The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Disordered IL-33/ST2 Activation in Decidualizing Stromal Cells Prolongs Uterine Receptivity in Women with Recurrent Pregnancy Loss
Open accessAbstract
Decidualization renders the endometrium transiently receptive to an implanting blastocyst although the underlying mechanisms remain incompletely understood. Here we show that human endometrial stromal cells (HESCs) rapidly release IL-33, a key regulator of innate immune responses, upon decidualization. In parallel, differentiating HESCs upregulate the IL-33 transmembrane receptor ST2L and other pro-inflammatory mediators before mounting a profound anti-inflammatory response that includes downregulation of ST2L and increased expression of the soluble decoy receptor sST2. We demonstrate that HESCs secrete factors permissive of embryo implantation in mice only during the pro-inflammatory phase of the decidual process. IL-33 knockdown in undifferentiated HESCs was sufficient to abrogate this pro-inflammatory decidual response. Further, sequential activation of the IL-33/ST2L/sST2 axis was disordered in decidualizing HESCs from women with recurrent pregnancy loss. Signals from these cultures prolonged the implantation window but also caused subsequent pregnancy failure in mice. Thus, Il-33/ST2 activation in HESCS drives an autoinflammatory response that controls the temporal expression of receptivity genes. Failure to constrain this response predisposes to miscarriage by allowing out-of-phase implantation in an unsupportive uterine environment.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Wegmann, T. G., Lin, H., Guilbert, L., & Mosmann, T. R. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90235-d · Cited by 2,852
Rai, R., & Regan, L. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69204-0 · Cited by 1,227
Time of Implantation of the Conceptus and Loss of Pregnancy
Wilcox, A. J., Baird, D. D., & Weinberg, C. R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199906103402304 · Cited by 1,081
Carriere, V., Roussel, L., Ortega, N., Lacorre, D.-A., Americh, L., Aguilar, L., Bouche, G., & Girard, J.-P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606854104 · Cited by 966
Endometrial receptivity markers, the journey to successful embryo implantation.
Achache, H., & Revel, A. (2006) · Human Reproduction Update · doi:10.1093/humupd/dml004 · Cited by 952
Role of IL-33 in inflammation and disease
Miller, A. M. (2011) · Journal of Inflammation · doi:10.1186/1476-9255-8-22 · Cited by 481
Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease
Chapuis, J., Hot, D., Hansmannel, F., Kerdraon, O., Ferreira, S., Hubans, C., Maurage, C. A., Huot, L., Bensemain, F., Laumet, G., et al. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.10 · Cited by 201
Cloke, B., Huhtinen, K., Fusi, L., Kajihara, T., Yliheikkilä, M., Ho, K.-K., Teklenburg, G., Lavery, S., Jones, M. C., Trew, G., et al. (2008) · Endocrinology · doi:10.1210/en.2008-0356 · Cited by 159
Self-citation
Cited by
Interleukin-33 in tissue homeostasis, injury, and inflammation
Molofsky, A. B., Savage, A. K., & Locksley, R. M. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.006 · Cited by 638
Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium
Brighton, P. J., Maruyama, Y., Fishwick, K., Vrljicak, P., Tewary, S., Fujihara, R., Muter, J., Lucas, E. S., Yamada, T., Woods, L., et al. (2017) · eLife · doi:10.7554/elife.31274 · Cited by 323
Self-citation(2020) · doi:10.1038/s42003-020-0763-1 · Cited by 309
Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids
Rawlings, T. M., Makwana, K., Taylor, D. M., Molè, M. A., Fishwick, K. J., Tryfonos, M., Odendaal, J., Hawkes, A., Zernicka-Goetz, M., Hartshorne, G. M., et al. (2021) · eLife · doi:10.7554/elife.69603 · Cited by 269
Self-citationPlacental metabolomics for assessment of pregnancy complications: A systematic review
Mercer, G. V., & Cahill, L. S. (2026) · Molecular Omics · doi:10.1093/molecular-omics/aaiag015 · Cited by 2
Metadata
- Authors
- Salker, M. S., Nautiyal, J., Steel, J. H., Webster, Z., Šućurović, S., Nicou, M., Singh, Y., Lucas, E. S., Murakami, K., Chan, Y.-W., James, S., Abdallah, Y., Christian, M., Croy, B. A., Mulac-Jericevic, B., Quenby, S., & Brosens, J. J.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-12-27
- Volume
- 7
- Issue
- 12
- Pages
- e52252
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W1979277919
- Cited by
- 224
- References
- 8
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Disordered IL-33/ST2 Activation in Decidualizing Stromal Cells Prolongs Uterine Receptivity in Women with Recurrent Pregnancy Loss. https://app.cochat.ai/papers/10.1371/journal.pone.0052252
- The paper
- Salker, M. S., Nautiyal, J., Steel, J. H., Webster, Z., Šućurović, S., Nicou, M., Singh, Y., Lucas, E. S., Murakami, K., Chan, Y.-W., James, S., Abdallah, Y., Christian, M., Croy, B. A., Mulac-Jericevic, B., Quenby, S., & Brosens, J. J. (2012). Disordered IL-33/ST2 Activation in Decidualizing Stromal Cells Prolongs Uterine Receptivity in Women with Recurrent Pregnancy Loss. PLoS ONE. https://doi.org/10.1371/journal.pone.0052252
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
