Tracking the progression of social cognition in neurodegenerative disorders
Open accessAbstract
BACKGROUND AND PURPOSE: Behavioural-variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD) patients experience behavioural and emotion recognition alterations, yet understanding of how socioemotional processing is affected with disease progression is minimal. Additionally, evidence suggests that bvFTD patients with limited brain atrophy on neuroimaging at presentation (bvFTD-la) have a more benign course than those with marked atrophy (bvFTD-ma). Longitudinal investigation of these patients, however, is lacking. METHODS: We investigated general cognition, emotion recognition and sarcasm detection in 20 bvFTD (8 with limited brain atrophy) and 17 AD patients longitudinally and used mixed models analyses to determine the level and rates of decline across groups over time. RESULTS: At baseline, all patient groups performed worse than controls on general cognition and emotion recognition measures. The bvFTD-ma group showed significant impairment on the sarcasm detection task compared with controls. Longitudinally, an overall effect of time was present for general cognition (p<0.001); however, the rate of decline did not differ across groups. Trends for interactions between time and diagnosis were observed for both emotion recognition tasks (p=0.055; p=0.062), with the bvFTD-ma group declining more rapidly than AD or bvFTD-la groups. On the sarcasm detection task, the bvFTD-ma and AD patients declined, whereas bvFTD-la patients remained stable over time (p=0.002). CONCLUSIONS: Tasks of sarcasm detection represent a clinically useful tool to differentiate between bvFTD and AD at baseline. Furthermore, tasks of socioemotional functioning can track progression within bvFTD and identify bvFTD patients more likely to show a faster rate of decline.
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A longitudinal study on emotion recognition, assessed with the Ekman 60-faces test, reported decline during follow-up (1.5 years), with most rapid decline in bvFTD with marked atrophy.
“A longitudinal study on emotion recognition, assessed with the Ekman 60-faces test (Aw et al., 2002), reported decline during follow-up (1.5 years), with most rapid decline in bvFTD with marked atrophy (Kumfor et al., 2014).”
From The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials (2024) · cites this paper as Kumfor et al., 2014
Longitudinal assessment of sarcasm detection, assessed with TASIT, showed decline in cases with marked atrophy only, indicating it is relatively spared in early stages.
“Longitudinal assessment of sarcasm detection, assessed with The Awareness of Social Inference Test [TASIT; (McDonald et al., 2003)], showed a decline in cases with marked atrophy only, indicating it is relatively spared in early stages (Kumfor et al., 2014).”
From The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials (2024) · cites this paper as Kumfor et al., 2014
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- Authors
- Kumfor, F., Irish, M., Leyton, C., Miller, L., Lah, S., Devenney, E., Hodges, J. R., & Piguet, O.
- Affiliations
- UNSW Sydney (AU)
- ARC Centre of Excellence in Cognition and its Disorders (AU)
- The University of Sydney (AU)
- Corresponding author
- Kumfor, Fiona
- ORCID
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 2014-02-25
- Volume
- 85
- Issue
- 10
- Pages
- 1076-1083
- ISSN
- 0022-3050 (ISSN-L)
- 1468-330X
- OpenAlex
- W2120271824
- Cited by
- 97
- References
- 39
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 7 · 2023: 3 · 2022: 6 · 2021: 10 · 2020: 9 · 2019: 6 · 2018: 9 · 2017: 13 · 2016: 9 · 2015: 12 · 2014: 4
- FWCI
- 9.67
- Type
- journal article
- Language
- en
- Open access
- green
- handle.unsw.edu.au
- Licence
- cc-by-nc-nd
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- UNSWorks (UNSW Sydney) (submittedVersion, cc-by-nc-nd)
- HighWire Press Open Archive (submittedVersion)
- UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by-nc-nd)
- Funders
- University of New South Wales
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- behavioral variant frontotemporal dementia, Alzheimer's disease, social cognition, emotion recognition, sarcasm detection, brain atrophy, disease progression, cognitive decline, differential diagnosis, long-term tracking
- MeSH terms
- Aged, Alzheimer Disease, Atrophy, Brain, Cognition, Emotions, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Social Behavior, Case-Control Studies, Disease Progression, Recognition, Psychology, Frontotemporal Dementia, Neuroimaging
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