Cancer and the gut microbiota: An unexpected link
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Gut microbiota and its interactions with the host immune system play a role in oncogenesis and can alter the effectiveness of anticancer agents.
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GC is arguably the most intensely affected by gut bacteria owing to their spatial proximity.
“Among all tumors, GC is arguably the most intensely affected by gut bacteria owing to their spatial proximity, and their associations with the gut microbiome have been intensively investigated [93,94].”
From Bioinformatics Analysis and Validation of Potential Markers Associated with Prediction and Prognosis of Gastric Cancer (2024) · cites this paper as [93]
The ‘Dysbiosis and Carcinogenesis’ section says gut bacteria affect colorectal carcinogenesis and influence tumors both locally and systemically. It does not identify gastric cancer (GC) as the most intensely affected tumor or attribute such a ranking to spatial proximity. (LLM, conf=0.83)
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- Authors
- Zitvogel, L., Galluzzi, L., Viaud, S., Vétizou, M., Daillère, R., Merad, M., & Kroemer, G.
- Affiliations
- Inserm (FR)
- Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
- Corresponding author
- Zitvogel, Laurence
- Galluzzi, Lorenzo
- Venue
- Science Translational Medicine
- Published
- 2015-01-21
- Volume
- 7
- Issue
- 271
- Pages
- 271ps1-271ps1
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4690201
- OpenAlex
- W2164536401
- Cited by
- 465
- References
- 32
- Citations by year
- 2026: 21 · 2025: 31 · 2024: 35 · 2023: 37 · 2022: 42 · 2021: 62 · 2020: 64 · 2019: 48 · 2018: 46 · 2017: 36 · 2016: 28 · 2015: 15
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Association pour la Recherche sur le Cancer (ARC)
- European Commission (ArtForce)
- European Research Council (ERC)
- Agence Nationale de la Recherche (ANR)
- AXA Chair for Longevity Research
- Fondation pour la Recherche Medicale (FRM)
- Ligue contre le Cancer
- Fondation de France
- Institut National du Cancer (INCa)
- Canceropole Ile-de-France
- Fondation Bettencourt-Schueller
- LabEx Immuno-Oncology
- Site de Recherche Integree sur le Cancer (SIRIC)
- Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE)
- SIRIC Cancer Research and Personalized Medicine (CARPEM)
- Paris Alliance of Cancer Research Institutes (PACRI)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut microbiota, cancer, carcinogenesis, tumor progression, host-microbe interactions, intestinal epithelium, host immune system, environmental factors, cancer therapy, microbiome manipulation
- MeSH terms
- Antineoplastic Agents, Humans, Neoplasms, Gastrointestinal Tract, Carcinogenesis, Microbiota, Dysbiosis
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