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Intake of Fruit Juice and Incidence of Type 2 Diabetes: A Systematic Review and Meta-Analysis
Open accessAbstract
BACKGROUND: Several prospective studies have been conducted to examine the relationship between fruit juice intake and risk of incident type 2 diabetes, but results have been mixed. In the present study, we aimed to estimate the association between fruit juice intake and risk of type 2 diabetes. METHODS: PubMed and Embase databases were searched up to December 2013. All prospective cohort studies of fruit juice intake with risk of type 2 diabetes were included. The pooled relative risks (RRs) with 95% confidence intervals (CIs) for highest vs. lowest category of fruit juice intake were estimated using a random-effects model. RESULTS: A total of four studies (191,686 participants, including 12,375 with type 2 diabetes) investigated the association between sugar-sweetened fruit juice and risk of incident type 2 diabetes, and four studies (137,663 participants and 4,906 cases) investigated the association between 100% fruit juice and risk of incident type 2 diabetes. A higher intake of sugar-sweetened fruit juice was significantly associated with risk of type 2 diabetes (RR = 1.28, 95%CI = 1.04-1.59, p = 0.02), while intake of 100% fruit juice was not associated with risk of developing type 2 diabetes (RR = 1.03, 95% CI = 0.91-1.18, p = 0.62). CONCLUSIONS: Our findings support dietary recommendations to limit sugar-sweetened beverages, such as fruit juice with added sugar, to prevent the development of type 2 diabetes.
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“Further, intake of sugar-sweetened fruit juice, but not 100% fruit juice, is associated with incident diabetes in longitudinal studies (Figure 6).257, 266”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [266]
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Metadata
- Authors
- Xi, B., Li, S., Liu, Z., Tian, H., Yin, X., Huai, P., Tang, W., Zhou, D., & Steffen, L. M.
- Affiliations
- Shandong University (CN)
- University of Minnesota (US)
- Linyi People's Hospital (CN)
- Corresponding author
- Zhou, Donghao
- Steffen, Lyn M.
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-03-28
- Volume
- 9
- Issue
- 3
- Pages
- e93471
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3969361
- OpenAlex
- W2043939834
- Cited by
- 161
- References
- 25
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 11 · 2023: 12 · 2022: 9 · 2021: 14 · 2020: 8 · 2019: 25 · 2018: 21 · 2017: 11 · 2016: 22 · 2015: 11 · 2014: 7
- FWCI
- 2.71
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- fruit juice, type 2 diabetes, 100% fruit juice, sugar-sweetened beverages, dietary intake, diabetes risk, prospective cohort
- MeSH terms
- Adult, Beverages, Diabetes Mellitus, Type 2, Diet, Fruit, Humans, Middle Aged, Prospective Studies, Risk, Risk Factors, Sweetening Agents, Incidence, Dietary Sucrose
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