Cited by 320Endoplasmic Reticulum Stress and DiseasePharmacological Receptor Mechanisms and EffectsIon Channels and Receptors

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Sigma-1 receptor chaperone at the ER-mitochondrion interface mediates the mitochondrion-ER-nucleus signaling for cellular survival.

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Mori, Tomohisa, Hayashi, Teruo, Hayashi, Eri, Su, Tsung-Ping·2013·PLoS ONE

DOI 10.1371/journal.pone.0076941PMC PMC3799859

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Abstract

The membrane of the endoplasmic reticulum (ER) of a cell forms contacts directly with mitochondria whereby the contact is referred to as the mitochondrion-associated ER membrane or the MAM. Here we found that the MAM regulates cellular survival via an MAM-residing ER chaperone the sigma-1 receptor (Sig-1R) in that the Sig-1R chaperones the ER stress sensor IRE1 to facilitate inter-organelle signaling for survival. IRE1 is found in this study to be enriched at the MAM in CHO cells. We found that IRE1 is stabilized at the MAM by Sig-1Rs when cells are under ER stress. Sig-1Rs stabilize IRE1 and thus allow for conformationally correct IRE1 to dimerize into the long-lasting, activated endonuclease. The IRE1 at the MAM also responds to reactive oxygen species derived from mitochondria. Therefore, the ER-mitochondrion interface serves as an important subcellular entity in the regulation of cellular survival by enhancing the stress-responding signaling between mitochondria, ER, and nucleus.

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Authors: Mori, T., Hayashi, T., Hayashi, E., & Su, T.-P.
Affiliations: United States Department of Health and Human Services (US)
Corresponding author: Su, Tsung-Ping
ORCID: Mori, Tomohisa
Hayashi, Eri
Su, Tsung-Ping
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2013-10-18
Volume: 8
Issue: 10
Pages: e76941
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0076941
PMC: PMC3799859
OpenAlex: W1994289493
Cited by: 317
References: 51
Citations by year: 2026: 22 · 2025: 24 · 2024: 20 · 2023: 29 · 2022: 26 · 2021: 38 · 2020: 33 · 2019: 34 · 2018: 18 · 2017: 29 · 2016: 16 · 2015: 10 · 2014: 17
FWCI: 8.51
Type: journal article
Language: en
Open access: gold
doi.org
Licence: public-domain
creativecommons.org/publicdomain/zero/1.0/ (unspecified)
Locations: PLoS ONE (publishedVersion, public-domain)
Europe PMC (PubMed Central) (publishedVersion, public-domain)
PubMed Central (publishedVersion, public-domain)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Figshare (submittedVersion, cc-by)
Funders: U.S. Department of Health and Human Services
National Institutes of Health
National Institute on Drug Abuse
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Receptor Mechanisms and Effects
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: sigma-1 receptor, mitochondria-associated membranes, endoplasmic reticulum, IRE1, endoplasmic reticulum stress, mitochondrial reactive oxygen species, molecular chaperones, protein stabilization, endonuclease activation, cell survival
MeSH terms: Sigma-1 Receptor, Animals, Cell Nucleus, Cell Survival, Cricetulus, Endoplasmic Reticulum, Endoribonucleases, Cricetinae, HeLa Cells, Humans, Immunohistochemistry, Intracellular Membranes, Mitochondria, Mutation, Protein Binding, Blotting, Western, Signal Transduction, CHO Cells, Protein Serine-Threonine Kinases, Reactive Oxygen Species, Receptors, sigma, Microscopy, Confocal, Molecular Chaperones, RNA Interference, Cell Line, Tumor, Mice

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Sigma-1 receptor chaperone at the ER-mitochondrion interface mediates the mitochondrion-ER-nucleus signaling for cellular survival.

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