Interleukin-1β Induces Blood–Brain Barrier Disruption by Downregulating Sonic Hedgehog in Astrocytes

Structure and function of the blood–brain barrier

Abbott, N. J., Patabendige, A. A. K., Dolman, D. E. M., Yusof, S. R., & Begley, D. J. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.030 · Cited by 5,185

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2038 · Cited by 4,110

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

Zlokovic, B. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.003 · Cited by 3,280

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

Chiang, C. C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H., & Beachy, P. A. (1996) · Nature · doi:10.1038/383407a0 · Cited by 3,062

Astrocytes induce blood–brain barrier properties in endothelial cells

Janzer, R. C., & RAFF, M. C. (1987) · Nature · doi:10.1038/325253a0 · Cited by 1,613

A controlled trial of natalizumab for relapsing multiple sclerosis.

Miller, D. H., Khan, O., Sheremata, W., Blumhardt, L., Rice, G., Libonati, M., Willmer-Hulme, A., Dalton, C., Miszkiel, K., & O'Connor, P. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020696 · Cited by 1,265

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

Alvarez, J. I., Dodelet-Devillers, A., Kebir, H., Ifergan, I., Fabre, P. J., Terouz, S., Sabbagh, M., Wosik, K., Bourbonnière, L., Bernard, M., et al. (2011) · Science · doi:10.1126/science.1206936 · Cited by 845

Evaluation of Patients Treated with Natalizumab for Progressive Multifocal Leukoencephalopathy

Yousry, T. A., Major, E. O., Ryschkewitsch, C. F., Fahle, G. A., Fischer, S. H., Hou, J., Curfman, B. L., Miszkiel, K., Mueller‐Lenke, N., Sánchez, E., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054693 · Cited by 789

The Blood-Brain Barrier in Brain Homeostasis and Neurological Diseases

Weiss, N., Miller, F., Cazaubon, S., & Couraud, P.-O. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.10.022 · Cited by 731

Blood-brain barrier disruption in multiple sclerosis

Minagar, A., & Alexander, J. S. (2003) · Multiple Sclerosis · doi:10.1191/1352458503ms965oa · Cited by 685

Microglia: The Hub of Intercellular Communication in Ischemic Stroke

Zhang, Y., Lian, L., Fu, R., Liu, J., Shan, X., Jin, Y., & Xu, S. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.889442 · Cited by 51

Is Beta-Amyloid Accumulation a Cause or Consequence of Alzheimer's Disease?

Wang, S., Mims, P. N., Roman, R. J., & Fan, F. (2016) · PubMed · Cited by 48

Astrocytic Sonic Hedgehog Alleviates Intracerebral Hemorrhagic Brain Injury via Modulation of Blood-Brain Barrier Integrity

Xing, G., Zhao, T., Zhang, X., He, L., Li, X., Cui, P., Li, M., Li, D., Zhang, N., & Jiang, W. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.575690 · Cited by 49

Transcriptome Analysis Reveals Neuroprotective aspects of Human Reactive Astrocytes induced by Interleukin 1β

Teh, D. B. L., Prasad, A., Jiang, W., Ariffin, M. Z., Khanna, S., Belorkar, A., Wong, L., Liu, X., & All, A. H. (2017) · Scientific Reports · doi:10.1038/s41598-017-13174-w · Cited by 50

Microglia-Mediated Neurovascular Unit Dysfunction in Alzheimer’s Disease

Huang, W., Xia, Q., Zheng, F., Zhao, X. L., Ge, F., Xiao, J., Liu, Z., Shen, Y., Ye, K., Wang, D., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221064 · Cited by 47

Astragaloside IV promotes cerebral angiogenesis and neurological recovery after focal ischemic stroke in mice via activating PI3K/Akt/mTOR signaling pathway

Shi, G., Chen, J., Zhang, C., Zhao, X., Wang, J., Chen, R., Xu, R., Song, D., & Zhang, X. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e22800 · Cited by 45

A comprehensive review on the role of chemokines in the pathogenesis of multiple sclerosis

Ghafouri‐Fard, S., Tamizkar, K. H., & Taheri, M. N. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-020-00648-6 · Cited by 44

Advanced Human BBB‐on‐a‐Chip: A New Platform for Alzheimer's Disease Studies

Yoon, J., Kim, J., Shah, Z., Awasthi, A., Mahajan, A., & Kim, Y. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202002285 · Cited by 45

Function of Glia in Aging and the Brain Diseases

Vallés, S. L., Iradi, A., Aldasoro, M., Vila, J. M., Aldasoro, C., de la Torre, J., Campos-Campos, J., & Jorda, A. (2019) · International Journal of Medical Sciences · doi:10.7150/ijms.37769 · Cited by 45

Dynamic modulation of the blood–brain barrier in the healthy brain

Friedman, A., Prager, O., Serlin, Y., & Kaufer, D. (2025) · Nature reviews. Neuroscience · doi:10.1038/s41583-025-00976-5 · Cited by 48

The relationship between Alzheimer’s disease and intestinal microflora structure and inflammatory factors

Wang, S.-S., Li, X., Liu, P., Li, J., & Liu, L. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.972982 · Cited by 42

Morphogens and blood-brain barrier function in health and disease

Wevers, N. R., & de Vries, H. E. (2015) · Tissue Barriers · doi:10.1080/21688370.2015.1090524 · Cited by 42

Neuroinflammation in Alzheimer’s Disease: Microglia, Molecular Participants and Therapeutic Choices

Wang, H., Shen, Y., Chuang, H.-Y., Chiu, C., Ye, Y., & Zhao, L. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666190503151648 · Cited by 43

Distinct Cellular Tropism and Immune Responses to Alphavirus Infection

Kafai, N. M., Diamond, M., & Fox, J. M. (2022) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101220-014952 · Cited by 42

Brain Endothelial Cells in Blood–Brain Barrier Regulation and Neurological Therapy

Xiang, Y., Gu, Q., & Liu, D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125843 · Cited by 46

Imaging blood–brain barrier disruption in neuroinflammation and Alzheimer’s disease

Lee, R., & Funk, K. E. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1144036 · Cited by 42

Interleukin-1 Receptor Antagonist as Therapy for Traumatic Brain Injury

Lindblad, C., Rostami, E., & Helmy, A. E. (2023) · Neurotherapeutics · doi:10.1007/s13311-023-01421-0 · Cited by 43

Differential effects of EPA and DHA on DSS-induced colitis in mice and possible mechanisms involved

Zhang, Z., Xue, Z., Yang, H., Zhao, F., Liu, C., Chen, J., Lu, S., Zou, Z., Zhou, Y., & Zhang, X. (2021) · Food & Function · doi:10.1039/d0fo02308f · Cited by 40

Neuroimmune Crosstalk Between the Peripheral and the Central Immune System in Amyotrophic Lateral Sclerosis

Yu, W., He, J., Cai, X., Yu, Z., Zou, Z., & Fan, D. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.890958 · Cited by 41

Exploring Pro-Inflammatory Immunological Mediators: Unraveling the Mechanisms of Neuroinflammation in Lysosomal Storage Diseases

Pandey, M. K. (2023) · Biomedicines · doi:10.3390/biomedicines11041067 · Cited by 40

MAGP2 controls Notch via interactions with RGD binding integrins: Identification of a novel ECM–integrin–Notch signaling axis

DeFord, P., Brown, K., Richards, R. L., King, A., Newburn, K., Westover, K., & Albig, A. R. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2016.01.011 · Cited by 39

Circadian rhythms and glial cells of the central nervous system

Brécier, A., Li, V. W., Smith, C. S., Halievski, K., & Ghasemlou, N. (2022) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12917 · Cited by 40

Activation of glial cells induces proinflammatory properties in brain capillary endothelial cells in vitro

Burkhart, A., Helgudóttir, S. S., Mahamed, Y. A., Fruergaard, M. B., Holm-Jacobsen, J. N., Haraldsdóttir, H., Dahl, S. E., Pretzmann, F., Routhe, L. G., Lambertsen, K. L., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-78204-w · Cited by 37

NLRX1 inhibits the early stages of CNS inflammation and prevents the onset of spontaneous autoimmunity

Gharagozloo, M., Mahmoud, S., Simard, C., Yamamoto, K., Bobbala, D., Ilangumaran, S., Smith, M. D., Lamontagne, A., Jarjoura, S., Denault, J., et al. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000451 · Cited by 38

Inflammation (IL-1β) Modifies the Effect of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids on Core Symptoms of Autism Spectrum Disorder—An Exploratory Pilot Study

Mazahery, H., Conlon, C. A., Beck, K. L., Mugridge, O., Kruger, M. C., Stonehouse, W., Camargo, C. A., Meyer, B. J., Tsang, B., & von Hurst, P. R. (2020) · Nutrients · doi:10.3390/nu12030661 · Cited by 37

Interleukin-4 Contributes to Degeneration of Dopamine Neurons in the Lipopolysaccharide-treated Substantia Nigrain vivo

Bok, E., Cho, E. J., Chung, E. S., Shin, W.-H., & Jin, B. K. (2018) · Experimental Neurobiology · doi:10.5607/en.2018.27.4.309 · Cited by 36

Understanding Abnormal SMO-SHH Signaling in Autism Spectrum Disorder: Potential Drug Target and Therapeutic Goals

Rahi, S., & Mehan, S. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-01010-1 · Cited by 38

Blood-brain Barrier and Neurovascular Unit Dysfunction in Parkinson's Disease: From Clinical Insights to Pathogenic Mechanisms and Novel Therapeutic Approaches

Khor, S. L. Q., Ng, K. Y., Koh, R. Y., & Chye, S. M. (2023) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527322666230330093829 · Cited by 37

The blood brain barrier: Insights from development and ageing

Delaney, C. P., & Campbell, M. (2017) · Tissue Barriers · doi:10.1080/21688370.2017.1373897 · Cited by 36

Rheumatoid arthritis and neurodegenerative dementia: a nested case-control study and a follow-up study using a national sample cohort

Min, C., Bang, W. J., Kim, M., Oh, D. J., & Choi, H. G. (2019) · Clinical Rheumatology · doi:10.1007/s10067-019-04769-x · Cited by 34

Quinones as preventive agents in Alzheimer’s diseases: focus on NLRP3 inflammasomes

Chen, D., Gao, H., Peng, C., Pei, S., Dai, A., Yu, X., Zhou, P., Wang, Y., & Cai, B. (2020) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.13332 · Cited by 34

Disinhibition of Cathepsin C Caused by Cystatin F Deficiency Aggravates the Demyelination in a Cuprizone Model

Liang, J., Li, N., Zhang, Y., Hou, C., Yang, X., Shimizu, T., Wang, X., Ikenaka, K., Fan, K., & Ma, J. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00152 · Cited by 34

Brain profiling in murine colitis and human epilepsy reveals neutrophils and TNFα as mediators of neuronal hyperexcitability

Barnes, S. E., Zera, K. A., Ivison, G. T., Buckwalter, M. S., & Engleman, E. G. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02262-4 · Cited by 33

Unveiling Cerebral Leishmaniasis: parasites and brain inflammation in Leishmania donovani infected mice

de Melo, G. D., Goyard, S., Fiette, L., Boissonnas, A., Combadière, C., Machado, G. F., Minoprio, P. M. C., & Lang, T. (2017) · Scientific Reports · doi:10.1038/s41598-017-09085-5 · Cited by 34

Targeting Infectious Agents as a Therapeutic Strategy in Alzheimer’s Disease

Fülöp, T., Munawara, U., Larbi, A., Desroches, M., Rodrigues, S., Catanzaro, M., Guidolin, A., Khalil, A., Bernier, F., Barron, A. E., et al. (2020) · CNS Drugs · doi:10.1007/s40263-020-00737-1 · Cited by 32

Rusty Microglia: Trainers of Innate Immunity in Alzheimer's Disease

Sfera, A., Gradini, R., Cummings, M., Diaz, E. L., Price, A. I., & Osorio, C. P. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.01062 · Cited by 32

Low-level laser therapy modulates demyelination in mice

Duarte, K. C. N., Soares, T. T., Magri, A. M. P., Garcia, L. A., Sueur, L. D. P. L., Rennó, A. C. M., & de Castro, G. M. (2018) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2018.09.024 · Cited by 32

A Journey to the Central Nervous System: Routes of Flaviviral Neuroinvasion in Human Disease

Marshall, E. M., Koopmans, M., & Rockx, B. (2022) · Viruses · doi:10.3390/v14102096 · Cited by 34

The importance of microvascular inflammation in ageing and age-related diseases: a position paper from the ESH working group on small arteries, section of microvascular inflammation

Mengozzi, A., Ciuceis, C. D., Dell’Oro, R., Georgiopoulos, G. A., Lazaridis, A. A., Nosalski, R., Pavlidis, G., Tual‐Chalot, S., Rosei, C. A., Anyfanti, P., et al. (2023) · Journal of Hypertension · doi:10.1097/hjh.0000000000003503 · Cited by 32

Microarray expression profiling identifies genes, including cytokines, and biofunctions, as diapedesis, associated with a brain metastasis from a papillary thyroid carcinoma

Schulten, H.-J., Hussein, D. M., Al-Adwani, F., Karim, S., Al-Maghrabi, J. A., Al‐Sharif, M., Jamal, A., Bakhashab, S., Weaver, J. U., Alghamdi, F. A., et al. (2016) · PubMed Central · doi:10.25405/ncl.34294743 · Cited by 31

Dysregulation of sonic hedgehog pathway and pericytes in the brain after lentiviral infection

Bohannon, D. G., Ko, A., Filipowicz, A. R., Kuroda, M. J., & Kim, W. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1463-y · Cited by 31

Tert-butylhydroquinone enhanced angiogenesis and astrocyte activation by activating nuclear factor-E2-related factor 2/heme oxygenase-1 after focal cerebral ischemia in mice

Chen, Y., Zhang, X., Yang, Y., Zhang, L., Cui, L., Zhang, C., Chen, R., Xie, Y., He, J., & He, W. (2019) · Microvascular Research · doi:10.1016/j.mvr.2019.103891 · Cited by 31

Psychiatric Comorbidities of Inflammatory Bowel Disease: It Is a Matter of Microglia’s Gut Feeling

Fakhfouri, G., Mijailović, N. R., & Rahimian, R. (2024) · Cells · doi:10.3390/cells13020177 · Cited by 31

Behavioural Effects of Using Sulfasalazine to Inhibit Glutamate Released by Cancer Cells: A Novel target for Cancer-Induced Depression

Nashed, M. G., Ungard, R. G., Young, K., Zacal, N., Seidlitz, E. P., Fazzari, J., Frey, B. N., & Singh, G. (2017) · Scientific Reports · doi:10.1038/srep41382 · Cited by 32

Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments

Gulej, R., Patai, R., Ungvari, A., Kállai, A., Tarantini, S., Yabluchanskiy, A., Huffman, D. M., Conboy, M. J., Conboy, I. M., Mika Kivimaki, B., et al. (2025) · GeroScience · doi:10.1007/s11357-025-01657-y · Cited by 29

Environmental Microcystin exposure in underlying NAFLD-induced exacerbation of neuroinflammation, blood-brain barrier dysfunction, and neurodegeneration are NLRP3 and S100B dependent

Mondal, A., Saha, P., Bose, D., Chatterjee, S., Seth, R. K., Xiao, S., Porter, D. E., Brooks, B. W., Scott, G., Nagarkatti, M., et al. (2021) · Toxicology · doi:10.1016/j.tox.2021.152901 · Cited by 29

The Cellular Dysfunction of the Brain–Blood Barrier from Endothelial Cells to Astrocytes: The Pathway towards Neurotransmitter Impairment in Schizophrenia

Stanca, S., Rossetti, M., Panichi, L. B., & Bongioanni, P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021250 · Cited by 28

The Crosstalk between the Blood–Brain Barrier Dysfunction and Neuroinflammation after General Anaesthesia

Yang, X., & Chen, X. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44110386 · Cited by 27

Ectodysplasin A regulates epithelial barrier function through sonic hedgehog signalling pathway

Li, S., Zhou, J., Zhang, L., Li, J., Yu, J., Ning, K., Qu, Y., He, H., Chen, Y., Reinach, P. S., et al. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13311 · Cited by 27

Endothelial Protrusions in Junctional Integrity and Barrier Function

Alves, N. G., Motawe, Z. Y., Yuan, S. Y., & Breslin, J. W. (2018) · Current topics in membranes · doi:10.1016/bs.ctm.2018.08.006 · Cited by 28

The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly people

Jacobs, T., Jacobson, S. R., Fortea, J., Berger, J. S., Vedvyas, A., Marsh, K., He, T., Gutiérrez‐Jiménez, E., Fillmore, N. R., Gonzalez, M., et al. (2024) · Immunity & Ageing · doi:10.1186/s12979-024-00435-2 · Cited by 27

Endothelial Cells and the Blood–Brain Barrier: Critical Determinants of Ineffective Reperfusion in Stroke

Li, X., Simo, L., Zhao, Q., Kim, E., Ding, Y., & Geng, X. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.16663 · Cited by 28

New Tricks for an Old (Hedge)Hog: Sonic Hedgehog Regulation of Astrocyte Function

Garcia, A. D. R. (2021) · Cells · doi:10.3390/cells10061353 · Cited by 25

The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the development and function of the blood–brain barrier

Miyazaki, W., Fujiwara, Y., & Katoh, T. (2015) · NeuroToxicology · doi:10.1016/j.neuro.2015.11.003 · Cited by 25

Sonic Hedgehog Agonist Protects Against Complex Neonatal Cerebellar Injury

Nguyen, V., Sabeur, K., Maltepe, E., Ameri, K., Bayraktar, O. A., & Rowitch, D. H. (2017) · The Cerebellum · doi:10.1007/s12311-017-0895-0 · Cited by 25

Microbiome‐skin‐brain axis: A novel paradigm for cutaneous wounds

Hadian, Y., Fregoso, D. R., Nguyen, C., Bagood, M. D., Dahle, S. E., Gareau, M. G., & Isseroff, R. R. (2020) · Wound Repair and Regeneration · doi:10.1111/wrr.12800 · Cited by 26

Astrocyte Dysfunctions in Obsessive Compulsive Disorder: Rethinking Neurobiology and Therapeutic Targets

Gonzalez, L., & Bezzi, P. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70092 · Cited by 24

Astrocyte involvement in brain metastasis: from biological mechanisms to therapeutic strategies

Zhou, T., Yan, Y., Lin, M., Zeng, C., Mao, X., Zhu, Y., Han, J., Li, D., & Zhang, J. (2025) · Cancer and Metastasis Reviews · doi:10.1007/s10555-025-10276-0 · Cited by 24

Inflammasomes: a rising star on the horizon of COVID-19 pathophysiology

Wang, M., Yu, F., Chang, W., Zhang, Y., Zhang, L., & Li, P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1185233 · Cited by 25

Macrophage-Derived Angiopoietin-Like Protein 2 Exacerbates Brain Damage by Accelerating Acute Inflammation after Ischemia-Reperfusion

Amadatsu, T., Morinaga, J., Kawano, T., Terada, K., Kadomatsu, T., Miyata, K., Endo, M., Kasamo, D., Kuratsu, J., & Oike, Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166285 · Cited by 24

Role of innate inflammation in traumatic brain injury

Bourgeois-Tardif, S., Beaumont, L. D., Rivera, J. C., Chemtob, S., & Weil, A. G. (2021) · Neurological Sciences · doi:10.1007/s10072-020-05002-3 · Cited by 24

Unveiling the hidden connection: the blood-brain barrier’s role in epilepsy

Han, J., Wang, Y., Wei, P., Lu, D., & Shan, Y. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1413023 · Cited by 25

Astroglial cells as neuroendocrine targets in forebrain development: Implications for sex differences in psychiatric disease

Rurak, G. M., Woodside, B. C., Aguilar‐Valles, A., & Salmaso, N. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100897 · Cited by 24

SARS-CoV-2 may trigger inflammasome and pyroptosis in the central nervous system: a mechanistic view of neurotropism

Sepehrinezhad, A., Gorji, A., & Negah, S. S. (2021) · Inflammopharmacology · doi:10.1007/s10787-021-00845-4 · Cited by 23

Revealing the mechanisms of blood–brain barrier in chronic neurodegenerative disease: an opportunity for therapeutic intervention

Yu, S., Chen, X., Yang, T., Cheng, J., Liu, E., Jiang, L., Song, M., Shu, H., & Ma, Y. (2024) · Reviews in the Neurosciences · doi:10.1515/revneuro-2024-0040 · Cited by 24

Down-regulation of astrocytic sonic hedgehog by activation of endothelin ETB receptors: Involvement in traumatic brain injury-induced disruption of blood brain barrier in a mouse model

Michinaga, S., Inoue, A., Sonoda, K., Mizuguchi, H., & Kōyama, Y. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105042 · Cited by 23

Candidate SNP Markers of Familial and Sporadic Alzheimer's Diseases Are Predicted by a Significant Change in the Affinity of TATA-Binding Protein for Human Gene Promoters

Пономаренко, П. М., Чадаева, И. В., Рассказов, Д. А., Sharypova, E. B., Kashina, E. V., Drachkova, I. A., Zhechev, D. A., Ponomarenko, M. P., Savinkova, L. K., & Kolchanov, N. A. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00231 · Cited by 22

Cenicriviroc prevents dysregulation of astrocyte/endothelial cross talk induced by ischemia and HIV-1 via inhibiting the NLRP3 inflammasome and pyroptosis

Fattakhov, N. S., Ngo, A., Torices, S., Joseph, J.-A., Okoro, A., Moore, C., Naranjo, O., Becker, S., & Toborek, M. J. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00600.2023 · Cited by 22

Asymptomatic Herpes Simplex Virus Type 1 Infection Causes an Earlier Onset and More Severe Experimental Autoimmune Encephalomyelitis

Duarte, L. F., Altamirano-Lagos, M. J., Tabares-Guevara, J. H., Opazo, M. C., Díaz, M., Andino‐Navarrete, R., Muza, C., Vallejos, O. P., Riedel, C. A., Bueno, S. M., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.635257 · Cited by 21

HMGB1 Promotes the Release of Sonic Hedgehog From Astrocytes

Xiao, Y., Sun, Y., Liu, W. D., Zeng, F., Shi, J., Li, J., Chen, H., Tu, C., Xu, Y. X., Tan, Z., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.584097 · Cited by 21

Transient Opening of the Blood-Brain Barrier by Vasoactive Peptides to Increase CNS Drug Delivery: Reality Versus Wishful Thinking?

Smith-Cohn, M., Burley, N. B., & Grossman, S. A. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20999220131163504 · Cited by 21

Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease

Bettinetti‐Luque, M., Trujillo‐Estrada, L., García‐Fuentes, E., Andreo‐Lopez, J., Sanchez-Varo, R. M., Garrido‐Sánchez, L., Mediavilla, A. G., López, M. G., García‐Caballero, M., Gutiérrez, A., et al. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16243 · Cited by 21

Multifaceted Roles of Metzincins in CNS Physiology and Pathology: From Synaptic Plasticity and Cognition to Neurodegenerative Disorders

Brzdąk, P., Nowak, D., Wiera, G., & Mozrzymas, J. W. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00178 · Cited by 21

The sonic hedgehog pathway mediates Tongxinluo capsule‐induced protection against blood‐brain barrier disruption after ischaemic stroke in mice

Liu, S., Chang, L., & Wei, C. (2018) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13186 · Cited by 21

Aerobic exercise attenuates neurodegeneration and promotes functional recovery – Why it matters for neurorehabilitation & neural repair

Zhang, D., Lu, Y., Zhao, X., Zhang, Q., & Li, L. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104862 · Cited by 21

Transcriptomic Profile of Blood–Brain Barrier Remodeling in Cerebral Amyloid Angiopathy

Situ, M., Citalán‐Madrid, A. F., Stamatovic, S. M., Keep, R. F., & Andjelkovic, A. V. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.931247 · Cited by 21

Effects of fetal growth restriction on the perinatal neurovascular unit and possible treatment targets

Wu, B., Chand, K. K., Bell, A., Miller, S., Colditz, P. B., Malhotra, A. K., & Wixey, J. A. (2023) · Pediatric Research · doi:10.1038/s41390-023-02805-w · Cited by 22

Brain interleukins and Alzheimer’s disease

Abdelhamed, H. G., Hassan, A. A., Sakraan, A., Al-Deeb, R. T., Mousa, D. M., Ezz, H. S. A., Noor, N. A., Khadrawy, Y. A., & Radwan, N. M. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01538-5 · Cited by 20

Neuroimmune signaling at the brain borders

Frederick, N. M., Tavares, G. A., & Louveau, A. (2022) · Immunological Reviews · doi:10.1111/imr.13126 · Cited by 20

Astrocytes in ischemic stroke: Crosstalk in central nervous system and therapeutic potential

Liu, J., Guo, Y., Zhang, Y., Zhao, X., Fu, R., Hua, S., & Xu, S. (2023) · Neuropathology · doi:10.1111/neup.12928 · Cited by 21

Abrogated Caveolin-1 expression via histone modification enzyme Setdb2 regulates brain edema in a mouse model of influenza-associated encephalopathy

Imakita, N., Kitabatake, M., Ouji-Sageshima, N., Hara, A., Takemura, S., Kasahara, K., Matsukawa, A., Wanaka, A., Mikasa, K., & Ito, T. (2019) · Scientific Reports · doi:10.1038/s41598-018-36489-8 · Cited by 19

Discovery of benzo[cd]indol-2-one and benzylidene-thiazolidine-2,4-dione as new classes of NLRP3 inflammasome inhibitors via ER-β structure based virtual screening

Abdullaha, M., Ali, M., Kour, D., Kumar, A., & Bharate, S. B. (2019) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.103500 · Cited by 19

Natural products as potential modulators of pro-inflammatory cytokines signalling in Alzheimer's disease

Yadav, V., Mythri, C., & Kumarasamy, M. (2024) · Brain Behavior and Immunity Integrative · doi:10.1016/j.bbii.2024.100048 · Cited by 22

Cell death after traumatic brain injury: Detrimental role of anoikis in healing

Sater, A., Rael, L. T., Tanner, A. H., Lieser, M. J., Acuna, D. L., Mains, C. W., & Bar‐Or, D. (2018) · Clinica Chimica Acta · doi:10.1016/j.cca.2018.04.008 · Cited by 18

Tissue Plasminogen Activator Causes Brain Microvascular Endothelial Cell Injury After Oxygen Glucose Deprivation by Inhibiting Sonic Hedgehog Signaling

Gong, P., Li, M., Zou, C., Tian, Q., & Zhou, X. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2697-2 · Cited by 18

Hypercapnia exacerbates the disruption of the blood‑brain barrier by inducing interleukin‑1β overproduction in the blood of hypoxemic adult rats

Ding, H., Liu, X., Li, X., Wen, M., Li, Y., Han, Y., Huang, L., Liu, M., & Zeng, H. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4604 · Cited by 18

The Zonulin-transgenic mouse displays behavioral alterations ameliorated via depletion of the gut microbiota

Miranda-Ribera, A., Serena, G., Liu, J., Fasano, A., Kingsbury, M. A., & Fiorentino, M. R. (2021) · Tissue Barriers · doi:10.1080/21688370.2021.2000299 · Cited by 18

Anti-NMDAR antibodies, the blood–brain barrier, and anti-NMDAR encephalitis

Gong, X., Wang, N., Zhu, H., Tang, N., Wu, K., & Meng, Q. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1283511 · Cited by 18

Involvement of nitric oxide in the induction of interleukin-1 beta in microglia

Sudo, K., Takezawa, Y., Kohsaka, S., & Nakajima, K. (2015) · Brain Research · doi:10.1016/j.brainres.2015.08.030 · Cited by 17

An explanation of the role of pyroptosis playing in epilepsy

Zhang, X., Zhao, T., Su, S., Li, L., Zhang, Y., Yan, J., Cui, X., Sun, Y., Zhao, J., Han, X., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112386 · Cited by 15

Targeting NLRP3 signaling with a novel sulfonylurea compound for the treatment of vascular cognitive impairment and dementia

Akif, A., Nguyen, T. T. M., Liu, L., Xu, X., Kulkarni, A. A., Jiang, J., Zhang, Y., & Hao, J. (2025) · Fluids and Barriers of the CNS · doi:10.1186/s12987-025-00665-6 · Cited by 16

Cerebral adrenoleukodystrophy: a demyelinating disease that leaves the door wide open: Figure 1

Aubourg, P. (2015) · Brain · doi:10.1093/brain/awv271 · Cited by 15

Neutrophils-astrocyte interactions in central nervous system inflammation

Yuan, B., Zhang, X., Liu, L., Chai, Y., Zhang, J., & Chen, X. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07945-x · Cited by 15

Inhibiting the IRAK4/NF-κB/NLRP3 signaling pathway can reduce pyroptosis in hippocampal neurons and seizure episodes in epilepsy

Zhao, T., Zhang, X., Cui, X., Su, S., Li, L., Chen, Y., Wang, N., Sun, L., Zhao, J., Zhang, J., et al. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114794 · Cited by 15

Research progress of propofol in alleviating cerebral ischemia/reperfusion injury

Zheng, H., Xiao, X., Han, Y., Wang, P., Zang, L., Wang, L., Zhao, Y., Shi, P., Yang, P., Guo, C., et al. (2024) · Pharmacological Reports · doi:10.1007/s43440-024-00620-6 · Cited by 15

The Stenosis of Cerebral Arteries and Impaired Brain Glucose Uptake by Long-Lasting Inflammatory Cytokine Release from Dermatitis Is Rescued by Anti-IL-1 Therapy

Kato, S., Matsushima, Y., Mizutani, K., Kawakita, F., Fujimoto, M., Okada, K., Kondo, M., Habe, K., Suzuki, H., Mizutani, H., et al. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.04.016 · Cited by 15

Impact of Bone Fracture on Ischemic Stroke Recovery

Wei, M., Lyu, H., Huo, K., & Su, H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051533 · Cited by 15

The Progress in Diagnosis and Treatment of Exosomes and MicroRNAs on Epileptic Comorbidity Depression

Wei, N., Zhang, H., Wang, J., Wang, S., Lv, W., Luo, L., & Xu, Z. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00405 · Cited by 15

n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung–Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout

Hernandez, J., Schäffer, J., Herden, C., Pflieger, F. J., Reiche, S., Körber, S. S. E., Kitagawa, H., Welter, J., Michels, S., Culmsee, C., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713524 · Cited by 15

The Blood−Brain Barrier in Neuroimmune Interactions and Pathological Processes

Dyatlova, A. S., Novikova, N. S., Yushkov, B. G., Korneva, E. A., & Черешнев, В. А. (2022) · Herald of the Russian Academy of Sciences · doi:10.1134/s1019331622050100 · Cited by 16

Roles of astrocytic sonic hedgehog production and its signal for regulation of the blood-brain barrier permeability

(2024) · Vitamins and Hormones · doi:10.1016/bs.vh.2024.04.006 · Cited by 13

IL-1β Regulates Blood-Brain Barrier Permeability via Reactivation of the Hypoxia-Angiogenesis Program

Argaw, A. T., Zhang, Y., Snyder, B., Zhao, M., Kopp, N., Lee, S. C., Raine, C. S., Brosnan, C. F., & John, G. R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.8.5574 · Cited by 349

Netrin 1 regulates blood–brain barrier function and neuroinflammation

Podjaski, C., Alvarez, J. I., Bourbonniere, L., Larouche, S., Terouz, S., Bin, J. M., Lécuyer, M.-A., Saint-Laurent, O., Larochelle, C., Darlington, P. J., et al. (2015) · Brain · doi:10.1093/brain/awv092 · Cited by 185

Blood–brain barrier genetic disruption leads to protective barrier formation at the Glia Limitans

Mora, P., Hollier, P.-L., Guimbal, S., Abélanet, A., Diop, A., Cornuault, L., Couffinhal, T., Horng, S. H., Gadeau, A., Renault, M., et al. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000946 · Cited by 52

Astrocytic Sonic Hedgehog Alleviates Intracerebral Hemorrhagic Brain Injury via Modulation of Blood-Brain Barrier Integrity

Xing, G., Zhao, T., Zhang, X., He, L., Li, X., Cui, P., Li, M., Li, D., Zhang, N., & Jiang, W. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.575690 · Cited by 49