for neuroprotection from brain injury
Barreto, G. E., González, J., Torres, Y. P., & Morales, L. (2011) · Neuroscience Research · doi:10.1016/j.neures.2011.06.004 · Cited by 190 · see citing works
Amyloid-β and τ serve antioxidant functions in the aging and Alzheimer brain
Smith, M. A., Casadesús, G., Joseph, J. A., & Perry, G. L. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01021-3 · Cited by 189 · see citing works
Alzheimer’s disease and oxygen radicals: new insights
Praticò, D. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00919-4 · Cited by 186 · see citing works
Liu, P., Zhao, H., Wang, R., et al. (2014) · Stroke · doi:10.1161/strokeaha.114.007482 · Cited by 181 · see citing works
Innate immune receptor expression in normal brain aging
Letiembre, M., Hao, W., Liu, Y., Walter, S., Mihaljevic, I., Rivest, S., Hartmann, T., & Fassbender, K. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.01.004 · Cited by 175 · see citing works
Minoretti, P., Gazzaruso, C., Vito, C. D., Emanuele, E., Bianchi, M., Coen, E., Reino, M., & Geroldi, D. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.08.047 · Cited by 164 · see citing works
Mitochondrial respiratory chain complexes as sources and targets of thiol-based redox-regulation
Dröse, S., Brandt, U., & Wittig, I. (2014) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2014.02.006 · Cited by 153 · see citing works
Schmid, C. D., Melchior, B., Masek, K., Puntambekar, S. S., Danielson, P. E., Lo, D. D., Sutcliffe, J. G., & Carson, M. J. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05984.x · Cited by 149 · see citing works
Oxidative Stress and Metabolic Syndrome: Cause or Consequence of Alzheimer's Disease?
Contreras, D. L., Carvajal, K., Toral-Ríos, D., Franco-Bocanegra, D., & Campos‐Peña, V. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/497802 · Cited by 148 · see citing works
Neuroprotection from Stroke in the Absence of MHCI or PirB
Steinmetz, J. D., Barreto, G. E., Xu, L., Kim, T., Brott, B. K., Ouyang, Y., Naserke, T., Djurisic, M. R., Xiong, X., Shatz, C. J., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.01.020 · Cited by 135 · see citing works
Neuropathology of Alzheimer disease: pathognomonic but not pathogenic
Castellani, R. J., Lee, H., Zhu, X., Nunomura, A., Perry, G. L., & Smith, M. A. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0071-y · Cited by 133 · see citing works
Characterisation of the active/de-active transition of mitochondrial complex I
Babot, M., Birch, A., Labarbuta, P., & Galkin, A. S. (2014) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2014.02.018 · Cited by 133 · see citing works
Cellular and molecular mechanisms of antioxidants in Parkinson's disease
Sutachan, J. J., Casas, Z., Albarracín, S. L., Stab, B. R., Samudio, I. J., González, J., Morales, L., & Barreto, G. E. (2012) · Nutritional Neuroscience · doi:10.1179/1476830511y.0000000033 · Cited by 123 · see citing works
Dai, X., Li, N., Yu, L., Chen, Z.-Y., Hua, R., Qin, X., & Zhang, Y.-M. (2014) · Cell Stress and Chaperones · doi:10.1007/s12192-014-0552-1 · Cited by 123 · see citing works
Toll-like receptors are key players in neurodegeneration
Arroyo, D. S., Soria, J. A., Gaviglio, E. A., Rodriguez‐Galán, M. C., & Iribarren, P. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.05.006 · Cited by 117 · see citing works
Unique transcriptome signature of mouse microglia
Beutner, C., Linnartz‐Gerlach, B., Schmidt, S. V., Beyer, M., Mallmann, M. R., Staratschek‐Jox, A., Schultze, J. L., & Neumann, H. (2013) · Glia · doi:10.1002/glia.22524 · Cited by 100 · see citing works
Nutritional intervention in brain aging: reducing the effects of inflammation and oxidative stress.
Lau, F. C., Shukitt‐Hale, B., & Joseph, J. A. (2007) · PubMed · Cited by 100 · see citing works
Cabezas, R., El-Bachá, R. D. S., González, J., & Barreto, G. E. (2012) · Neuroscience Research · doi:10.1016/j.neures.2012.07.008 · Cited by 98 · see citing works
The Role of Anti-Inflammatory Agents in Parkinson???s Disease
McGeer, E. G., & McGeer, P. L. (2007) · CNS Drugs · doi:10.2165/00023210-200721100-00001 · Cited by 95 · see citing works
Matrix Metalloproteinase-8 Plays a Pivotal Role in Neuroinflammation by Modulating TNF-α Activation
Lee, E.-J., Han, J. E., Woo, M.-S., Shin, J. A., Park, E., Kang, J. L., Moon, P. G., Baek, M., Son, W.-S., Ko, Y. T., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303240 · Cited by 90 · see citing works
Okamoto, T. (2006) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/187153006779025685 · Cited by 74 · see citing works
Immunity to self and self-maintenance: a unified theory of brain pathologies
Schwartz, M., & Ziv, Y. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.01.003 · Cited by 74 · see citing works
Targeting Microglial Activation in Stroke Therapy: Pharmacological Tools and Gender Effects
Chen, Y., Won, S. J., Xu, Y., & Swanson, R. A. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666131228203906 · Cited by 74 · see citing works
Debate: “Is Increasing Neuroinflammation Beneficial for Neural Repair?”
Crutcher, K. A., Gendelman, H. E., Kipnis, J., Perez-Polo, J. R., Perry, V. H., Popovich, P. G., & Weaver, L. C. (2006) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-006-9021-7 · Cited by 73 · see citing works
JNK inhibition and inflammation after cerebral ischemia
Benakis, C., Bonny, C., & Hirt, L. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.11.001 · Cited by 72 · see citing works
Antioxidant protection and neurodegenerative disease: The role of amyloid-β and tau
Castellani, R. J., Lee, H., Perry, G. L., & Smith, M. A. (2006) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/153331750602100213 · Cited by 70 · see citing works
Immune System in the Brain: A Modulatory Role on Dendritic Spine Morphophysiology?
Bitzer-Quintero, O. K., & González‐Burgos, I. (2012) · Neural Plasticity · doi:10.1155/2012/348642 · Cited by 63 · see citing works
Qian, F., Guo, X., Wang, X., Yuan, X., Chen, S., Malawista, S. E., Bockenstedt, L. K., Allore, H. G., & Montgomery, R. R. (2014) · Aging · doi:10.18632/aging.100642 · Cited by 62 · see citing works
Early Onset Alzheimer’s Disease and Oxidative Stress
Meraz‐Ríos, M. A., Franco-Bocanegra, D., Toral-Ríos, D., & Campos‐Peña, V. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/375968 · Cited by 62 · see citing works
Zhang, Z., Zhang, Z., Wu, Y., & Schluesener, H. J. (2011) · NeuroImmunoModulation · doi:10.1159/000326771 · Cited by 55 · see citing works
Cortical biochemistry in MCI and Alzheimer disease
Forman, M. S., Mufson, E. J., Leurgans, S. E., Praticò, D., Joyce, S. C., Leight, S., Lee, V. M.-Y., & Trojanowski, J. Q. (2007) · Neurology · doi:10.1212/01.wnl.0000256373.39415.b1 · Cited by 54 · see citing works
Vontell, R., Supramaniam, V. G., Thornton, C., Wyatt‐Ashmead, J., Mallard, C. E., Gressèns, P., Rutherford, M., & Hagberg, H. (2013) · Developmental Neuroscience · doi:10.1159/000346158 · Cited by 51 · see citing works
Inflammation and dementia: epidemiologic evidence
Peila, R., & Launer, L. J. (2006) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2006.00693.x · Cited by 47 · see citing works
Kurpius, D., Wilson, N., Fuller, L. C., Hoffman, A., & Dailey, M. E. (2006) · Glia · doi:10.1002/glia.20355 · Cited by 46 · see citing works
Ahmad, A., Rasheed, N., Gupta, P., Singh, S., Siripurapu, K. B., Ashraf, G. M., Kumar, R., Chand, K., Maurya, R., Banu, N., et al. (2012) · Phytomedicine · doi:10.1016/j.phymed.2012.02.012 · Cited by 42 · see citing works
Christensen, L. B., Woods, T. A., Carmody, A., Caughey, B. W., & Peterson, K. E. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-70 · Cited by 42 · see citing works
PDGF-BB Protects Mitochondria from Rotenone in T98G Cells
Cabezas, R., Ávila, M. F., González, J., et al. (2014) · Neurotoxicity Research · doi:10.1007/s12640-014-9509-5 · Cited by 41 · see citing works
Sequence Variants of Toll Like Receptor 4 and Late-Onset Alzheimer's Disease
Chen, Y.-C., Yip, P.-K., Huang, Y.-L., Sun, Y., Wen, L.-L., Chu, Y.-M., & Chen, T.-F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050771 · Cited by 38 · see citing works
Brain Region Specific Monoamine and Oxidative Changes During Restraint Stress
Ahmad, A., Rasheed, N., Ashraf, G. M., Kumar, R., Banu, N., Khan, F., Al-Sheeha, M., & Palit, G. (2012) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100013433 · Cited by 31 · see citing works
Moreira, P. I., Zhu, X., Lee, H., Honda, K., Smith, M. A., & Perry, G. L. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.01.024 · Cited by 22 · see citing works
Ávila-Rodriguez, M., Torrente, D., Cabezas, R., et al. (2013) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2013.12.010 · Cited by 11 · see citing works
Ahmad, A., Rasheed, N., Gupta, P., et al. (2013) · Medicinal Plants - International Journal of Phytomedicines and Related Industries · doi:10.5958/j.0975-6892.5.4.031 · Cited by 6 · see citing works
Increased Expression of Toll‐Like Receptor 4 on Neurons After Surgery in Aged Rats
Wang, Y.-X., He, H., & Ouyang, W. (2013) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12090 · Cited by 4 · see citing works
Aliev, G. M., Burzynski, G. S., Ashraf, G. M., Jabir, N. R., Cacabelos, R., Benberin, V. V., & Burzynski, S. R. (2011) · Springer eBooks · doi:10.1007/978-3-642-30018-9_206 · Cited by 3 · see citing works
Self-citationAliev, G. M., Horecký, J., Vančová, O., et al. (2009) · Springer eBooks · doi:10.1007/978-3-642-30018-9_205 · Cited by 2 · see citing works
Self-citationRansohoff, R. M., & Benveniste, E. N. (2005) · CRC Press eBooks · doi:10.1201/9781420039849-11 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Akbari, E., Asemi, Z., Daneshvar Kakhaki, R., Bahmani, F., Kouchaki, E., Tamtaji, O. R., Hamidi, G. A., & Salami, M. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00256 · Cited by 946 · see citing works
“Increased biomarkers of oxidative stress (Furman et al., 2016), inflammation and chronic neuroinflammation are reported to be associated with many neurodegenerative disorders of central nervous system (CNS) including AD (Leszek et al., 2016).”
BackgroundInfluentialInflammatory Response in the CNS: Friend or Foe?
Sochocka, M., Diniz, B. S., & Leszek, J. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0297-1 · Cited by 573 · see citing works
“The long-drawn release of pro-inflammatory mediators propels the inflammatory cycle by increased microglial activation and proliferation, thus stimulating enhanced release of pro-inflammatory agents [75].”
BackgroundSelf-citationTesta, G., Staurenghi, E., Zerbinati, C., Gargiulo, S., Iuliano, L., Giaccone, G., Fantò, F., Poli, G., Leonarduzzi, G., & Gamba, P. (2016) · Redox Biology · doi:10.1016/j.redox.2016.09.001 · Cited by 293 · see citing works
“Besides changes in oxysterol levels, it has also become evident that inflammation and oxidative stress are self-reinforcing during AD progression: inflammation can be triggered or enhanced by oxidative stress, through activation of the redox sensitive transcription factor NF-κB, and vice versa [14,23].”
BackgroundSairazi, N. S. M., & Sirajudeen, K. N. S. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/6565396 · Cited by 250 · see citing works
Oxidative Stress and the Microbiota‐Gut‐Brain Axis
Dumitrescu, L., Mitrea, I., Cozma, L., Tulbă, D., Hinescu, M. E., Ceafalan, L. C., Gherghiceanu, M., & Popescu, B. O. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/2406594 · Cited by 212 · see citing works
“There is a dual relationship between OS and inflammation: OS can be induced by inflammatory responses, and inflammation can be triggered or enhanced by ROS through activation of nuclear factor-kappa B (NF-κB), which controls the expression of many genes, including some involved in inflammatory responses leading to the…”
Background3-Nitrotyrosine: a versatile oxidative stress biomarker for major neurodegenerative diseases
Bandookwala, M., & Sengupta, P. (2020) · International Journal of Neuroscience · doi:10.1080/00207454.2020.1713776 · Cited by 187 · see citing works
Jurado-Coronel, J. C., Cabezas, R., Ávila Rodríguez, M. F., Echeverria, V., García-Segura, L. M., & Barreto, G. E. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.09.002 · Cited by 180 · see citing works
“Oxidative stress, excitotoxicity and neuroinflammation play an important role in neuronal death in PD (Albarracin et al., 2012; Leszek et al., 2016; Sutachan et al., 2012; Cabezas et al., 2014), being important the involvement of nitric oxide (NO) and other reactive nitrogen species (Fukae et al.”
BackgroundRahman, M. H., Bajgai, J., Fadriquela, A., Sharma, S., Trinh, T. T., Akter, R., Jeong, Y. J., Goh, S. H., Kim, C.-S., & Lee, K.-J. (2021) · Molecules · doi:10.3390/molecules26175327 · Cited by 182 · see citing works
“Furthermore, the pathophysiology of NDs can also include neuroinflammation [34,35].”
BackgroundAnsari, F., Pourjafar, H., Tabrizi, A., & Homayouni, A. (2020) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201021666200107113812 · Cited by 170 · see citing works
Role of the peripheral innate immune system in the development of Alzheimer's disease
Page, A. Y. L., Dupuis, G., Frost, E. H., Larbi, A., Pawelec, G., Witkowski, J. M., & Fülöp, T. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.12.019 · Cited by 158 · see citing works
“This feedback loop between brain and periphery establishes a continuous cross-talk between these two compartments (Holmes et al., 2003; Leszek et al., 2016; Blach-Olszewska et al., 2015; Busse et al., 2017).”
Rizor, A., Pajarillo, E. A. B., Johnson, J., Aschner, M., & Lee, E.-S. (2019) · Antioxidants · doi:10.3390/antiox8080265 · Cited by 159 · see citing works
“Although reactive astrocytes contribute to limiting CNS damage during acute injury, prolonged astrogliosis leads to neurotoxicity [46].”
BackgroundThe Critical Role of SIRT1 in Parkinson’s Disease: Mechanism and Therapeutic Considerations
Li, X., Feng, Y., Wang, X.-X., Truong, D., & Wu, Y. (2020) · Aging and Disease · doi:10.14336/ad.2020.0216 · Cited by 134 · see citing works
“no doubt that neuroinflammation plays a role in the progression of PD [85].”
BackgroundPiirainen, S., Youssef, A. M., Song, C., Kalueff, A. V., Landreth, G. E., Malm, T., & Tian, L. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.046 · Cited by 125 · see citing works
“Various physiological and cellular stressors, including aging and ypoxia, can “prime” microglia and exacerbate neuroinflammation n AD, as reviewed elsewhere (Head et al., 2016; Heikkinen et al., 014; Leszek et al., 2016; Song et al., 2016).”
Peroxisomes in Immune Response and Inflammation
Cara, F. D., Andreoletti, P., Trompier, D., Véjux, A., Bülow, M. H., Sellin, J., Lizard, G., Cherkaoui‐Malki, M., & Savary, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163877 · Cited by 127 · see citing works
“Given the role that peroxisomes play in oxidative stress, there is growing evidence that suggest that peroxisomes have similar contributions to pathophysiological features in other neurodegenerative diseases such as Alzheimer’s disease, multiple sclerosis, Parkinson’s disease, and Huntington’s disease, in which high l…”
BackgroundIn Vitro Model of Neuroinflammation: Efficacy of Cannabigerol, a Non-Psychoactive Cannabinoid
Gugliandolo, A., Pollastro, F., Grassi, G., Bramanti, P., & Mazzon, E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071992 · Cited by 119 · see citing works
“Indeed, inflammatory cells can produce reactive species at the site of inflammation causing oxidative stress, while reactive oxygen/nitrogen species may initiate an intracellular signaling cascade that induces the expression of pro-inflammatory genes [15,19].”
BackgroundRAGE-TLR Crosstalk Sustains Chronic Inflammation in Neurodegeneration
Gąsiorowski, K., Brokos, B., Echeverrı́a, V., Barreto, G. E., & Leszek, J. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0419-4 · Cited by 117 · see citing works
Self-citationInducible and reversible phenotypes in a novel mouse model of Friedreich’s Ataxia
Chandran, V., Gao, K., Swarup, V., Versano, R., Dong, H., Jordan, M. C., & Geschwind, D. H. (2017) · eLife · doi:10.7554/elife.30054 · Cited by 96 · see citing works
“This implicates a vital role for chemokines and 244 immune response in FRDA pathology, as has been suggested for other neurodegenerative 245 diseases(45-48).”
BackgroundCobourne-Duval, M. K., Taka, E., Mendonca, P., & Soliman, K. F. A. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.04.018 · Cited by 92 · see citing works
Ser, H., Tan, L. T., Palanisamy, U. D., et al. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00899 · Cited by 91 · see citing works
“In recent years, the accumulation of free radicals or oxidative stress has been identified as one of the major contribution to neuronal loss and occur early in all major neurodegenerative diseases (Lin and Beal, 2006; Fischer and Maier, 2015; Leszek et al., 2016).”
BackgroundFractalkine Modulates Microglia Metabolism in Brain Ischemia
Lauro, C., Chece, G., Monaco, L., Antonangeli, F., Peruzzi, G., Rinaldo, S., Paone, A., Cutruzzolà, F., & Limatola, C. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00414 · Cited by 90 · see citing works
Cerium Oxide Nanoparticles: Recent Advances in Tissue Engineering
Hosseini, M., & Mozafari, M. (2020) · Materials · doi:10.3390/ma13143072 · Cited by 90 · see citing works
Gut Inflammation in Association With Pathogenesis of Parkinson’s Disease
Chen, Q.-Q., Haikal, C., Li, W., & Li, J. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00218 · Cited by 88 · see citing works
Focused Review: Cytotoxic and Antioxidant Potentials of Mangrove-Derived Streptomyces
Ser, H., Tan, L. T., Law, J. W., Chan, K., Duangjai, A., Saokaew, S., Pusparajah, P., Mutalib, N. A., Khan, T. M., Goh, B. H., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02065 · Cited by 84 · see citing works
“, Parkinson’s disease and Alzheimer’s disease), cardiovascular diseases and also cancer (Gemma et al., 2007; Abdollahi et al., 2014; Fischer and Maier, 2015; Leszek et al., 2016).”
BackgroundDenver, P., & McClean, P. L. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.238608 · Cited by 85 · see citing works
“…microglial activation and unresolved inflammation in the brain is harmful to neurons and synapses and promotes a state of chronic dysregulation of glial cells and subsequent deterioration of brain structure and function (Frank-Cannon et al., 2009; Steardo et al., 2015; Leszek et al., 2016).”
BackgroundSelvaraj, K., Ravichandran, S., Krishnan, S., Radhakrishnan, R. K., Manickam, N., & Kandasamy, M. (2021) · Reproductive Sciences · doi:10.1007/s43032-020-00441-x · Cited by 84 · see citing works
Jeon, M.-T., Kim, K.-S., Kim, E. S., Lee, S., Kim, J., Hoe, H.-S., & Kim, D.-G. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101333 · Cited by 76 · see citing works
“Infiltrating macrophages contribute to oxidative stress and neuroinflammation by producing ROS, nitric oxide, and pro-inflammatory cytokines in brains with NDs, such as stroke, PD and AD (Gesuete et al., 2016; Leszek et al., 2016).”
BackgroundInflammation, insulin signaling and cognitive function in aged APP/PS1 mice
Denver, P., English, A. R., & McClean, P. L. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.03.032 · Cited by 78 · see citing works
López‐Cerdán, A., Andreu, Z., Hidalgo, M. R., Grillo-Risco, R., Català-Senent, J. F., Soler-Sáez, I., Neva-Alejo, A., Gordillo, F., de la Iglesia-Vayá, M., & Garcia‐García, F. (2022) · Biology of Sex Differences · doi:10.1186/s13293-022-00477-5 · Cited by 77 · see citing works
“Oxidative stress, excitotoxicity, and neuroinflammation influence neuron death in PD [5, 6], while nitric oxide and other reactive nitrogen species [7, 8] promote PD progression.”
BackgroundRelationship Between Obesity, Alzheimer’s Disease, and Parkinson’s Disease: an Astrocentric View
Martín-Jiménez, C., Gaitán-Vaca, D. M., Echeverrı́a, V., González, J., & Barreto, G. E. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0193-8 · Cited by 77 · see citing works
Redox Signaling, Neuroinflammation, and Neurodegeneration
Aguilera, G., Colín-González, A. L., Rangel‐López, E., Chavarría, A., & Santamarı́a, A. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7099 · Cited by 79 · see citing works
The Controversial Role of 24-S-Hydroxycholesterol in Alzheimer’s Disease
Gamba, P., Giannelli, S., Staurenghi, E., Testa, G., Sottero, B., Biasi, F., Poli, G., & Leonarduzzi, G. (2021) · Antioxidants · doi:10.3390/antiox10050740 · Cited by 76 · see citing works
“Of note, it has been widely reported that increased oxidative stress in the AD brain intensifies neurodegeneration by favoring generation of reactive oxygen species (ROS) and lipid peroxidation [8,9].”
BackgroundThe Pathophysiology of Nitrogen Dioxide During Inhaled Nitric Oxide Therapy
Petit, P. C., Fine, D. H., Vásquez, G. B., et al. (2016) · ASAIO Journal · doi:10.1097/mat.0000000000000425 · Cited by 75 · see citing works
Sochocka, M., Sobczyński, M., Sender-Janeczek, A., Zwolińska, K., Błachowicz, O., Tomczyk, T., Ziętek, M., & Leszek, J. (2017) · Current Alzheimer Research · doi:10.2174/1567205014666170316163340 · Cited by 75 · see citing works
“Inflammation and pro-inflammatory mediators, blood vessel damage, and oxidative stress have been found to be capable of inducing neurodegeneration, resulting in neuronal loss and brain injury [10, 12-14].”
Self-citationKenawy, S. M., Hegazy, R. R., Hassan, A. H. M., El-Shenawy, S. M. A., Gomaa, N., Zaki, H. F., & Attia, A. S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183565 · Cited by 74 · see citing works
Antidiabetic potential of saffron and its active constituents
Yaribeygi, H., Zare, V., Butler, A. E., Barreto, G. E., & Sahebkar, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27843 · Cited by 74 · see citing works
“…stress is a consequence of an imbalance between free radical species and the antioxidant defense system in favor of free radicals (Alexiou et al., 2018; Cabezas, El ‐ Bachá, González & Barreto, 2012; Leszek et al., 2016; Sutachan et al., 2012; Yaribeygi, Faghihi, Mohammadi, & Sahebkar, 2018).”
Chu, C., Yu, L., Li, Y. H., Guo, H., Zhai, Q., Chen, W., & Tian, F. (2023) · Nutrients · doi:10.3390/nu15071737 · Cited by 71 · see citing works
“Reducing oxidative stress, as one of the pathogenic mechanisms of PD, has emerged as one of numerous novel pharmacological therapies that may provide new avenues for PD treatment [5].”
BackgroundMyelin in Alzheimer’s disease: culprit or bystander?
Maitre, M., Jeltsch-David, H., Okechukwu, N. G., Klein, C., Patte-Mensah, C., & Mensah-Nyagan, A.-G. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01554-5 · Cited by 66 · see citing works
Adetuyi, B. O., & Farombi, E. O. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13660 · Cited by 70 · see citing works
Cansız, D., Ünal, İ., Üstündağ, Ü. V., Alturfan, A. A., Altinoz, M. A., Elmacı, İ., & Emekli‐Alturfan, E. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06532-5 · Cited by 69 · see citing works
Kim, J.-E., Lee, H., Park, J., Cha, B., & Hoe, H. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02549-0 · Cited by 72 · see citing works
“Superoxide dismutase 2 (SOD2), a major antioxidant enzyme in mitochondria, is reportedly induced in the CNS under various neuroinflammatory conditions [17].”
BackgroundInfluentialXie, J., Hong, E., Ding, B., Jiang, W., Zheng, S., Xie, Z., Tian, D., & Chen, Y. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.578060 · Cited by 69 · see citing works
“Bax, an apoptotic counterpart to bcl-2, can antagonize bcl-2, and the relative ratio between Bax and bcl-2 is a key factor in determining the degree of inhibition of apoptosis (Li et al., 2018).”
BackgroundHidalgo‐Lanussa, O., Ávila-Rodriguez, M., Báez-Jurado, E., Zamudio-Rodriguez, J. A., Echeverrı́a, V., García‐Segura, L. M., & Barreto, G. E. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0777-y · Cited by 67 · see citing works
Urrutia, P. J., Hirsch, É. C., González-Billault, C. E., & Núñez, M. T. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14005 · Cited by 66 · see citing works
“Inflammation and oxidative stress are common features of neurodegenerative diseases of the central nervous system, such asADandParkinson’s disease (Fischer andMaier 2015; Leszek et al. 2016).”
BackgroundXu, Y., Cui, C., Sun, M., Zhu, Y., Chu, M., Shi, Y., Lin, S. L., Yang, X., & Shen, Y. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26010 · Cited by 65 · see citing works
“P disease (PD) is a neurodegenerative disease characterized by progressive loss of dopaminergic neurons in the substantia nigra (SN), leading to clinical symptoms such as resting tremor, bradykinesia, postural instability, and attitudinal reflex deficiency [Lotharius and Brundin, 2002; Dauer and Przedborski, 2003], wh…”
BackgroundHilliard, A. L., Mendonca, P., & Soliman, K. F. A. (2020) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2020.577269 · Cited by 64 · see citing works
“However, chronic neuroinflammation tends to cause more neuronal damage and eventual degradation (Kempuraj et al., 2016; Leszek et al., 2016; Cobourne-Duval et al., 2018).”
Ashraf, J. M., Ansari, M. A., Fatma, S., Abdullah, S. M., Iqbal, J., Madkhali, A. M., Hamali, H. A., Ahmad, S., Jerah, A. A., Echeverrı́a, V., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0935-x · Cited by 59 · see citing works
“Carboxymethyl lysine (CML) content was measured by ELISA as described earlier, with minor modification [34].”
MethodMajkutewicz, I., Kurowska, E., Podlacha, M., Myślińska, D., Grembecka, B., Ruciński, J., Pierzynowska, K., & Wrona, D. (2018) · Brain Research · doi:10.1016/j.brainres.2018.02.016 · Cited by 58 · see citing works
Oxidative Stress in Poultry and the Therapeutic Role of Herbal Medicine in Intestinal Health
Li, Y., Wang, K., & Li, C. (2024) · Antioxidants · doi:10.3390/antiox13111375 · Cited by 57 · see citing works
“…increasing the intestinal permeability, with the disruption of tight junction proteins [40]. toxic ROS metabolites produced by intestinal cells can disrupt the microecological balance of the intestine by activating NF-κ B, producing various cytokines and triggering an inflammatory response [44].”
Astrocytes and endoplasmic reticulum stress: A bridge between obesity and neurodegenerative diseases
Martín-Jiménez, C., García-Vega, Á. S., Cabezas, R., Aliev, G., Echeverrı́a, V., González, J., & Barreto, G. E. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.08.001 · Cited by 55 · see citing works
“One of the studied relationships between astrocytes in the pathogenesis of neurodegenerative diseases involves Toll-like receptors (TLRs) signaling (Blach-Olszewska et al., 2015; Gasiorowski et al., 2017; Leszek et al., 2016).”
BackgroundSelf-citationMorshedi, M., Bavafa-Valenlia, K., Hosseinifard, E.-S., Shahabi, P., Abbasi, M. M., Ghorbani, M., Barzegari, A., Sadigh‐Eteghad, S., & Saghafi‐Asl, M. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.03.022 · Cited by 52 · see citing works
LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation
Yan, R., & Liu, Z. (2016) · Protein & Cell · doi:10.1007/s13238-016-0326-x · Cited by 50 · see citing works
“In addition, there are extensive reports in the literature suggesting that dysregulated inflammation is involved in the development of Parkinson’s disease (Leszek et al., 2016).”
BackgroundChi, H., Cao, W., Zhang, M., Su, D., Yang, H., Li, Z., Li, C., She, X., Wang, K., Gao, X., et al. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-020-02053-3 · Cited by 49 · see citing works
“The noise exposure procedure followed the method reported in our previous work [19].”
BackgroundMethodThe Role of Cyclo(His-Pro) in Neurodegeneration
Grottelli, S., Ferrari, I., Pietrini, G., Peirce, M. J., Minelli, A., & Bellezza, I. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081332 · Cited by 47 · see citing works
Stress and Alzheimer’s disease: A senescence link?
Lyons, C. E., & Bartolomucci, A. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.05.010 · Cited by 47 · see citing works
Shou, J., & Shaw, P. (2022) · Cells · doi:10.3390/cells11050796 · Cited by 46 · see citing works
“While inflammation and oxidative stress consist of distinct biochemical cascades, the processes are closely intertwined and function in parallel [154].”
BackgroundGarcinol, a multifaceted sword for the treatment of Parkinson's disease
Deb, S., Phukan, B. C., Mazumder, M. K., Dutta, A., Paul, R. K., Bhattacharya, P., Sandhir, R., & Borah, A. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.04.004 · Cited by 45 · see citing works
Mazumder, M. K., Choudhury, S., & Borah, A. (2019) · IBRO Reports · doi:10.1016/j.ibror.2019.05.003 · Cited by 44 · see citing works
“The major sources of the RONS are the NADPH oxidase, xanthine oxidase and mitochondria, and thus mitochondrial dysfunctions have been reported to cause OS and neurodegeneration in animal models of PD and AD (Beal, 2005; Jiang et al., 2016; Kim et al., 2015; Subramaniam and Chesselet, 2013; Lipski et al., 2011; Leszek…”
BackgroundThe Role of Formyl Peptide Receptors in Neurological Diseases via Regulating Inflammation
Zhu, J., Li, L., Ding, J., Huang, J., Shao, A., & Tang, B. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.753832 · Cited by 43 · see citing works
Emerging Biosensing Technologies for Neuroinflammatory and Neurodegenerative Disease Diagnostics
Abreu, C. M., Soares-dos-Reis, R., Melo, P., Relvas, J. B., Guimarães, J., Sá, M. J., Cruz, A., & Pinto, I. M. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00164 · Cited by 42 · see citing works
“…regulating the activity of the transcription factors AP1 and NF-κB, which in turn control the production and release of inflammatory mediators, such as the cytokines TNFα, IL-1β, IL-6, and IL-8, reactive oxygen and nitrogen species (Ortiz et al., 2013; Leszek et al., 2016; Labzin et al., 2018).”
BackgroundAnderson, G., & Maes, M. H. J. (2017) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527315666161122144659 · Cited by 41 · see citing works
Lipotoxicity, neuroinflammation, glial cells and oestrogenic compounds
Hidalgo‐Lanussa, O., Báez-Jurado, E., Echeverrı́a, V., Ashraf, G. M., Sahebkar, A., García‐Segura, L. M., Melcangi, R. C., & Barreto, G. E. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12776 · Cited by 41 · see citing works
Trojan, E., Bryniarska, N., Leśkiewicz, M., Regulska, M., Chamera, K., Szuster-Głuszczak, M., Leopoldo, M., Lacivita, E., & Basta‐Kaim, A. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666191019170244 · Cited by 42 · see citing works
Jia, Y., Zhang, D., Li, H., Luo, S., Xiao, Y., Li, H., Zhou, F., Wang, C., Feng, L., Wang, G., et al. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114422 · Cited by 41 · see citing works
Ahmed, M. M., Johnson, N. R., Boyd, T. D., Coughlan, C. M., Chial, H. J., & Potter, H. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.718426 · Cited by 41 · see citing works
Dominiak, A., Wilkaniec, A., Jęśko, H. M., Czapski, G. A., Lenkiewicz, A. M., Kurek, E., Wroczyński, P., & Adamczyk, A. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.02.014 · Cited by 40 · see citing works
“Immune activation within the central nervous system (CNS) is involved in the pathogenesis of many neurodegenerative diseases, including Alzheimer's or Parkinson's diseases as well as various neuropsychiatric disorders, like autism (Chez et al., 2007; Leszek et al., 2016; Li et al., 2009; Pasqualetti et al., 2015).”
Petkau, T. L., Hill, A., Connolly, C., Lu, G., Wagner, P., Kosior, N., Blanco, J., & Leavitt, B. R. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz009 · Cited by 37 · see citing works
Deng, S., Ai, Y., Gong, H., Feng, Q., Li, X., Chen, C., Liu, Z., Wang, Y., Peng, Q., & Zhang, L. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.01.136 · Cited by 39 · see citing works
Reduction of the RNA Binding Protein TIA1 Exacerbates Neuroinflammation in Tauopathy
LeBlang, C. J., Medalla, M., Nicoletti, N. W., Hays, E. C., Zhao, J., Shattuck, J. E., Cruz, A. L., Wolozin, B. L., & Luebke, J. I. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00285 · Cited by 38 · see citing works
Nie, Y., Yang, J., Zhou, L., Yang, Z., Liang, J., Liu, Y., Ma, X., Qian, Z., Hong, P., Kalueff, A. V., et al. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02403-3 · Cited by 37 · see citing works
L-linalool exerts a neuroprotective action on hemiparkinsonian rats
de Lucena, J. D., Gadelha-Filho, C. V. J., da Costa, R. O., de Araújo, D. P., Lima, F. A. V., Neves, K. R. T., & Viana, G. S. D. B. (2020) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-019-01793-1 · Cited by 36 · see citing works
“In conclusion, considering that neuroinflammation and oxidative stress play key roles on the neuropathological features of PD (Mosley et al. 2006; Taylor et al. 2013; Leszek et al. 2016) and that LIN exerts both anti-inflammatory and antioxidant actions, our results strongly suggest that LIN neuroprotective activity i…”
Tylek, K., Trojan, E., Leśkiewicz, M., Regulska, M., Bryniarska, N., Curzytek, K., Lacivita, E., Leopoldo, M., & Basta‐Kaim, A. (2021) · Cells · doi:10.3390/cells10092373 · Cited by 36 · see citing works
Wei, T., Wang, Y., Xu, W., et al. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104588 · Cited by 33 · see citing works
Alzheimer’s disease: review of current nanotechnological therapeutic strategies
Baranowska‐Wójcik, E., & Szwajgier, D. (2020) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2020.1719069 · Cited by 33 · see citing works
Regulska, M., Szuster-Głuszczak, M., Trojan, E., Leśkiewicz, M., & Basta‐Kaim, A. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200807144530 · Cited by 60 · see citing works
“Therefore, these data indicate that the resolution of inflammatory response is a multistage and active process [50], and the failure of one or more steps may be involved in the prolonged inflammation and the pathogenesis of chronic inflammatory diseases due to constant stimulation of the immune system, increased pro-i…”
BackgroundPalomares, T., Cordero, M., Bruzos-Cidón, C., Torrecilla, M., Ugedo, L., & Alonso‐Varona, A. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0714-0 · Cited by 33 · see citing works
“Nowadays, neuroinflammation, along with one of its main intrinsic features, oxidative stress, is considered one of most important pathophysiological explanations for the development and progression of neurodegenerative diseases [1, 2].”
BackgroundChiaravalloti, A., Fiorentini, A., Ursini, F., Martorana, A., Koch, G., Belli, L., Toniolo, S., Pietro, B. D., Motta, C., & Schillaci, O. (2016) · Medicine · doi:10.1097/md.0000000000004206 · Cited by 32 · see citing works
“On the other side, the identification of intratechal-synthesized Ig could represent only the epiphenomenon of the presence of deranged immune cells inside the CNS, and these cells contributing to neuropathology with Ig-independent mechanisms.([15]) Contrarily to Qalb, the percentage of AD subjects showing alterations…”
BackgroundMartorana, F., Foti, M., Virtuoso, A., Gaglio, D., Aprea, F., Latronico, T., Rossano, R., Riccio, P., Papa, M., Alberghina, L., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8056904 · Cited by 31 · see citing works
“Nevertheless, chronic astrocytic activation (reactive gliosis) may hold deleterious consequences that limit functional repair of brain parenchyma [4, 6, 7].”
BackgroundAnti-oxidative activity of probiotics; focused on cardiovascular disease, cancer, aging, and obesity
Kavyani, B., Ahmadi, S., Nabizadeh, E., & Abdi, M. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.107001 · Cited by 29 · see citing works
Geng, L., Liu, W., & Chen, Y. (2019) · Journal of Biological Research - Thessaloniki · doi:10.1186/s40709-019-0102-1 · Cited by 29 · see citing works
Wiatrak, B., & Balon, K. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02204-w · Cited by 27 · see citing works
Loughman, A., Adler, C. J., & Macpherson, H. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-220760 · Cited by 26 · see citing works
“Microglial activation is a central component of the neuroinflammatory cascade leading to cognitive decline in AD [69].”
BackgroundPutative neural consequences of captivity for elephants and cetaceans
Jacobs, B., Rally, H., Doyle, C., O’Brien, L., Tennison, M., & Marino, L. (2022) · Reviews in the Neurosciences · doi:10.1515/revneuro-2021-0100 · Cited by 25 · see citing works
“One neural consequence under such conditions is microglia activation and a sustained release of inflammatory mediators (Leszek et al. 2016).”
BackgroundTaurine counteracts the neurotoxic effects of streptozotocin-induced diabetes in rats
Caletti, G., Herrmann, A. P., Pulcinelli, R. R., Reinhardt, L. S., Morás, A. M., Vianna, P., Chies, J. A. B., Moura, D. J., Barros, H. M. T., & Gomez, R. (2017) · Amino Acids · doi:10.1007/s00726-017-2495-1 · Cited by 25 · see citing works
Tan, X., Zhou, Y., Gong, P., Guan, H., Wu, B., Hou, L., Feng, X., Zheng, W., & Li, J. (2018) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2018.12.014 · Cited by 22 · see citing works
Oxidative Stress Assessment in Alzheimer’s Disease: A Clinic Setting Study
Vergallo, A., Giampietri, L., Baldacci, F., Volpi, L., Chico, L., Pagni, C., Giorgi, F. S., Ceravolo, R., Tognoni, G., Siciliano, G., et al. (2017) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317517728352 · Cited by 22 · see citing works
Fournier, C. N., Houser, M. C., Tansey, M. G., Glass, J. D., & Hertzberg, V. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.10.007 · Cited by 21 · see citing works
Zhao, H., Cheng, J., Liu, T., Jiang, J., Koch, F. C., Sachdev, P. S., Basser, P. J., Wen, W. X., & Initiative, A. D. N. (2021) · Human Brain Mapping · doi:10.1002/hbm.25628 · Cited by 20 · see citing works
“Axonal loss and glial swelling are prominent features of AD (Englund, 1998; Stokin et al., 2005), this may lead to the enlarged perivascular spaces in the pathogenesis of AD (Fischer & Maier, 2015; Kawahara, 2010; Leszek et al., 2016; Reddy, 2009; Santos et al., 2010; Shu et al., 2013).”
Cotinine: A Therapy for Memory Extinction in Post-traumatic Stress Disorder
Mendoza, C., Barreto, G. E., Iarkov, A., Tarasov, V. V., Aliev, G. M., & Echeverrı́a, V. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0869-3 · Cited by 21 · see citing works
Self-citationNeshan, M., Malakouti, S. K., Kamalzadeh, L., Makvand, M., Campbell, A., & Ahangari, G. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210480 · Cited by 19 · see citing works
Mohamad, H. E., Abo–Elmatty, D. M., Wahba, N. S., Shaheen, M. A., Sakr, R., & Wahba, A. S. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120613 · Cited by 19 · see citing works
Forte, A. R. C. C., Lessa, P. H. C., Filho, A. J. M. C., de Aquino, P. E. A., Brito, L. M., PINHEIRO, L. C. S., Juruena, M. F., de Lucena, D. F., de Rezende, P. H. F., & Vasconcelos, S. M. M. (2023) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x2023e12484 · Cited by 19 · see citing works
“On the other hand, inflammation can be triggered or enhanced by oxidative stress through activation of nuclear factor-kappa B (NF-kB), which controls the expression of many genes, including inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2), which are involved in proinflammatory cytokine production (68…”
BackgroundProbiotics that Ameliorate Cognitive Impairment through Anti-Inflammation and Anti-Oxidation in Mice
Lee, S., Eom, S., Lee, J., Pyeon, M., Kim, K., Choi, K. Y., Lee, J., Shin, D. J., Lee, K. H., Oh, S., et al. (2023) · Food Science of Animal Resources · doi:10.5851/kosfa.2023.e22 · Cited by 18 · see citing works
Gut microbiota influence frailty syndrome in older adults: mechanisms and therapeutic strategies
Wang, X., Fan, L., Meng, C., Wang, Y., Deng, L.-E., Yuan, Z., Zhang, J., Li, Y., & Lv, S. (2023) · Biogerontology · doi:10.1007/s10522-023-10082-7 · Cited by 20 · see citing works
“ROS can also trigger or enhance inflammation through direct activation of NF-κB (Leszek et al. 2016).”
Wakulik, K., Wiatrak, B., Szczukowski, Ł., Bodetko, D., Szandruk-Bender, M., Dobosz, A., Świątek, P., & Gąsiorowski, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072575 · Cited by 18 · see citing works
Self-citationLiu, J., Hui, A., Wang, J., Hu, Q., Li, S., Chen, Y., Wu, Z., & Zhang, W. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110675 · Cited by 17 · see citing works
Asejeje, F. O., Abiola, M. A., Adeyemo, O. A., Ogunro, O. B., & Ajayi, A. M. (2024) · Neuroscience Letters · doi:10.1016/j.neulet.2024.137710 · Cited by 17 · see citing works
Signoriello, E., Mallardo, M., Nigro, E., et al. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02287-z · Cited by 17 · see citing works
Asghari, A., Hosseini, M., Beheshti, F., Shafei, M. N., & Mehri, S. (2018) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2018.1480602 · Cited by 17 · see citing works
“A relationship between oxidative stress and neuroinflammation and their contribution in neurodegeneration have been widely suggested [64,65].”
BackgroundRather, M. A., Khan, A., Jahan, S., Siddiqui, A. J., & Wang, L. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.05.042 · Cited by 16 · see citing works
The human body as an energetic hybrid? New perspectives for chronic disease treatment?
Gajewski, M., Rzodkiewicz, P., & Maśliński, S. (2017) · Reumatologia/Rheumatology · doi:10.5114/reum.2017.67605 · Cited by 15 · see citing works
“This observation links oxidative stress with the development of neuronal death and neural dysfunction [16, 17].”
Background
- Authors
- Leszek, J., E. Barreto, G., G|siorowski, K., Koutsouraki, E., Ávila-Rodrigues, M., & Aliev, G.
- Venue
- CNS & Neurological Disorders - Drug Targets
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2016-03-10
- Volume
- 15
- Issue
- 3
- Pages
- 329-336
- ISSN
- 1568-007X (ISSN-L)
- 1871-5273
- OpenAlex
- W2271123303
- Semantic Scholar
- 91475bee1cf3d32abe2d7e1be1755b559ca3dc93
- Cited by
- 206
- References
- 88
- Citations by year
- 2026: 13 · 2025: 19 · 2024: 23 · 2023: 16 · 2022: 13 · 2021: 23 · 2020: 20 · 2019: 16 · 2018: 31 · 2017: 23 · 2016: 9
- FWCI
- 14.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- CNS & Neurological Disorders - Drug Targets (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- neuroinflammation, neurodegeneration, microglial activation, oxidative stress, nitrosative stress, Toll-like receptor signaling, cytokines, Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis, age-related macular degeneration, tauopathy
- MeSH terms
- Animals, Brain, Humans, Immunity, Innate, Inflammation, Cytokines, Microglia, Oxidative Stress, Disease Progression, Neurodegenerative Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review