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Morbidity before and after the Diagnosis of Hyperthyroidism: A Nationwide Register-Based Study
Open accessAbstract
BACKGROUND: Hyperthyroidism has been linked with different morbidities, like atrial fibrillation, stroke and diabetes mellitus. However, our knowledge regarding the extent and temporal relation between hyperthyroidism and other diseases is fragmented. Here, we aimed at evaluating various morbidities before and after the diagnosis of hyperthyroidism. METHODS: Observational cohort study. From nationwide Danish health registers 2631 hyperthyroid singletons and 375 twin pairs discordant for hyperthyroidism were identified and followed for an average of 6 years (range 0-13). Data on the occurrence of cardiovascular diseases, lung diseases, diabetes mellitus, rheumatic diseases and malignant diseases was obtained by person-to-person record linkage with the National Danish Patient Register and/or the Danish National Prescription Registry (lung diseases and diabetes mellitus). Logistic and Cox regression models were used to assess the risk of morbidity before and after the diagnosis of hyperthyroidism, respectively. All Cox regression analyses were adjusted for the degree of co-morbidity preceding the diagnosis of hyperthyroidism, using the Charlson score. RESULTS: Hyperthyroid individuals had a significantly higher risk of being diagnosed with cardiovascular diseases (odds ratio (OR) 1.65; 95% confidence interval (CI): 1.45-1.87), lung diseases (OR 1.53; 95% CI: 1.29-1.60), and diabetes mellitus (OR 1.43, 95% CI: 1.20-1.72), but not with malignant diseases (OR 1.16, 95% CI: 0.99-1.36) prior to the diagnosis of hyperthyroidism. After the diagnosis of hyperthyroidism, subjects had a significantly higher risk of being diagnosed with cardiovascular diseases (hazard ratio (HR) 1.34; 95% CI: 1.15-1.56), lung diseases (HR 1.28; 95% CI: 1.10-1.49), and diabetes mellitus (HR 1.46; 95% CI: 1.16-1.84), but not with rheumatic diseases (HR 1.39, 95% CI: 0.92-2.09) or malignant diseases (HR 1.18, 95% CI 0.97-1.42). CONCLUSIONS: We demonstrate a significantly increased burden of morbidity, both before and after the diagnosis of hyperthyroidism.
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“An elevated risk of T2DM in patients with hyperthyroidism has been documented (6, 7).”
From The progression of secondary diabetes: A review of modeling studies (2022) · cites this paper as [6]
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“A number of studies have reported the rising incidence of diabetes mellitus in patients with thyroid hormone dysregulation and vice versa (6, 7).”
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“Thus, overtreatment of hypothyroidism most likely carries a similar risk of increased morbidity (39,40) and mortality, (41) as shown for hyperthyroidism.”
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Cites
Charlson, M. E., Pompei, P., Ales, K. L., & MacKenzie, C. R. (1987) · Journal of Chronic Diseases · doi:10.1016/0021-9681(87)90171-8 · Cited by 49,742
Limitations of the Application of Fourfold Table Analysis to Hospital Data
Berkson, J. (1946) · Biometrics Bulletin · doi:10.2307/3002000 · Cited by 1,810
Thygesen, L. C., Daasnes, C., Thaulow, I., & Brønnum‐Hansen, H. (2011) · Scandinavian Journal of Public Health · doi:10.1177/1403494811399956 · Cited by 1,089
Boelaert, K., Newby, P. R., Simmonds, M. J., Holder, R. L., Carr-Smith, J. D., Heward, J. M., Manji, N., Allahabadia, A., Armitage, M., Chatterjee, K. V., et al. (2010) · The American Journal of Medicine · doi:10.1016/j.amjmed.2009.06.030 · Cited by 480
Effects of Thyroid Hormone on the Cardiovascular System
Fazio, S. (2004) · Recent Progress in Hormone Research · doi:10.1210/rp.59.1.31 · Cited by 445
Brix, T. H., Kyvik, K. O., Christensen, K., & Hegedűs, L. D. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7242 · Cited by 425
Self-citationCooper, D. S. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14073-1 · Cited by 384
LAURBERG, P., PEDERSEN, K. M., VESTERGAARD, H., & SIGURDSSON, G. (1991) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1991.tb00368.x · Cited by 361
Selmer, C., Olesen, J. B., Hansen, M. L., Lindhardsen, J., Olsen, A.-M. S., Madsen, J. C., Faber, J., Hansen, P. R., Pedersen, O. D., Torp-Pedersen, C., et al. (2012) · BMJ · doi:10.1136/bmj.e7895 · Cited by 323
Brix, T. H. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.2.930 · Cited by 311
Self-citationMECHANISMS IN ENDOCRINOLOGY: Heart failure and thyroid dysfunction
Biondi, B. (2012) · European Journal of Endocrinology · doi:10.1530/eje-12-0627 · Cited by 291
Comorbidity in elderly cancer patients in relation to overall and cancer-specific mortality
Jørgensen, T. L., Hallas, J., Friis, S., & Herrstedt, J. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.46 · Cited by 281
Bak, S., Gaist, D., Sindrup, S. H., Skytthe, A., & Christensen, K. (2002) · Stroke · doi:10.1161/hs0302.103619 · Cited by 236
Self-citationCardiovascular involvement in patients with different causes of hyperthyroidism
Biondi, B., & Kahaly, G. J. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.105 · Cited by 230
Twin studies as a model for exploring the aetiology of autoimmune thyroid disease
Brix, T. H., & Hegedűs, L. D. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04318.x · Cited by 185
Self-citationThyroid Hormone and the Cardiovascular System
Danzi, S. E., & Klein, I. L. (2012) · Medical Clinics of North America · doi:10.1016/j.mcna.2012.01.006 · Cited by 172
A critical review and meta-analysis of the association between overt hyperthyroidism and mortality
Brandt, F., Green, A., Hegedüs, L., & Brix, T. H. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0299 · Cited by 170
Self-citationCigarette Smoking and Risk of Clinically Overt Thyroid Disease
Brix, T. H., Hansen, P. S., Kyvik, K. O., & Hegedűs, L. D. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.5.661 · Cited by 148
Self-citationFamilial association between type 1 diabetes and other autoimmune and related diseases
Hemminki, K., Li, X., Sundquist, J., & Sundquist, K. (2009) · Diabetologia · doi:10.1007/s00125-009-1427-3 · Cited by 147
Nicotine, cigarette smoking and cardiac arrhythmia: an overview
D’Alessandro, A., Boeckelmann, I., Hammwhöner, M., & Goette, A. (2011) · European Journal of Preventive Cardiology · doi:10.1177/1741826711411738 · Cited by 142
Disease Associations with Autoimmune Thyroid Disease
Jenkins, R. C., & Weetman, A. P. (2002) · Thyroid · doi:10.1089/105072502320908312 · Cited by 140
Amiodarone and the thyroid: a 2012 update.
Bogazzi, F., Tomisti, L., Bartalena, L., Aghini-Lombardi, F., & Martino, E. (2012) · PubMed · doi:10.3275/8298 · Cited by 131
Siu, C.-W., Zhang, X.-H., Yung, C., Kung, A. W. C., Lau, C.-P., & Tse, H.-F. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1877 · Cited by 121
Prevalence of Thyroid Dysfunction in Patients with Type 2 Diabetes
Díez, J. J., Sánchez, P. P., & Iglesias, P. (2011) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0031-1271691 · Cited by 121
Skytthe, A., Kyvik, K. O., Holm, N. V., & Christensen, K. (2011) · Scandinavian Journal of Public Health · doi:10.1177/1403494810387966 · Cited by 104
Self-citationThyroid Disease and Vascular Function
Owen, P. J. D., Sabit, R., & Lazarus, J. H. (2007) · Thyroid · doi:10.1089/thy.2007.0051 · Cited by 101
Genetics and Cardiovascular Disease
Ashley, E. A., Hershberger, R. E., Caleshu, C. A., Ellinor, P. T., Garcia, J. G. N., Herrington, D. M., Ho, C. Y., Johnson, J. A., Kittner, S. J., MacRae, C. A., et al. (2012) · Circulation · doi:10.1161/cir.0b013e31825b07f8 · Cited by 97
Almagro, P., Salvadó, M., García‐Vidal, C., Rodríguez‐Carballeira, M., Cuchí, E., de-Torres, J. P., & Heredia, J. L. (2011) · Respiration · doi:10.1159/000331224 · Cited by 94
Brandt, F., Thvilum, M., Almind, D., Christensen, K., Green, A., Hegedüs, L., & Brix, T. H. (2013) · Thyroid · doi:10.1089/thy.2012.0500 · Cited by 86
Self-citationThvilum, M., Brandt, F., Almind, D., Christensen, K., Hegedűs, L. D., & Brix, T. H. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3375 · Cited by 83
Self-citationBrandt, F., Almind, D., Christensen, K., Green, A., Brix, T. H., & Hegedüs, L. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2268 · Cited by 83
Self-citationGenetic influences on chronic obstructive pulmonary disease – A twin study
Ingebrigtsen, T. S., Thomsen, S. F., Vestbo, J., van der Sluis, S., Kyvik, K. O., Silverman, E. K., Svartengren, M., & Backer, V. (2010) · Respiratory Medicine · doi:10.1016/j.rmed.2010.05.004 · Cited by 80
A review of the evidence for and against increased mortality in hypothyroidism
Thvilum, M., Brandt, F., Brix, T. H., & Hegedűs, L. D. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.29 · Cited by 77
Self-citationYue, W., Chong, B.-H., Zhang, X.-H., Liao, S.-Y., Jim, M., Kung, A. W. C., Tse, H., & Siu, C. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.03981.x · Cited by 54
Thomsen, A. F., Kvist, T. K., Andersen, P., & Kessing, L. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01894 · Cited by 51
Genetics and Cardiovascular Disease
Acton, R. T., Go, R. C. P., & Roseman, J. M. (2007) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(07)70220-9 · Cited by 46
Pulmonary Complications of Endocrine and Metabolic Disorders
Milla, C. E., & Zirbes, J. M. (2011) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2011.01.004 · Cited by 38
Regulation of breathing in hyperthyroidism: relationship to hormonal and metabolic changes
Pino-Garcia, J., Rio, F. G., Díez, J. J., Mendieta, M. A. G., Racionero, M. A., Lobato, S. D., & Villamor, J. (1998) · European Respiratory Journal · doi:10.1183/09031936.98.12020400 · Cited by 35
Erem, C., Üçüncü, Ö., Yılmaz, M., Koçak, M., Nuhoğlu, İ., & Ersöz, H. Ö. (2009) · Endocrine · doi:10.1007/s12020-009-9271-2 · Cited by 31
Ilias, Ι., Tselebis, A., Theotoka, I., & Hatzimichelakis, E. (2004) · PubMed · Cited by 16
Illness-induced changes in thyroid hormone metabolism: focus on the tissue level.
Kwakkel, J., Fliers, E., & Boelen, A. (2011) · PubMed · Cited by 12
Brix, T. H., Hansen, P. S., Kyvik, K. O., & Hegedüs, L. (2000) · University of Southern Denmark Research Portal (University of Southern Denmark) · Cited by 11
Self-citationPrevalence of thyroid dysfunction in untreated cancer patients: a cross-sectional study
Dişel, U., Beşen, A. A., Karadeniz, C., Mertsoylu, H., Sezer, A., Köse, F., Sümbül, A. T., Gürkut, Ö., Muallaoğlu, S., Abalı, H., et al. (2012) · Medical Oncology · doi:10.1007/s12032-012-0254-4 · Cited by 10
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1 of the 44 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Rothman XJ, Greenland S, Lash TL (2008) Modern Epidemiology: Case Control studies. Lippincott Williams & Wilkins. Philadelphia 2008.
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Gharib, H., Papini, E., Garber, J. R., Duick, D. S., Harrell, R. M., Hegedűs, L. D., Paschke, R., Valcavi, R., & Vitti, P. (2016) · Endocrine Practice · doi:10.4158/ep161208.gl · Cited by 1,285
Self-citationSmith, T. J., & Hegedűs, L. D. (2016) · New England Journal of Medicine · doi:10.1056/nejmra1510030 · Cited by 1,338
Self-citationThyroid dysfunction and diabetes mellitus: two closely associated disorders
Biondi, B., Kahaly, G. J., & Robertson, R. P. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00163 · Cited by 598
Biondi, B., Bartalena, L., Cooper, D. S., Hegedüs, L., Laurberg, P., & Kahaly, G. J. (2015) · European Thyroid Journal · doi:10.1159/000438750 · Cited by 323
Self-citationSelmer, C., Olesen, J. B., Hansen, M. L., von Kappelgaard, L. M., Madsen, J. C., Hansen, P. R., Pedersen, O. D., Faber, J., Torp-Pedersen, C., & Gislason, G. H. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4184 · Cited by 288
Metadata
- Authors
- Brandt, F., Thvilum, M., Almind, D., Christensen, K., Green, A., Hegedüs, L., & Brix, T. H.
- Affiliations
- Odense University Hospital (DK)
- University of Southern Denmark (DK)
- Corresponding author
- Brandt, Frans
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-06-20
- Volume
- 8
- Issue
- 6
- Pages
- e66711
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3688572
- OpenAlex
- W2044489693
- Cited by
- 142
- References
- 44
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 10 · 2023: 15 · 2022: 17 · 2021: 13 · 2020: 17 · 2019: 6 · 2018: 12 · 2017: 11 · 2016: 8 · 2015: 9 · 2014: 15 · 2013: 1
- FWCI
- 8.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
- Funders
- Novo Nordisk
- Syddansk Universitet
- Novo Nordisk Fonden
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Ophthalmology › Ophthalmology and Eye Disorders
- Keywords
- hyperthyroidism, comorbidities, cardiovascular disease, lung disease, diabetes mellitus, rheumatic diseases, cancer, atrial fibrillation, stroke, hyperthyroidism diagnosis, twin discordance, Charlson Comorbidity Index, Denmark, patient registry, data linkage
- MeSH terms
- Aged, Cardiovascular Diseases, Denmark, Diabetes Mellitus, Female, Humans, Hyperthyroidism, Lung Diseases, Male, Middle Aged, Morbidity, Registries, Time Factors, Cohort Studies, Logistic Models, Proportional Hazards Models
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