The Use of Combining Ability Analysis to Identify Elite Parents for Artemisia annua F1 Hybrid Production
Open accessAbstract
Artemisia annua is an important medicinal crop used for the production of the anti-malarial compound artemisinin. In order to assist in the production of affordable high quality artemisinin we have carried out an A. annua breeding programme aimed at improving artemisinin concentration and biomass. Here we report on a combining ability analysis of a diallel cross to identify robust parental lines for hybrid breeding. The parental lines were selected based on a range of phenotypic traits to encourage heterosis. The general combining ability (GCA) values for the diallel parental lines correlated to the positive alleles of quantitative trait loci (QTL) in the same parents indicating the presence of beneficial alleles that contribute to parental performance. Hybrids generated from crossing specific parental lines with good GCA were identified as having an increase in both artemisinin concentration and biomass when grown either in glasshouse or experimental field trials and compared to controls. This study demonstrates that combining ability as determined by a diallel cross can be used to identify elite parents for the production of improved A. annua hybrids. Furthermore, the selection of material for breeding using this approach was found to be consistent with our QTL-based molecular breeding approach.
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The CNAP Artemisia Research Project screened more than 23,000 parental lines and developed about 768 hybrid lines, of which 268 most promising were selected for field trials.
“They screened more than 23,000 parental lines for the desired traits and developed about 768 hybrid lines, of which the 268 most promising hybrids were selected for field trials (Graham et al. 2010; Townsend et al. 2013).”
From Enhancing artemisinin content in and delivery from Artemisia annua: a review of alternative, classical, and transgenic approaches (2021) · cites this paper as Townsend et al. 2013
The Results section (page unavailable) reports 30 selected parental lines and 366 hybrids with enough seed for screening, not about 768 hybrids. Materials and Methods, “Hybrid Field Trials” (page unavailable), says 48 hybrid lines were selected for field trials, contrary to the claimed 268. The paper does not report screening more than 23,000 parental lines. (LLM, conf=0.84)
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Self-citation
- Authors
- Townsend, T., Segura, V., Chigeza, G., Penfield, T., Rae, A., Harvey, D., Bowles, D., & Graham, I. A.
- Affiliations
- University of York (GB)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Agricultural Research Council of South Africa (ZA)
- University of Exeter (GB)
- Corresponding author
- Graham, Ian A.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-04-23
- Volume
- 8
- Issue
- 4
- Pages
- e61989
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3633910
- OpenAlex
- W2078245667
- Cited by
- 56
- References
- 28
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 1 · 2019: 7 · 2018: 3 · 2017: 7 · 2016: 7 · 2015: 7 · 2014: 3 · 2013: 2
- FWCI
- 7.63
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Bill and Melinda Gates Foundation
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Agricultural Practices and Plant Genetics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Genetics and Plant Breeding
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- Artemisia annua, combining ability, general combining ability, diallel cross, hybrid breeding, biomass, heterosis, quantitative trait loci, molecular breeding, parent selection, medicinal plant breeding
- MeSH terms
- Alleles, Antimalarials, Breeding, Chimera, Crosses, Genetic, Hybrid Vigor, Phenotype, Biomass, Artemisia annua, Artemisinins, Quantitative Trait Loci
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