Large and Sustained Induction of Chemokines during Impaired Wound Healing in the Genetically Diabetic Mouse: Prolonged Persistence of Neutrophils and Macrophages during the Late Phase of Repair
Open accessAbstract
Chemokines are seen as the stimuli that largely control leukocyte migration. To assess whether the severely impaired process of cutaneous repair observed in genetically diabetic db/db mice is associated with a dysregulated infiltration of immune cells, we determined the expressional kinetics for the murine growth-regulated oncogene/melanoma growth stimulatory activity homolog macrophage inflammatory protein-2, and the macrophage chemoattractant protein-1, respectively. Wound repair in db/db mice was characterized by a sustained inflammatory response and a prolonged expression of macrophage inflammatory protein-2 and macrophage chemoattractant protein-1. Immuno-histochemistry revealed that keratinocytes at the wound margins expressed macrophage chemoattractant protein-1, whereas macrophage inflammatory protein-2 immunopositive signals were observed only in keratinocytes of hair follicles located adjacent to the wound site. Inactivation studies using neutralizing antibodies against macrophage chemoattractant protein-1 or macrophage inflammatory protein-2 indicated that sustained expression of these chemokines participated in a prolonged presence of neutrophils and macrophages at the wound site during diabetic repair. Furthermore, our data provide evidence that late infiltration (day 13 after injury) of neutrophils and macrophages into wounds in db/db mice was associated with a simultaneous downregulation of mRNA for receptors specific for macrophage inflammatory protein-2 and macrophage chemoattractant protein-1 in these animals.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Prolonged secretion of chemokines in the diabetic mouse supports the p38 inhibition mechanism.
“This is supported by the prolonged secretion of chemokines in the diabetic mouse.105”
From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [105]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Chomczyński, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 47,092 · see citing works
Wound Healing--Aiming for Perfect Skin Regeneration
Martin, P. B. (1997) · Science · doi:10.1126/science.276.5309.75 · Cited by 4,814 · see citing works
Chemokines — Chemotactic Cytokines That Mediate Inflammation
Luster, A. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802123380706 · Cited by 3,634 · see citing works
Chemokines and leukocyte traffic
Baggiolini, M. (1998) · Nature · doi:10.1038/33340 · Cited by 2,710 · see citing works
Abnormal splicing of the leptin receptor in diabetic mice
Lee, G.-H., Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I., & Friedman, J. M. (1996) · Nature · doi:10.1038/379632a0 · Cited by 2,327 · see citing works
Chen, H., Charlat, O., Tartaglia, L. A., Woolf, E. A., Weng, X., Ellis, S. J., Lakey, N. D., Culpepper, J., More, K. J., Breitbart, R. E., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81294-5 · Cited by 2,214 · see citing works
Rollins, B. J. (1997) · Blood · doi:10.1182/blood.v90.3.909 · Cited by 1,983 · see citing works
The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum.
(1975) · PubMed Central · Cited by 1,437 · see citing works
PDGF and FGF stimulate wound healing in the genetically diabetic mouse.
Greenhalgh, D. G., Sprugel, K. H., Murray, M. J., & Ross, R. (1990) · Europe PMC (PubMed Central) · Cited by 681 · see citing works
Loots, M. A. M., Lamme, E. N., Zeegelaar, J., Mekkes, J. R., Bos, J. D., & Middelkoop, E. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00381.x · Cited by 620 · see citing works
Large induction of keratinocyte growth factor expression in the dermis during wound healing
Werner, S., Peters, K. G., Longaker, M. T., Fuller-Pace, F., Banda, M. J., & Williams, L. T. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.15.6896 · Cited by 612 · see citing works
Hübner, G., Brauchle, M. A., Smola, H., Madlener, M., Fässler, R., & Werner, S. (1996) · Cytokine · doi:10.1006/cyto.1996.0074 · Cited by 499 · see citing works
Rollins, B. J., Yoshimura, T., Leonard, E. J., & Pober, J. S. (1990) · Europe PMC (PubMed Central) · Cited by 492 · see citing works
Growth factors and wound healing: Part II. Role in normal and chronic wound healing
Bennett, N. T., & Schultz, G. S. (1993) · The American Journal of Surgery · doi:10.1016/s0002-9610(05)80589-6 · Cited by 455 · see citing works
Rollins, B. J., Morrison, E. D., & Stiles, C. D. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.11.3738 · Cited by 438 · see citing works
Engelhardt, E., Toksoy, A., Goebeler, M., Debus, S., Bröcker, E.-B., & Gillitzer, R. (1998) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65699-4 · Cited by 435 · see citing works
Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor.
Pennica, D., Hayflick, J. S., Bringman, T. S., Palladino, M. A., & Goeddel, D. V. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.18.6060 · Cited by 388 · see citing works
DiPietro, L. A. (1995) · Shock · doi:10.1097/00024382-199510000-00001 · Cited by 386 · see citing works
Wound healing: the role of the macrophage and other immune cells.
DiPietro, L. A. (1995) · PubMed · Cited by 366 · see citing works
Diabetes-Obesity Syndromes in Mice
Coleman, D. L. (1982) · Diabetes · doi:10.2337/diab.31.1.s1 · Cited by 354 · see citing works
Chemokine receptors: Structure, function and role in microbial pathogenesis
Murphy, P. M. (1996) · Cytokine & Growth Factor Reviews · doi:10.1016/1359-6101(96)00009-3 · Cited by 320 · see citing works
Recombinant basic fibroblast growth factor stimulates wound healing in healing-impaired db/db mice.
Tsuboi, R., & Rifkin, D. B. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.1.245 · Cited by 305 · see citing works
Tekamp-Olson, P., Gallegos, C., Bauer, D. M., McClain, J., Sherry, B. A., Fabre, M., van Deventer, S. J. H., & Cerami, A. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.3.911 · Cited by 289 · see citing works
Expression of CCR2 by Endothelial Cells
Weber, K. S. C., Nelson, P. J., Gröne, H., & Weber, C. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.9.2085 · Cited by 280 · see citing works
MIP-1alpha as a critical macrophage chemoattractant in murine wound repair.
DiPietro, L. A., Burdick, M., Low, Q., Kunkel, S. L., & Strieter, R. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1020 · Cited by 273 · see citing works
CXC CHEMOKINE RECEPTOR EXPRESSION ON HUMAN ENDOTHELIAL CELLS
Murdoch, C., Monk, P. N., & Finn, A. H. R. (1999) · Cytokine · doi:10.1006/cyto.1998.0465 · Cited by 272 · see citing works
Gray, P. W., Glaister, D., Chen, E., et al. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.137.11.3644 · Cited by 265 · see citing works
Mouse lysozyme M gene: isolation, characterization, and expression studies.
Cross, M. A., Mangelsdorf, I., Wedel, A., & Renkawitz, R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.17.6232 · Cited by 252 · see citing works
Popovich, P. G., Stokes, B. T., & Whitacre, C. C. (1996) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19960815)45:4 · Cited by 249 · see citing works
Strieter, R. M., Wiggins, R. C., Phan, S. H., Wharram, B. L., Showell, H. J., Remick, D. G., Chensue, S. W., & Kunkel, S. L. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)92366-8 · Cited by 238 · see citing works
Wound healing and the diabetic patient.
Goodson, W. H., & Tk, H. (1979) · PubMed · Cited by 177 · see citing works
Fantuzzi, L., Borghi, P., Ciolli, V., Pavlakis, G. N., Belardelli, F., & Gessani, S. (1999) · Blood · doi:10.1182/blood.v94.3.875.415k28_875_883 · Cited by 171 · see citing works
Barker, J. N., Jones, M. L., Mitra, R. S., et al. (1991) · PubMed · Cited by 163 · see citing works
Iida, N., & Grotendorst, G. R. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.10.5596-5599.1990 · Cited by 145 · see citing works
Modulation of JE/MCP-1 expression in dermal wound repair.
DiPietro, L. A., Polverini, P. J., Rahbe, S. M., & Kovacs, E. J. (1995) · Europe PMC (PubMed Central) · Cited by 129 · see citing works
Wound healing and the diabetic patient
Tershakowec, M. (1980) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-198010000-00117 · Cited by 116 · see citing works
Interleukin‐8 receptor‐mediated chemotaxis of normal human epidermal cells
Michel, G., Kemény, L. V., Peter, R. U., Beetz, A., Ried, C., Arenberger, P., & Ruzicka, T. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80677-9 · Cited by 115 · see citing works
The CXC Receptor 2 Is Overexpressed in Psoriatic Epidermis
Kulke, R., Bornscheuer, E., Schlüter, C., Bartels, J., Röwert, J., Sticherling, M., & Christophers, E. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00074.x · Cited by 108 · see citing works
Kurosaka, K., Watanabe, N., & Kobayashi, Y. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.11.6245 · Cited by 92 · see citing works
Garay-Rojas, E., Harper, M., Hraba-Renevey, S., & Kress, M. (1996) · Gene · doi:10.1016/0378-1119(95)00896-9 · Cited by 89 · see citing works
Down-regulation of CXCR2 expression on human polymorphonuclear leukocytes by TNF-alpha.
Asagoe, K., Yamamoto, K., Takahashi, A., Suzuki, K. T., Maeda, A., Nohgawa, M., Harakawa, N., Takano, K., Mukaida, N., Matsushima, K., et al. (1998) · PubMed · Cited by 73 · see citing works
T lymphocytes and the lack of activated macrophages in wound margin biopsies from chronic leg ulcers
Moore, K., Ruge, F., & Harding, K. G. (1997) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1997.18041895.x · Cited by 72 · see citing works
Monocyte Chemoattractant Protein-1 mRNA Expression in the Human Burn Wound
Gibran, N. S., Ferguson, M. W. J., Heimbach, D. M., & Isik, F. F. (1997) · Journal of Surgical Research · doi:10.1006/jsre.1997.5017 · Cited by 63 · see citing works
Rosner, K., Ross, C., Karlsmark, T., Petersen, A. A., Gottrup, F., & Vejlsgaard, G. L. (1995) · APMIS · doi:10.1111/j.1699-0463.1995.tb01109.x · Cited by 63 · see citing works
Down-Regulation of CXCR2 Expression on Human Polymorphonuclear Leukocytes by TNF-α
Asagoe, K., Yamamoto, K., Takahashi, A., Suzuki, K. T., Maeda, A., Nohgawa, M., Harakawa, N., Takano, K., Mukaida, N., Matsushima, K., et al. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.9.4518 · Cited by 63 · see citing works
Weber, C., Draude, G., Weber, K. S. C., Wübert, J., Lorenz, R. L., & Weber, P. C. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00021-0 · Cited by 58 · see citing works
Interaction of Phagocytes with Apoptotic Cells Leads to Production of Pro-inflammatory Cytokines
Uchimura, E., Kodaira, T., Kurosaka, K., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7556 · Cited by 56 · see citing works
Cloning of a cDNA encoding a mouse homolog of the interleukin-8 receptor
Harada, A., Kuno, K., Nomura, H., et al. (1994) · Gene · doi:10.1016/0378-1119(94)90278-x · Cited by 38 · see citing works
Chemotaxis of freshly separated and cultured human keratinocytes
Gyulai, R., Hunyadi, J., Kenderessy, A. S., Kemény, L. V., & DOBOZY, A. (1994) · Clinical and Experimental Dermatology · doi:10.1111/j.1365-2230.1994.tb01201.x · Cited by 36 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Knighton DR, Fiegel V. Growth factors and repair of diabetic wounds. In: Levin ME, O'Neal LW, Bowker JH: eds. The Diabetic Foot, 5th edn. St. Louis: Mosby Year Book, 1993:pp
Cited by
Sorted by citations
Inflammation in Wound Repair: Molecular and Cellular Mechanisms
Eming, S. A., Krieg, T., & Davidson, J. M. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700701 · Cited by 2,429 · see citing works
Inflammation and wound healing: the role of the macrophage
Koh, T. J., & DiPietro, L. A. (2011) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399411001943 · Cited by 1,667 · see citing works
Chemokines in cutaneous wound healing
Gillitzer, R., & Goebeler, M. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.69.4.513 · Cited by 943 · see citing works
Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury
Lai, Y., Di Nardo, A., Nakatsuji, T., Leichtle, A., Yang, Y., Cogen, A. L., Wu, Z.-R., Hooper, L. V., Schmidt, R. R., von Aulock, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2062 · Cited by 781 · see citing works
Macrophage Dysfunction Impairs Resolution of Inflammation in the Wounds of Diabetic Mice
Khanna, S., Biswas, S., Shang, Y., Collard, E., Azad, A., Kauh, C., Bhasker, V., Gordillo, G. M., Sen, C. K., & Roy, S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009539 · Cited by 694 · see citing works
The molecular biology of chronic wounds and delayed healing in diabetes
Blakytny, R., & Jude, E. (2006) · Diabetic Medicine · doi:10.1111/j.1464-5491.2006.01773.x · Cited by 632 · see citing works
Accelerated wound closure in neutrophil-depleted mice
Dovi, J. V., He, L.-K., & DiPietro, L. A. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0802406 · Cited by 525 · see citing works
Resolvins, Specialized Proresolving Lipid Mediators, and Their Potential Roles in Metabolic Diseases
Spite, M., Clària, J., & Serhan, C. N. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.10.006 · Cited by 464 · see citing works
Regulation of angiogenesis: Wound healing as a model
EMING, S., BRACHVOGEL, B., ODORISIO, T., & KOCH, M. (2007) · Progress in Histochemistry and Cytochemistry · doi:10.1016/j.proghi.2007.06.001 · Cited by 392 · see citing works
Dysregulation of monocyte/macrophage phenotype in wounds of diabetic mice
Mirza, R., & Koh, T. J. (2011) · Cytokine · doi:10.1016/j.cyto.2011.06.016 · Cited by 342 · see citing works
Interrelation of immunity and tissue repair or regeneration
Eming, S. A., Hammerschmidt, M., Krieg, T., & Roers, A. (2009) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2009.04.009 · Cited by 321 · see citing works
Galkowska, H., Wojewodzka, U., & Olszewski, W. L. (2006) · Wound Repair and Regeneration · doi:10.1111/j.1743-6109.2006.00155.x · Cited by 317 · see citing works
Microbial symbionts accelerate wound healing via the neuropeptide hormone oxytocin
Poutahidis, T., Kearney, S. M., Levkovich, T., Qi, P., Varian, B. J., Lakritz, J. R., Ibrahim, Y. M., Chatzigiagkos, A., Alm, E. J., & Erdman, S. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078898 · Cited by 310 · see citing works
The Innate Immune System in Acute and Chronic Wounds
MacLeod, A. S., & Mansbridge, J. N. (2016) · Advances in Wound Care · doi:10.1089/wound.2014.0608 · Cited by 289 · see citing works
“This is supported by the prolonged secretion of chemokines in the diabetic mouse.(105) By contrast, in venous ulcers, miR-21 has been reported to be elevated.”
BackgroundLongitudinal shift in diabetic wound microbiota correlates with prolonged skin defense response
Grice, E. A., Snitkin, E. S., Yockey, L. J., Bermudez, D. M., Program, N. C. S., Liechty, K. W., Segre, J. A., Mullikin, J., Blakesley, R., Young, A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004204107 · Cited by 227 · see citing works
The Role of MicroRNA-146a in the Pathogenesis of the Diabetic Wound-Healing Impairment
Xu, J., Wu, W., Zhang, L., Dorset-Martin, W., Morris, M. W., Mitchell, M. E., & Liechty, K. W. (2012) · Diabetes · doi:10.2337/db12-0145 · Cited by 225 · see citing works
Gallagher, K. A., Joshi, A., Carson, W. F., Schaller, M., Allen, R., Mukerjee, S., Kittan, N., Feldman, E. L., Henke, P. K., Hogaboam, C., et al. (2015) · Diabetes · doi:10.2337/db14-0872 · Cited by 206 · see citing works
Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds
Wilkinson, H. N., & Hardman, M. J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00773 · Cited by 173 · see citing works
Macrophage PPARγ and impaired wound healing in type 2 diabetes
Mirza, R. E., Fang, M. M., Novak, M. L., Urao, N., Sui, A., Ennis, W. J., & Koh, T. J. (2015) · The Journal of Pathology · doi:10.1002/path.4548 · Cited by 177 · see citing works
The matricellular protein CCN1 mediates neutrophil efferocytosis in cutaneous wound healing
Jun, J.-I., Kim, K.-H., & Lau, L. F. (2015) · Nature Communications · doi:10.1038/ncomms8386 · Cited by 173 · see citing works
Wound Administration of M2-Polarized Macrophages Does Not Improve Murine Cutaneous Healing Responses
Jetten, N., Roumans, N., Gijbels, M. J., Romano, A., Post, M. J., de Winther, M. P. J., van der Hulst, R. R. W. J., & Xanthoulea, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102994 · Cited by 162 · see citing works
Goren, I., Müller, E., Schiefelbein, D., Christen, U., Pfeilschifter, J., Mühl, H., & Frank, S. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700842 · Cited by 151 · see citing works
Self-citationInflammation in surgical wound healing: Friend or foe?
Szpaderska, A. M., & DiPietro, L. A. (2005) · Surgery · doi:10.1016/j.surg.2005.01.006 · Cited by 96 · see citing works
Leptin and Wound Inflammation in Diabetic<i>ob/ob</i>Mice
Goren, I., Kämpfer, H., Podda, M., Pfeilschifter, J., & Frank, S. (2003) · Diabetes · doi:10.2337/diabetes.52.11.2821 · Cited by 95 · see citing works
Self-citationMyeloid cell dysfunction and the pathogenesis of the diabetic chronic wound
Wicks, K., Torbica, T., & Mace, K. A. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.04.006 · Cited by 93 · see citing works
Role of IL-17A and neutrophils in fibrosis in experimental hypersensitivity pneumonitis
Hasan, S. A., Eksteen, B., Reid, D., Paine, H. V., Alansary, A., Johannson, K., Gwozd, C., Goring, K.-A. R., Vo, T., Proud, D., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.01.015 · Cited by 88 · see citing works
Topical application of substance P promotes wound healing in streptozotocin-induced diabetic rats
Kant, V., Kumar, D., Kumar, D., Prasad, R., Gopal, A., Pathak, N. N., Kumar, P., & Tandan, S. K. (2015) · Cytokine · doi:10.1016/j.cyto.2014.12.015 · Cited by 79 · see citing works
TLR2 expression and signaling-dependent inflammation impair wound healing in diabetic mice
Dasu, M. R., Thangappan, R. K., Bourgette, A., DiPietro, L. A., Isseroff, R., & Jialal, I. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.158 · Cited by 73 · see citing works
Kaesler, S., Bugnon, P., Gao, J., Murphy, P. M., Goppelt, A., & Werner, S. (2004) · Wound Repair and Regeneration · doi:10.1111/j.1067-1927.2004.012112.x · Cited by 50 · see citing works
Yang, L.-L., Liu, J.-Q., Bai, X.-Z., Fan, L., Han, F., Jia, W.-B., Su, L.-L., Shi, J.-H., Tang, C.-W., & Hu, D.-H. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.09.077 · Cited by 48 · see citing works
Wardecki, T., Werner, P., Thomas, M., Templin, M. F., Schmidt, G., Brandner, J. M., & Merfort, I. (2016) · Journal of Natural Products · doi:10.1021/acs.jnatprod.6b00027 · Cited by 23 · see citing works
- Authors
- Wetzler, C., Kämpfer, H., Stallmeyer, B., Pfeilschifter, J., & Frank, S.
- Affiliations
- Goethe University Frankfurt (DE)
- Corresponding author
- Frank, Stefan
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2000-08
- Volume
- 115
- Issue
- 2
- Pages
- 245-253
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W1965434649
- Cited by
- 584
- References
- 50
- Citations by year
- 2026: 18 · 2025: 25 · 2024: 23 · 2023: 40 · 2022: 31 · 2021: 28 · 2020: 30 · 2019: 36 · 2018: 22 · 2017: 30 · 2016: 31 · 2015: 28 · 2014: 32 · 2013: 28 · 2012: 20
- FWCI
- 10.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (SFB 553)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Macrophage Migration Inhibitory Factor
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Keywords
- chemokines, wound healing, diabetic wound healing, db/db mice, CXCL2, MCP-1, neutrophil infiltration, macrophage infiltration, keratinocytes, hair follicle, chronic inflammation
- MeSH terms
- Animals, Dermatitis, Diabetes Mellitus, Macrophages, Mice, Inbred C57BL, Neutrophils, Skin, Time Factors, Wound Healing, Wounds and Injuries, Down-Regulation, Keratinocytes, Receptors, Interleukin, Chemokines, Chemokine CCL2, Receptors, Chemokine, Receptors, Interleukin-8B, Mice, Receptors, CCR2, Chemokine CXCL2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
