Adipose-derived stem cells secretome and its potential application in “stem cell-free therapy”
Open accessAbstract
Adipose-derived stem cells (ASCs) secrete many cytokines, proteins, growth factors, and extracellular vesicles with beneficial outcomes that can be used in regenerative medicine. It has great potential, and the development of new treatment strategies using the ASCs secretome is of global interest. Besides cytokines, proteins, and growth factors, the therapeutic effect of secretome is hidden in non-coding RNAs such as miR-21, miR-24, and miR-26 carried via exosomes secreted by adequate cells. The whole secretome, including ASC-derived exosomes (ASC-exos) has been proven in many studies to have immunomodulatory, proangiogenic, neurotrophic, and epithelization activity and can potentially be used for neurodegenerative, cardiovascular, respiratory, inflammatory, and autoimmune diseases as well as wound healing treatment. Due to limitations in the use of stem cells in cell-based therapy, its secretome with emphasis on exosomes seems to be a reasonable and safer alternative with increased effectiveness and fewer side effects. Moreover, the great advantage of cell-free therapy is the possibility of biobanking the ASCs secretome. In this review, we focus on the current state of knowledge on the use of the ASCs secretome in stem cell-free therapy.
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MSC-derived exosomes have advantages over existing drugs or MSCs, including improved stability, limited immune rejection, convenient administration, and easy internalization into recipient cells.
“When compared with existing drugs or mesenchymal stem cells (MSCs), MSC-derived exosomes generate distinct advantages and reduce side effects, such as improved stability, limited immune rejection, convenient administration, and easy internalization into recipient cells [15].”
From Exosome-functionalized magnesium-organic framework-based scaffolds with osteogenic, angiogenic and anti-inflammatory properties for accelerated bone regeneration. (2022) · cites this paper as [15]
Section 3.2 reports that adipose-derived MSC exosomes are stable in the body compared with whole cells and describes a reduced risk of tumorigenicity. It does not establish advantages over existing drugs or substantiate limited immune rejection, convenient administration, or easy internalization by recipient cells. Page numbers are unavailable in our copy. (LLM, conf=0.86)
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Kang, Y., Xu, C., Meng, L., Dong, X., Qi, M., & Jiang, D. (2022) · Bioactive materials · doi:10.1016/j.bioactmat.2022.02.012 · Cited by 253 · see citing works
“effects, such as improved stability, limited immune rejection, convenient administration, and easy internalization into recipient cells [15].”
Background
- Authors
- Trzyna, A., & Banaś-Ząbczyk, A.
- Affiliations
- University of Rzeszów (PL)
- Corresponding author
- Banaś-Ząbczyk, Agnieszka
- Venue
- Biomolecules
- Publisher
- MDPI AG
- Published
- 2021-06-13
- Volume
- 11
- Issue
- 6
- Pages
- 878
- ISSN
- 2218-273X (ISSN-L)
- PMC
- PMC8231996
- OpenAlex
- W3168570978
- Cited by
- 201
- References
- 181
- Citations by year
- 2026: 32 · 2025: 38 · 2024: 47 · 2023: 38 · 2022: 37 · 2021: 9
- FWCI
- 4.74
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomolecules (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Keywords
- adipose-derived stem cells, secretome, exosomes, cell-free therapy, extracellular vesicles, microRNA, cytokines, growth factors, immunomodulation, angiogenesis, neurotrophic activity, wound healing, regenerative medicine, biobanking
- MeSH terms
- Adipose Tissue, Animals, Humans, Stem Cells, Adipocytes, Biological Specimen Banks, MicroRNAs, Exosomes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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