Netrin 1 regulates blood–brain barrier function and neuroinflammation
Open accessAbstract
Blood–brain barrier function is driven by the influence of astrocyte-secreted factors. During neuroinflammatory responses the blood–brain barrier is compromised resulting in central nervous system damage and exacerbated pathology. Here, we identified endothelial netrin 1 induction as a vascular response to astrocyte-derived sonic hedgehog that promotes autocrine barrier properties during homeostasis and increases with inflammation. Netrin 1 supports blood–brain barrier integrity by upregulating endothelial junctional protein expression, while netrin 1 knockout mice display disorganized tight junction protein expression and barrier breakdown. Upon inflammatory conditions, blood–brain barrier endothelial cells significantly upregulated netrin 1 levels in vitro and in situ, which prevented junctional breach and endothelial cell activation. Finally, netrin 1 treatment during experimental autoimmune encephalomyelitis significantly reduced blood–brain barrier disruption and decreased clinical and pathological indices of disease severity. Our results demonstrate that netrin 1 is an important regulator of blood–brain barrier maintenance that protects the central nervous system against inflammatory conditions such as multiple sclerosis and experimental autoimmune encephalomyelitis. Astrocyte-derived Sonic Hedgehog helps to maintain the integrity of the blood-brain barrier, but many of its downstream effectors are unknown. Podjaski et al. show that in multiple sclerosis, Sonic Hedgehog upregulates netrin-1 expression on the CNS vasculature, inducing an autocrine response that reduces blood-brain barrier permeability and dampens neuroinflammation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Neural guidance molecules such as netrins and semaphorins also shape the growing cerebrovasculature and BBB functions.
“and neural guidance molecules such as netrins and semaphorins also shape the growing cerebrovasculature and BBB functions (22, 475, 596, 628).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [475]
The Results show that netrin 1 contributes to blood–brain barrier integrity in human endothelial cells and newborn mice, and the Introduction reports angiogenic effects of netrins. But the Results found no difference in CNS vessel numbers in newborn netrin 1 knockout mice; this paper does not establish that netrin 1 shapes the growing cerebrovasculature. It does not address semaphorins, which may be covered by the sentence’s other citations. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Kebir, H., Kreymborg, K., Ifergan, I., Dodelet-Devillers, A., Cayrol, R., Bernard, M., Giuliani, F., Arbour, N., Becher, B., & Prat, A. (2007) · Nature Medicine · doi:10.1038/nm1651 · Cited by 1,759 · see citing works
Self-citationNetrin-1 Is Required for Commissural Axon Guidance in the Developing Vertebrate Nervous System
Serafini, T. A., Colamarino, S. A., Leonardo, E. D., Wang, H., Beddington, R. S. P., Skarnes, W. C., & Tessier‐Lavigne, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81795-x · Cited by 1,286 · see citing works
Unterberg, A. W., Stover, J., Kress, B., & Kiening, K. L. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.06.046 · Cited by 881 · see citing works
The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence
Alvarez, J. I., Dodelet-Devillers, A., Kebir, H., Ifergan, I., Fabre, P. J., Terouz, S., Sabbagh, M., Wosik, K., Bourbonnière, L., Bernard, M., et al. (2011) · Science · doi:10.1126/science.1206936 · Cited by 845 · see citing works
Self-citationSixt, M., Engelhardt, B., Pausch, F., Hallmann, R., Wendler, O., & Sorokin, L. M. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.5.933 · Cited by 504 · see citing works
Dynamics of CNS Barriers: Evolution, Differentiation, and Modulation
Abbott, N. J. (2005) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-004-1374-y · Cited by 471 · see citing works
Cayrol, R., Wosik, K., Berard, J. L., Dodelet-Devillers, A., Ifergan, I., Kebir, H., Haqqani, A. S., Kreymborg, K., Krug, S., Moumdjian, R., et al. (2008) · Nature Immunology · doi:10.1038/ni1551 · Cited by 444 · see citing works
Self-citationHypoxia-inducible factor–dependent induction of netrin-1 dampens inflammation caused by hypoxia
Rosenberger, P., Schwab, J. M., Mirakaj, V., Masekowsky, E., Mager, A., Morote–Garcia, J. C., Unertl, K. E., & Eltzschig, H. K. (2009) · Nature Immunology · doi:10.1038/ni.1683 · Cited by 406 · see citing works
van Gils, J. M., Derby, M. C., Fernandes, L. R., Ramkhelawon, B., Ray, T. D., Rayner, K. J., Parathath, S., Distel, E., Feig, J. L., Alvarez-Leite, J. I., et al. (2012) · Nature Immunology · doi:10.1038/ni.2205 · Cited by 365 · see citing works
Netrins Promote Developmental and Therapeutic Angiogenesis
Wilson, B. D., Ii, M., Park, K. W., Suli, A., Sorensen, L. K., Larrieu-Lahargue, F., Urness, L. D., Suh, W., Asai, J., Kock, G. A. H., et al. (2006) · Science · doi:10.1126/science.1124704 · Cited by 352 · see citing works
The axonal attractant Netrin-1 is an angiogenic factor
Park, K. W., Crouse, D., Lee, M., Karnik, S. K., Sorensen, L. K., Murphy, K. J., Kuo, C. J., & Li, D. Y. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405984101 · Cited by 335 · see citing works
Disruption of central nervous system barriers in multiple sclerosis
Alvarez, J. I., Cayrol, R., & Prat, A. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.06.017 · Cited by 334 · see citing works
Self-citationNetrin-1 inhibits leukocyte migration in vitro and in vivo
Ly, N. P., Komatsuzaki, K., Fraser, I. P., Tseng, A. A., Prodhan, P., Moore, K. J., & Kinane, T. B. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506233102 · Cited by 267 · see citing works
Srinivasan, K., Strickland, P. A., Valdes, A. M., Shin, G. C., & Hinck, L. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00054-6 · Cited by 263 · see citing works
Wosik, K., Cayrol, R., Dodelet-Devillers, A., Berthelet, F., Bernard, M., Moumdjian, R. A., Bouthillier, A., Reudelhuber, T. L., & Prat, A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2088-07.2007 · Cited by 259 · see citing works
Self-citationMolecular sieving characteristics of the cultured endothelial monolayer
Siflinger-Birnboim, A., Vecchio, P. J. D., Cooper, J. A., Blumenstock, F. A., Shepard, J. M., & Malik, A. B. (1987) · Journal of Cellular Physiology · doi:10.1002/jcp.1041320115 · Cited by 256 · see citing works
Inflammatory Cell Migration into the Central Nervous System: A Few New Twists on an Old Tale
Man, S., Ubogu, E. E., & Ransohoff, R. M. (2007) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00067.x · Cited by 235 · see citing works
Shekarabi, M., Moore, S. W., Tritsch, N. X., Morris, S. J., Bouchard, J., & Kennedy, T. E. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1920-04.2005 · Cited by 175 · see citing works
Self-citationEvolution of the blood–brain barrier in newly forming multiple sclerosis lesions
Gaitán, M. I., Shea, C. D., Evangelou, I. E., Stone, R. D., Fenton, K. M., Bielekova, B., Massacesi, L., & Reich, D. S. (2011) · Annals of Neurology · doi:10.1002/ana.22472 · Cited by 174 · see citing works
Pfeiffer, F., Schäfer, J., Lyck, R., Makrides, V., Brunner, S., Schaeren-Wiemers, N., Deutsch, U., & Engelhardt, B. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0883-2 · Cited by 160 · see citing works
Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B
Lejmi, E., Leconte, L., Pédron-Mazoyer, S., Ropert, S., Raoul, W., Lavalette, S., Bouras, I., Féron, J.-G., Maitre-Boube, M., Assayag, F., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804008105 · Cited by 148 · see citing works
Netrins and neogenin promote myotube formation
Kang, J.-S., Yi, M.-J., Zhang, W., Feinleib, J. L., Cole, F., & Krauss, R. S. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200405039 · Cited by 146 · see citing works
Larochelle, C., Cayrol, R., Kebir, H., Alvarez, J. I., Lécuyer, M.-A., Ifergan, I., Viel, É., Bourbonnière, L., Beauseigle, D., Terouz, S., et al. (2012) · Brain · doi:10.1093/brain/aws212 · Cited by 145 · see citing works
Self-citationTadagavadi, R. K., Wang, W., & Ramesh, G. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000435 · Cited by 131 · see citing works
The netrin receptor UNC5B promotes angiogenesis in specific vascular beds
Navankasattusas, S., Whitehead, K. J., Suli, A., Sorensen, L. K., Lim, A. H., Zhao, J., Park, K. W., Wythe, J. D., Thomas, K. R., Chien, C.-B., et al. (2008) · Development · doi:10.1242/dev.013623 · Cited by 127 · see citing works
The vascular contribution to Alzheimer's disease
Altman, R., & Rutledge, J. C. (2010) · Clinical Science · doi:10.1042/cs20100094 · Cited by 118 · see citing works
Ranganathan, P. V., Jayakumar, C., Mohamed, R., Dong, Z., & Ramesh, G. (2013) · Kidney International · doi:10.1038/ki.2012.423 · Cited by 113 · see citing works
Traction on Immobilized Netrin-1 Is Sufficient to Reorient Axons
Moore, S. W., Biais, N., & Sheetz, M. P. (2009) · Science · doi:10.1126/science.1173851 · Cited by 106 · see citing works
Netrin-4 induces lymphangiogenesis in vivo
Larrieu-Lahargue, F., Welm, A. L., Thomas, K. R., & Li, D. Y. (2010) · Blood · doi:10.1182/blood-2009-11-252338 · Cited by 101 · see citing works
Netrin-1 Signaling Dampens Inflammatory Peritonitis
Mirakaj, V., Gatidou, D., Pötzsch, C., König, K., & Rosenberger, P. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002671 · Cited by 79 · see citing works
Moore, S. W., Correia, J. P., Sun, K. L. W., Pool, M., Fournier, A. E., & Kennedy, T. E. (2008) · Development · doi:10.1242/dev.024133 · Cited by 77 · see citing works
Self-citationEarly netrin‐1 expression impairs central nervous system remyelination
Tepavčević, V., Kerninon, C., Aigrot, M. S., Meppiel, E., Mozafari, S., Arnould-Laurent, R., Ravassard, P., Kennedy, T. E., Nait‐Oumesmar, B., & Lubetzki, C. (2014) · Annals of Neurology · doi:10.1002/ana.24201 · Cited by 75 · see citing works
Self-citationFunctions of lipid raft membrane microdomains at the blood–brain barrier
Dodelet-Devillers, A., Cayrol, R., van Horssen, J., Haqqani, A. S., de Vries, H. E., Engelhardt, B., Greenwood, J., & Prat, A. (2009) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0488-6 · Cited by 70 · see citing works
Self-citationMaintenance of Axo-Oligodendroglial Paranodal Junctions Requires DCC and Netrin-1
Jarjour, A. A., Bull, S.-J., Almasieh, M., Rajasekharan, S., Baker, K. A., Mui, J., Antel, J., Polo, A. D., & Kennedy, T. E. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3285-08.2008 · Cited by 69 · see citing works
Self-citationNetrin-4 Enhances Angiogenesis and Neurologic Outcome after Cerebral Ischemia
Hoang, S., Liauw, J. A., Choi, M., Choi, M. Y., Guzman, R. G., & Steinberg, G. K. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.128 · Cited by 68 · see citing works
Netrin-4 regulates angiogenic responses and tumor cell growth
Nacht, M., Martin, T. B. S., Byrne, A. T., Klinger, K. W., Teicher, B. A., Madden, S. L., & Jiang, Y. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.11.018 · Cited by 61 · see citing works
Partial Netrin-1 Deficiency Aggravates Acute Kidney Injury
Grenz, A., Dalton, J. H., Bauerle, J. D., Badulak, A., Ridyard, D. G., Gandjeva, A., Aherne, C. M., Brodsky, K. S., Kim, J. H., Tuder, R. M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014812 · Cited by 53 · see citing works
Mutz, C. W., Mirakaj, V., Vagts, D. A., Westermann, P., Waibler, K., König, K., Iber, T., Nöldge‐Schomburg, G., & Rosenberger, P. (2010) · Critical Care · doi:10.1186/cc9301 · Cited by 36 · see citing works
Durrani, S., Haider, K. H., Ahmed, R. P. H., Jiang, S., & Ashraf, M. M. (2011) · Stem Cells and Development · doi:10.1089/scd.2011.0475 · Cited by 33 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Blood-Brain Barrier: From Physiology to Disease and Back
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,294 · see citing works
The role of inflammation in the development of epilepsy
Rana, A., & Musto, A. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1192-7 · Cited by 658 · see citing works
Mou, Y., Du, Y., Zhou, L., Yue, J., Hu, X., Liu, Y., Chen, S., Lin, X., Zhang, G., Xiao, H., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.796288 · Cited by 432 · see citing works
Ferritin Nanocarrier Traverses the Blood Brain Barrier and Kills Glioma
Fan, K., Jia, X., Zhou, M., Wang, K., Conde, J., He, J., Tian, J., & Yan, X. (2018) · ACS Nano · doi:10.1021/acsnano.7b06969 · Cited by 398 · see citing works
Erickson, M. A., & Banks, W. A. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014647 · Cited by 394 · see citing works
Barrier function in the peripheral and central nervous system—a review
Reinhold, A., & Rittner, H. L. (2016) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-016-1920-8 · Cited by 279 · see citing works
The quiescent endothelium: signalling pathways regulating organ-specific endothelial normalcy
Ricard, N., Bailly, S., Guignabert, C., & Simons, M. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00517-4 · Cited by 223 · see citing works
Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS
Chao, C., Gutiérrez‐Vázquez, C., Rothhammer, V., Mayo, L., Wheeler, M. A., Tjon, E. C., Zandee, S., Blain, M., de Lima, K. A., Takenaka, M. C., et al. (2019) · Cell · doi:10.1016/j.cell.2019.11.016 · Cited by 205 · see citing works
Self-citationMass Cytometry Imaging for the Study of Human Diseases—Applications and Data Analysis Strategies
Baharlou, H., Canete, N. P., Cunningham, A. L., Harman, A. N., & Patrick, E. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02657 · Cited by 176 · see citing works
Glial influences on BBB functions and molecular players in immune cell trafficking
Lécuyer, M., Kébir, H., & Prat, A. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.10.004 · Cited by 163 · see citing works
Self-citationNeuroinflammation as a Key Driver of Secondary Neurodegeneration Following Stroke?
Stuckey, S. M., Ong, L. K., Collins‐Praino, L. E., & Turner, R. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222313101 · Cited by 157 · see citing works
Endothelial Unc5B controls blood-brain barrier integrity
Boyé, K., Geraldo, L. H., Furtado, J., Pibouin-Fragner, L., Poulet, M., Kim, D., Nelson, B., Xu, Y., Jacob, L., Maïssa, N., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28785-9 · Cited by 139 · see citing works
Resolution of inflammation during multiple sclerosis
Ruiz, F., Vigne, S., & Pot, C. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00765-0 · Cited by 133 · see citing works
Glial-endothelial crosstalk regulates blood–brain barrier function
Cheslow, L., & Alvarez, J. I. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.09.010 · Cited by 113 · see citing works
Self-citationThe effect of systemic inflammation on human brain barrier function
Elwood, E., Lim, Z., Naveed, H., & Galea, I. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.10.020 · Cited by 109 · see citing works
Dual role of ALCAM in neuroinflammation and blood–brain barrier homeostasis
Lécuyer, M., Saint‐Laurent, O., Bourbonnière, L., Larouche, S., Larochelle, C., Michel, L., Charabati, M., Abadier, M., Zandee, S., Jahromi, N. H., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614336114 · Cited by 105 · see citing works
Self-citationBlood–brain barrier and its function during inflammation and autoimmunity
Sonar, S. A., & Lal, G. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.1ru1117-428r · Cited by 108 · see citing works
Impact on the brain of the inflammatory response to surgery
Saxena, S., & Maze, M. (2018) · La Presse Médicale · doi:10.1016/j.lpm.2018.03.011 · Cited by 103 · see citing works
Nishihara, H., Gastfriend, B. D., Soldati, S., Perriot, S., Mathias, A., Sano, Y., Shimizu, F., Gosselet, F., Kanda, T., Palecek, S., et al. (2020) · The FASEB Journal · doi:10.1096/fj.202001507rr · Cited by 73 · see citing works
The blood–brain barrier: a help and a hindrance
Rust, R., Yin, H. R., Buil, B. A., Sagare, A. P., & Kisler, K. (2025) · Brain · doi:10.1093/brain/awaf068 · Cited by 102 · see citing works
Autophagy as a Cellular Stress Response Mechanism in the Nervous System
Peker, N., & Gözüaçık, D. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.01.017 · Cited by 84 · see citing works
Multiplexed imaging of immune cells in staged multiple sclerosis lesions by mass cytometry
Ramaglia, V., Sheikh‐Mohamed, S., Legg, K., Park, C., Rojas, O. L., Zandee, S., Fu, F., Ornatsky, O., Swanson, E. C., Pitt, D., et al. (2019) · eLife · doi:10.7554/elife.48051 · Cited by 82 · see citing works
Self-citationMicroRNA-223 protects neurons from degeneration in experimental autoimmune encephalomyelitis
Morquette, B., Juźwik, C. A., Drake, S., Charabati, M., Zhang, Y., Lécuyer, M., Galloway, D. A., Dumas, A., de Faria, O., Paradis-Isler, N., et al. (2019) · Brain · doi:10.1093/brain/awz245 · Cited by 84 · see citing works
Self-citationWang, L., Geng, J., Qu, M., Yuan, F., Wang, Y., Pan, J., Li, Y., Ma, Y., Zhou, P., Zhang, Z., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-019-2206-9 · Cited by 83 · see citing works
The peripheral immune response after stroke—A double edge sword for blood‐brain barrier integrity
Li, Y., Zhu, Z., Huang, T., Zhou, Y., Wang, X., Yang, L., Chen, Z., Yu, W., & Li, P. (2018) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13081 · Cited by 83 · see citing works
Targeting sonic hedgehog signaling in neurological disorders
Patel, S. S., Tomar, S., Sharma, D., Mahindroo, N., & Malairaman, U. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.008 · Cited by 83 · see citing works
Kim, Y. R., Kim, Y. M., Lee, J., Park, J., Lee, J. E., & Hyun, Y. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.613733 · Cited by 82 · see citing works
Xie, Z., Huang, L., Enkhjargal, B., Reis, C., Wan, W., Tang, J., Cheng, Y. Z., & Zhang, J. H. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.11.012 · Cited by 76 · see citing works
Chen, J., Wang, Y., Li, M., Zhu, X., Liu, Z., Chen, Q., & Xiong, K. (2023) · Translational Stroke Research · doi:10.1007/s12975-022-01122-4 · Cited by 76 · see citing works
Lyck, R., Lécuyer, M.-A., Abadier, M., Wyss, C. B., Matti, C., Rosito, M., Enzmann, G., Zeis, T., Michel, L., García Martín, A. B., et al. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16678639 · Cited by 75 · see citing works
Self-citationChasseigneaux, S., Moraca, Y., Cochois, V., Boulay, A.-C., Gilbert, A., Crom, S. L., Blugeon, C., Firmo, C., Cisternino, S., Laplanche, J., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-30739-5 · Cited by 73 · see citing works
Guyon, J., Chapouly, C., Andrique, L., Bikfalvi, A., & Daubon, T. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.622615 · Cited by 67 · see citing works
Role of Hedgehog Signaling in Vasculature Development, Differentiation, and Maintenance
Chapouly, C., Guimbal, S., Hollier, P.-L., & Renault, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20123076 · Cited by 63 · see citing works
Brain repair mechanisms after cell therapy for stroke
Rust, R., Nih, L. R., Liberale, L., Yin, H. R., Amki, M. E., Ong, L. K., & Zloković, B. V. (2024) · Brain · doi:10.1093/brain/awae204 · Cited by 65 · see citing works
Axon Guidance Molecules Guiding Neuroinflammation
Lee, W. S., Lee, W., Bae, Y. C., & Suk, K. (2019) · Experimental Neurobiology · doi:10.5607/en.2019.28.3.311 · Cited by 61 · see citing works
Resolution of inflammation pathways in preeclampsia—a narrative review
Perucci, L. O., Júnior, M. D. C., Dusse, L. M. S., Gomes, K. B., & Sousa, L. P. (2017) · Immunologic Research · doi:10.1007/s12026-017-8921-3 · Cited by 57 · see citing works
Truncated netrin-1 contributes to pathological vascular permeability in diabetic retinopathy
Miloudi, K., Binet, F., Wilson, A. M., Cerani, A., Oubaha, M., Ménard, C., Henriques, S., Mawambo, G., Dejda, A., Nguyen, P. T., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84767 · Cited by 54 · see citing works
Self-citationXing, Y., Lai, J., Liu, X., Zhang, N., Ming, J., Liu, H., & Xi, Z. (2017) · Journal of Molecular Endocrinology · doi:10.1530/jme-16-0239 · Cited by 54 · see citing works
Sharabi, S., Bresler, Y., Ravid, O., Shemesh, C., Atrakchi, D., Beeri, M. S., Gosselet, F., Dehouck, L., Last, D., Guez, D., et al. (2019) · Drug Delivery · doi:10.1080/10717544.2019.1571123 · Cited by 54 · see citing works
Li, Y., Wu, P., Bihl, J. C., & Shi, H. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200106154203 · Cited by 53 · see citing works
Glial regulation of the blood-brain barrier in health and disease
Broux, B., Gowing, E., & Prat, A. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-015-0516-2 · Cited by 50 · see citing works
Self-citationCharabati, M., Grasmuck, C., Ghannam, S., Bourbonnière, L., Fournier, A. P., Lécuyer, M., Tastet, O., Kébir, H., Rébillard, R., Hoornaert, C., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abj0473 · Cited by 51 · see citing works
Self-citationAhn, E. H., Kang, S. S., Liu, X., Cao, X., Choi, S. Y., Musazzi, L., Mehlen, P., & Ye, K. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101905 · Cited by 51 · see citing works
Huang, J., Li, J., Li, S., Yang, X., Huo, N., Chen, Q., Wang, W., Yang, N., Wang, Y., & Zhou, N. (2024) · Science Advances · doi:10.1126/sciadv.adm8454 · Cited by 50 · see citing works
Onishi, K., & Zou, Y. (2017) · eLife · doi:10.7554/elife.25269 · Cited by 49 · see citing works
Yu, J., Li, C., Ding, Q., Que, J., Liu, K., Wang, H., & Liao, S. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00700 · Cited by 49 · see citing works
Xie, Z., Huang, L., Enkhjargal, B., Reis, C., Wan, W., Tang, J., Cheng, Y. Z., & Zhang, J. H. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.03.025 · Cited by 47 · see citing works
Astrocytic neogenin/netrin-1 pathway promotes blood vessel homeostasis and function in mouse cortex
Yao, L., Hu, J., Li, Q., Lee, D., Ren, X., Zhang, J., Sun, D., Zhang, H., Wang, Y.-G., Mei, L., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci132372 · Cited by 47 · see citing works
Lipopolysaccharide downregulates the expression of ZO-1 protein through the Akt pathway
Zou, P., Yang, F., Ding, Y., Zhang, D., Liu, Y., Zhang, J., Wu, D., & Wang, Y. (2022) · BMC Infectious Diseases · doi:10.1186/s12879-022-07752-1 · Cited by 48 · see citing works
Charabati, M., Zandee, S., Fournier, A. P., Tastet, O., Thai, K., Zaminpeyma, R., Lécuyer, M., Bourbonnière, L., Larouche, S., Klément, W., et al. (2022) · Brain · doi:10.1093/brain/awac389 · Cited by 45 · see citing works
Self-citationEGFL7 reduces CNS inflammation in mouse
Larochelle, C., Uphaus, T., Broux, B., Gowing, E., Paterka, M., Michel, L., Stanković, N. D., Bicker, F., Lemaître, F., Prat, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03186-z · Cited by 43 · see citing works
Self-citationRefueling the Ischemic CNS: Guidance Molecules for Vascular Repair
Rust, R., Grönnert, L., Weber, R., Mulders, G., & Schwab, M. E. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.05.006 · Cited by 44 · see citing works
Sánchez‐Fernández, A., Zandee, S., Amo‐Aparicio, J., Charabati, M., Prat, A., Garlanda, C., Eisenmesser, E. Z., Dinarello, C. A., & López‐Vales, R. (2020) · Theranostics · doi:10.7150/thno.47435 · Cited by 43 · see citing works
Self-citationXie, Z., Enkhjargal, B., Reis, C., Huang, L., Wan, W., Tang, J., Cheng, Y. Z., & Zhang, J. H. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.005198 · Cited by 44 · see citing works
Sun, Z., Zhao, H., Fang, D., Davis, C. T., Shi, D., Lei, K., Rich, B. E., Winter, J. M., Guo, L., Sorensen, L. K., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.07.015 · Cited by 42 · see citing works
Li, Y., Wan, S., Liu, G., Cai, W., Huo, D., Li, G., Yang, M., Wang, Y., Guan, G., Ding, N., et al. (2017) · Advanced Science · doi:10.1002/advs.201700278 · Cited by 42 · see citing works
Increased Serum Netrin-1 Is Associated With Improved Prognosis of Ischemic Stroke
Guo, D., Zhu, Z., Zhong, C., Peng, H. Y., Wang, A., Xu, T., Peng, Y., Xu, T., Chen, C.-S., Li, Q., et al. (2019) · Stroke · doi:10.1161/strokeaha.118.024631 · Cited by 42 · see citing works
Sun, L., Ju, T., Wang, T., Zhang, L., Ding, F., Zhang, Y., An, R., Sun, Y., Li, Y., Lu, Y., et al. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00124 · Cited by 42 · see citing works
Historical and current perspectives on blood endothelial cell heterogeneity in the brain
Matsuoka, R. L., Buck, L. D., Vajrala, K. P., Quick, R. E., & Card, O. A. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04403-1 · Cited by 39 · see citing works
Chen, N., Chen, X., Xie, J., Wu, C., & Qian, J. X. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10438 · Cited by 39 · see citing works
He, X., Liu, Y., Lin, X.-H., Yuan, F., Long, D., Zhang, Z., Wang, Y., Xuan, A., & Yang, G. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1291-5 · Cited by 39 · see citing works
Netrin-1 is a novel regulator of vascular endothelial function in diabetes
Toque, H. A., Fernandez‐Flores, A., Mohamed, R., Caldwell, R. B., Ramesh, G., & Caldwell, R. W. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186734 · Cited by 38 · see citing works
The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders
Prajapati, A., Mehan, S., & Khan, Z. (2023) · Biogerontology · doi:10.1007/s10522-023-10034-1 · Cited by 39 · see citing works
Astrocytes in the Traumatic Brain Injury: the Good and the Bad
Yuan, M., & Wu, H. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113943 · Cited by 36 · see citing works
Netrin‐1 and its receptor Unc5b are novel targets for the treatment of inflammatory arthritis
Mediero, A., Wilder, T., Ramkhelawon, B., Moore, K. J., & Cronstein, B. N. (2016) · The FASEB Journal · doi:10.1096/fj.201600615r · Cited by 36 · see citing works
Clobetasol Modulates Adult Neural Stem Cell Growth via Canonical Hedgehog Pathway Activation
Vicario, N., Bernstock, J. D., Spitale, F. M., Giallongo, C., Giunta, M. A. S., Volti, G. L., Gulisano, M., Leanza, G., Tibullo, D., Parenti, R., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081991 · Cited by 36 · see citing works
Netrin‐1 and multiple sclerosis: a new biomarker for neuroinflammation?
Mulero, P., Córdova, C., Hernández, M., Martín, R., Gutiérrez, B., Muñoz, J. C., Redondo, N., Gallardo, I., Téllez, N., & Nieto, M. L. (2017) · European Journal of Neurology · doi:10.1111/ene.13340 · Cited by 34 · see citing works
Ibrahim, W. W., Sayed, R. H., Kandil, E. A., & Wadie, W. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110583 · Cited by 34 · see citing works
Understanding netrins and semaphorins in mature endothelial cell biology
Zhang, H., Vreeken, D., Bruikman, C. S., van Zonneveld, A. J., & van Gils, J. M. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.09.015 · Cited by 34 · see citing works
Bohannon, D. G., Long, D., & Kim, W. (2021) · Cells · doi:10.3390/cells10040890 · Cited by 34 · see citing works
The hedgehog pathway suppresses neuropathogenesis in CD4 T cell-driven inflammation
Benallegue, N., Kébir, H., Kapoor, R., Crockett, A. M., Li, C., Cheslow, L., Abdel-Hakeem, M. S., Gesualdi, J., Miller, M. C., Wherry, E. J., et al. (2021) · Brain · doi:10.1093/brain/awab083 · Cited by 31 · see citing works
Self-citationUnraveling Axon Guidance during Axotomy and Regeneration
Domínguez-Romero, M. E., & Slater, P. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158344 · Cited by 33 · see citing works
Dysregulation of sonic hedgehog pathway and pericytes in the brain after lentiviral infection
Bohannon, D. G., Ko, A., Filipowicz, A. R., Kuroda, M. J., & Kim, W. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1463-y · Cited by 31 · see citing works
Li, K., Wang, J., Chen, L., Guo, M., Zhou, Y., Li, X., 张宗泽, & Peng, M. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.751570 · Cited by 31 · see citing works
Aloizou, A., Siokas, V., Pateraki, G., Liampas, I., Bakirtzis, C., Tsouris, Z., Lazopoulos, G., Călina, D. C., Docea, A. O., Tsatsakis, A. M., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10040630 · Cited by 30 · see citing works
Toomajian, V., Tundo, A., Ural, E. E., Greeson, E. M., Contag, C. H., & Makela, A. V. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c04920 · Cited by 29 · see citing works
Netrin-1 in Glioblastoma Neovascularization: The New Partner in Crime?
Vásquez, X., Sánchez‐Gómez, P., & Palma, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158248 · Cited by 28 · see citing works
Yang, X., & Chen, X. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44110386 · Cited by 27 · see citing works
Netrin-1 in Post-stroke Neuroprotection: Beyond Axon Guidance Cue
Liao, S., Yu, J., & Luo, Y. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220302150723 · Cited by 26 · see citing works
Netrin-4 expression by human endothelial cells inhibits endothelial inflammation and senescence
Zhang, H., Vreeken, D., Leuning, D. G., Bruikman, C. S., Junaid, A., Stam, W., de Bruin, R. G., Sol, W. M. P. J., Rabelink, T. J., van den Berg, B. M., et al. (2021) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2021.105960 · Cited by 26 · see citing works
Casas, B. S., Vitória, G., Prieto, C. P., Casas, M., Chacón, C., Uhrig, M., Ezquer, F. E., Ezquer, M., Rehen, S. K., & Palma, V. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01653-0 · Cited by 25 · see citing works
Reverse transendothelial cell migration in inflammation: to help or to hinder?
Burn, T. N., & Alvarez, J. I. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2444-2 · Cited by 25 · see citing works
Self-citationNeuroinflammation: Extinguishing a blaze of T cells
Benallegue, N., Kébir, H., & Alvarez, J. I. (2022) · Immunological Reviews · doi:10.1111/imr.13122 · Cited by 25 · see citing works
Self-citationMaking Connections: Guidance Cues and Receptors at Nonneural Cell–Cell JunctionsPreprint
Beamish, I. V., Hinck, L., & Kennedy, T. E. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a029165 · Cited by 23 · see citing works
Self-citationThe role of axon guidance molecules in the pathogenesis of epilepsy
Liu, Z., Pan, C., & Huang, H. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01620 · Cited by 23 · see citing works
Zhang, H., Younsi, A., Zheng, G., Tail, M., Harms, A.-K., Roth, J., Hatami, M., Skutella, T., Unterberg, A. W., & Zweckberger, K. (2021) · European Spine Journal · doi:10.1007/s00586-021-06796-2 · Cited by 22 · see citing works
Kokulu, K., Mutlu, H., & Sert, E. T. (2020) · Clinical Toxicology · doi:10.1080/15563650.2020.1743302 · Cited by 22 · see citing works
Bohannon, D. G., Okhravi, H. R., Kim, J., Kuroda, M. J., Didier, E. S., & Kim, W. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.08.006 · Cited by 21 · see citing works
Ji, X., Liu, H., Chen, A., Wang, Y., Zhao, H., Zhang, Q., Li, M., Qi, F., Chen, Z., Wang, X., et al. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.04.025 · Cited by 20 · see citing works
The blood-brain interface: a culture change
Galea, I., & Perry, V. H. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.10.014 · Cited by 20 · see citing works
MARCKS Is Necessary for Netrin-DCC Signaling and Corpus Callosum Formation
Brudvig, J. J., Cain, J. T., Schmidt-Grimminger, G. G., Stumpo, D. J., Roux, K. J., Blackshear, P. J., & Weimer, J. M. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0990-3 · Cited by 20 · see citing works
Li, L., Huang, Y., Gao, Y., Shi, T., Xu, Y., Li, H., Hyytiäinen, M. M., Keski‐Oja, J., Jiang, Q., Hu, Y., et al. (2018) · BMC Cancer · doi:10.1186/s12885-018-5056-4 · Cited by 20 · see citing works
Lu, Z., Zhang, D., Cui, K., Fu, X., Man, J., Lu, H., Yu, L., Gao, Y., Liu, X., Liao, L., et al. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.12.011 · Cited by 19 · see citing works
Netrin-1 as a Multitarget Barrier Stabilizer in the Peripheral Nerve after Injury
Chen, J. T.-C., Schmidt, L., Schürger, C., Hankir, M. K., Krug, S. M., & Rittner, H. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810090 · Cited by 17 · see citing works
Lin, R., Li, M., Luo, M., Teng, T., Pan, Y., & Huang, H. (2019) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-019-0167-8 · Cited by 17 · see citing works
Huang, H., Lin, F. Y., Jiang, J., Chen, Y., Mei, A., & Zhu, P. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0671-6 · Cited by 16 · see citing works
Wang, J., Zhai, W., Yu, Z., Sun, L., Li, H., Shen, H., Li, X., Liu, C., & Chen, G. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00432 · Cited by 16 · see citing works
A Review of the Biological Mechanisms of Dexmedetomidine for Postoperative Neurocognitive Disorders
Yu, S., Leng, Y., Wang, Y., & Guoqing, Z. (2022) · Medical Science Monitor · doi:10.12659/msm.937862 · Cited by 16 · see citing works
Cerebral adrenoleukodystrophy: a demyelinating disease that leaves the door wide open: Figure 1
Aubourg, P. (2015) · Brain · doi:10.1093/brain/awv271 · Cited by 15 · see citing works
Diverse roles for axon guidance pathways in adult tissue architecture and function
Laws, K. M., & Bashaw, G. J. (2022) · Natural Sciences · doi:10.1002/ntls.20220021 · Cited by 15 · see citing works
- Authors
- Podjaski, C., Alvarez, J. I., Bourbonniere, L., Larouche, S., Terouz, S., Bin, J. M., Lécuyer, M.-A., Saint-Laurent, O., Larochelle, C., Darlington, P. J., Arbour, N., Antel, J. P., Kennedy, T. E., & Prat, A.
- Affiliations
- Montreal Neurological Institute and Hospital (CA)
- Centre Hospitalier de l’Université de Montréal (CA)
- ORCID
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-04-22
- Volume
- 138
- Issue
- 6
- Pages
- 1598-1612
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- PMC
- PMC4614143
- OpenAlex
- W1963680784
- Cited by
- 185
- References
- 39
- Citations by year
- 2026: 11 · 2025: 16 · 2024: 18 · 2023: 8 · 2022: 26 · 2021: 20 · 2020: 18 · 2019: 21 · 2018: 15 · 2017: 17 · 2016: 10 · 2015: 4 · 2013: 1
- FWCI
- 8.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (113558_1)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- netrin-1, blood-brain barrier, neuroinflammation, Sonic hedgehog, astrocytes, endothelial cells, tight junctions, endothelial barrier integrity, experimental autoimmune encephalomyelitis, multiple sclerosis, autocrine signaling, blood-brain barrier permeability
- MeSH terms
- Netrin-1, Animals, Anti-Inflammatory Agents, Blood Proteins, Blood-Brain Barrier, Encephalomyelitis, Autoimmune, Experimental, Humans, Inflammation, Membrane Proteins, Multiple Sclerosis, Nerve Growth Factors, Permeability, Up-Regulation, Mice, Knockout, Inflammation Mediators, Tight Junctions, Tumor Suppressor Proteins, Endothelial Cells, Mice, Primary Cell Culture
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
