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Cited by 161Dementia and Cognitive Impairment ResearchFace Recognition and PerceptionNeural and Behavioral Psychology Studies

Discrete neural correlates for the recognition of negative emotions: insights from frontotemporal dementia

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Kumfor, Fiona, Irish, Muireann, Hodges, John R., Piguet, Olivier·2013·PLoS ONE
DOI 10.1371/journal.pone.0067457PMC PMC3689735
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Abstract

Patients with frontotemporal dementia have pervasive changes in emotion recognition and social cognition, yet the neural changes underlying these emotion processing deficits remain unclear. The multimodal system model of emotion proposes that basic emotions are dependent on distinct brain regions, which undergo significant pathological changes in frontotemporal dementia. As such, this syndrome may provide important insight into the impact of neural network degeneration upon the innate ability to recognise emotions. This study used voxel-based morphometry to identify discrete neural correlates involved in the recognition of basic emotions (anger, disgust, fear, sadness, surprise and happiness) in frontotemporal dementia. Forty frontotemporal dementia patients (18 behavioural-variant, 11 semantic dementia, 11 progressive nonfluent aphasia) and 27 healthy controls were tested on two facial emotion recognition tasks: The Ekman 60 and Ekman Caricatures. Although each frontotemporal dementia group showed impaired recognition of negative emotions, distinct associations between emotion-specific task performance and changes in grey matter intensity emerged. Fear recognition was associated with the right amygdala; disgust recognition with the left insula; anger recognition with the left middle and superior temporal gyrus; and sadness recognition with the left subcallosal cingulate, indicating that discrete neural substrates are necessary for emotion recognition in frontotemporal dementia. The erosion of emotion-specific neural networks in neurodegenerative disorders may produce distinct profiles of performance that are relevant to understanding the neurobiological basis of emotion processing.

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  • Emotion recognition impairments in bvFTD have been reported in a multitude of tests including the Ekman 60 Faces Test and the Social Cognition and Emotional Assessment.

    “Emotion recognition impairments have been reported in a multitude of tests including when the patient is asked to label the emotion expressed [e.g. Ekman 60 Faces Test (Lavenu et al. , 1999; DiehlSchmid et al. , 2007 a ; Kumfor et al. , 2013); and Social Cognition and Emotional Assessment (SEA) (Funkiewiez et al. , 2012; Karch et al. , 2018)].”

    From Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders (2020) · cites this paper as Kumfor et al. , 2013

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Cited by

Sorted by citations

Authors
Kumfor, F., Irish, M., Hodges, J. R., & Piguet, O.
Affiliations
UNSW Sydney (AU)
Corresponding author
Piguet, Olivier
ORCID
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2013-06-21
Volume
8
Issue
6
Pages
e67457
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0067457
PMC
PMC3689735
OpenAlex
W1998013977
Cited by
161
References
22
Citations by year
2026: 4 · 2025: 6 · 2024: 4 · 2023: 10 · 2022: 10 · 2021: 20 · 2020: 15 · 2019: 18 · 2018: 15 · 2017: 15 · 2016: 19 · 2015: 12 · 2014: 10 · 2013: 2 · 2012: 1
FWCI
10.19
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • UNSWorks (UNSW Sydney) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by)
Funders
  • Medical Research Council
  • Australian Research Council (510106, CE 110001021, FF0776229)
  • National Health and Medical Research Council (1022684, 510106, FF0776229)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
frontotemporal dementia, emotion recognition, facial emotion recognition, negative emotions, amygdala, insula, temporal lobe, subcallosal cingulate, gray matter loss, behavioral variant frontotemporal dementia, semantic dementia, progressive nonfluent aphasia, social cognition
MeSH terms
Aged, Behavior, Brain, Brain Mapping, Emotions, Facial Expression, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Case-Control Studies, Recognition, Psychology, Frontotemporal Dementia

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