The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Pro-Inflammatory Chemokine CCL2 (MCP-1) Promotes Healing in Diabetic Wounds by Restoring the Macrophage Response
Open accessAbstract
Prior studies suggest that the impaired healing seen in diabetic wounds derives from a state of persistent hyper-inflammation characterized by harmful increases in inflammatory leukocytes including macrophages. However, such studies have focused on wounds at later time points (day 10 or older), and very little attention has been given to the dynamics of macrophage responses in diabetic wounds early after injury. Given the importance of macrophages for the process of healing, we studied the dynamics of macrophage response during early and late phases of healing in diabetic wounds. Here, we report that early after injury, the diabetic wound exhibits a significant delay in macrophage infiltration. The delay in the macrophage response in diabetic wounds results from reduced Chemokine (C-C motif) ligand 2 (CCL2) expression. Importantly, one-time treatment with chemoattractant CCL2 significantly stimulated healing in diabetic wounds by restoring the macrophage response. Our data demonstrate that, rather than a hyper-inflammatory state; the early diabetic wound exhibits a paradoxical and damaging decrease in essential macrophage response. Our studies suggest that the restoration of the proper kinetics of macrophage response may be able to jumpstart subsequent healing stages. CCL2 chemokine-based therapy may be an attractive strategy to promote healing in diabetic wounds.
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Cites
Singer, A. J., & Clark, R. A. F. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909023411006 · Cited by 6,106
Type 2 diabetes as an inflammatory disease
Donath, M. Y., & Shoelson, S. E. (2011) · Nature Reviews Immunology · doi:10.1038/nri2925 · Cited by 3,737
Differential Roles of Macrophages in Diverse Phases of Skin Repair
Lucas, T., Waisman, A., Ranjan, R., Roes, J., Krieg, T., Müller, W., Roers, A., & Eming, S. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903356 · Cited by 1,205 · cited 1×
“Given the importance of macrophages for the process of healing [7–11] and their potential role in pathology associated with”
Menke, N. B., Ward, K. R., Witten, T. M., Bonchev, D. G., & Diegelmann, R. F. (2007) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2006.12.005 · Cited by 792
The molecular biology of chronic wounds and delayed healing in diabetes
Blakytny, R., & Jude, E. (2006) · Diabetic Medicine · doi:10.1111/j.1464-5491.2006.01773.x · Cited by 632
Wetzler, C., Kämpfer, H., Stallmeyer, B., Pfeilschifter, J., & Frank, S. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00029.x · Cited by 584
Ishida, Y., Gao, J.-L., & Murphy, P. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.1.569 · Cited by 310
Cited by
Guan, Y., Niu, H., Liu, Z., Dang, Y., Shen, J., Zayed, M., Ma, L., & Guan, J. (2021) · Science Advances · doi:10.1126/sciadv.abj0153 · Cited by 631
More Than Just Attractive: How CCL2 Influences Myeloid Cell Behavior Beyond Chemotaxis
Gschwandtner, M., Derler, R., & Midwood, K. S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02759 · Cited by 611
The M2a macrophage subset may be critically involved in the fibrogenesis of endometriosis in mice
Duan, J., Liu, X., Wang, H., & Guo, S.-W. (2018) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2018.05.017 · Cited by 121
Cai, Y., Chen, K., Liu, C., & Qu, X. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.04.019 · Cited by 112
Camões, S. P., Bulut, O., Yazar, V., Gaspar, M. M., Simões, S., Ferreira, R., Vitorino, R., Santos, J. M., Gursel, I., & Miranda, J. P. (2022) · Journal of Advanced Research · doi:10.1016/j.jare.2022.01.013 · Cited by 55
Metadata
- Authors
- Wood, S., Jayaraman, V., Huelsmann, E. J., Bonish, B., Burgad, D., Sivaramakrishnan, G., Qin, S., DiPietro, L. A., Zloza, A., Zhang, C., & Shafikhani, S. H.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-03-11
- Volume
- 9
- Issue
- 3
- Pages
- e91574
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W1999935208
- Cited by
- 249
- References
- 7
- FWCI
- 12.38
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Pro-Inflammatory Chemokine CCL2 (MCP-1) Promotes Healing in Diabetic Wounds by Restoring the Macrophage Response. https://app.cochat.ai/papers/10.1371/journal.pone.0091574
- The paper
- Wood, S., Jayaraman, V., Huelsmann, E. J., Bonish, B., Burgad, D., Sivaramakrishnan, G., Qin, S., DiPietro, L. A., Zloza, A., Zhang, C., & Shafikhani, S. H. (2014). Pro-Inflammatory Chemokine CCL2 (MCP-1) Promotes Healing in Diabetic Wounds by Restoring the Macrophage Response. PLoS ONE. https://doi.org/10.1371/journal.pone.0091574
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
