The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
High Prevalence of Mucosa-Associated E. coli Producing Cyclomodulin and Genotoxin in Colon Cancer
Open accessAbstract
Some Escherichia coli strains produce toxins designated cyclomodulins (CMs) which interfere with the eukaryotic cell cycle of host cells, suggesting a possible link between these bacteria and cancers. There are relatively few data available concerning the colonization of colon tumors by cyclomodulin- and genotoxic-producing E. coli. We did a qualitative and phylogenetic analysis of mucosa-associated E. coli harboring cyclomodulin-encoding genes from 38 patients with colorectal cancer (CRC) and 31 with diverticulosis. The functionality of these genes was investigated on cell cultures and the genotoxic activity of strains devoid of known CM-encoding gene was investigated. Results showed a higher prevalence of B2 phylogroup E. coli harboring the colibatin-producing genes in biopsies of patients with CRC (55.3%) than in those of patients with diverticulosis (19.3%), (p<0.01). Likewise, a higher prevalence of B2 E. coli harboring the CNF1-encoding genes in biopsies of patients with CRC (39.5%) than in those of patients with diverticulosis (12.9%), (p = 0.01). Functional analysis revealed that the majority of these genes were functional. Analysis of the ability of E. coli to adhere to intestinal epithelial cells Int-407 indicated that highly adherent E. coli strains mostly belonged to A and D phylogroups, whatever the origin of the strains (CRC or diverticulosis), and that most E. coli strains belonging to B2 phylogroup displayed very low levels of adhesion. In addition, 27.6% (n = 21/76) E. coli strains devoid of known cyclomodulin-encoding genes induced DNA damage in vitro, as assessed by the comet assay. In contrast to cyclomodulin-producing E. coli, these strains mainly belonged to A or D E. coli phylogroups, and exhibited a non significant difference in the distribution of CRC and diverticulosis specimens (22% versus 32.5%, p = 0.91). In conclusion, cyclomodulin-producing E. coli belonging mostly to B2 phylogroup colonize the colonic mucosa of patients with CRC.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“These pks-positive E. coli strains have been detected in approximately 20% of healthy individuals, 40% of patients with inflammatory bowel disease, and 60% of patients with CRC”
From Selection, Comparative Genomics, and Potential Probiotic Features of Escherichia coli 5C, a pks-Negative Strain Isolated from Healthy Infant Donor Feces (2026) · cites this paper as [153]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
Kaper, J. B., Nataro, J. P., & Mobley, H. L. T. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro818 · Cited by 5,583
Versalovic, J. A., Koeuth, T., & Lupski, R. L. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.24.6823 · Cited by 3,249
Rapid and Simple Determination of the Escherichia coli Phylogenetic Group
Clermont, O., Bonacorsi, S., & Bingen, É. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.10.4555-4558.2000 · Cited by 2,647
Intestinal inflammation targets cancer-inducing activity of the microbiota
Arthur, J. C., Perez-Chanona, E., Mühlbauer, M., Tomkovich, S., Uronis, J. M., Fan, T.-J., Campbell, B. J., Abujamel, T., Dogan, B., Rogers, A. B., et al. (2012) · Science · doi:10.1126/science.1224820 · Cited by 2,263
Wu, S., Rhee, K.-J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H.-R., Huso, D. L., Brancati, F. L., Wick, E., McAllister, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2015 · Cited by 1,812
Wood, R., Mitchell, M., Sgouros, J., & Lindahl, T. (2001) · Science · doi:10.1126/science.1056154 · Cited by 1,719
Molecular mechanisms of Escherichia coli pathogenicity
Croxen, M. A., & Finlay, B. B. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2265 · Cited by 1,222
Escherichia coli Induces DNA Double-Strand Breaks in Eukaryotic Cells
Nougayrède, J.-P., Homburg, S., Taieb, F., Boury, M., Brzuszkiewicz, E., Gottschalk, G., Buchrieser, C., Hacker, J., Dobrindt, U., & Oswald, E. (2006) · Science · doi:10.1126/science.1127059 · Cited by 1,188
Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells
Cuevas-Ramos, G., Petit, C. R., Marcq, I., Boury, M., Oswald, E., & Nougayrède, J.-P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001261107 · Cited by 855
Flagged first, then by citations
Research works printed but not linked: 3
- HM Martin, 2004, Enhanced Escherichia coli adherence and invasion in Crohn's disease and colon cancer, Gastroenterology, 127, 80
- HM Martin, 2004, Enhanced Escherichia coli adherence and invasion in Crohn's disease and colon cancer, Gastroenterology, 127, 80
- O Marchès, 2003, Enteropathogenic and enterohaemorrhagic Escherichia coli deliver a novel effector called Cif, which blocks cell cycle G2/M transition, Molecular Microbiology, 50, 1553, 10.1046/j.1365-2958.2003.03821.x · DOI
Cited by
Sorted by citations
Items 201–300 of 538
Metabolic models predict bacterial passengers in colorectal cancer
Garza, D. R., Taddese, R., Wirbel, J., Zeller, G., Boleij, A., Huynen, M. A., & Dutilh, B. E. (2020) · Cancer & Metabolism · doi:10.1186/s40170-020-0208-9 · Cited by 38
Gut microbiota, an emergent target to shape the efficiency of cancer therapy
Kouidhi, S., Zidi, O., Belkhiria, Z., Raïs, H., Ayadi, A., Ayed, F. B., Mosbah, A., Cherif, A., & Gaaied, A. B. A. E. (2023) · Exploration of Targeted Anti-tumor Therapy · doi:10.37349/etat.2023.00132 · Cited by 37
Hamid, M. A., Pammer, L. M., Oberparleiter, S., Günther, M., Amann, A., Gruber, R., Mair, A., Nocera, F. I., Ormanns, S., Zimmer, K., et al. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-00892-y · Cited by 41
Molecular Paths Linking Metabolic Diseases, Gut Microbiota Dysbiosis and Enterobacteria Infections
Sérino, M. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.01.010 · Cited by 37
Khan, S., Zaidi, S., Alouffi, A., Hassan, I., Imran, A., & Khan, R. A. (2020) · ACS Omega · doi:10.1021/acsomega.9b04042 · Cited by 36
Elsalem, L., Jum’ah, A. A., Alfaqih, M. A., & Aloudat, O. (2020) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s243337 · Cited by 38
Exploring the microbiota to better understand gastrointestinal cancers physiology
Panebianco, C., Potenza, A., Andriulli, A., & Pazienza, V. (2018) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2017-1163 · Cited by 46
Influence of the microenvironment on modulation of the host response by typhoid toxin
Martin, O. C. B., Bergonzini, A., Chiloeches, M. L., Paparouna, E., Butter, D., Theodorou, S. D. P., Haykal, M. M., Boutet-Robinet, E. A., Tebaldi, T., Wakeham, A. C., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108931 · Cited by 34
Wami, H. T., Wallenstein, A., Sauer, D., Stoll, M., von Bünau, R., Oswald, É., Müller, R., & Dobrindt, U. (2021) · Microbial Genomics · doi:10.1099/mgen.0.000577 · Cited by 41
Nouri, R., Hasani, A., Shirazi, K. M., Alivand, M. R., Sepehri, B., Sotoudeh, S., Hemmati, F., Fattahzadeh, A., Abdinia, B., & Rezaee, M. A. (2021) · Canadian Journal of Infectious Diseases and Medical Microbiology · doi:10.1155/2021/2131787 · Cited by 36
Avilés‐Jiménez, F., Yu, G., Torres-Poveda, K., Madrid‐Marina, V., & Torres, J. (2017) · Archives of Medical Research · doi:10.1016/j.arcmed.2017.11.008 · Cited by 34
Zhang, S., Fu, J., Dogan, B., Scherl, E., & Simpson, K. W. (2018) · The Journal of Antibiotics · doi:10.1038/s41429-018-0081-8 · Cited by 34
Biosynthesis and bioactivities of microbial genotoxin colibactins
Tang, J., Liu, X., Ye, W., Li, Z., & Qian, P. (2022) · Natural Product Reports · doi:10.1039/d1np00050k · Cited by 36
Physiological drivers of pks+ E. coli in colorectal cancer
Jans, M., & Vereecke, L. (2025) · Trends in Microbiology · doi:10.1016/j.tim.2025.04.010 · Cited by 33
The intestinal microbiome and surgical disease
Krezalek, M. A., Skowron, K. B., Guyton, K. L., Shakhsheer, B. A., Hyoju, S. K., & Alverdy, J. C. (2016) · Current Problems in Surgery · doi:10.1067/j.cpsurg.2016.06.001 · Cited by 35
The role played by bacterial infections in the onset and metastasis of cancer
Khatun, S., Appidi, T., & Rengan, A. K. (2021) · Current Research in Microbial Sciences · doi:10.1016/j.crmicr.2021.100078 · Cited by 33
Wong, J. J., Ho, F. K., Choo, P. Y., Chong, K. K. L., Ho, C. M. B., Neelakandan, R., Keogh, D., Barkham, T., Chen, J. L., Liu, C., et al. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010766 · Cited by 35
Andrews, M. C., Reuben, A., Gopalakrishnan, V., & Wargo, J. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00946 · Cited by 33
Miyasaka, T., Yamada, T., Uehara, K., Sonoda, H., Matsuda, A., Shinji, S., Ohta, R., Kuriyama, S., Yokoyama, Y., Takahashi, G., et al. (2024) · Cancer Science · doi:10.1111/cas.16088 · Cited by 36
Depurination of Colibactin-Derived Interstrand Cross-Links
Xue, M., Wernke, K. M., & Herzon, S. B. (2020) · Biochemistry · doi:10.1021/acs.biochem.9b01070 · Cited by 36
Human Microbiome and Its Medical Applications
Zhang, Y., Zhou, L., Xia, J., Dong, C., & Luo, X. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.703585 · Cited by 32
The gut microbiota can orchestrate the signaling pathways in colorectal cancer
Bennedsen, A. L. B., Furbo, S., Bjarnsholt, T., Raskov, H., Gögenür, I., & Kvich, L. (2022) · Apmis · doi:10.1111/apm.13206 · Cited by 30
Phenol‐soluble modulin α induces G2/M phase transition delay in eukaryotic HeLa cells
Deplanche, M., Filho, R. A. E.-A., Alekseeva, L. G., Ladier, E., Jardin, J., Henry, G., Azevedo, V., Miyoshi, A., Beraud, L., Laurent, F. J., et al. (2015) · The FASEB Journal · doi:10.1096/fj.14-260513 · Cited by 31
Microbial factors in inflammatory diseases and cancers
Ong, H. S., & Yim, H. C. H. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-5987-2_7 · Cited by 29
Rastogi, Y. R., Saini, A. K., Thakur, V. K., & Saini, R. V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093212 · Cited by 32
Tremblay, W., Mompart, F., Lopez, E., Quaranta, M., Bergoglio, V., Hashim, S., Bonnet, D., Alric, L., Mas, E., Trouche, D., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.656795 · Cited by 30
Iwasaki, M., Kanehara, R., Yamaji, T., Katagiri, R., Mutoh, M., Tsunematsu, Y., Sato, M., Watanabe, K., Hosomi, K., Kakugawa, Y., et al. (2021) · Cancer Science · doi:10.1111/cas.15196 · Cited by 30
Yu, L., Zhang, M., & Hou, J. (2022) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2022.2088247 · Cited by 32
Suresh, A., Ranjan, A. K., Jadhav, S., Hussain, A., Shaik, S., Alam, M., Baddam, R., Wieler, L. H., & Ahmed, N. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02631 · Cited by 30
Escherichia coli: The Good, the Bad and the Ugly
Dalmasso, J. D. G. (2015) · Clinical Microbiology Open Access · doi:10.4172/2327-5073.1000195 · Cited by 28
Gut Microbiota and Cancer of the Host: Colliding Interests
Baffy, G. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-34025-4_5 · Cited by 30
Xing, J., Liao, Y., Zhang, H., Zhang, W., Zhang, Z., Zhang, J., Wang, D., & Tang, D. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.804689 · Cited by 29
Targeting colorectal cancer-associated bacteria: A new area of research for personalized treatments
Faïs, T., Delmas, J., Cougnoux, A., Dalmasso, G., & Bonnet, R. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1155020 · Cited by 30
Self-citationKaewkod, T., Tobe, R., Tragoolpua, Y., & Mihara, H. (2020) · Journal of Applied Microbiology · doi:10.1111/jam.14817 · Cited by 30
Bacterial cyclomodulins: types and roles in carcinogenesis
Morgan, R. N., Saleh, S. E., Farrag, H. A., & Aboulwafa, M. (2021) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2021.1944052 · Cited by 27
Piciocchi, A., Germinario, E. A. P., García‐Etxebarria, K., Rossi, S., Sanchez-Mete, L., Porowska, B., Stigliano, V., Trentino, P., Oddi, A., Accarpio, F., et al. (2021) · Toxins · doi:10.3390/toxins13080569 · Cited by 29
Structural basis of colibactin activation by the ClbP peptidase
Velilla, J. A., Volpe, M. R., Kenney, G. E., Walsh, R. M., Balskus, E. P., & Gaudet, R. (2022) · Nature Chemical Biology · doi:10.1038/s41589-022-01142-z · Cited by 27
Model Colibactins Exhibit Human Cell Genotoxicity in the Absence of Host Bacteria
Shine, E. E., Xue, M., Patel, J. R., Healy, A. R., Surovtseva, Y. V., Herzon, S. B., & Crawford, J. M. (2018) · ACS Chemical Biology · doi:10.1021/acschembio.8b00714 · Cited by 27
Current understandings of colibactin regulation
Addington, E., Sandalli, S., & Roe, A. J. (2024) · Microbiology · doi:10.1099/mic.0.001427 · Cited by 27
Ahmad, A., Mahmood, N., Raza, M. A., Mushtaq, Z., Saeed, F., Afzaal, M., Hussain, M., Amjad, H., & Al-Awadi, H. M. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e29495 · Cited by 32
Tozzi, M., Fiore, A., Travaglione, S., Marcon, F., Rainaldi, G., Germinario, E. A. P., Laterza, I., Donati, S., Macchia, D., Spada, M., et al. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03271-w · Cited by 25
Kim, M., Lee, S., Choi, S., Lee, H., Kwon, S. S., Byun, J., Kim, Y. A., Rhee, K., Choi, J. R., Kim, T. I., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-76467-7 · Cited by 25
Duijster, J. W., Franz, E., Neefjes, J., & Mughini‐Gras, L. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.790256 · Cited by 29
Implication of gut microbes and its metabolites in colorectal cancer
Kumar, A., Ali, A., Kapardar, R. K., Dar, G. M., Nimisha, Apurva, A., Sharma, A. K., Verma, R., Sattar, R. S. A., Ahmad, E., et al. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-04422-2 · Cited by 26
Georgeson, P., Steinfelder, R. S., Harrison, T. A., Pope, B. J., Zaidi, S. H. E., Qu, C., Lin, Y., Joo, J. E., Mahmood, K., Clendenning, M., et al. (2023) · medRxiv · doi:10.1101/2023.03.10.23287127 · Cited by 26
Gut Microbiota and Colorectal Cancer Risk Factors
Feizi, H., Rezaee, M. A., Ghotaslou, R., Sadrkabir, M., Jadidi‐Niaragh, F., Gholizadeh, P., Taghizadeh, S., Ghanbarov, K., Yousefi, M., & Kafil, H. S. (2022) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201023666221005103340 · Cited by 25
Miller, R. A., & Wiedmann, M. (2016) · Toxins · doi:10.3390/toxins8050121 · Cited by 24
Zhou, T., Hirayama, Y., Tsunematsu, Y., Suzuki, N., Tanaka, S., Uchiyama, N., Goda, Y., Yoshikawa, Y., Iwashita, Y., Sato, M., et al. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c01495 · Cited by 27
REDIKER, Marcus. O Navio Negreiro. Uma história humana. São Paulo: Companhia das Letras, 2011.
Brito, Ê. J. D. C. (2012) · REVER - Revista de Estudos da Religião · doi:10.21724/rever.v12i1.10497 · Cited by 25
Carlini, F., Maroccia, Z., Fiorentini, C., Travaglione, S., & Fabbri, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212610 · Cited by 24
Rye, M. S., Garrett, K. L., Holt, R. A., Platell, C. F. E., & McCoy, M. J. (2022) · PLoS ONE · doi:10.1371/journal.pone.0262416 · Cited by 24
Tariq, H., Noreen, Z., Ahmad, A., Khan, L., Ali, M., Malik, M., Javed, A., Rasheed, F., Fatima, A., Kocagoz, T., et al. (2022) · PLOS ONE · doi:10.1371/journal.pone.0262662 · Cited by 22
A tale of two bacteria – Bacteroides fragilis, Escherichia coli, and colorectal cancer
Lichtenstern, C. R., & Lamichhane-Khadka, R. (2023) · Frontiers in Bacteriology · doi:10.3389/fbrio.2023.1229077 · Cited by 23
Zhang, G., & Sun, D. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1501973 · Cited by 23
Hisamatsu, T., Miyoshi, J., Oguri, N., Morikubo, H., Saito, D., Hayashi, A., Omori, T., & Matsuura, M. (2025) · Cells · doi:10.3390/cells14080567 · Cited by 22
Vitali, F., Tortora, K., Paola, M. D., Bartolucci, G., Menicatti, M., Filippo, C. D., & Caderni, G. (2022) · Scientific Reports · doi:10.1038/s41598-022-05249-0 · Cited by 22
Lamaudière, M. T. F., Arasaradnam, R. P., Weedall, G. D., & Morozov, I. Y. (2023) · mSphere · doi:10.1128/msphere.00626-22 · Cited by 22
Welham, Z., Li, J., Engel, A. F., & Molloy, M. P. (2023) · Cancers · doi:10.3390/cancers15205045 · Cited by 23
Cytotoxic Escherichia coli strains encoding colibactin colonize laboratory mice
García, A., Mannion, A. J., Feng, Y., Madden, C. M., Bakthavatchalu, V., Shen, Z., Ge, Z., & Fox, J. G. (2016) · Microbes and Infection · doi:10.1016/j.micinf.2016.07.005 · Cited by 22
Wang, X., Undi, R. B., Ali, N., & Huycke, M. M. (2021) · Disease Models & Mechanisms · doi:10.1242/dmm.048793 · Cited by 20
Suresh, A., Shaik, S., Baddam, R., Ranjan, A. K., Qumar, S., Jadhav, S., Semmler, T., Ghazi, I. A., Wieler, L. H., & Ahmed, N. (2021) · mBio · doi:10.1128/mbio.03634-20 · Cited by 22
Adherent-invasive Escherichia coli in Crohn’s disease: the 25th anniversary
Barnich, N., Arthur, J. C., Buisson, A., Campbell, B. J., Carbonnel, F., Chassaing, B., Coombes, B. K., Denizot, J., Dogan, B., Faith, J. J., et al. (2025) · Gut · doi:10.1136/gutjnl-2025-335331 · Cited by 21
Jameel, M., & Kwok, H. F. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.06.011 · Cited by 20
Can we change our microbiome to prevent colorectal cancer development?
Manzat-Saplacan, R. M., Mircea, P. A., Bălăcescu, L., Chira, R. I., Berindan‐Neagoe, I., & Bălăcescu, O. (2015) · Acta Oncologica · doi:10.3109/0284186x.2015.1054949 · Cited by 20
E. coli and colon cancer: Is mutY a culprit?
Khan, A. A., & Cash, P. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.08.003 · Cited by 20
Cyclo(phenylalanine‐proline) induces DNA damage in mammalian cellsviareactive oxygen species
Lee, K., Jeong, J. E., Kim, I. H., Kim, K., & Ju, B. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12678 · Cited by 22
Ho, M., Mettouchi, A., Wilson, B. A., & Lemichez, E. (2018) · Pathogens and Disease · doi:10.1093/femspd/fty045 · Cited by 20
Extension of Diagnostic Fragmentation Filtering for Automated Discovery in DNA Adductomics
Murray, K. J., Carlson, E. S., Stornetta, A., Balskus, E. P., Villalta, P. W., & Balbo, S. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.0c04895 · Cited by 21
Prevalence and implications of pKs-positive Escherichia coli in colorectal cancer
de Souza, J. B., Campos, L. A. D. A., Palácio, S. B., de Castro, M. C. A. B., & Cavalcanti, I. M. F. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122462 · Cited by 20
de Souza, J. B., Coriolano, D. D. L., Silva, R. C. D. S., Júnior, S. D. D. C., Campos, L. A. D. A., Cavalcanti, I. D. L., Nogueira, M. C. D. B. L., Pereira, V. R. A., de Castro, M. C. A. B., & Cavalcanti, I. M. F. (2024) · Pharmaceuticals · doi:10.3390/ph17060802 · Cited by 21
Zechner, E. L., & Kienesberger, S. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2430423 · Cited by 20
Gut microbiota in cancer initiation, development and therapy
Zhang, R., Zhang, X., Lau, H. C.-H., & Yu, J. Q. (2024) · Science China Life Sciences · doi:10.1007/s11427-024-2831-x · Cited by 19
Genetics, genomics and clinical features of adenomatous polyposis
Joo, J. E., Viana-Errasti, J., Buchanan, D. D., & Valle, L. (2025) · Familial Cancer · doi:10.1007/s10689-025-00460-0 · Cited by 20
Mempin, M., Hu, H., Vickery, K., Kadin, M. E., Prince, H. M., KOUTTAB, N. M., Morgan, J. W., Adams, W. P., & Deva, A. K. (2021) · Cancers · doi:10.3390/cancers13215298 · Cited by 19
The microbiome-product colibactin hits unique cellular targets mediating host–microbe interaction
Mousa, W. K. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.958012 · Cited by 23
Pal, P., & Shastry, R. P. (2023) · Folia Microbiologica · doi:10.1007/s12223-023-01085-5 · Cited by 18
Bacterial small molecule metabolites implicated in gastrointestinal cancer development
Turocy, T., & Crawford, J. M. (2024) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01103-4 · Cited by 22
Khan, A. A. (2014) · Journal of Computational Biology · doi:10.1089/cmb.2014.0001 · Cited by 19
François, R. M. M., Massicard, J.-M., & Weissman, K. J. (2024) · Natural Product Reports · doi:10.1039/d4np00046c · Cited by 18
The specificity and structure of DNA cross-linking by the gut bacterial genotoxin colibactin
Carlson, E. S., Haslecker, R., Lecchi, C., Ramos, M. A. A., Vennelakanti, V., Honaker, L., Stornetta, A., Millán, E. S., Johnson, B. A., Kulik, H. J., et al. (2025) · Science · doi:10.1126/science.ady3571 · Cited by 18
Zakariah, M., Khan, S., Chaudhary, A. A., Rolfo, C. D., Ismail, M. M. B., & Alotaibi, Y. A. (2018) · Molecules · doi:10.3390/molecules23050994 · Cited by 18
E. coli diversity: low in colorectal cancer
Tang, L. M., Zhou, Y., Zhu, S., Liang, G.-D., Zhuang, H., Zhao, M.-F., Chang, X., Li, H., Liu, Z., Guo, Z., et al. (2020) · BMC Medical Genomics · doi:10.1186/s12920-020-0704-3 · Cited by 19
Bacterial infections in cancer: A bilateral relationship
Basu, A., Singh, R., & Gupta, S. (2022) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1771 · Cited by 19
Mirzarazi, M., Bashiri, S., Hashemi, A., Vahidi, M., Kazemi, B., & Bandehpour, M. (2022) · BMC Microbiology · doi:10.1186/s12866-022-02540-y · Cited by 18
Zaidi, A. H., Pratama, M. Y., Omstead, A. N., Gorbonova, A., Mansoor, R., Kreft, R., Jobe, B. A., Wagner, P. L., Kelly, R. J., & Goel, A. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01974-5 · Cited by 19
Garg, S., Sharma, N., Bharmjeet, & Das, A. (2023) · Cancer Reports · doi:10.1002/cnr2.1892 · Cited by 20
McCoy, C. S., Mannion, A. J., Feng, Y., Madden, C. M., Artim, S. C., Au, G. G., Dolan, M., Haupt, J. L., Burns, M. A., Sheh, A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-020-80000-1 · Cited by 18
Kovaleva, O. V., Алексеевна, П. П., Rashidova, M. A., Samoilova, D. V., Petrenko, A., Mochalnikova, V. V., Kataev, V., Khlopko, Y. A., Plotnikov, A. O., & Gratchev, A. N. (2021) · Biomedicines · doi:10.3390/biomedicines9070743 · Cited by 18
Gaab, M. E., Lozano, P. O., Ibañez, D., Manese, K. D., Riego, F. M., Tiongco, R. E., & Albano, P. M. (2022) · Laboratory Medicine · doi:10.1093/labmed/lmac072 · Cited by 18
Polyphenolic Compounds: Orchestrating Intestinal Microbiota Harmony during Aging
Pereira, Q. C., Fortunato, I. M., Oliveira, F. D. S., Alvarez, M. C., dos Santos, T. W., & Ribeiro, M. L. (2024) · Nutrients · doi:10.3390/nu16071066 · Cited by 19
Volpe, M. R., Wilson, M. R., Brotherton, C. A., Winter, E. S., Johnson, S. E., & Balskus, E. P. (2019) · ACS Chemical Biology · doi:10.1021/acschembio.9b00069 · Cited by 19
Evolution of Polymyxin Resistance Regulates Colibactin Production in Escherichia coli
Sadecki, P. W., Balboa, S. J., Lopez, L. R., Kedziora, K. M., Arthur, J. C., & Hicks, L. M. (2021) · ACS Chemical Biology · doi:10.1021/acschembio.1c00322 · Cited by 19
Wernke, K. M., Tirla, A., Xue, M., Surovtseva, Y. V., Menges, F., & Herzon, S. B. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c07559 · Cited by 18
Microbiota and Immune Responses in Colon Cancer
McAllister, F. M., Housseau, F., & Sears, C. L. (2014) · The Cancer Journal · doi:10.1097/ppo.0000000000000051 · Cited by 16
Tang-Fichaux, M., Branchu, P., Nougayrède, J., & Oswald, É. (2021) · Toxins · doi:10.3390/toxins13120897 · Cited by 18
D-Serine reduces the expression of the cytopathic genotoxin colibactin
Hallam, J. C., Sandalli, S., Floria, I., Turner, N. C. A., Tang-Fichaux, M., Oswald, É., O’Boyle, N., & Roe, A. J. (2023) · Microbial Cell · doi:10.15698/mic2023.03.793 · Cited by 18
Rayan, M., Sayed, T. S., Hussein, O., Therachiyil, L., Maayah, Z. H., Maccalli, C., Shahab Uddin, M. S., Prehn, J. H. M., & Korashy, H. M. (2024) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00538-0 · Cited by 20
Escherichia coli on colorectal cancer: A two‐edged sword
Chu, J., Wu, Y., Jing, Z., Zhanbo, Q., Zefeng, W., & Han, S. (2024) · Microbial Biotechnology · doi:10.1111/1751-7915.70029 · Cited by 17
Bakthavatchalu, V., Wert, K. J., Feng, Y., Mannion, A. J., Ge, Z., García, A., Scott, K. E., Caron, T. J., Madden, C. M., Jacobsen, J. T., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194443 · Cited by 16
Terlouw, D., Boot, A., Ducarmon, Q. R., Nooij, S., Suerink, M., van Leerdam, M. E., van Egmond, D., Tops, C. M., Zwittink, R. D., Ruano, D., et al. (2024) · BMC Cancer · doi:10.1186/s12885-024-11849-y · Cited by 15
Metadata
- Authors
- Buc, E., Dubois, D., Sauvanet, P., Raisch, J., Delmas, J., Darfeuille-Michaud, A., Pezet, D., & Bonnet, R.
- Affiliations
- Inserm (FR)
- Corresponding author
- Bonnet, Richard
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-02-14
- Volume
- 8
- Issue
- 2
- Pages
- e56964
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3572998
- OpenAlex
- W1996173530
- Cited by
- 535
- References
- 76
- Citations by year
- 2026: 20 · 2025: 42 · 2024: 62 · 2023: 44 · 2022: 62 · 2021: 83 · 2020: 49 · 2019: 49 · 2018: 31 · 2017: 21 · 2016: 25 · 2015: 17 · 2014: 20 · 2013: 8
- FWCI
- 16.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Institut National de la Santé et de la Recherche Médicale (USC-2018, U1071)
- Ligue Contre le Cancer
- Institut National de la Recherche Agronomique (U1071, USC-2018)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- Escherichia coli, cytotoxic necrotizing factor 1, colorectal cancer, diverticulosis, genotoxicity, DNA damage, bacterial adhesion, host cell cycle
- MeSH terms
- Adult, Aged, Aged, 80 and over, Bacterial Adhesion, Bacterial Toxins, Colonic Neoplasms, Escherichia coli, Humans, Intestinal Mucosa, Middle Aged, Mutagens, Phenotype, Prevalence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
